This chapter discusses instrumentation issues related to industrial process safety. Instrumentation safety may be broadly divided into two categories: how instruments themselves may pose a safety hazard (electrical signals possibly igniting hazardous atmospheres), and how instruments and control systems may be configured to detect unsafe process conditions and automatically shut an unsafe process down. In either case, the intent of this chapter is to help define and teach how to mitigate hazards encountered in certain instrumented processes. I purposely use the word mitigate rather than eliminate because the complete elimination of all risk is an impossibility. Despite our best efforts and intentions, no one can absolutely eliminate all dangers from industrial processes1 . What we can do, though, is significantly reduce those risks to the point they begin to approach the low level of background risks we all face in daily life, and that is no small achievement. An important philosophy to follow in the safe design is something called defense-in-depth. This is the principle of using multiple layers2 of protection, in case one or more of those layers fail. Applying defense-in-depth to process design means regarding each and every safety tool and technique as part of a multi-faceted strategy, rather than as a set of mutually-exclusive alternatives. To give a brief example of defense-in-depth applied to over-pressure protection in a fluid processing system, that system might defend against excessive fluid pressure using all of the following techniques: A pressure-control system with an operator-adjusted setpoint High-pressure alarms to force operator attention A safety shutdown system triggered by abnormally high pressure Temperature control systems (both regulatory and safety shutdown) to prevent excessive temperature from helping to create excessive fluid pressure 1 For that matter, it is impossible to eliminate all danger from life in general. Every thing you do (or dont do) involves some level of risk. The question really should be, how much risk is there in a given action, and how much risk am I willing to tolerate? To illustrate, there does exist a non-zero probability that something you will read in this book is so shocking it will cause you to suffer a heart attack. However, the odds of you walking away from this book and never reading it again over concern of epiphany-induced cardiac arrest are just as slim. 2 Also humorously referred to as the belt and suspenders school of engineering.