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Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Adenovirus
Febrile Pharyngitis;
Acute Hemorrhagic
Cystitis; Pneumonia;
Conjunctivitis
Person to person
close contact,
coughing,
sneezing, touching
an object or
surface with
adenoviruses on it,
then touching your
mouth, nose, or
eyes before
washing your
hands; infected
stool; swimming
pools (less
common)
dsDNA,
Linear
Icosahedral
Terrance Garnett
Summer 2016
Bunyavirus
California
Encephalitis;
Sandfly/Rift Valley
Fevers; CrimeanCongo Hemorrhagic
Fever; HantavirusHemorrhagic Fever;
Pneumonia
Ocular disease
Lesions on the eyes
+ blurred and
decreased vision;
Encephalitis
headaches, coma, or
seizures; (symptoms
of hemorrhaging)
jaundice + other
signs of liver
impairment,
followed by
vomiting blood,
bloody stool, or
bleeding from gums,
skin, nose, and
injection sites;
fatigue, fever and
muscle aches
(thighs, hips, back,
shoulders) +
headaches,
dizziness, chills, and
abdominal problems
(nausea, vomiting,
diarrhea, pain) et al.
Coronavirus
Common Cold;
SARS, MERS
Terrance Garnett
mild to moderate
upper-respiratory
tract illnesses
(URIs), symptoms
include: [short
ssRNA, (),
Circular, three
(3) Segments
Helical
ssRNA, (+),
Linear
Helical
Yes Envelope
Summer 2016
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
duration] runny
nose, cough, sore
throat, fever
much likely
spread from
infected person
through air
(coughing &
sneezing) + close
personal contact
(touching or
shaking hands or
contaminated
objects)
lower-respiratory
tract illnesses
(LRIs): pneumonia
[common in Pts
w/cardiopulmonary
disease or
compromised
immune systems, or
the elderly]
Terrance Garnett
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Summer 2016
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Flaviviruses
HCV;
No illness or only
mild illness (i.e.
Yellow Fever, Zika)
fever, chills, severe
headache, back pain,
general body aches,
nausea/vomiting,
fatigue, weakness;
transmitted to
people primarily
through the bite of
infected Aedes or
Haemagogus
species
mosquitoes;
ssRNA, (+),
Linear
Icosahedral
Yellow Fever;
Dengue;
St. Louis
Encephalitis;
West Nile Virus;
Zika virus
Yes Envelope
transmitted
between people by
the mosquitoes
Aedes aegypti and
Aedes albopictus
found throughout
the world;
transmitted to
people primarily
through the bite of
Neurologic illness - an infected Aedes
neck stiffness,
species mosquito
disorientation, coma, (Ae. aegypti and
tremors, seizures, or Ae. albopictus)
paralysis; et al.
same mosquitoes
that spread dengue
& chikungunya
viruses; et al.
Terrance Garnett
Summer 2016
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Togaviruses
Eastern Equine
Encephalitis; Western
Equine Encephalitis;
Rubella
transmitted via
direct or droplet
contact with
respiratory
secretions;
(Rubella virus)
multiplies in cells
of the respiratory
system viremic
spread to target
organs; congenital
infection is
transmitted
transplacentally; et
al.
