OralDosageFormsThatShouldNotBeCrushed

JohnF.Mitchell,PharmD,FASHP1

Lastupdated:January2014

DrugProduct
AcipHex
Actiq

ActiveIngredient(s)2
RABEprazole
fentaNYL

DosageForm(s)
Tablet
Lozenge

Actonel

risedronate

Tablet

AdalatCC
AdderallXR
AeroHistPlus
AfeditabCR
Afinitor
Aggrenox
AlavertAllergy(Sinus12Hour)
AllegraD
ALPRAZolamER
Altoprev
AmbienCR
AmibidDM
Ampyra

NIFEdipine
amphetaminesalts
combination
NIFEdipine
everolimus
combination
combination
combination
ALPRAZolam
lovastatin
zolpidem
combination
dalfampridine

Tablet
Capsule
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet

Amrix

cyclobenzaprine

Capsule

Page 1 of 16

Reasons/Comments3
Extendedrelease
Slowrelease
Note:thislollipopdeliverysystemrequiresthe
patienttoslowlydissolveinmouth
Irritant
Note:chewed,crushed,orsuckedtabletsmay
causeoropharyngealirritation
Extendedrelease
Extendedrelease(a)
Slowrelease(h)
Extendedrelease
Mucousmembraneirritant
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Note:formerlyfampridineSR
Extendedrelease

DrugProduct
Aplenzin
Apriso

ActiveIngredient(s)2
buPROPion
mesalamine

DosageForm(s)
Tablet
Capsule

Aptivus
AquatabC
AquatabD
Aricept23mg

tipranavir
combination
combination
donepezil

Capsule
Tablet
Tablet
Tablet

Arthrotec
Asacol
Aspirinentericcoated
Atelvia

diclofenac
mesalamine
aspirin
risedronate

Tablet
Tablet
Tablet,Caplet
Tablet

AzulfidineEN
AugmentinXR
AVINza
Avodart

sulfaSALAzine
combination
morphine
dutasteride

Tablet
Tablet
Capsule
Capsule

BayerRegular
BiaxinXL
BidexA
BidhistD
Biltricide
BiohistLA
BisaLax
BisacEvac

aspirin
clarithromycin
combination
combination
praziquantel
combination
combination
bisacodyl

Caplet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet

Page 2 of 16

Reasons/Comments3
Extendedrelease
Extendedrelease(a)
Note:maintainpHatlessthanorequalto6.0
Note:oilemulsionwithinspheres;taste
Slowrelease(h)
Slowrelease(b)
Note:crushingthe25mgtabletmaysignificantly
increasetherateofabsorption;the5and10mg
tabletarenotaffected
Delayedrelease;Entericcoated
Slowrelease
Delayedrelease;Entericcoated
Extendedrelease;Note:tabletcoatingisan
importantpartofthedelayedrelease
Delayedrelease
Extendedrelease(b,h)
Entericcoated(a;notpudding)
Note:drugmaycausefetalabnormalities;women
whoare,ormaybecome,pregnant,shouldnot
handlecapsules;allwomenshouldusecautionin
handlingcapsules,especiallyleakingcapsules
Entericcoated
Extendedrelease
Extendedrelease
Extendedrelease
Taste(h)
Extendedrelease(h)
Entericcoated(c)
Entericcoated(c)

DrugProduct
Bisacodyl
Boniva

ActiveIngredient(s)2
combination
ibandronate

DosageForm(s)
Tablet
Tablet

BromfedPD
BudeprionSR
CalanSR
Carbatrol
CardeneSR
Cardizem

combination
combination
verapamil
carBAMazepine
niCARdipine
diltiazem

Capsule
Tablet
Tablet
Capsule
Capsule
Tablet

CardizemCD
CardizemLA
CarduraXL
CartiaXT
CefaclorER
Ceftin

diltiazem
diltiazem
doxazosin
diltiazem
combination
cefuroxime

Capsule
Tablet
Tablet
Capsule
Tablet
Tablet

Cefuroxime

combination

Tablet

CellCept
CharcoalPlus
ChlorTrimeton
CiproXR
ClaritinD
ClaritinD24Hour
Colace
Colestid
Concerta

mycophenolate
charcoal,activated
combination
ciprofloxacin
combination
combination
docusate
colestipol
methylphenidate

Capsule,Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet

Page 3 of 16

Reasons/Comments3
Entericcoated(c)
Note:chewed,crushed,orsuckedtabletsmay
causeoropharyngealirritation
Extendedrelease(b)
Extendedrelease
Extendedrelease(h)
Extendedrelease(a)
Extendedrelease
Note:althoughnotinthePI,thedrughasa
coatingthatisintendedtoreleasethedrugover
approximately3hours
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Taste(b)
Note:usesuspensionforchildren
Taste(b)
Note:usesuspensionforchildren
Teratogenicpotential(i)
Entericcoated
Extendedrelease(b)
Extendedrelease(b)
Extendedrelease(b)
Extendedrelease
Taste(e)
Slowrelease
Extendedrelease

