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Myofasciitis in the Domestic Ferret. Vet Pathol 44:25–38 (2007). young ferrets,
Gross lesions -atrophy of skeletal muscle; red and white mottling and dilatation of the
esophagus; and splenomegaly. Histologically-suppurative to pyogranulomatous mypsitis
in the esophagus, heart, limbs, body wall, head, and lumbar regions. Myeloid hyperplasia
of spleen and/or bone marrow also is a prominent feature. Ultrastructural lesions include
mitochondrial swelling, intracellular edema, disruption of myofibrils and Z bands.
CNS Hypomyelination in Rat Terrier Dogs with Congenital Goiter and a Mutation
in the Thyroid Peroxidase Gene. Vet Pathol 44:50–56 (2007). Hyperplasia of the
follicular epithelium, myelin deficiency, most evident in the corpus callosum. A
homozygous nonsense mutation in the thyroid peroxidase gene.
Three Equine Cases of Mixed Hepatoblastoma with Teratoid Features. Vet Pathol
44:211–214 (2007). sheets and cords of fetal and embryonal epithelial cells that
frequently formed sinusoid-like structures. Intermixed with the neoplastic epithelial cells
were variable amounts of hemorrhage, necrosis, osteoid, and bone.
Immunohistochemically, the epithelial cells stained variably positive for alpha-
fetoprotein, frequently positive for vimentin, and occasionally positive for Cytokeratin.
Pulmonary Aspergillosis and Ischemic Distal Limb Necrosis Associated with Enteric
Salmonellosis in a Foal. Vet Pathol 44:215–217 (2007). Salmonella typhimurium-
disseminated pyogranulomas with intralesional fungal hyphae. The morphologic
characteristics of fungal hyphae were consistent with Aspergillus spp., and large numbers
of A fumigatus were isolated. Thus, limb lesions are consistent with symmetrical
peripheral gangrene, a potential complication of sepsis.
Fatal Streptococcus canis Infections in Intensively Housed Shelter Cats. Vet Pathol
44:218–221 (2007). 1. skin ulceration and chronic respiratory infection that progressed,
in some cats, to necrotizing sinusitis and meningitis. 2. progression from necrotizing
fasciitis with skin ulceration to toxic shock–like syndrome, sepsis, and death. S canis was
the sole pathogen identified in most cases.
Confocal Laser Scanning Analysis of an Equine Oral Mast Cell Tumor with
Atypical Expression of Tyrosine Kinase Receptor C-KIT. Cresyl violet-positive mast
cells accompanied by numerous eosinophils. Strong, diffuse, intracytoplasmatic
immunohistochemical signal for tryptase and a faint membrane-associated and
perinuclear signal for tyrosine kinase receptor KIT. Confocal laser scanning microscopy
confirmed an aberrant spatial colocalization of KIT in the Golgi apparatus, which may be
the result of a defective protein processing within the tumor cells.
Synovial Hemangioma in the Stifle Joint of a Dog. Vet Pathol 44:240–243 (2007).
vascular channels that were lined by well-differentiated endothelial cells and separated by
fibrous septa. Distension of some channels resulted in endothelial disruption, thrombosis,
hemorrhage, necrosis, and focal spindle-cell proliferation.
A Mixed Epithelial and Stromal Tumor of the Kidney in a Ringtail Lemur (Lemur
catta). Vet Pathol 44:243–246 (2007). The mesenchymal cells were arranged in
fascicles around cysts lined by a well-differentiated epithelium.
Cranial Nerve Hamartoma in a Dog. firm, white nodules across the petrosal crest of
the skull. Microscopically, the nodules were composed of normal myelinated nerve fibers
within a mucinous stroma.
Mitotic Index Is Predictive for Survival for Canine Cutaneous Mast Cell Tumors.
Vet Pathol 44:335–341 (2007). For grade II tumors with anMI #5, the median survival
time (MST) was 70 months, compared with 5 months for those with an MI .5 (P , .001).
Interstitial Cell Tumor and Sertoli Cell Tumor in the Testis of a Cat. Vet Pathol
44:394–397 (2007). The presence of penile papillae implied testosterone production.
Testes were not palpable, but the left testis was found in the scrotum by surgical
exploration and was mostly replaced by the 2 tumors. The interstitial cell tumor, but not
the Sertoli cell tumor, was immunohistochemically positive for Melan-A, consistent with
steroid production.
Auricular Chondritis Caused by Metal Ear Tagging in C57BL/6 Mice. Vet Pathol
44:458–466 (2007). Histopathologically, there were observed severe chondritis with
extensive granulomatous inflammation, newly formed cartilage nodules, and osseous
metaplasia accompanied by cellular infiltrates, such as CD4 T lymphocyte, macrophages,
neutrophils, and mast cells, and expression of Th1 cytokines, such as interferon-gamma,
tumor necrosis factor-alpha, and interleukin-2 in the tagged ear. Based on these results,
we concluded that the release of copper and iron ions from the metal ear tags played a
major role in the onset of auricular chondritis. Subsequent cellular interactions, such as
CD4 T cells, macrophages, fibroblasts, and mast cells, mediated by cytokines, such as
tumor necrosis factoralpha and interferon-gamma, caused an autoimmune response that
may have led to the progression of auricular chondritis as an autoimmune disease.
