Академический Документы
Профессиональный Документы
Культура Документы
January issue
Serial Passage of Sheep Scrapie Inoculum in Suffolk Sheep: US scrapie agent (No. 13-7)
appears to have been stabilized in susceptible (171 QQ) Suffolk sheep and may be considered a
specific isolate of sheep scrapie agent in the USA. Spongiform lesions present brainstem (obex),
colliculi, cerebellum and cereberum.
Bovine Viral Diarrhea Virus Abortion in Goats Housed with Persistently Infected Cattle:
goats experimentally comingled with heifers persistently infected with BVD type 2a. 12 out of
24 aborted. Grossly: placentitis, mummification, facial deformities; Histo: placentitis,
myocarditis, thymic depletion, choroid plexitis, encephalitis. Development of PI kid is less
likely.
Distribution of Bovine Viral Diarrhea Virus Antigen in Aborted Fetal and Neonatal Goats
by IHC: placenta, heart, brain, thymus are most reliable for BVDV antigen detection
Detection of Pathologic Prion Protein in the Olfactory Bulb of Natural and Experimental
Bovine Spongiform Encephalopathy Affected Cattle in Great Britain: involvement of the
olfactory bulb in BSE raises speculation as to an olfactory portal of infection or a route of
excretion of the prion agent.
Septicemia in a Neonatal Calf Associated with Chromobacterium violaceum: The calf had
necrosuppurative omphalophlebitis, hepatitis, splenitis, and encephalitis, necrotizing interstitial
pneumonia, anterior uveitis with hypopyon, polyarthritis. Lesions documented with C. violaceum
includes, visceral abscesses, necrosis, pleuropnuemonia, pericarditis.
March issue
Widespread Mismatch Repair Protein Expression in Canine Cutaneous Mast Cell Tumors:
Results do not support the hypothesis that inherited MMR defects predispose some dogs to MCT
development
Inflammatory Myofibroblastic Tumors (IMT) in Two Dogs: IMT are discrete masses
composed of a mixture of bland fusiform myofibroblastic cells and an inflammatory infiltrate
composed of varying proportions of lymphocytes, plasma cells, and histiocytes. IMTs are
regarded as pseudoneoplasms.
Malignant Round Cell Neoplasia in Llamas and Alpacas: Mean age of affected alpacas (3.1
years) was significantly less than that of affected llamas (8.0 years). B-cell lymphoma (12
cases) and T-cell lymphoma (6 cases). Six tumors did not express any lymphoid marker and were
classified as primitive malignant round cell tumor. Lymphomas are the most common tumor
affecting camelids. Liver and kidney are most commonly involved organs in round cell tumor.
Oligoastrocytoma of the Brain in a Hooded Crane: The tumor was composed of 2 discrete
components that resembled oligodendroglioma and astrocytoma. Oligodendrogliomatous cells
were partially immunoreactive for vimentin and myelin basic protein, and the astrogliomatous
component were vimentin, S-100, GFAP positive.
Cover illustration:
Acquired Melanosis Caused by Acorn Ingestion in the Nero Siciliano Pig: Diffuse black
discoloration of lymph node cortex and medulla and melanosis of fat. Acorns have high total
phenolic compounds. Hypothesized that swine tyrosinase could act on phenolic substances found
in acorns and increase the biosynthesis and the anomalous storage of melanin.
Main clinical signs= marching gait, alert gaze, head tremors, and poor growth. Histologically
vacuolization in neurons, thyroid follicular and pancreatic acinar cells was seen. Other plants
causing head and neck tremors (tremorgenic) are Ipomea, Phalaris, Solanum, Claviceps and
Asperigillus
May issue
The Role of Inflammation in Mouse Pulmonary Neoplasia: Inflammation is risk factor for
development of cancer. The most common inflammatory cell type in tumor tissue is macrophage.
Tumor tissue is sensitive to growth inhibitory properties of glucocorticoids. PGE2 has pro-
tumorigenic and PGI2 has anti-tumorigenic properties, deficiency of TNF, TNFr, IL-10 reduces
carcinogenesis, TLR-4 is protective in carcinogenesis, TLR-4 deficient mice are more
susceptible to tumor. iNOS deficient mice has less chances of lung cancer.
Identification of Cancer Stem Cells in Dog Glioblastoma: small fraction of cells in the tumor,
termed cancer stem cells (CSC) possess the ability to proliferate and self-renew extensively.
These cells are characterized by the expression of CD133 and nestin and ability to grow as
nonadherent spheres termed "neurospheres" when cultured in the presence of EGF and FGF
under serum-free conditions. CSC population from a Boxer dog with glioblastoma multiforme
(GBM) was cloned, this cell line is aneuploid, forms neurospheres in culture, possesses CSC
markers, and reproduces the original dog GBM when inoculated into the nude mouse brain.
