Protecting group

Removal conditions

Tert-Butyloxycarbonyl (Boc)

TFA, DCM, H2O 5% (water is added

to the mixture to prevent double
bond isomerization which occurred
under normal conditions)

2-(4-biphenyl)-isopropoxycarbonyl
(BPOC)

0.2-0.5 TFA

Trytil (Trt)

TFA, DCM

3,5dimethoxyphenylisopropoxycarbon
yl
(Ddz)

1-5% TFA, DCM

4-Methyltrityl (Mtt)

1% TFA-DCM