MRCOG PART 1 PRACTICE MCQs SET B

1. The following statements are true

A
Interleukin-1 is produced by macrophages
B
Interleukin-2 is a polypeptide hormone
C
Interferons are a family of related aglycoproteins
D
Colony Stimulating Factors (CSF) regulate bone marrow production
E
Tumour Necrosis Factor (TNF) indirectly lyses tumour cells
2. Regarding the adrenal gland in pregnancy
A
Is closely related to the fetoplacental unit
B
Maternal adrenal gland usually increases in size by 30%
C
Plasma cortisol level increases from 20 weeks gestation
D
There is no change in unbound cortisol levels
E
Glucocorticoid receptors steadily increase till term
3. The umbilical cord
A
Contains two veins and one artery
B
Average length is between 55-60 cm
C
The cord continues to grow in length up to and beyond term
D
Umbilical cord artery has well formed internal elastic lamina
E
Whartons Jelly is rich in mucopolysaccharides
4. The following diseases have satisfactory vaccines
A
Tuberculosis
B
Tetanus
C
Syphilis
D
AIDS
E
Smallpox
5. Regarding the urinary system
A
The ureter receives blood supply from renal, gonadal and vesical artery
B
The vitamin D metabolism of kidney converts 1,25 to 25-cholecalciferol
C
It is responsible for the homeostasis of acid-base balance
D
The pudendal nerve plays no role in micturition
E
The ureter can be injured at the lateral vaginal fornix during surgery
6. The following are true combinations
A
Infarction embolism causes vascular obstruction
B
Liver easily infracted organ
C
Pulmonary hypertension known outcome of pulmonary embolism
D
Wound healing by first intention more intense inflammatory reaction
E
Wound healing by second intention myofibroblasts cause wound contraction

MRCOG PART 1 PRACTICE MCQs SET B

7. The following are true regarding gonadotrophins

A
Glycoproteins
B
Contain sialic acid
C
LH and FSH are synthesized in the same cell
D
Contain an alpha subunit which is similar to thyrotrophin
E
Its secretion shows a circadian rhythm
8. The following bacteria are in the bacilli group
A
Leptospira
B
Clostridium
C
Pseudomonas
D
Enterobactericiae
E
Bacteroides
9. The following associations regarding cancer are true
A
Vagina stilboestrol
B
Liver aflatoxin
C
Skin paraffin
D
Melanoma sunlight
E
Ovary aniline dye
10. In septic shock
A
The causative organisms are invariably gram negative
B
A leucocytosis precedes death
C
Endotoxins are predominantly lipopolysaccharides
D
Antibiotic treatment may aggravate hypotension
E
There may be associated DIVC
11. Regarding Prothrombin
A
Is a Vitamin K dependant protein
B
Is synthesized in the liver
C
Converts fibrinogen to fibrin
D
Has a half life of 2-3 days
E
Has a molecular weight of 70 000
12. During pregnancy, thrombocytopenia may occur in association with
A
Bacterial infection
B
Viral infection
C
Alcoholism
D
Megaloblastic anaemia
E
Amniotic fluid embolism

MRCOG PART 1 PRACTICE MCQs SET B

13. The following terminology regarding blood clotting factors are true
A
Factor I fibrinogen
B
Factor II prothrombin
C
Factor III tissue factor
D
Factor IV calcium ions
E
Factor V - proconvertin
14. Basal fetal heart rate in utero
A
Varies with gestational age
B
Is not subject to parasympathetic activity before the 20th week of pregnancy
C
Frequently accelerates with external head compression
D
Accelerates during orgasm
E
Accelerates in response to maternal ingestion of atropine sulphate
15. In the fetus
A
The umbilical arteries carry oxygenated blood
B
The ductus venosus short-circuits the capillaries of the liver
C
The right atrium contains a mixture of oxygenated and venous blood
D
The foramen ovale connects the ventricles of the heart
E
The ductus arteriosus joins the aorta proximal to the aortic arch
16. The sequelae of a vasectomy include
A
Varicocoele
B
Sperm granuloma
C
Torsion of the testis
D
Sperm antibodies
E
Loss of libido
17. Ureteral dilatation during pregnancy is caused by the following
A
Uterine pressure at the pelvic brim
B
Pressure from the dilated right ovarian vein
C
Progesterone effect
D
The increased glomerular filtration rate
E
Increased size of the kidneys
18. Human spermatozoa
A
Require the presence of FSH for normal development
B
Normally fertilise the ovum in the uterus
C
Are matured in the epididymis
D
Contain hyaluronidase
E
Production is less at 38 than 36 Celsius

