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Medical Hypotheses
journal homepage: www.elsevier.com/locate/mehy
a r t i c l e
i n f o
Article history:
Received 21 May 2010
Accepted 7 July 2010
s u m m a r y
The hypothesis states that infantile colic is a pain syndrome and the excessive crying leads to aerophagia
and abdominal discomfort. The pain comes from sucking the bottle or the nipple. Feeding for the infant is
a heavy workload for the masticatory muscles.
The tiny digastricus muscle moves the hyoid bone, takes part in opening the mouth and retrusion of the
mandible and assists in mowing the tongue upward, forward and backwards. In the adult population pain
from this muscle is well documented. The hypothesis explains the crying as being due to muscular pain at
rst, later on pain from the origins and insertions of the muscle. Then with increased muscular strength
and development the pain fades away.
2010 Elsevier Ltd. All rights reserved.
Introduction
Infantile colic was rst described in 1894 and still today we
have no agreement on the exact cause. The rule of three from
1954 is generally accepted as a denition of infantile colic: crying
more than 3 h per day, for more than 3 days per week, and for more
than 3 weeks in an infant that is well-fed and otherwise healthy
[1]. The exact etiology of infantile colic is not well understood
and may of course be multifactorial. The gastrointestinal tract
has been suspected by many as harboring the cause and every parent of a colic infant focuses on the distended abdomen and the
obvious abdominal discomfort the infant is showing and many
therapeutic remedies target this.
Other causes as food allergy, atulence, intestinal hormone
abnormalities, parental factors and dysregulation of the nervous
system have been suggested [2].
In a much cited article by Lucassen et al. Effectiveness of treatments for infantile colic: systemic review from 1998, the authors
conclude that: Infantile colic should preferably be treated by
advising carers to reduce stimulation and with 1 week trial of
hypoallergenic formula milk [3]. Claiming that the care and stimulation of the infant may work to increase the symptoms but not
excluding the possibility that the milk or milk substitute can make
a difference.
With a self-limiting condition many types of therapies will
seem effective in single cases but in spite of all efforts, no accepted
form for therapy exists.
Although self-limiting and benign, infantile colic puts a heavy
strain on many parents and may in some instances be the underlying cause of abuse. Lee et al. published in 2007 ndings that provided convergent indirect evidence that crying, especially in the
The hypothesis
Feeding is a strenuous effort for the newborn infant. One can
say that this is the only hard work they have to perform in the infant period.
Sucking the bottle or the nipple is a well coordinated muscular
activity and many muscles are involved. It is not easy to show exactly in which muscle there is most fatigue during feeding, but one
muscle: the digastricus, is a very thin muscle with a demanding job
and is the focus of my intention.
The digastricus muscle is a small muscle located under the under side of the jaw. It consists of two bellies united by a single ten-
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