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parasites of the order Filariidae.[1] Of the hundreds of described filarial parasites, only 8 species
cause natural infections in humans. The World Health Organization (WHO) has identified
lymphatic filariasis as the second leading cause of permanent and long-term disability in the
world, after leprosy.
In lymphatic filariasis, repeated episodes of inflammation and lymphedema lead to lymphatic
damage, chronic swelling, and elephantiasis of the legs (see the image below), arms, scrotum,
vulva, and breasts .[2, 3, 4, 5, 6, 7]
Fever
Inguinal or axillary lymphadenopathy
Testicular and/or inguinal pain
Skin exfoliation
Limb or genital swelling - Repeated episodes of inflammation and lymphedema lead to
lymphatic damage, chronic swelling, and elephantiasis of the legs, arms, scrotum, vulva, and
breasts.
Dermatitis - Skin lesions include edema, pruritus, erythema, papules, scablike eruptions,
altered pigmentation, and lichenification
Skin nodules (ie, onchocercomas) - Skin nodules tend to be common over bony
prominences
Ocular lesions - Eye lesions are usually related to the duration and severity of infection
and are caused by an abnormal host immune response to microfilariae; loss of visual acuity
may occur
Loiasis
The diagnostic feature of loiasis is a Calabar swelling, ie, a large, transient area of localized,
nonerythematous subcutaneous edema. This is most common around the joints.
Mansonella infections
These are usually asympt omatic. If symptoms are present, they may include fever, pruritus,
skin lumps, lymphadenitis, and abdominal pain.