MRCOG PART 1 PRACTICE MCQs SET B

19. Cholesterol can be synthesized from acetate by

A
Ovary
B
Adrenal gland
C
Testis
D
Placenta
E
Pancreas
20. In the fetus
A
The umbilical arteries carry oxygenated blood
B
The ductus venosus short-circuits the capillaries of the liver
C
The foramen ovale is formed from the septum secundum overlapping the lower
part of the septum primum
D
The definite interventricular septum originates predominantly from the sinus
venosus
E
The ductus venosus shunts blood from the umbilical artery to the inferior vena
cava
21. In the newborn child
A
The mastoid antrum is full adult size
B
The mandible has a midline fibrous joint
C
The thorax is oval in cross section
D
The spinal cord extends to L3
E
Paranasal sinuses are full adult size
22. In the fetal circulation
A
Blood in the superior vena cava is more oxygenated than in the inferior vena cava
B
Blood from the SVC is preferentially shunted through the foramen ovale to the
left atrium
C
70% of blood from the right ventricle goes through the pulmonary artery to
perfuse the lungs
D
The ductus arteriosus is histologically different from the pulmonary artery
E
50% of blood bypasses the liver to enter the IVC
23. The following regarding viruses are true
A
The mumps virus is a paramyxoviridae
B
The dengue and yellow fever are flaviridae
C
Both rubella and yellow fever are of the same family of virus
D
Rotavirus is single stranded DNA
E
Hapatitis B virus is partially double stranded enveloped

MRCOG PART 1 PRACTICE MCQs SET B

24. Regarding the prostaglandins

A
There are 4 main groups of prostaglandin
B
Are very rapidly metabolized
C
Are highly concentrated in the liver and brain
D
Exert their effects by releasing calcium ion
E
Their concentration is higher at term compared to early pregnancy
25. Ketosis is a condition in which
A
Acetoacetic acid, beta-hydroxybutyric acid and acetone accumulate in the blood
B
Respiratory acidosis develops
C
There is failure of the liver to oxidize the ketone bodies
D
Ketone bodies are produced by the peripheral tissues
E
There is an excessive carbohydrate availability for metabolism
26. Mycobacterium tuberculosis
A
Is resistant to strong acids but not alkalis
B
Is an obligate aerobe
C
Divides every 6-8 hours
D
Cord formation on culture predicts a low virulence
E
Spread to female genital tract is usually haematogenous
27. Danazol
A
B
C
D
E

Is a synthetic steroid
Is bound by serum albumin in the plasma
Acts by pituitary gonadtrophin stimulation
Increases oestradiol
Has weak impeded androgenic activity

28. The vagina

A
Is a tube that is directed upwards and backwards with a little curvature posteriorly
B
Is lined by stratified squamous epithelium
C
Has two fornices, anterior and posterior, at the vault
D
Is attached to the cardinal ligament
E
Is formed from single sino-vaginal bulb on the posterior wall of the urogenital
sinus
29. Regarding arcinoid tumour:
A
Is malignant
B
Rapidly growing
C
Ocurs in Kulchitsky cells
D
Secretes 5-hydroxytrptamine
E
Commonest site is the ovarian teratoma

MRCOG PART 1 PRACTICE MCQs SET B

30. In the development of the immune system in the fetus

A
Lymphocytes (T-cells) develop in the yolk sac at about 8 weeks
B
B-lymphocytes develop in the liver and spleen at 20 weeks
C
Cord blood levels of IgG is higher than maternal levels
D
The ratio of T to B cells is the same as in the adult during the first week of life
E
There is a greater proportion of null cells
31. The infection and pathogen pairs are correct
A
AIDS HIV 1 & 2
B
Neoplasm HIV
C
Arthritis HSV
D
Cervicitis HPV
E
Anogenital warts HSV
32. Rubella
A
B
C
D
E

Commonly infects before age 2 years in the UK

Has a worldwide distribution
Has single stranded RNA
Has an incubation period of 14-21 days
Presents with rashes after 3 days of fever

33. Known complications of rubella include

A
Encephalitis
B
Persistent suboccipital lymph nodes
C
Persistent arthralgia
D
Haematuria
E
Fetal rubella syndrome
34. In pregnancy
A
The maximum plasma volume has been reached by 30 weeks
B
The plasma volume increases more in primigravidae than in multigravidae
C
The increases in red cell volume is of same order as the increase in plasma
volume
D
The fall in plasma proteins is mainly brought about by reduction in the globulin
fractions
E
The concentration of serum cholesterol falls
35. In the regulation of glucose metabolism
A
Insulin promotes the uptake of glucose by muscle cells
B
Glucose-6-phosphate occurs in muscle but not in the liver
C
Adrenaline promotes the breakdown of hepatic glycogen
D
Lactate is the end product of the aerobic metabolism of glucose
E
Insulin is secreted by the alpha cells of the islet of Langerhans