Immunohistochemical Expression of p63 and {Delta}Np63 in Mixed Tumors of Canine
Mammary Glands and Its Relation with p53 Expression;
Epithelioid Cells in Mediastinal Lymph Nodes of Cattle without Cancer: Out of 110 cattle,
66 had epitheloid cells in lymph nodes. Most of the epithelioid cells were individual or
aggregated in nodal sinuses; some epithelioid cells formed tubular structures. Epithelioid cells
were mostly considered to be mesothelial in origin by immunohistochemical and ultrastructural
examination.
Disseminated Chlorellosis in a Dog: lingual mass, lungs, liver, mesenteric and sublumbar
lymph nodes, and spinal meninges had pronounced green discoloration. Histologically,
pyogranulomatous inflammation and algal organisms were found. The algae had cell walls and
cytolasmic granules PAS positive. Ultrastructurally, the algae had a well-defined cell wall, stacks
of grana and thylakoid membrane, and dense bodies, typical of starch granules. Chlorella is a
chlorophyll-containing green alga closely related to Prototheca, which is thought to be its
achlorophyllous mutant. Unlike Prototheca, Chlorella spp. contains numerous starch granules
that are strongly PAS-positive and diastase sensitive, birefringent under polarized light. Only the
cell wall of Prototheca is PAS-positive. The life cycles of Chlorella and Prototheca are similar.
Both produce hyaline cells (sporangia) that mature to produce 2–20 sporangiospores
(endospores) asexually. After endosporulation, the outer sporangial wall ruptures, releasing the
sporangiospores to repeat the cycle.
Bilateral Ovarian Malignant Mixed Müllerian Tumor in a Dog: Histologically, both ovaries
had intermingled carcinomatous and sarcomatous components (cartilage, bone). The peritoneal
metastases were carcinomatous; pulmonary metastases were sarcomatous. Epithelial component
was formation of tubules and papillary structures. The carcinomatous components expressed
estrogen receptor which favored MMMT diagnosis over teratoma (the ectodermal component in
teratoma of hair filled follicle cyst was not present).
Pulmonary Myxoma in a Sheep: Myxoma is a rare tumor with a few reports of its occurrence
in the jaws of horses and cattle, the heart and synovia of dogs, the heart of a cat, and bronchi of a
mare
Gas Bubbles in Seals, Dolphins, and Porpoises Entangled and Drowned at Depth in
Gillnets. Vet Pathol 46:536–547 (2009). that peri- or postmortem phase change of
supersaturated blood and tissues is most likely. Studies have suggested that under some
circumstances, diving mammals are routinely supersaturated and that these mammals
presumably manage gas exchange and decompression anatomically and behaviorally
Clara Cell Secretory Protein Is Reduced in Equine Recurrent Airway Obstruction. Vet
Pathol 46:604–613 (2009). Chronically affected animals have lung remodeling
characterized by smooth muscle hyperplasia, collagen deposition, lymphoid hyperplasia,
and impaired aerobic performance. Clara cell secretory protein (CCSP) counters inflammation
in the lung. CCSP lung gene expression was significantly higher in healthy animals than in
animals with chronic RAO.
The Progenitor Cell Compartment in the Feline Liver: An (Immuno)Histochemical
Investigation. Vet Pathol 46:614–621 (2009). In acute and chronic feline liver diseases a
ductular reaction is present, whether in the parenchyma or in a portal or septal location. The
putative progenitor cells could easily be demonstrated by staining for CK7, whereas they were
generally negative for Hepar1 and MRP2. In a parenchymal ductular reaction mitotic figures and
cells with an intermediate hepatobiliary phenotype could be demonstrated. This is the first
account of hepatic progenitor cells in feline liver.
Haemorrhages in the pulmonary artery and aortic valve associated with Streptococcus
gallolyticus subspecies gallolyticus in a roe deer Veterinary Record (2009) 165, 237-239
DDx: Pulmonary artey hemorrhages: Orbivirus, Rift Valley fever sheep
Heartwater in sheep, Pulpy kidney disease in sheep, Septicaemic
pasteurellosis in sheep Haemorrhages of the pulmonary artery (with
unspecified location) have been associated with adenovirus haemorrhagic
disease in deer. And also include Streptococcus gallolyticus subspecies gallolyticus
induced septicemia, Streptococcus bovis (mink and humans) Histopathology: Vasculitis
characterized by fibrinoid degeneration of the tunica media with intramural and peripheral
haemorrhages in blood vessels of the wall of the pulmonary artery and the myocardium.
___________________________
-------------------------------------------------------------------------------------------------
---------------------------------------------------------------------------------------
--------------------------------------------------------------------------------
_____-------------------------------------------------