ssRNA, (+),
Linear
Icosahedral
Terrance Garnett
Yes Envelope
Summer 2016
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Filoviruses
Ebola; Marburg
Hemorrhagic Fever
(often fatal)
Diarrhea/Vomiting,
Abdominal
(stomach) pain,
Unexplained
hemorrhage
(bleeding or
bruising);
Spread to others
through direct
contact broken
skin or mucous
membranes: eyes,
nose, or mouth;
blood or body
fluids - urine,
saliva, sweat,
feces, vomit,
breast milk, and
semen) of a person
who is sick with or
has died from
Ebola; infected
fruit bats or
primates (apes and
monkeys);
ssRNA, (),
Linear
Helical
fever, chills,
headache, myalgia;
maculopapular rash
Yes Envelope
Nosocomial
transmission
Terrance Garnett
Summer 2016
Enterovirus
(Picornaviruses)
Terrance Garnett
Mild illness
includes: fever,
runny nose,
sneezing, cough,
skin rash, mouth
blisters, body and
muscle aches
infection NonPolio Enterovirus:
viral conjunctivitis;
viral meningitis
(infection of the
covering of the
spinal cord and/or
brain); viral
encephalitis
(infection of the
brain); myocarditis
(infection of the
heart); pericarditis
(infection of the sac
around the heart);
acute flaccid
paralysis (a sudden
onset of weakness in
one or more arms or
legs); inflammatory
muscle disease
(slow, progressive
muscle weakness)
Close contact
shaking hands,
touching objects,
or surfaces that
have the virus on
them; drinking
water that has the
virus in it;
ssRNA, (+),
Linear
Icosahedral
No Envelope
Pregnant women
who are infected
with a non-polio
enterovirus shortly
before delivery can
pass the virus to
their babies
Summer 2016
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Epstein-Barr Virus
(HHV-4)
Infectious
Mononucleosis
fever,
hepatosplenomegaly,
pharyngitis,
lymphadenopathy
(posterior cervical
nodes);
Fatigue, fever,
inflamed throat,
swollen lymph
nodes in the neck,
enlarged spleen,
swollen liver, rash
Respiratory
Secretions, Saliva,
kissing disease,
(common in teens,
young adults)
dsDNA,
Linear
Icosahedral
spreads through
respiratory
secretions (saliva,
sputum, or nasal
mucus) when an
infected person
coughs or sneezes
Associated with
lymphomas (e.g.
Endemic Burkitt
Lymphoma),
nasopharyngeal
carcinoma
Parvovirus
Erythrovirus B19
aplastic crises in
sickle cell disease,
slapped cheeks,
rash in children
[Erythema
Infectiosum, or Fifth
(5th) Disease]
Feline Panleukopenia
Terrance Garnett
No Envelope
Summer 2016
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Hantavirus (see
Bunyavirus)
Hantavirus
Pulmonary Syndrome
(HPS), Hemorrhagic
Fever with Renal
Syndrome (HFRS)
fatigue, fever +
muscle aches,
headaches,
dizziness, chills,
nausea, vomiting,
diarrhea, &
abdominal pain
(United States)
ssRNA, (),
deer mice, cotton
Circular, three
rats, rice rats,
(3) Segments
white-footed
mouse = are the
reservoir of the
virus; rodents shed
virus in their urine,
droppings, +
saliva; transmitted
to people when
they breathe in air
contaminated with
the virus
airborne
transmission
Helical
Hantaviruses replicate
exclusively in the host cell
cytoplasm; HPS can be fatal,
mortality rate of 38%
Hepatitis A Virus
(HAV) [RNA
Picornavirus]
Hepatitis A
Fever, jaundice,
ALT, & AST;
Asymptomatic
(Usually), Acute
Fecal-oral
(shellfish,
travelers, Day
Care)
ssRNA, (+),
Linear
Icosahedral
Hepatitis B Virus
(HBV) [DNA
Hepadnavirus]
Hepatitis B:
Fever, jaundice,
ALT, & AST;
Serum Sickness
(fever, arthralgias,
rash) Carcinoma
Parenteral, Sexual,
Perinatal
Partially
dsDNA,
Circular
Icosahedral
Acute/Chronic
Terrance Garnett
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Summer 2016
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Herpes Simplex
Virus1
Gingivostomatitis,
Keratoconjunctivitis,
Herpes Labialis,
Herpetic Whitlow on
finger, Temporal
Lobe Encephalitis
Most individuals
infected with HSV-1
or HSV-2 are
asymptomatic or
have very mild
symptoms that go
unnoticed or are
mistaken for another
skin condition;
Respiratory
Secretions, Saliva
Infections
transmitted
through contact
with lesions,
mucosal surfaces,
genital secretions,
or oral secretions
dsDNA,
Linear
Icosahedral
Terrance Garnett
Summer 2016
10
Herpes Simplex
Virus2
Herpes Genitalis;
Neonatal Herpes
Terrance Garnett
typically appear as
one or more vesicles