MRCOG PART 1 PRACTICE MCQs SET B

36. Exotoxins
A
Are derived from gram negative bacteria
B
Have specific actions
C
Are more toxic than endotoxins
D
Are neutralized by their homologous antitoxin
E
Can be made into toxoids
37. Polyuria occurs
A
In hypercalcaemia
B
In chronic renal failure
C
In potassium depletion
D
In the recovery phase of acute tubular necrosis
E
On exercise
38. Oestrogens
A
Are metabolized mainly to sulphate conjugates
B
Excretion in bile is greater than that in urine
C
Half-life in the circulation is 5-6 hours
D
After hydroxylation at the 2 and 4 positions the resulting catecholoestrogens will
not bind to oestrogen receptors
E
Oestradiol is the oestrogen in pregnancy
39. Regarding acute infections of maternal origin
A
Rubella at 8 weeks POA spontaneous abortion
B
Hydrops fetalis HPV 19
C
Varicella zoster virus good prognosis
D
Coxsackie myocarditis of the noewborn
E
CMV - teratogenic
40. Regarding chronic infection of maternal origin
A
CMV most common agent of intrauterine infection
B
HSV infection is always symptomatic
C
Postnatal HSV presents at end of 2nd week of life
D
HSV causes intrauterine growth retardation
E
HBS Ag high risk perinatal infection
41. Regarding HIV
A
Only infects intrauterine
B
Is acquired via the birth canal
C
Is an indication for caesarian section
D
Affected mothers can breastfeed their babies
E
Rate of transmission is 25%

MRCOG PART 1 PRACTICE MCQs SET B

42. The following statements are correct

A
Large doses of thiopentone cause tocolysis
B
Halothane doesnt enter fetal circulation
C
NO2 increases the incidence of abortion
D
Local anaesthesia is not transferable to the fetus
E
Morphine can cause fatal respiratory depression
43. Phaechromocytoma
A
Is usually benign
B
Is derived from chromaffin cells in the adrenal cortex
C
Secretes aldosterone and catecholamines
D
Metastasis is usually to the lung
E
Contain totipotent cells
44. The following statements relating to adrenal glands are correct
A
The average weight of a normal adrenal gland in adult is 1 gram
B
Each gland is drained by the three separate veins
C
The medulla is endodermal in origin
D
The zona reticularis of the cortex lies next to the medulla
E
Aldosterone is produced by cells of the zona glomerulosa of the cortex
45. Total cerebral blood low is most markedly increased by
A
Hypercapnoea
B
Hypoxia
C
Cerebral activity
D
Vasomotor reflexes
E
Increase in mean arterial pressure
46. Carbon dioxide is transported in the blood
A
In combination with haemoglobin
B
As hydrochloric acid
C
In combination with plasma proteins
D
Mainly as bicarbonate
E
In physical solution in plasma
47. During normal coitus
A
Lengthening of the upper vagina precedes lubrication in the sexually stimulated
woman
B
Retraction of the clitoral body occurs during the plateau phase of the female
sexual cycle
C
Female vaginal contractions occur at 0.8 second intervals during orgasm
D
Increase in penile length on erection is proportional to flaccid penile length
E
The prostate gland is relatively insensitive to sexual stimulation

MRCOG PART 1 PRACTICE MCQs SET B

48. Prostaglandins
A
Are small molecular weight polypeptides
B
Are chemically related to thromboxanes
C
Have been clearly shown to be responsible for luteolysis in man
D
Inhibit the secretion of rennin
E
Are produced in the seminal vesicles of man
49. The anterior abdominal wall:
A
Transversalis fascia terminates at arcuate line
B
Interval oblique forms the anterior and posterior walls of the rectus sheath
C
The pyramidalis muscles is often absent
D
The superior epigastric artery lies superficial to the rectus abdominis
E
The external oblique muscle arises from the lower eight ribs
50. The following statements about vitamins are true:
A
Many vitamins can be synthesized in adequate amounts in the body
B
Vitamin K is water soluble
C
Deficiency of pyridoxine (vitamin B6) can cause convulsions
D
Naturally occurring folate contains a single glutamic acid residue
E
Excessive vitamin D intake causes renal failure
51. In hypothyroidism:
A
Myxoedema results from lipid infiltration of the dermis
B
Mental changes are entirely reversible with substitution therapy
C
Anaemia is present in most patients
D
Enlargement of the sella turcica is diagnostic of primary hypothyroidism
E
Barbiturates should be avoided
52. The following progestogens are derived from testosterone:
A
Ethynodiol
B
Megestrol
C
Norgestrel
D
Chlormadione
E
Norethisterone
53. Histopathology
A
Labia majora keratinising squamous epithelial
B
Cervix keratinizing squamous epithelial
C
Squamous metaplasia premalignant condition
D
MGH (multiglandular hyperplasia) pregnancy
E
High karyotyping index Oestrogenic stimulant

