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Agar (bacteriological) | C14H24O9 - PubChem

NIH

U.S. National Library of Medicine

National Center for Biotechnology Information

of Medicine National Center for Biotechnology Information Compound Summary for CID 71571511 PUBCHEM COMPOUND AGAR
of Medicine National Center for Biotechnology Information Compound Summary for CID 71571511 PUBCHEM COMPOUND AGAR

Compound Summary for CID 71571511of Medicine National Center for Biotechnology Information PUBCHEM COMPOUND AGAR (BACTERIOLOGICAL) Agar

PUBCHEM

Information Compound Summary for CID 71571511 PUBCHEM COMPOUND AGAR (BACTERIOLOGICAL) Agar (Bacteriological)

COMPOUND

AGAR (BACTERIOLOGICAL)Compound Summary for CID 71571511 PUBCHEM COMPOUND Agar (Bacteriological) Vendors Drug Information Pharmacology

Agar (Bacteriological)

COMPOUND AGAR (BACTERIOLOGICAL) Agar (Bacteriological) Vendors Drug Information Pharmacology Literature Cite this

Vendors

Drug Information

Pharmacology

Literature

Cite this Record

Cite this Record

Drug Information Pharmacology Literature Cite this Record PubChem CID: 71571511 Chemical Names: Agar

PubChem CID:

71571511

Chemical Names:

Agar (bacteriological); 9002-18-0;

More
More

Molecular Formula:

C

14

H

24

O

9

Molecular Weight:

336.33496 g/mol

InChI Key:

GYYDPBCUIJTIBM-DYOGSRDZSA-N

Modify Date:

2016-02-07

Create Date:

2013-06-21

Agar (bacteriological) is a complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.

medium for immunodiffusion and immunoelectrophoresis. from MeSH Agar agar is a tan powder. (NTP, 1992) Physical

from MeSH

Agar agar is a tan powder. (NTP, 1992)

from MeSH Agar agar is a tan powder. (NTP, 1992) Physical Description from CAMEO Chemicals 1

Physical Description from CAMEO Chemicals

Agar (bacteriological) | C14H24O9 - PubChem

Agar (bacteriological) | C14H24O9 - PubChem Contents https://pubchem.ncbi.nlm.nih.gov/compound/71571511#section=Top

Contents

1 2D Structure

2 3D Conformer

3 Names and Identifiers

4 Chemical and Physical Properties

5 Related Records

6 Chemical Vendors

7 Drug and Medication Information

8 Pharmacology and Biochemistry

9 Use and Manufacturing

10 Identification

11 Safety and Hazards

12 Toxicity

13 Literature

14 Classification

15 Information Sources

Agar (bacteriological) | C14H24O9 - PubChem

1 2D Structure

Search Download Get Image Magnify from PubChem 3 de 23

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Download

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Get Image

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Magnify

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from PubChem

Agar (bacteriological) | C14H24O9 - PubChem

2 3D Conformer

Search Download Get Image Magnify Show Hydrogens Show Atoms Animate
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Download
Get Image
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Show Hydrogens
Show Atoms
Animate

from PubChem

Agar (bacteriological) | C14H24O9 - PubChem

3 Names and Identifiers

3.1 Computed Descriptors

3.1.1 IUPAC Name

(2R,3S,4S,5R)-2-(hydroxymethyl)-6-[[(4R,5S)-4-hydroxy-3-methyl-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-

4-methoxyoxane-3,5-diol

4-methoxyoxane-3,5-diol from PubChem 3.1.2 InChI

from PubChem

3.1.2 InChI

InChI=1S/C14H24O9/c1-5-8(16)13-11(7(21-5)4-20-13)23-14-10(18)12(19-2)9(17)6(3-15)22-14/h5-18H,3-4H2,1-2H3

/t5?,6-,7?,8-,9+,10-,11?,12+,13+,14?/m1/s1

 
  from PubChem

from PubChem

3.1.3

InChI Key

GYYDPBCUIJTIBM-DYOGSRDZSA-N

 
 
  from PubChem

from PubChem

3.1.4

Canonical SMILES

CC1C(C2C(C(O1)CO2)OC3C(C(C(C(O3)CO)O)OC)O)O

 
 
  from PubChem

from PubChem

3.1.5

Isomeric SMILES

CC1[C@H]([C@H]2C(C(O1)CO2)OC3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)OC)O)O