on or around the
genitals, rectum or
mouth vesicles
break and leave
painful ulcers that
may take two to four
weeks to heal; first
outbreak of herpes is
often associated
with a longer
duration of herpetic
lesions, increased
viral shedding
(making HSV
transmission more
likely) + systemic
symptoms: fever,
body aches, swollen
lymph nodes,
headache
recurrent outbreaks
are typically shorter
in duration and less
severe than the first
outbreak of genital
herpes, although the
infection can stay in
the body
indefinitely, the
number of outbreaks
Sexual Contact,
Perinatal;
Infections
transmitted
through contact
with lesions,
mucosal surfaces,
genital secretions,
or oral secretions
dsDNA,
Linear
Icosahedral
Summer 2016
11
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
tends to decrease
over time,
recurrences &
subclinical shedding
are much less
frequent for genital
HSV-1 infection
than for genital
HSV-2 infection
Terrance Garnett
Summer 2016
12
Influenza
Influenza virus
(Orthomyxoviruses)
Terrance Garnett
Uncomplicated
influenza:
characterized by the
abrupt onset of
constitutional and
respiratory signs and
symptoms fever,
myalgia, headache,
malaise,
nonproductive
cough, sore throat,
rhinitis; (Among
children) otitis
media,
nausea/vomiting
also are commonly
reported; resolves
after 37 days for
the majority of
persons (cough +
malaise can persist
for >2 weeks);
Influenza virus
infections cause:
primary influenza
viral pneumonia;
exacerbate
underlying medical
conditions (e.g.,
pulmonary or
cardiac disease);
lead to secondary
Influenza viruses
are spread from
person to person
primarily through:
Large-particle
respiratory droplet
transmission (e.g.
person coughs or
sneezes) requires
close contact
between source
and recipient
persons (droplets
do not remain
suspended in the
air + generally
travel only less
than or equal to 1
meter through the
air); Contact with
respiratory-droplet
contaminated
surfaces; Airborne
transmission (via
small-particle
residue [less than
or equal to 5m]
of evaporated
droplets that might
remain suspended
in the air for long
periods of time)
ssRNA, (),
eight (8)
segments
genome
Helical
Summer 2016
13
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
bacterial pneumonia,
sinusitis, or otitis
media; or contribute
to coinfections with
other viral or
bacterial pathogens
Patients at risk
for fatal bacterial
superinfection S
aureus, S
pneumonia, H
influenza
Terrance Garnett
Summer 2016
14
Marburg
Hemorrhagic Fever
(Marburg HF)
Terrance Garnett
5 to 10 day
incubation: fever,
chills, headache,
myalgia;
maculopapular rash
= most prominent on
trunk (chest, back,
stomach); [Severe]
jaundice,
inflammation of the
pancreas, severe
weight loss,
delirium, shock,
liver failure, massive
hemorrhaging,
multi-organ
dysfunction
Unknown how
Marburg virus first
transmits from its
animal host to
humans, after this
initial crossover of
virus from host
animal to humans,
transmission
occurs through
person-to-person
contact direct
contact to droplets
of body fluids
from infected
persons; contact
with equipment +
other objects
contaminated with
infectious blood or
tissues; Spread of
the virus between
humans in close
environments &
direct contact =
caregivers in the
home/hospital
(nosocomial
transmission)
ssRNA, (),
Linear
Helical
Summer 2016
15
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Measles (rubeola)
virus
[Paramyxoviruses]
Measles
Usual Presentation:
prodromal fever (as
high as 105F),
cough, conjunctivitis
Koplik spots
(bright red spots
with blue-white
center on buccal
mucosa) (1-2
days later)
maculopapular
rash: starts at the
head/neck, spreads
downwards
Measles is one of
ssRNA, (),
Helical
the most
Linear,
contagious of all
Nonsegmented
infectious
diseases; persons
with close contact
to a measles
patient will
develop measles;
virus is transmitted
by direct contact
with infectious
droplets or by
airborne spread
when infected
person breathes,
coughs, or sneezes
Measles virus
remains infectious
in the air for up to
two (2) hours
after an infected
person leaves an
area
Terrance Garnett
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Vitamin A supplementation
can reduce morbidity &
mortality from measles (i.e.