MRCOG PART 1 PRACTICE MCQs SET B

54. The respiratory centre

A
Is situated in the medulla oblongata
B
Is inhibited during vomiting
C
Send out regular impulses to the inspiratory muscles during quiet respiration
D
Is reflexly regulated by vagal impulses
E
Is sensitive to blood pH alterations
55. Which of the following are characteristics of damaged cells
A
Fatty infiltration
B
Plasma membrane blebbing
C
Mitochondrial swelling
D
Nuclear karyorrhesis
E
Increased cytosolic calcium
56. The anterior relation of the sacro-iliac joints are
A
Common iliac vein
B
Ilio-lumbar artery
C
Sciatic nerve
D
Gluteus maximus
E
Superior gluteal artery
57. The anterior pituitary produces the following hormones
A
Prolactin
B
Vasopressin
C
Human placental lactogen
D
Thyroxine
E
Growth hormone
58. Metabolic responses to hypovolaemic shock include
A
Respiratory alkalosis
B
Metabolic alkalosis
C
Increased glycogenolysis
D
Increased gluconeogenesis
E
Increased glycogenesis
59. During early placentation
A
The chorion frondosum lies adjacent to the decidua capsularis
B
The layer of Nitabuch cheeks invasion of the villi
C
The secondary villi have no mesodermal core
D
Chorio-decidual spaces form in the cytotrophoblastic layer
E
The body stalk develops into the umbilical cord

10

MRCOG PART 1 PRACTICE MCQs SET B

60. In the anterior abdominal wall

A
The posterior wall of the rectus sheath below the Douglas fold is formed by the
transversalis fascia only
B
The deep inguinal ring is 1 cm above the middle of the inguinal ligament
C
The conjoint tendon is formed from the internal and external oblique muscles
D
The internal spermatic fascia originates from the external oblique muscle
E
The dermatome at the umbilical level is T12
61. An abnormal karyotype is characteristic of
A
Phenylketonuria
B
Turners Syndrome
C
Aplasia of the vagina
D
Congenital adrenogenital hyperplasia
E
Downs Syndrome
62. Blood coagulation may be delayed by
A
Deficiency of prothrombin
B
Deficiency of factor IX (Christmas factor)
C
Heparin
D
Calcium citrate
E
Potassium oxalate
63. Which of the following are true
A
TB can cause hypopituitary state
B
Galactorhoea is a result of 1 hypoparathyroidism
C
Craniopharyngioma causes high prolactin levels
D
Dopamine and serotonin are neurotransmitters
E
Action of stomatostatin on pancreas inhibits insulin secretion
64. Regarding acid base balance
A
The conversion of H+ ion is important for metabolism
B
Base donates protons
C
The neutral pH at 37C is 7.0
D
The ICF pH 6.8-7.3
E
The major protein buffer in blood is haemoglobin
65. Hyperoestrogenic effects are common in
A
Granulosa cell tumour
B
Thecoma
C
Leydig cell tumour
D
Disgerminomas
E
Mature cystic teratoma

11

MRCOG PART 1 PRACTICE MCQs SET B

66. The healing of a wound is delayed by

A
Vitamin C deficiency
B
Starvation
C
The administration of glucocorticoids
D
Lack of blood supply
E
Infection
67. Regarding rubella :
A
It can occur in children under 2 years old
B
It is always teratogenic
C
Reinfection can result in positive rubella-specific IgM
D
Placental infection occurs from ascending genital infection
E
Rubella vaccine causes fetal damage if given to rubella-susceptible pregnant
women during the first trimester
68. The inguinal lymph nodes receive lymph from
A
Perianal skin
B
Infraumbilical region
C
Prostate
D
Testis
E
Clefts between toes
69. The following structures leave the pelvis by passing through the greater sciatic
foramen above the piriformis muscle
A
The sciatic nerve
B
The superior gluteal nerve
C
The internal pudendal vessels
D
The nerve to quadratus femoris muscle
E
The inferior gluteal nerve
70. Adrenocorticotropic hormone (ACTH)
A
Controls glucocorticoid production
B
Controls catecholamine production
C
Is increased by the secretion of a hypothalamic releasing factor
D
Is suppressed by a high level of circulating glucocorticoid
E
Shows diurnal physiological variations
71. The ductus venosus
A
Connects the left branch of the portal hepatic vein to the umbilical vein
B
Conveys blood to the inferior vena cava before birth
C
After birth becomes the ligamentum teres of the liver
D
Becomes the lateral umbilical ligament of the adult
E
Receives blood from the umbilical vein

