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Vitamin C
Dr. Anand R
Assistant Professor
Department of Biochemistry
CMC Vellore
10th December 2015
Objectives
List the dietary sources of Vitamin B12, C and folic
acid
Explain the functions of Vitamin B12, C and folic acid
List the diseases occurring due to deficiency of each
of the vitamins
Vitamins
Micronutrients (requirement in the range of
microgram- milligrams per day)
Organic compounds required for normal
health, growth and reproduction
Most of the vitamins are naturally occurring ,
specially in plant sources (animal sources
also)
Vitamins
Water soluble
vitamins
Vitamin B
complex
Vitamin C
Fat soluble
vitamins
Vit A, D, E, K
Act on nuclear
receptors
Vitamin B complex
Thiamine B1
Riboflavin B2
Niacin B3
Pantothenic acid - B5
Pyridoxine B6
Biotin B7
Folic acid B9
Cobalamin - B12
Folic acid
Sources
Yeast, liver, egg
Green leafy vegetables, potatoes
Cereals, oil seeds, pulses
Intestinal bacteria
Absorbed from jejunum
Recommended dietary allowance
200-400 microgram/ day
Megaloblastic anemia
http://imagebank.hematology.org
Spina bifida
http://neuropathology-web.org/chapter11/chapter11bNTD.html
Anencephaly
http://nursingcrib.com/
Folate antagonists
Because folate is important for DNA synthesis,
the antagonists are used as treatment as
antibiotics, malaria and cancer
Eg: Methotrexate: anticancer
Vitamin B12
Sources
Absent in plant foods
Animal products
Meat, poultry, fish, eggs, milk, milk products
Liver is a good source
RDA: 1 microgram/ day
Folate trap
Vitamin B12 is essential for folate metabolism
When vitamin B12 is deficient it causes functional
folate deficiency- called folate trap
Malnutrition
Vegetarians
Children, old age
Alcholics and drug addicts
Vitamin C
Vitamin C
Other names: ascorbic acid
Deficiency: scurvy
James Lind: performed one of the clinical
experiments using vitamin C as a treatment for
scurvy
Properties of vitamin C
Destroyed by heating and storage
Sources
Citrus fruits: lime, oranges, tomato, berries
(strawberry, cranberry, gooseberry, raspberry
etc)
Guavas, melons, grapes
Green leafy vegetables, raw cabbage
RDA: 60 75 mg/day
References:
1.Text book of Medical Biochemistry [Dinesh
Puri] 3rd edn
2. Biochemistry 1stedition [Pankaja Naik]
3. Textbook of Biochemistry (Vasudevan and
Sreekumari) 7th edn