malnourished children)
Summer 2016
16
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Poliovirus
(Picornaviruses)
Polio = poliomyelitis
Enters body
through mouth &
spread through
contact with feces
of infected person,
droplets from a
sneeze or cough;
spread via fecaloral
contamination;
very contagious,
spreads through
person-to-person
contact; virus can
live in an infected
persons feces for
many weeks;
poliovirus only
infects humans
ssRNA, (+),
Linear
Icosahedral
Terrance Garnett
Summer 2016
17
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Rabies virus
(Rhabdoviruses)
Rabies
Progression of
disease: fever,
malaise agitation,
photophobia,
hydrophobia,
hypersalivation
paralysis, coma
death
(U.S.) Infection
more commonly
from bat, raccoon,
+ skunk bites Vs.
dog bites; Aerosol
Transmission (e.g.
via bat caves)
possible
ssRNA, (),
Linear
Terrance Garnett
Summer 2016
18
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Rhinovirus
(Picornaviruse)
rhinorrhea, nasal
obstruction,
sneezing; upper
respiratory tract
may cause otitis
media + sinusitis
ssRNA, (+),
Linear
Icosahedral
Terrance Garnett
Summer 2016
19
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Rotavirus
(Reoviruses)
Infantile
gastroenteritis
Acute Diarrhea #1
cause of fatal
diarrhea in children
Rotavirus spreads
easily among
infants and young
children both
before and after
they become sick
with diarrhea;
rotavirus shed in
feces (stool)
spreads via fecaloral route
dsRNA,
Segmented: 10
12 segments
Icosahedral
(double)
Terrance Garnett
Summer 2016
20
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Fever, postauricular
lymphadenopathy,
arthralgias; fine,
confluent rash that
starts on face &
spreads centrifugally
to involve trunk &
extremities
spreads when an
infected person
coughs or sneezes
may spread the
disease to others
up to one week
before the rash
appears, and
remain contagious
up to 7 days after;
can cause
miscarriage or
serious birth
defects in a
developing baby if
a woman is
infected while she
is pregnant
ssRNA, (+),
Linear
Icosahedral
Congenital Rubella:
bkueberry muffin
appearance due to
dermal
extramedullary
hematopoiesis
Terrance Garnett
Summer 2016
21
Poxvirus (Variola
virus)
Terrance Garnett
Person to Person:
dsDNA,
direct + prolonged Linear (largest
DNA virus)
An illness with acute face-to-face
contact; spread
onset of fever
through direct
>101F (38.3C)
contact with
followed by a rash
infected bodily
characterized by
fluids or
firm, deep seated
contaminated
vesicles or pustules
in the same stage of objects (bedding or
clothing); [Rarely]
development
spread by virus
without other
carried in the air
apparent cause
(acknowledging that (enclosed settings there are many other buildings, buses,
and trains)
causes of vesicular
Humans only
and pustular rash
illnesses) Healthcare natural hosts of
providers evaluating variola, Smallpox
is not known to be
cases should
transmitted by
familiarize
insects or animals
themselves with
diseases that can be
confused with
smallpox: varicella,
herpes simplex, drug
reactions, erythema
multiforme
Complex
brick or ovalshaped
Smallpox eradicated
worldwide by use of the
live-attenuated vaccine;
Cowpox (milkmaid
blisters); Yes Envelope;
DNA-dependent RNA
polymerase
Summer 2016
22
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Varicella-Zoster
(HHV-3;
Herpesvirus; HZV)
Varicella-zoster
(chickenpox,
shingles),
Encephalitis,
Pneumonia
Respiratory
Secretions enters
respiratory tract &
conjunctiva
primary viremia
occurs 4 to 6 days
after infection,
disseminates the
virus to other
organs: liver,
spleen, sensory
ganglia;
respiratory contact
with airborne
droplets or by
direct
contact/inhalation
of aerosols from
vesicular fluid of
skin lesions of
acute varicella or
zoster
dsDNA, (+)
Linear
Icosahedral
Terrance Garnett
Summer 2016
23
Pathogen
Disease Name(s)
S/S of Disease
Acquire Infection
Genome
Type, (+)/()
Sense,
Genome
Shape
Morphology
Flaviviruses
(Arbovirus)
Yellow Fever
Transmitted by
Aedes mosquitoes;
monkey or human
reservoir
ssRNA, (+),
Linear
Icosahedral
Terrance Garnett
Summer 2016
24