12

MRCOG PART 1 PRACTICE MCQs SET B

72. The ureter

A
On the right crosses the external iliac vessels to enter the pelvis
B
Lies portero-superior to the internal iliac artery on the side wall of the pelvis
C
Lies superior to the uterine artery as it passes through the base of the broad
ligament
D
Th narrowest where it joins the bladder wall
E
On the side wall of the pelvis lies medial to the obturator nerve and vessels
73. With regards to carbohydrates
A
Digestion of carbohydrates begins in the mouth
B
1g of carbohydrates yields the same amount of energy as 1g of protein
C
Fructose absorption requires energy
D
Gastrointestinal glucose absorption is facilitated by insulin
E
Absorption of glucose by the enterocytes take place mainly in the terminal ileum
74. Cervical ectropion
A
Is frequently asymptomatic
B
Consists of squamous epithelium
C
Is related to trauma during childbirth
D
Is exaggerated by bi-valve speculum examination
E
May be corrected by trachelorrhapy
75. Precocious puberty
A
Is constitutional in the majority of cases
B
May initially manifest as precocious telarche
C
Occurs with intra-cranial tumours
D
Occurs with ovarian tumours
E
Occurs in Albright Syndrome
76. Which of the following are characteristic of benign tumours
A
High degree of differentiation
B
More mitoses than normal tissues
C
Many abnormal mitotic features
D
Marked nuclear pleomorphism
E
Encapsulation
77. Which of the following antimicrobial drugs may adversely affect the fetus if
given to the mother in late pregnancy
A
Oxytetracycline
B
Long acting sulphonamides
C
Ampicillin
D
Streptomycin
E
Erythromycin

13

MRCOG PART 1 PRACTICE MCQs SET B

78. The fetal membrane comprises of

A
Amnion
B
Chorion
C
Yolk sac
D
All of the above
E
A and B only
79. In the human feto-placental unit
A
The intervillous space contains fetal blood
B
The invasion of maternal spiral arteries by throphoblast causes dilatation
C
Two-cell membranes separate the maternal and fetal circulations
D
The spiral arteries enter the placental cotyledons
E
Cytotrophoblast cells disappear towards term
80. During early placentation
A
The chorion frondosum lies adjacent to the decidua capsularis
B
The layer of Nitabuch checks invasion of villi
C
The secondary villi has no mesodermal core
D
Chorio-decidual spaces form in the cytotrophoblastic layer
E
The boy stalk develops into the umbilical cord
81. Throphoblasts
A
Enter the maternal circulation in normal pregnancy
B
Are lysed in the maternal lung
C
Are genetically maternal
D
Produce human chorionic gonadotrophin
E
Are immunologically inert
82. The functions of the placenta include
A
Production of erythrocytes
B
The formation of immunological barriers
C
Excretion of waste products
D
Production of insulin
E
Production of progesterone
83. The following statements about placental pathology are appropriate
A
Placenta extrachorialis predisposes to postpartum haemorrhage
B
A velamentous insertion of the cord is of no clinical importance
C
Placental succenturiata (succenturiate lobe) predisposes to antepartum
haemorrhage
D
A haemangioma of the placenta causes oligohydramnios
E
Placenta percreta penetrates through the serosal surface of the uterus

14

MRCOG PART 1 PRACTICE MCQs SET B

84. The following substances cross the placenta to the fetus against a concentration
gradient
A
Calsium
B
Magnesium
C
Amino acids
D
Iron
E
Fat soluble vitamins
85. The following crosses the placenta to the fetus
A
Thyroxine
B
Triiodothyronine
C
Thiouracil
D
TSH
E
LATS
86. The following statements relate to syphilis
A
Treponema pallidum is a gram negative organism
B
The primary chancre usually appears within one week of exposure to infection
C
Spirochaetes are distributed through out the body at the time of appearance of the
primary chancre
D
Serology is positive in all cases of tertiary syphilis
E
The Reiter protein complement fixation test is the most reliable verification test
available
87. Cytomegalovirus
A
Has infected 80% of the adult population
B
Is demonstrable in 0.5 to 1.5% of neonates
C
Is an adenovirus
D
Cause neonatal jaundice
E
Is commonly present in the salivary glands
88. The following antibiotics act by inhibiting bacterial cell wall synthesis
A
Cephalosporins
B
Cephamycins
C
Aminoglycosides
D
Polymyxins
E
Rifamycins
89. In the human testis
A
Spermatogenesis takes place in the seminiferous tubules
B
Spermatozoa arise directly from germ cells
C
Sertoli cellsregulate spermatogenesis
D
FSH stimulates spermatogenesis by increasing the protein content of Sertoli cells
E
Spermatogenesis only occurs at normal deep body temperature