Natural Peste des Petits Ruminants Virus Infection: Novel Pathologic Findings
Resembling Other Morbillivirus Infections. Vet Pathol 44:479–486 (2007).
Pathologic findings included erosiveulcerative stomatitis, fibrino-necrotic tracheitis,
bronchointerstitial pneumonia, multifocal coagulation necroses in the liver, and severe
lymphocytolysis in lymphoid tissues. Syncytial cells were conspicuous, especially in the
oral mucosa, pulmonary alveoli, liver, and lymphoid tissues. these previously unreported
pathologic findings in natural peste des petits ruminants virus infection establish a basis
for resemblance to other morbillivirus infections, such as canine distemper and distemper
of sea mammals.
Dental Benign Cementomas in Three Horses. Vet Pathol 44:533–536 (2007). multiple
bony enlargements of the upper and lower jaw extending into the oral cavity.
Histopathologically, the tumors consisted of excessive deposition of cementum-like
tissue. Cells, resembling cementoblasts, lined irregularly shaped lacunae, which were
present in the tumor tissue, and showed minimal cellular pleomorphism.Mitotic figures
were not present.
Canine Adenovirus Type 1 Infection of a Eurasian River Otter (Lutra lutra). Vet
Pathol 44:536–539 (2007). The liver was found to be swollen and friable
Microscopically, there was multifocal hepatic necrosis. with large basophilic intranuclear
inclusions. Transmission electron microscopy revealed characteristic hexagonal virus
particles sized approximately 70 nm in diameter in the nuclei of the hepatocytes.
Aleutian Disease in Two Domestic Striped Skunks (Mephitis mephitis). Vet Pathol
44:687–690 (2007). Aleutian mink disease parvovirus (ADV) is known to infect several
members of the Mustelidae family, with mink and ferrets being the most commonly
reported hosts. Aleutian disease (AD) in adult animals is characterized by
hypergammaglobulinemia and immune- complex disease. The most common form of
AD involves a persistent infection due to the inability of the host immune response to
neutralize and eliminate the virus. Lymphoplasmacytic infiltration of various organs,
immune complex deposits in blood vessels, and severe mesangioproliferative
glomerulonephritis ultimately lead to death.
Multiple Hepatic Peribiliary Cysts in a Young Pig. Vet Pathol 44:707–709 (2007). All
lobes of the liver contained numerous cysts of varying size containing serous fluid in all
lobes. Histopathologically, the cysts were located mainly around the large bile duct and
in the connective tissue of the portal tracts. The cysts were lined by a single layer of
columnar, cuboidal, and flattened epithelial cells. Occasionally, goblet cells were
observed. The epithelial cells were stained with periodic acid–Schiff/alcian blue and
high-iron diamine/alcian blue, indicating the presence of neutral mucin, sialomucin, and
sulfomucin.
Omental Leiomyoma in a Male Adult Horse. Vet Pathol 44:722–726 (2007). multiple
white-to-yellow lobules. Histologically, the mass consisted of slightly pleomorphic
spindloid-shaped cells arranged in interlacing bundles containing elongated nuclei with
blunt ends. The majority of tumor cells revealed a positive immunoreaction for a-smooth
muscle actin, vimentin, and neuron-specific enolase and were negative for S-100, factor
VIII–related antigen, and glial fibrillary acidic protein.
Nov
S-100 IHC- S-100 is normally present in cells derived from the neural crest (Schwann
cells, melanocytes, and glial cells), chondrocytes, adipocytes, myoepithelial cells,
macrophages, Langerhans cells, dendritic cells, and keratinocytes.
S100 proteins are involved in regulation of protein phosphorylation, transcription factors,
Ca++ homeostasis, the dynamics of cytoskeleton constituents, enzyme activities, cell
growth and differentiation, and the inflammatory response. It can be found in
melanomas, 50% of malignant peripheral nerve sheath tumors, and clear cell sarcomas.
Eosinophilic Substance is ‘‘Not Amyloid’’ in the Mouse Nasal Septum. Vet Pathol
44:796–802 (2007). An eosinophilic substance (ES) is usually observed in the mouse
nasal septum and increases in volume with aging. It has been described as amyloid in
textbooks and one report. However, it has been described as ‘‘not amyloid’’ in other
reports because there was a negative reaction to Congo red. The ES reacted negatively to
Congo red but was strongly positive to periodic acid–Schiff reaction with prior diastase
treatment. In the electron microscope observation, the ES consisted of amorphous
material and collagen, but no nonbranching fibrils. The above-mentioned findings
indicated that the ES was not amyloid and suggested the ES might consist of not only
collagen but also complex carbohydrate, which was produced by the nasal gland
epithelial cells.