DrugProduct
Commit

ActiveIngredient(s)2
Nicotine

DosageForm(s)
Lozenge

CoregCR

carvedilol

Capsule

CotazymS
Creon
Crixivan

pancrelipase
pancrelipase
indinavir

Capsule
Capsule
Capsule

Cymbalta

DULoxetine

Capsule

Cytoxan

cyclophosphamide

Tablet

Cytovene
Depakene

ganciclovir
divalproex

Capsule
Capsule

Reasons/Comments3
Note:integritycompromisedbychewingor
crushing
Extendedrelease(a)
Note:mayaddcontentsofcapsuletochilled,not
warm,applesauceandconsumeimmediately
Entericcoated(a)
Extendedrelease(a)
Taste
Note:capsulemaybeopenedandmixedwithfruit
puree(e.g.,banana)
Extendedrelease(a)
Note:mayaddcontentsofcapsuletoapplejuice
orapplesaucebutNOTchocolate
Note:drugmaybecrushedbutcompany
recommendsusinginjection
Skinirritant
Slowrelease;mucousmembraneirritant(b)

Depakote
DepakoteER
DepakoteSprinkles
DetrolLA
Dexilant
Diclegis
DilacorXR
DilatrateSR
DiltCD
DiltiaXT
DitropanXL
DivalproexER
Doxidan

divalproex
divalproex
divalproex
tolterodine
dexlansoprazole
doxylamine/pyridoxine
diltiazem
isosorbide
diltiazem
diltiazem
oxybutynin
combination
bisacodyl

Tablet
Tablet
Capsule
Capsule
Capsule
Tablet
Capsule
Capsule
Capsule
Capsule
Tablet
Tablet
Tablet

Delayedrelease
Extendedrelease
Extendedrelease(a)
Extendedrelease
Delayedrelease(a)
Delayedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Entericcoated(c)

Page 4 of 16

DrugProduct
Drisdol
Droxia

ActiveIngredient(s)2
ergocalciferol
hydroxyurea

DosageForm(s)
Capsule
Capsule

Dulcolax
DynaCircCR
ECNaprosyn
Ecotrin(all)
E.E.S.400
EfferK
EffervescentPotassium
EffexorXR
Embeda
EMycin
Enablex
EntocortEC
Equetro
Ergomar
Erivedge

bisacodyl
isradipine
combination
aspirin
erythromycin
potassiumbicarbonate

venlafaxine
morphinesulfate
erythromycin
darifenacin
budesonide
carBAMazepine
ergotamine
vismodegib

Tablet;Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Tablet
Capsule
Capsule
Tablet
Capsule

EryTab
ErythromycinStearate
ErythromycinBase
ErythromycinDelayedRelease
Evista
Exalgo

erythromycin

raloxifene
HYDROmorphone

Tablet
Tablet
Tablet
Capsule
Tablet
Tablet

Page 5 of 16

Reasons/Comments3
Liquidfilled(d)
Note:exposuretothepowdermaycauseserious
skintoxicities;healthcareworkersshouldwear
glovestoadminister
Entericcoated(c);Liquidfilled
Extendedrelease
Delayedrelease;entericcoated
Entericcoated
Entericcoated(b)
Effervescenttablet(f)
Effervescenttablet(f)
Extendedrelease
Extendedrelease(a);donotgiveviaN/Gtube
Entericcoated
Slowrelease
Extendedrelease;Entericcoated(a)
Extendedrelease(a)
Sublingualform(g)
Note:PIindicatespotentialteratogenic;MSDS
warnsagainstskincontact;healthcareworkers
shouldtakeappropriatecautions
Delayedrelease;Entericcoated
Entericcoated
Entericcoated
EntericcoatedPellets(a)
Taste;teratogenicpotential(i)
Extendedrelease
Note:breaking,chewing,crushing,dissolving
beforeswallowingorinjectingcouldresultin
overdose

DrugProduct
Exjade

ActiveIngredient(s)2
deferasirox

DosageForm(s)
Tablet

Extendryl(all)
Feenamint
Feldene
FentaNYL

combination
bisacodyl
piroxicam

Capsule
Tablet
Capsule
Lozenge

Fentora

fentaNYL

Tablet

Feosol
Feratab
Fergon
FeroGrad500mg
FerroSequels
FlagylER
FleetLaxative
Flomax
FocalinXR
Fortamet
Fosamax
Gleevec

ferroussulfate
ferroussulfate
ferrousgluconate
combination
combination
metroNIDAZOLE
bisacodyl
tamsulosin
dexmethylphenidate
metFORMIN
alendronate
imatinib

Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Tablet
Tablet

GlucophageXR
GlucotrolXL
Glumetza
Gralise
Guaifed
GuaifedPD
GuaiFENesin/Pseudoephedrine

metFORMIN
glipiZIDE
metFORMIN
gabapentin
combination
combination

Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet

Page 6 of 16

Reasons/Comments3
Note:donotgiveastablet;tabletsaremeantto
begivenasaliquid;seecompanyinsert.
Extendedrelease(b)
Entericcoated(c)
Mucousmembraneirritant
Slowrelease
Note:thislollipopdeliverysystemrequiresthe
patienttoslowlydissolveinmouth
Note:buccaltablet;swallowingthetabletwhole
orcrushingmayreduceeffectiveness
Entericcoated(b)
Entericcoated(b)
Entericcoated
Slowrelease
Slowrelease
Extendedrelease.
Entericcoated(c)
Slowrelease
Extendedrelease(a)
Extendedrelease
Mucousmembraneirritant
Taste(h)
Note:maybedissolvedinwaterorapplejuice
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease

DrugProduct
GuaifenexDM
GuaifenexGP
GuaifenexPSE
GuaimaxD
Halfprin81
Horizant
HistaVentDA
Hydrea

ActiveIngredient(s)2
combination
combination
combination
combination
aspirin
gabapentin
combination
hydroxyurea

DosageForm(s)
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule

Imdur
InderalLA
IndomethacinSR
InnoPranXL
Intelence

isosorbide
propranolol
indomethacin
propranolol
etravirine

Tablet
Capsule
Capsule
Capsule
Tablet

Intermezzo
Intuniv
Invega
IsoptinSR
IsordilSublingual
IsosorbideDinitrateSublingual
IsosorbideSR
ISOtretinoin
Jakafi
Jalyn

zolpidem
guanFACINE
paliperidone
verapamil
isosorbide
isosorbide
isosorbide
ISOtretinoin
ruxolitinib
dutasteride/tamsulosin

Tablet(sublingual)
Tablet
Tablet
Tablet
Tablet(sublingual)
Tablet(sublingual)
Tablet
Capsule
Tablet
Capsule

JanumetXR

sitaGLIPtin/metFORMIN

Tablet

Page 7 of 16

Reasons/Comments3
Extendedrelease(h)
Extendedrelease
Extendedrelease(h)
Extendedrelease
Entericcoated
Extendedrelease
Extendedrelease(h)
Note:exposuretothepowdermaycauseserious
skintoxicities;healthcareworkersshouldwear
glovestoadminister
Extendedrelease(h)
Extendedrelease
Extendedrelease(a,b)
Extendedrelease
Note:tabletshouldbeswallowedwholeandnot
crushed;tabletmaybedispersedinwater
(g)
Extendedrelease
Extendedrelease
Extendedrelease(h)
(g)
(g)
Extendedrelease
Mucousmembraneirritant
Note:seePIformakingasuspension
Note:womenwhoare,ormaybecome,
pregnant,shouldnothandlecrushedor
brokentablets(I)
Extendedrelease

DrugProduct
Kadian

ActiveIngredient(s)2
morphine

DosageForm(s)
Capsule

Kaletra

lopinavir/ritoavir

Tablet

Kapidex
Kapvay
Kazano

dexlansoprazole
cloNIDine
alogliptin/metFORMIN

Capsule
Tablet
Tablet

KeppraXR
Ketek
Khedezla
KlorCon
KlorConM

levETIRAcetam
telithromycin
desvenlafaxine
potassium
potassium

Tablet
Tablet
Tablet
Tablet
Tablet

KombiglyzeXR

combination

Tablet

KDur

potassium

Tablet

KLyte
KLyteCL
KLyteDS
KTab
LaMICtalXR
LescolXL
Letairis

potassium
potassium
potassium
potassium
lamoTRIgine
fluvastatin
ambrisentan

Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet

Page 8 of 16

Reasons/Comments3
Extendedrelease(a)
Note:mayaddcontentsofcapsuletoapplesauce
withoutcrushing)
Filmcoated(b)
Note:activeingredientsaresurroundedbyawax
matrixtopreventhealthcareexposure;women
whoare,ormaybecome,pregnant,shouldnot
handlecrushedorbrokentablets
Delayedrelease(a)
Extendedrelease
Note:notscored;nostudiesavailablefrom
company
Extendedrelease(b)
Slowrelease(b)
Extendedrelease
Extendedrelease(b)
Extendedrelease(b,h)
Note:tomakealiquid,placetabletin120mLof
water;dispersefor2minutes;stir
Extendedrelease
Note:tabletmatrixmayremaininstool
Extendedrelease
Note:tomakealiquid,breaktabletinhalfand
dispersein120mLofwaterfor2minutes;stir
Effervescenttablet(f)
Effervescenttablet(f)
Effervescenttablet(f)
Extendedrelease(b)
Extendedrelease
Extendedrelease
Slowrelease