15

MRCOG PART 1 PRACTICE MCQs SET B

90. In the adult female
A
The fallopian tubes convey ova from the ovaries to the uterus
B
The fallopian tube segment closest to the ovary is called the ampulla
C
The uterus and connective tissue capsules of the ovaries are connected by the
broad ligament
D
The middle layer of the uterus is muscular
E
The structure of the inner layer of the uterus varies during the menstrual cycle
91. In the human ovary
A
Ovarian follicles are formed during fetal life
B
Each ovarian follicle contains several primordial ova
C
The zona granulosa is formed from proliferating follicle cells
D
FSH causes mature Graffian follicle to rupture
E
The ovum is released into the fallopian tube
92. Progesterone
A
Is produced by the developing ovarian follicle
B
Transforms the endometrium into a secretory endothelium
C
Enhances the contractile reponse of the myometrium to oxytocin
D
Is produced by the placenta throughout pregnancy
E
Is metabolized mainly in the liver
93. The following are sedative agents
A
Lorazepam
B
Promethazine
C
Maxolon
D
Lignocaine
E
Droperidol
94. The following are correct statements
A
Ovarian artery supplies to the uterus
B
Vaginal artery supplies the cervix
C
Lumbar plexus psoas major, psoas minor
D
Sacral plexus iliacus
E
Ventral root brachial plexus
95. Innervation of the female genitalia
A
Ilio-inguinal nerve
B
Inferior rectal nerve
C
Superior rectal nerve
D
Inferior perineal nerve
E
Labial nerve

16

MRCOG PART 1 PRACTICE MCQs SET B

96. Regarding lymphatic drainage of the genital organs

A
Superior inguinal lymph node fallopian tubes
B
Internal iliac lymph node nulva
C
Paraaortic lymph node ovaries
D
Lower 1/3 vagina sacral lymph node
E
Cervix paracervical lymph node
97. Regarding uterine contraction
A
There are no contractions before 25 week POA
B
Highly sensitive to oxytocin due to raised prostaglandin level
C
Is caused by a fall in oestrogen level
D
Is associated with raised pregnanediol
E
Causes raised prostaglandin level
98. The following are effects of prostaglandin
A
PGI2 vasodilator effects
B
TXA2 stimulate platelet aggregation
C
PG1 is derived from linoleic acid
D
PG3 is derived from plants
E
Alkaloic acid is associated with PG1
99. During sexual intercourse
A
Increased activity in sacral parasympathetic nerves causes the penis
B
The vagina is engorged with blood
C
Vaginal stimulation causes the release of oxytocin
D
Ejaculation is produced by smooth muscle contranction at the root of the penis
E
Impairment of the parasympathetic innervation causes failure of ejaculation
100.

The side effects of cytotoxic drugs may include

A
Immunosuppression
B
Gastrointestinal disturbances
C
Renal dysfunction
D
Loss of hair
E
Inhibition of wound healing

101.

The antifungal drug griseofulvin

A
Is effective gainst ringworm caused by all known forms of fungi
B
Is used by topical administration and may not be given orally
C
Is normally used in combination with topical zinc undecenoate ot tolnaftate
D
Can inhibit mammalian cell division
E
Has a broader spectrum of action than clotrimazole

17

MRCOG PART 1 PRACTICE MCQs SET B

102.

Nystatin
A
Is used in the treatment of candidiasis
B
Binds selectively to biological membranes which do not contain sterols
C
Does not exert toxic effects mammalian cells
D
Acts on fungi in a manner which differs from that of ampothericin
E
Is the drug of choice for the treatment of pulmonary aspergillosis

103.

The Wasserman reaction is a

A
Precipitin test
B
Complement fixation test
C
Haemagglutination inhibition test
D
Agglutination test
E
Treponemal immobilization test

104.

Which of the following cell types may be found in germinal cetres?

A
LYmphoblasts
B
Plasma cells
C
Macrophages
D
Eosinophils
E
Mast cells

105.

Ultrasound
A
Produces images of tissue structure
B
Enables both size and nature of structure to be ascertained
C
Is not applicable to study the eye
D
Is essentially similar to x-ray
E
Is a non-invasive technique

106.

Regarding morphine
A
The major pathway for its detoxification is by oxidation to gentisic acid
B
It increases biliary tract pressure
C
It is eliminated mainly in the conjugated state via glomerular filtration
D
It is secreted in the bile
E
It alters the threshold or responsiveness of nerve endings to noxious stimulation

107.

Patients with testicular feminizing syndrome

A
Have well-formed breasts
B
Complain of secondary amenorrhoea
C
Lack pubic hair
D
Have XY karyotype
E
Are liable to develop malignant change in the gonads

18

MRCOG PART 1 PRACTICE MCQs SET B

108.

The following are the primary branches of the celiac artery

A
Left gastric artery
B
Right gastro-epiploic artery
C
Gastroduodenal artery
D
Hepatic artery
E
Splenic artery

109.

The following statements relating to the adrenal glands are correct

A
The average weight of a normal adrenal gland in the adult is 1 gram
B
Each gland is drained by the 3 separate veins
C
The medulla is endodermal in origin
D
The zona reticularis of the cortex lies next to the medulla
E
Aldosterone is produced by cells of the zona glomerulosa of the cortex

110.