 
 
  from PubChem

from PubChem

3.2 Other Identifiers

3.2.1 EC Number

232-658-1

PubChem 3.2 Other Identifiers 3.2.1 EC Number 232-658-1 from ECHA 3.3 Synonyms 3.3.1 MeSH Synonyms 5

from ECHA

3.3 Synonyms

3.3.1 MeSH Synonyms

Agar (bacteriological) | C14H24O9 - PubChem

Agar

from MeSH 3.3.2 Depositor-Supplied Synonyms 1. Agar

from MeSH

3.3.2 Depositor-Supplied Synonyms

1. Agar (bacteriological)

2. 9002-18-0

3.3.2 Depositor-Supplied Synonyms 1. Agar (bacteriological) 2. 9002-18-0 from PubChem 6 de 23 10/02/2016 11:09 a.

from PubChem

Agar (bacteriological) | C14H24O9 - PubChem

4 Chemical and Physical Properties

4.1 Computed Properties

Molecular Weight

336.33496 g/mol

 

Molecular Formula

C

14

H

24

O

9

XLogP3

-2.2

 

Hydrogen Bond Donor Count

4

Hydrogen Bond Acceptor Count

9

Rotatable Bond Count

4

Exact Mass

336.142032

g/mol

Monoisotopic Mass

336.142032

g/mol

Topological Polar Surface Area

127 A^2

 

Heavy Atom Count

23

 

Formal Charge

0

Complexity

408

 

Isotope Atom Count

0

Defined Atom Stereocenter Count

6

Undefined Atom Stereocenter Count

4

Defined Bond Stereocenter Count

0

Undefined Bond Stereocenter Count

0

Covalently-Bonded Unit Count

1

Count 0 Covalently-Bonded Unit Count 1 from PubChem 4.2 Experimental Properties 4.2.1 Physical

from PubChem

4.2 Experimental Properties

4.2.1 Physical Description

Agar agar is a tan powder. (NTP, 1992)

Physical Description Agar agar is a tan powder. (NTP, 1992) from CAMEO Chemicals 4.2.2 Color Transparent

from CAMEO Chemicals

4.2.2 Color

Transparent strips or coarse or fine powder

Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34

and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34 from HSDB 7 de

from HSDB

Agar (bacteriological) | C14H24O9 - PubChem

Thin, translucent, membranous pieces, or pale buff powder

Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 26

ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 26 from HSDB usually in

from HSDB

usually

in the form of chopped shreds, sheets, flakes, granules, or powder.

Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed. Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V12 (94) 844

from HSDBNY. John Wiley and Sons, 1991-Present., p. V12 (94) 844 4.2.3 Odor Odorless Budavari, S. (ed.).

4.2.3 Odor

Odorless

Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34

Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34 from HSDB 4.2.4 Taste Tasteless Budavari,

from HSDB

4.2.4 Taste

Tasteless

Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34

Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34 from HSDB 4.2.5 Solubility less than

from HSDB

4.2.5 Solubility

less than 1 mg/mL at 63 ° F

(NTP, 1992)

4.2.5 Solubility less than 1 mg/mL at 63 ° F (NTP, 1992) from CAMEO Chemicals Slowly

from CAMEO Chemicals

Slowly sol in hot water to a viscid soln

Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34

Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34 from HSDB Insol in cold water

from HSDB

Insol in cold water

Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34

Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34 from HSDB Insol in alcohol Budavari,

from HSDB

Insol in alcohol

Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34

Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 34 from HSDB 4.2.6 Decomposition When heated

from HSDB

4.2.6 Decomposition

When heated to decomposition, it emits acrid smoke and fumes.

