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Filariasis is a disease group affecting humans and animals, caused by filariae; ie, nematode

parasites of the order Filariidae.[1] Of the hundreds of described filarial parasites, only 8 species
cause natural infections in humans. The World Health Organization (WHO) has identified
lymphatic filariasis as the second leading cause of permanent and long-term disability in the
world, after leprosy.
In lymphatic filariasis, repeated episodes of inflammation and lymphedema lead to lymphatic
damage, chronic swelling, and elephantiasis of the legs (see the image below), arms, scrotum,
vulva, and breasts .[2, 3, 4, 5, 6, 7]

Filariasis. Unilateral left lower leg elephantiasis


secondary to Wuchereria bancrofti infection in a boy.

Signs and symptoms


Lymphatic filariasis

Fever
Inguinal or axillary lymphadenopathy
Testicular and/or inguinal pain
Skin exfoliation
Limb or genital swelling - Repeated episodes of inflammation and lymphedema lead to
lymphatic damage, chronic swelling, and elephantiasis of the legs, arms, scrotum, vulva, and
breasts.

The following acute syndromes have been described in filariasis:

Acute adenolymphangitis (ADL)


Filarial fever - Characterized by fever without associated adenitis
Tropical pulmonary eosinophilia (TPE)
Onchocerciasis
The clinical triad of infection in onchocerciasis is as follows:

Dermatitis - Skin lesions include edema, pruritus, erythema, papules, scablike eruptions,
altered pigmentation, and lichenification
Skin nodules (ie, onchocercomas) - Skin nodules tend to be common over bony
prominences
Ocular lesions - Eye lesions are usually related to the duration and severity of infection
and are caused by an abnormal host immune response to microfilariae; loss of visual acuity
may occur
Loiasis
The diagnostic feature of loiasis is a Calabar swelling, ie, a large, transient area of localized,
nonerythematous subcutaneous edema. This is most common around the joints.
Mansonella infections
These are usually asympt omatic. If symptoms are present, they may include fever, pruritus,
skin lumps, lymphadenitis, and abdominal pain.

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