The cerebral blood flow is most markedly increased by

A
Hypercapnoea
B
Hypoxia
C
Cerebral activity
D
Vasomotor reflexes
E
Increase in mean arterial pressure

111.

Carbon dioxide is transported in the blood

A
In combination with haemoglobin
B
As hydrochloric acid
C
In combination with plasma proteins
D
Mainly as bicarbonate
E
In physical solution in plasma

112.

The respiratory centre

A
Is situated in the medulla oblongata
B
Is inhibited during vomiting
C
Sends out regular impulses to the inspiratory muscles during quiet respiration
D
Is reflexly regulated by vagal impulses
E
Is sensitive to blood pH alterations

113.

Transexual patients characterictically

A
Have normal external genitalia
B
Have abnormal karyotype
C
Have abnormal hormone profiles
D
Are of subnormal intelligence
E
Are maladjusted socially

19

MRCOG PART 1 PRACTICE MCQs SET B

114.

Oestrogens
A
Are synthesized from cholesterol
B
Are secreted by the anterior pituitary gland
C
Are secreted by thr adrenal gland
D
Are secreted by the stromal cells of the ovary
E
Are principally excreted in the urine

115.

Cervical erosions
A
Are often asymptomatic
B
Show ulcerative features on microscopic examination
C
Are associated with pregnancy
D
Are associated with oral contraceptive use
E
Are associated with later development of cervical carcinoma

116. Which of the following separate maternal and fetal blood in the human
placenta?
A
Throphoblast
B
Maternal vascular endothelium
C
Fetal vascular endothelium
D
Maternal connective tissue
E
Fetal connective tissue
117.

Progesteron is
A
Synthesized by the throphoblast
B
Mainly excreted as pregnanediol glucoronide
C
Synthesized from cholesterol
D
A smooth muscle stimulant
E
A glycoprotein

118. Lymphatic drainage from the uterine cervix is through the following lymph
node
A
Superficial femoral
B
Superficial inguinal
C
External iliac
D
Obturator
E
Lumbosacral
119.

Pudendal nerve carries the following nerves

A
Sensory from the anterior part of the labia majora
B
Sensory from the perineum
C
Sensory from the lower part of the uterus
D
Motor to the external anal sphincter
E
Sensory from the clitoris

20

MRCOG PART 1 PRACTICE MCQs SET B

120.

The following structures support the uterus in position

A
The broad ligament
B
The infundibulo-pelvic ligaments
C
The transverse cervical ligaments
D
The vagina
E
The transverse perineal muscles

121.

Urogenital diaphragm is pierced by the

A
Ureters
B
Rectum
C
Vagina
D
Urethra
E
Obturator nerve

122.

The following associations of types of epithetlium are correct

A
Ciliated and uterine body
B
Stratified squamous and vagina
C
Transitional and bladder
D
Columnar and cervix
E
Transitional and urethra

123.

The ovarian ligaments

A
Contain the ureters
B
Contain the ovarian arteries
C
Are attached laterally to the pelvic wall
D
Lie anterior to the broad ligament
E
Are homologous to part of the gubernaculums testis in the male

124.

The following are synovial joints

A
Symphysis pubis
B
Sacro-iliac
C
Sacro-coccygeal
D
Lumbo-sacral
E
Patello-femoral

125.

The following statements relate to nerves of the pelvis

A
The genitofemoral nerve arises from L1 and L2
B
The levator ani is in part supplied by the perineal nerve
C
The pudendal nerve lies just posterior to the sacro-tuberous ligament
D
The skin of the anal triangle is supplied by S1 and S2 fibres
E
The obturator nerve arises from the sacral plexus

21

MRCOG PART 1 PRACTICE MCQs SET B

126.

The following diseases are commonly made worse by pregnancy

A
Gout
B
Systemic lupus erythematosus
C
Migraine
D
Hyperthyroidism
E
Addisons disease

127.

The following structures lie in the posterior triangle of the neck

A
Supraclavicular lymph glands
B
Common carotid artery
C
Subclavian artery
D
Vagus nerve
E
Brachial plexus

128.

The following are primary branches of the coeliac artery

A
Left gastric artery
B
Right gastro-epiploic artery
C
Gastro-duodenal artery
D
Hepatic artery
E
Splenic artery

129.

Ectopic breast tissue may appear anywhere along

A
Toldts line
B
Semicircular line
C
Milk line
D
Subway line
E
Red line

130.

The ovarian artery contributes to the blood supply of the

A
Fallopian tube
B
Round ligament
C
Uterus
D
All of the above
E
None of the above

131.

The following pelvic structures are extensively covered by peritoneum

A
Uterine corpus
B
Uterine cervix
C
Ovary
D
All of the above
E
None of the above

22

MRCOG PART 1 PRACTICE MCQs SET B

132. Which of the following diseases are shown to be commonly related to

infection with streptococci
A
Scarlet fever
B
Glomerulonephritis
C
Cellulitis
D
Acute rheumatic fever
E
Thyroiditis
133.