Agar (bacteriological) | C14H24O9 - PubChem

Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 78

from HSDB1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 78 4.2.7 Viscosity RELATIVELY LOW VISCOSITIES FOR

4.2.7 Viscosity

RELATIVELY LOW VISCOSITIES FOR SEAWEED EXTRACTS; VISCOSITY IS DEPENDENT ON TEMP & PH, BUT FAIRLY CONSTANT FROM PH 4.5-9.0

Furia, T.E. (ed.). CRC Handbook of Food Additives. 2nd ed. Cleveland: The Chemical Rubber Co., 1972., p. 305

from HSDBCRC Handbook of Food Additives. 2nd ed. Cleveland: The Chemical Rubber Co., 1972., p. 305 9

Agar (bacteriological) | C14H24O9 - PubChem

5 Related Records

5.1 Related Compounds with Annotation

Download5.1 Related Compounds with Annotation Literature (2) 3D Structure (1) Bioactivities (1)

Literature (2)

3D Structure (1)

Bioactivities (1)

Patents (28)

Literature (2) 3D Structure (1) Bioactivities (1) Patents (28) neoagarobiose glucopyranosyl-(1-4)-1,6- …
Literature (2) 3D Structure (1) Bioactivities (1) Patents (28) neoagarobiose glucopyranosyl-(1-4)-1,6- …

neoagarobiose

glucopyranosyl-(1-4)-1,6-

 
  from PubChem

from PubChem

5.2

Related Compounds

Same Connectivity

8

records

Same Parent, Connectivity

8

records

Similar Compounds

496 records

 

Similar Conformers

9

records

 
  from PubChem

from PubChem

5.3

Substances

5.3.1

Related Substances

Same

3

records

 
  from PubChem

from PubChem

5.3.2 Substances by Category

Download  from PubChem 5.3.2 Substances by Category Chemical Vendors (1) Governmental Organizations (2) 10 de

Chemical Vendors (1)Governmental Organizations (2)

Governmental Organizations (2)Chemical Vendors (1)

Agar (bacteriological) | C14H24O9 - PubChem

Agar (bacteriological) | C14H24O9 - PubChem https://pubchem.ncbi.nlm.nih.gov/compound/71571511#section=Top from PubChem

from PubChem

Agar (bacteriological) | C14H24O9 - PubChem

6 Chemical Vendors

Refine/Analyze Download Vendor/Supplier Purchasable

Refine/Analyze

Refine/Analyze Download Vendor/Supplier Purchasable Chemical PubChem

Download

Vendor/Supplier

Purchasable Chemical

PubChem SID

ApexBio Technology

A2530

163614733

Chemical PubChem SID ApexBio Technology A2530 163614733 from PubChem 12 de 23 10/02/2016 11:09 a. m.

from PubChem

Agar (bacteriological) | C14H24O9 - PubChem

7 Drug and Medication Information

7.1 Therapeutic Uses

IT MAY BE EATEN AS A CEREAL SUBSTITUTE OR ADDED TO OTHER FOODS, OR IT MAY BE DISSOLVED IN HOT WATER & ALLOWED TO GEL BEFORE BEING TAKEN. HOWEVER, AGAR IS A RELATIVELY INEFFECTIVE BULK-FORMING AGENT IN THE USUAL DOSE OF 4 TO 16 G.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 979

ed. New York: Macmillan Publishing Co., Inc., 1975., p. 979 from HSDB ALSO EMPLOYED AS AN

from HSDB

ALSO

EMPLOYED AS AN EMULSIFYING AGENT IN A VARIETY OF PROPRIETARY NOSTRUMS COMBINED

WITH MINERAL OIL & OTHER CATHARTICS, BUT THE DOSE OF AGAR IN THESE PREPARATIONS IS TOO SMALL TO CONTRIBUTE TO THEIR LAXATIVE EFFECT.

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 979

from HSDBed. New York: Macmillan Publishing Co., Inc., 1975., p. 979 MEDICATION (VET): LAXATIVE USED IN CONSTIPATION.

MEDICATION (VET): LAXATIVE

USED

IN CONSTIPATION.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 6

Drugs. New York: Springer Publishing Company, 1974., p. 6 from HSDB MECHANISTIC STUDIES REVEALED ANTIPEPTIC EFFECT

from HSDB

MECHANISTIC STUDIES REVEALED ANTIPEPTIC EFFECT OF AGAR WAS DUE TO A SUBSTRATE-INHIBITOR INTERACTION WITH HEMOGLOBIN. POSSIBLE SIGNIFICANCE IN THE INHIBITORY EFFECT OF AGAR IN ULCER THERAPY.

