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  • Meyer Hair Cortisol As A Biomarker of Long-Term HPA Activity-And Stress

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    Meyer Hair Cortisol as a Biomarker of Long-term HPA Activity-And Stress

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    Propiciar condições para o desenvolvimento da capacidade de reflexão filosófica, entendida como uma reflexão (radical, rigorosa e de conjunto) sobre a condição humana e, mais particularmente, sobre os problemas que a complexa realidade organizacional apresenta.

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    15 просмотров15 страниц

    Meyer Hair Cortisol As A Biomarker of Long-Term HPA Activity-And Stress

    Загружено:

    ThaisWalper
    Propiciar condições para o desenvolvimento da capacidade de reflexão filosófica, entendida como uma reflexão (radical, rigorosa e de conjunto) sobre a condição humana e, mais particularmente, sobre os problemas que a complexa realidade organizacional apresenta.

    Авторское право:

    © All Rights Reserved
    Скачайте в формате PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    из 15

    HairCortisolasaBiomarkerof

    LongTermHPAActivityand
    Stress
    JerroldS.Meyer,Ph.D.
    DepartmentofPsychology
    NeuroscienceandBehaviorProgram
    UniversityofMassachusetts,Amherst01003

    ComparisonofDifferentMatricesfor
    GlucocorticoidMeasurement
    Sample Type

    Time Frame

    Steroids Invasiveness Stability

    Blood

    point

    minutes

    total

    modest

    Saliva

    point

    minutes

    free

    minimal

    2-3

    Urine

    state

    hours/day

    free

    none

    Feces

    state

    hours/day

    free

    none

    2-3

    Hair

    chronic

    weeks/months

    free

    minimal

    PotentialMechanismsofCortisol
    IncorporationandEliminationinHair

    Meyer&Novak(2012)

    MethodologyofHairCortisolAnalysis
    Washhairwithmildsolvent(isopropanol)toremove
    externalcortisolfromsweatandsebum.
    Grinddriedhairintoapowdertoincreasesurfacearea
    forextraction.
    Extractcortisolwithmethanol.
    Evaporatemethanolandreconstituteinassaybuffer.
    Analyzecortisolusingsensitiveandspecificenzyme
    immunoassay(Salimetrics).
    Meyeretal.(2014)

    ApplicationsofHairCortisol

    Chronicstress
    Psychopathology
    Drugabuse
    Development
    Wildlifeconservation
    Archivalsamples

    HairCortisolConcentrationsinRhesus
    MonkeysSubjectedtoRelocationStress

    RhesusmonkeysattheNewEnglandPrimateResearchCenterweresubjectedtoan
    administrativelymandatedrelocationtoanewbuilding.Hairsampleswerecollected
    premoveandagain2monthsand1yearlater.Davenportetal.(2006)

    HairCortisolConcentrationsinInfant
    RhesusMonkeysRearedbyAbusivevs.
    NurturingMothers
    Cortisol accumulated in hair from birth through 6 months
    300

    Hair cortisol (pg/mg hair)

    250

    Control
    Maltreated

    * (p=0.035)
    *

    200

    150

    100

    50

    Sanchezetal.(unpublisheddata)

    NormativeDevelopmentalChangesin
    HairCortisolLevels

    Dettenborn etal.(2012)

    HairCortisolConcentrationsinShift
    WorkersComparedtoDayWorkers

    Manenschijnetal.(2011)

    HairCortisolConcentrationsinPTSD
    Patients

    ParticipantswereyoungUgandanwomenwhohadbeenseverelytraumatized,someof
    whomsubsequentlydevelopedPTSD.HaircortisolwassignificantlyelevatedinthePTSD
    groupcomparedtothetraumatizedcontrols.Steudte etal.(2011)

    HairCortisolConcentrationsinAlcoholics
    (abstinentvs.acutewithdrawal)

    Alcoholicsubjectswereeitherinacutewithdrawal(2nd to12th day)orhadbeenabstinentfor


    atleast14weeks.Stalder etal.(2010)

    HairCortisolandAdverseChildhood
    ExperiencesinCollegeStudents

    Haircortisollevelsweresignificantlylowerincollegestudentswhoscoredhigheronthe
    AdverseChildhoodExperiencequestionnaire.Kalmakis etal.(inpreparation)

    PolarBearMuseumvs.RecentSamples

    1892-1927

    1988-2007
    Bechshft etal.(2012)

    Summary
    Cortisolisslowlydepositedintothegrowinghairshaft
    overperiodsofweekstomonths.
    Haircortisolcanserveasanintegratedmeasureof
    longtermhypothalamicpituitaryadrenocortical
    activity,andthuschronicstress.
    Hairsamplingisnoninvasive
    Cortisolishighlystableinhairforyears,evenwhen
    maintainedatambienttemperature.
    Othersteroidhormones(e.g.,progesterone,
    testosterone)arealsodepositedinhair.
    Limitationsofhaircortisolincludealackofsensitivity
    toacutestressorsorchangesincircadianrhythmicity.

    Resources
    Contactinfo:
    emailjmeyer@psych.umass.edu;phone4135452168
    References:
    (1)MeyerandNovak(2012)Minireview:Haircortisol:Anovelbiomarkerof
    hypothalamicpituitaryadrenocorticalactivity.Endocrinology153:41204127.
    (2)Meyeretal.(2014)Extractionandanalysisofcortisolfromhumanandmonkey
    hair.JournalofVisualizedExperiments 83:e50882.

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