Dysplasia
A
Is an abnormal maturation epithelial cells
B
Is an irreversible process
C
Often arises from a background of squamous metaplasia
D
Invariably progresses to cancer
E
Shows increase mitoses

134.

Cancer suppressor genes include

A
Retinoblastoma gene
B
Adenomatous polyposis coli gene
C
P53 gene
D
nM gene
E
Bcl 2 gene

135.

The terminal ileum mainly absorbs

A
Iron
B
Cyanocobalamin
C
Fatty acids
D
Bile salts
E
Water-soluble vitamins

136.

The fat embolism syndrome

A
Is associated with severe skeletal injuries
B
Usually manifests within 12 hours of injury
C
Is associated with thrombocythaemia
D
Is fatal in the majority of cases in postmortem
E
Can be diagnosed histologically by paraffin-embedded tissue injection

137.

The human placenta

A
Produces pregnanediol
B
Is haemochorial
C
Has anastomoses between villous vessels
D
Has syncytiotrophoblast as the major component of the trophoblast near term
E
Is anchored to the myometrium by stem villi

23

MRCOG PART 1 PRACTICE MCQs SET B

138.

The kidneys secrete

A
1,25-dehydrocholecalciferol
B
Rennin
C
Angiotensin
D
Vasopressin
E
Erythropoietin

139.

The following statements about haemophilia are true

A
All sons of affected males will inherit the condition
B
Half of the sons of a carrier female will inherit the condition
C
The incidence of haemophilia in the daughters of an affected male (married to a
normal female) will be one in four
D
If a carrier female marries anaffected male, all of the offspring will inherit the
haemophilia gene
E
Normal daughters cannot be born to a carrier female

140.

The following statements relate to the normal distribution

A
The mean and mode are equal
B
The median is one standard deviation below the mean
C
99.7% of the population lies within two standard deviations of the mean
D
The standard error of the mean is the variance divided by the square root of the
number of observations
E
No other symmetrical distribution is possible

141.

The volume of amniotic fluid

A
Is closely related to the fetal crown-rump length in the 3rd trimester of pregnancy
B
May be predicted by ultrasound
C
Is excessive in severe rhesus disease
D
Increases following amniocentesis
E
Is reduced in severe pre-eclampsia

142.

Spermatogenesis
A
Is a process requiring 110 + 5 days in the human male
B
Requires both FSH and LH to stimulate sperm maturation
C
Is associated with an increase in testosterone in the intertubular tissue of the testis
D
Is abnormal in a male with a karyotype 47XXY
E
Is depressed by mycoplasma infection of the male genital tract

143.

The placental barrier between mother and fetus is composed of

A
Fetal capillary endothelium
B
Throphoblasts
C
Maternal capillary endothelium
D
All the above
E
A and B only

24

MRCOG PART 1 PRACTICE MCQs SET B

144.

The following statements relate to clostridia and clostridial infection

A
All clostridia are anaerobes
B
Clostridium tetani produces central spores
C
Clostridium perfringens (Welchii) is the only organism which causes gas
gangrene
D
Clostridium perfringens (Welchii) must be actively treated when isolated from
vaginal swabs
E
Patients with tetanus must be barrier nursed

145.

The following obtains the following substances by simple diffusion

A
Water
B
Sodium
C
Oxygen
D
Calcium
E
Iron

146.

An episiotomy during childbirth

A
Prevents uterine injury
B
Enlarges the pelvic outlet
C
Prevents tearing of the perineal muscles
D
Cause tearing of the central tendon of the perineum
E
Helps prevent uterine prolapse

147.

Renin
A
B
C
D
E

Has a molecular weight of 40,000

Is only produced in the kidney
Is released when there is a rise in blood pressure
Is released by decreased blood sodium concentration
Falls in amount with a rise in plasma potassium

148.

Which of the following statements are true

A
Warfarin does not cross the placenta to enter the fetus
B
Plasma insulin is lower on the fetal side
C
Local anaesthetic crosses the placenta readily
D
Corticosteroid administration may lead to higher oestriol secretion in the maternal
urine
E
Low urinary oestriol concentration may occur with acute urinary tract infection

149.

Human chorionic gonadotrophin

A
Has all the properties of LH
B
Can transform a normal cyclic corpus luteum into a pseudopregnant corpus
luteum
C
Is responsible for the onset of parturition
D
Is detectable before implantation of the ovum
E
Is significantly elevated in pre-eclampsia

25

MRCOG PART 1 PRACTICE MCQs SET B

150. These methods of placental transfer are appropriate for the following
substances
A
Oxygen active
B
Fats pinocytosis
C
Iron active
D
Carbon dioxide passive
E
Antibodies - pinocytosis

26