GOUDA MW; JODHKA G; INHIBITORY EFFECT OF AGAR ON PEPSIN ACTIVITY; CAN J PHARM SCI 12 (1): 4 (1977)

OF AGAR ON PEPSIN ACTIVITY; CAN J PHARM SCI 12 (1): 4 (1977) from HSDB NINE

from HSDB

NINE FULL- TERM INFANTS GIVEN A FORMULA SUPPLEMENTED WITH AGAR EXCRETED MORE BILIRUBIN IN FECES WITHIN FIRST 5 DAYS OF LIFE, & LOST LESS WEIGHT THAN CONTROL INFANTS. RESULTS SUGGEST POSSIBLE USE OF AGAR FOR MGMNT OF CERTAIN TYPES OF HYPERBILIRUBINEMIA.

POLAND RL, ODELL GB; NEW ENGLAND J MEDICINE 284 (1): 1 (1971)

RL, ODELL GB; NEW ENGLAND J MEDICINE 284 (1): 1 (1971) from HSDB As a bulk

from HSDB

As a bulk laxative, particularly in chronic constipation

Leung, A.Y., Foster, S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. New York, NY. John Wiley & Sons, Inc. 1996., p. 10

New York, NY. John Wiley & Sons, Inc. 1996., p. 10 from HSDB 7.2 Minimum/Potential Fatal

from HSDB

7.2 Minimum/Potential Fatal Human Dose

1(?)= PRACTICALLY NON-TOXIC: PROBABLE ORAL LETHAL DOSE (HUMAN) ABOVE 15 G/KG, MORE THAN 1 QUART FOR 70 KG PERSON (150 LB). /GUMS, VEGETABLE/

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore:

Williams and Wilkins, 1976., p. II-6

Commercial Products. 4th ed. Baltimore: Williams and Wilkins, 1976., p. II-6 from HSDB 13 de 23

from HSDB

Agar (bacteriological) | C14H24O9 - PubChem

8 Pharmacology and Biochemistry

8.1 MeSH Pharmacological Classification

Culture Media

Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN. See a list of PubChem compounds matching this category.

See a list of PubChem compounds matching this category. from MeSH 8.2 Absorption, Distribution and Excretion

from MeSH

8.2 Absorption, Distribution and Excretion

It passes through the intestinal tract mostly unabsorbed.

Leung, A.Y., Foster, S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. New York, NY. John Wiley & Sons, Inc. 1996., p. 10

from HSDBNew York, NY. John Wiley & Sons, Inc. 1996., p. 10 8.3 Mechanism of Action THESE

8.3 Mechanism of Action

THESE SUBSTANCES DISSOLVE OR SWELL IN WATER TO FORM AN EMOLLIENT GEL OR VISCOUS SOLN THAT SERVES TO MAINTAIN THE FECES SOFT & HYDRATED. THE RESULTING BULK PROMOTES PERISTALSIS, & TRANSIT TIME IS REDUCED. /BULK-FORMING LAXATIVES/

Goodman, L.S., and A. Gilman. (eds.) The Pharmacological Basis of Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 978

Therapeutics. 5th ed. New York: Macmillan Publishing Co., Inc., 1975., p. 978 from HSDB 14 de

from HSDB

Agar (bacteriological) | C14H24O9 - PubChem

9 Use and Manufacturing

9.1 Methods of Manufacturing

HARVESTING, EXTRACTION, & PROCESSING OF VARIOUS RED-PURPLE SPECIES OF ALGAE OF THE CLASS RHODOPHYCEAE

SRI

RED-PURPLE SPECIES OF ALGAE OF THE CLASS RHODOPHYCEAE SRI from HSDB The agar can be extracted

from HSDB

The agar can be extracted from the seaweed with hot water, followed by freezing and thawing for purification. Commercial extraction procedures involve washing, chemical extraction, filtration, gelation, freezing, bleaching, washing, drying, and milling.

Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed. Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V12 (94) 844

from HSDBNY. John Wiley and Sons, 1991-Present., p. V12 (94) 844 9.2 Formulations/Preparations Grades: technical; USP; FCC.

9.2 Formulations/Preparations

Grades: technical; USP; FCC.

Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 26

ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 26 from HSDB 9.3 Consumption

from HSDB

9.3 Consumption

ABOUT 38% AS AN INGREDIENT OF CULTURE MEDIA; 19% IN BAKED GOODS; 10% IN CONFECTIONS; 10% IN MEAT & POULTRY; 8% IN DESSERTS & BEVERAGES; 4% IN LAXATIVES & HEALTH FOODS; 4% IN PET FOODS; 3% IN IMPRESSION MATERIALS; 3% IN MISC APPLICATIONS; 1% IN PHARMACEUTICALS (1968)

SRI

 
  from HSDB

from HSDB

9.4

U.S. Production

(1972) 6.7X10+8 GRAMS (CONSUMPTION)

 

SRI

 
  from HSDB

from HSDB

(1975) 3.24X10+8 GRAMS

 

SRI

 
  from HSDB

from HSDB

9.5 U.S. Imports

(1972) 5.36X10+8 GRAMS

SRI

Agar (bacteriological) | C14H24O9 - PubChem

Agar (bacteriological) | C14H24O9 - PubChem https://pubchem.ncbi.nlm.nih.gov/compound/71571511#section=Top from HSDB

from HSDB

(1975) 4.05X10+8 GRAMS

SRI

from HSDBfrom HSDB (1975) 4.05X10+8 GRAMS SRI 16 de 23 10/02/2016 11:09 a. m.

Agar (bacteriological) | C14H24O9 - PubChem

10 Identification

10.1 Analytic Laboratory Methods

AOAC Method 945.57. Agar in Meat. Qualitative Test.

Association of Official Analytical Chemists. Official Methods of Analysis. 15th ed. and Supplements. Washington, DC: Association of Analytical Chemists, 1990, p. 945

Supplements. Washington, DC: Association of Analytical Chemists, 1990, p. 945 from HSDB 17 de 23 10/02/2016

from HSDB

Agar (bacteriological) | C14H24O9 - PubChem

11 Safety and Hazards

11.1 Accidental Release Measures

11.1.1 Disposal Methods

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

agencies for guidance on acceptable disposal practices. from HSDB 11.2 Stability and Reactivity 11.2.1 Air and

from HSDB

11.2 Stability and Reactivity

11.2.1 Air and Water Reactions

Water insoluble.

from CAMEO ChemicalsReactivity 11.2.1 Air and Water Reactions Water insoluble. 11.2.2 Reactive Group Alcohols and Polyols; Ethers from

11.2.2 Reactive Group

Alcohols and Polyols; Ethers

from CAMEO Chemicals11.2.2 Reactive Group Alcohols and Polyols; Ethers 11.3 Regulatory Information 11.3.1 FDA Requirements

11.3 Regulatory Information

11.3.1 FDA Requirements

Substance added directly to human food affirmed as generally recognized as safe (GRAS).

21 CFR 184.1115 (4/1/99)

from HSDBrecognized as safe (GRAS). 21 CFR 184.1115 (4/1/99) Agar-agar used as a stabilizer in animal drugs,

Agar-agar used as a stabilizer in animal drugs, feeds, and related products is generally recognized as safe when used in accordance with good manufacturing or feeding practice.

21 CFR 582.7115 (4/1/99)

manufacturing or feeding practice. 21 CFR 582.7115 (4/1/99) from HSDB Manufacturers, packers, and distributors of drug

from HSDB

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

21 CFR 200-299, 300-499, 820, and 860 (4/1/99)

as amended; 21 U.S.C. 321-392). 21 CFR 200-299, 300-499, 820, and 860 (4/1/99) from HSDB 18

from HSDB

Agar (bacteriological) | C14H24O9 - PubChem

12 Toxicity

12.1 Toxicological Information

12.1.1 Human Toxicity Excerpts

ASIDE FROM AN OCCASIONAL ALLERGIC REACTION, THESE DRUGS CAN BE INGESTED IN LARGE AMT, WITH LITTLE DANGER OR DISTRESS EXCEPT FOR DIARRHEA, FLATULENCE, & RARELY FECAL IMPACTION. /GUMS, VEGETABLE/

Gosselin, R.E., H.C. Hodge, R.P. Smith, and M.N. Gleason. Clinical Toxicology of Commercial Products. 4th ed. Baltimore:

Williams and Wilkins, 1976., p. II-6

4th ed. Baltimore: Williams and Wilkins, 1976., p. II-6 from HSDB 12.1.2 Non-Human Toxicity Excerpts Under

from HSDB

12.1.2 Non-Human Toxicity Excerpts

Under the conditions of this bioassay, the agar isolated from Pterocladia was not carcinogenic for F344 rats or B6C3F1 mice of either sex. Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Negative; Male Mice: Negative; Female Mice: Negative.

