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  • MOOC Petersen 2 1 VoltageGatedChannels 20140525

    Загружено:

    Juhi Neogi
    1 просмотров15 страниц
    This document discusses voltage-gated ion channels. It explains that the open probability of voltage-gated ion channels depends on the membrane potential. Voltage-gated sodium channels cause explosive depolarization, while voltage-gated potassium channels stabilize the hyperpolarized membrane potential. The document also notes that voltage-gated sodium and potassium channels have single channel conductances of around 20 pS and are important for generating voltage-dependent currents.

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    voltage gated ion channels

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    This document discusses voltage-gated ion channels. It explains that the open probability of voltage-gated ion channels depends on the membrane potential. Voltage-gated sodium channels cause explosive depolarization, while voltage-gated potassium channels stabilize the hyperpolarized membrane potential. The document also notes that voltage-gated sodium and potassium channels have single channel conductances of around 20 pS and are important for generating voltage-dependent currents.

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    © All Rights Reserved
    Скачайте в формате PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    1 просмотров15 страниц

    MOOC Petersen 2 1 VoltageGatedChannels 20140525

    Загружено:

    Juhi Neogi
    This document discusses voltage-gated ion channels. It explains that the open probability of voltage-gated ion channels depends on the membrane potential. Voltage-gated sodium channels cause explosive depolarization, while voltage-gated potassium channels stabilize the hyperpolarized membrane potential. The document also notes that voltage-gated sodium and potassium channels have single channel conductances of around 20 pS and are important for generating voltage-dependent currents.

    Авторское право:

    © All Rights Reserved
    Скачайте в формате PDF, TXT или читайте онлайн в Scribd
    Отметить как неприемлемый контент
    из 15

    2.

    1 Voltage-gated channels
    Cellular Mechanisms of Brain Function
    Prof. Carl Petersen

    Voltage-gated ion channels

    Cellular Mechanisms of Brain Function

    Voltage-gated ion channels


    Linear

    Non-linear

    Cellular Mechanisms of Brain Function

    Protein structure of voltage-gated ion channels

    Cellular Mechanisms of Brain Function

    Voltage-gating mechanisms

    Cellular Mechanisms of Brain Function

    Voltage-dependent open probability

    Cellular Mechanisms of Brain Function

    Voltage-dependent conductance

    Cellular Mechanisms of Brain Function

    Voltage-dependent currents

    Cellular Mechanisms of Brain Function

    Voltage-dependent ion channels

    Cellular Mechanisms of Brain Function

    Voltage-dependent Na + and K + channels

    Cellular Mechanisms of Brain Function

    Voltage-gated Na + and K + channels

    Cellular Mechanisms of Brain Function

    Some numbers single channel conductance


    gNa and gK: ~20 pS

    Cellular Mechanisms of Brain Function

    Some numbers explosive Na + conductance

    Cellular Mechanisms of Brain Function

    Some numbers stabilising K + conductance

    Cellular Mechanisms of Brain Function

    Voltage-gated ion channels


    The open probability of a
    voltage-gated ion channel
    depends strongly upon the
    membrane potential (Vm).
    Voltage-gated Na+ channels
    drive explosive depolarisation.
    Voltage-gated K+ channels
    stabilise hyperpolarised Vm.
    Cellular Mechanisms of Brain Function

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