Carcinogenesis Bioassay of Agar in F344/N Rats and B6C3F1 Mice Technical Report Series No. 230 (1982) NIH Publication No. 82-1786 U.S. Department of Health and Human Services, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709

from HSDBHealth Sciences, Research Triangle Park, NC 27709 One study has demonstrated agar to have antipeptic

One study has demonstrated agar to have antipeptic activities in vitro. Another study

serum or tissue cholesterol levels in rats. When fed to rats at 5 and 15% levels in their diet, agar impaired 16 protein utilization.

suggested that it may elevate

Leung, A.Y., Foster, S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. New York, NY. John Wiley & Sons, Inc. 1996., p. 10

New York, NY. John Wiley & Sons, Inc. 1996., p. 10 from HSDB Agar is nontoxic

from HSDB

Agar is nontoxic and can be ingested in large doses without much distress. It passes through the intestinal tract mostly unabsorbed. However, a 1981 study found that mice fed agar had significantly more colon tumors per animal (twice as many) than those fed diets without agar, despite the fact that agar fed animals had decreased levels of fecal neutral sterol and bile acid concentrations.

Leung, A.Y., Foster, S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. New York, NY. John Wiley & Sons, Inc. 1996., p. 10

New York, NY. John Wiley & Sons, Inc. 1996., p. 10 from HSDB 12.1.3 Non-Human Toxicity

from HSDB

12.1.3 Non-Human Toxicity Values

LD50 Rat oral 11 g/kg

Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996.,

p. 78

1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 78 from HSDB LD50 Mouse oral 16

from HSDB

LD50 Mouse oral 16 g/kg

Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996.,

p. 78

9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 78 from HSDB 19

from HSDB

Agar (bacteriological) | C14H24O9 - PubChem

LD50 Rabbit oral 5800 mg/kg

Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996.,

p. 78

1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 78 from HSDB LD50 Hamster oral 6100

from HSDB

LD50 Hamster oral 6100 mg/kg

Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996.,

p. 78

from HSDB1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 78 12.1.4 National Toxicology Program Reports A

12.1.4 National Toxicology Program Reports

A carcinogenesis bioassay of agar isolated from Pterocladia

B6C3F1 mice of either sex which were fed diets containing 25,000 or 50,000 ppm of the test substance for 103 wk.

Groups of 50 untreated rats and mice of either sex served as

isolated from Pterocladia was not carcinogenic for F344 rats or B6C3F1 mice of either sex. Levels of Evidence of Carcinogenicity: Male Rats: Negative; Female Rats: Negative; Male Mice: Negative; Female Mice: Negative.

was conducted on groups of 50 F344 rats and 50

Under the conditions of this bioassay, the agar

Carcinogenesis Bioassay of Agar in F344/N Rats and B6C3F1 Mice Technical Report Series No. 230 (1982) NIH Publication No. 82-1786 U.S. Department of Health and Human Services, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709

Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 from HSDB 20 de 23 10/02/2016

from HSDB

Agar (bacteriological) | C14H24O9 - PubChem

13 Literature

13.1 NLM Curated PubMed Citations

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References by MeSH Subheading

 

administration and dosage adverse effects analysis antagonists and inhibitors chemical synthesis chemistry classification diagnostic use economics enzymology

history isolation and purification metabolism microbiology pharmacokinetics pharmacology physiology radiation effects standards therapeutic use

toxicity

ultrastructure

radiation effects standards therapeutic use toxicity ultrastructure from PubChem 21 de 23 10/02/2016 11:09 a. m.

from PubChem

Agar (bacteriological) | C14H24O9 - PubChem

14 Classification

14.1 Ontologies

14.1.1 MeSH Tree

14.1 Ontologies 14.1.1 MeSH Tree Refine/Analyze Download 1 t o 1 o f 1 List

Refine/Analyze

Download14.1 Ontologies 14.1.1 MeSH Tree Refine/Analyze 1 t o 1 o f 1 List View Tree

1 to 1 of 1

Tree Refine/Analyze Download 1 t o 1 o f 1 List View Tree View Agar from

List View

Tree ViewMeSH Tree Refine/Analyze Download 1 t o 1 o f 1 List View Agar from MeSH

Agar

Refine/Analyze Download 1 t o 1 o f 1 List View Tree View Agar from MeSH

from MeSH