DrugProduct
Levbid
Levsinex
Lialda
Liquibid
Lithobid
Lodrane24
Lodrane24D
LoHist12Hour
Lovaza

ActiveIngredient(s)2
hyoscyamine
hyoscyamine
mesalamine
combination
lithium
brompheniramine
combination
brompheniramine
combination

DosageForm(s)
Tablet
Capsule
Tablet
Tablet
Tablet
Capsule
Capsule
Tablet
Capsule

LuvoxCR
MaxifedDM
MaxifedDMX
MaxiphenDM
MestinonER
MetadateER
MetadateCD
MethylinER
MetoprololER
MicroKExtencaps
MirapexER
Moxatag
Morphinesulfateextendedrelease
Motrin
MSContin
Mucinex
MucinexDM
Myfortic
Myrbetriq
NamendaXR

fluvoxaMINE
combination
combination
combination
pyridostigmine
methylphenidate
methylphenidate
methylphenidate

potassiumchloride
pramipexole
amoxicillin

ibuprofen
morphine
guiaFENesin
combination
mycophenolate
mirabegron
memantine

Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet
Tablet
Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule

Page 9 of 16

Reasons/Comments3
Extendedrelease(h)
Extendedrelease
Delayedrelease
Extendedrelease(h)
Extendedrelease
Extendedrelease
Extendedrelease
Extendedrelease
Note:contentsofcapsulemayerodewallsof
styrofoamorplasticmaterials
Extendedrelease
Slowrelease(h)
Slowrelease(h)
Slowrelease(h)
Extendedrelease(b)
Extendedrelease
Extendedrelease(a)
Extendedrelease
Extendedrelease
Extendedrelease(a,b)
Extendedrelease
Extendedrelease
Extendedrelease
Taste(e)
Extendedrelease(b)
Slowrelease
Slowrelease
Delayedrelease
Extendedrelease
Extendedrelease(a)

DrugProduct
Naprelan
NexIUM
Niaspan
NicotinicAcid
NifediacCC
NifedicalXL
Nitrostat
NorflexER
NorpaceCR
Norvir

ActiveIngredient(s)2
naproxen
esomeprazole
nicotinicacid

NIFEDipine
NIFEDipine
nitroglycerin
orphenadrine
disopyramide
ritonavir

DosageForm(s)
Tablet
Capsule
Tablet
Capsule;Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Tablet

Noxafil

posaconazole

Tablet

NucyntaER

tapentadone

Tablet

Oleptro
Oracea
OramorphSR
OrphenadrinecitrateER
OxyCONTIN

traZODone
doxycycline
morphine

oxyCODONE

Tablet
Capsule
Tablet
Tablet
Tablet

OxymorphoneER
PancreaseDelayedRelease
PancreaseMT
Pancrecarb
Pancrelipase

pancrealipase
pancrealipase
pancrealipase

Tablet
Capsule
Capsule
Capsule
Capsule

Page 10 of 16

Reasons/Comments3
Extendedrelease
Delayedrelease(a)
Extendedrelease
Slowrelease(h)
Extendedrelease
Extendedrelease
Sublingualroute(g)
Extendedrelease
Extendedreleaseformwithinaspecialcapsule
Note:crushingtabletshasresultedindecreased
bioavailabilityofdrug(b)
Delayedrelease
Note:companyliteraturenotavailabletoshow
implications
Extendedrelease
Note:toxicdosemayoccuriftabletissplitor
crushed,causingrapidreleaseandabsorptionofa
potentiallyfataldose
Extendedrelease
Delayedrelease
Extendedrelease(b)
Extendedrelease
Extendedrelease
Note:tabletdisruptionmaycauseapotentially
fataloverdoseofoxyCODONE
Extendedrelease
Extendedrelease(a)
Entericcoated(a)
Entericcoated(a)
Entericcoated(a)

DrugProduct
PaxilCR
Pentasa
Pradaxa

ActiveIngredient(s)2
PARoxetine
mesalamine
dabigatran

DosageForm(s)
Tablet
Capsule
Capsule

PreHistD
Plendil
Prevacid
PrevacidSoluTab

combination
felodipide
lansoprazole
lansoprazole

Tablet
Tablet
Capsule
Tablet

PrevacidSuspension

lansoprazole

Suspension

PriLOSEC
PriLOSECOTC
Pristiq
ProcardiaXL
Propecia

omeprazole
omeprazole
desvenlafaxine
NIFEDipine
finasteride

Capsule
Tablet
Tablet
Tablet
Tablet

ProquinXR
Proscar

ciprofloxicin
finasteride

Tablet
Tablet

Extendedrelease
Note:womenwhoare,ormaybecome,pregnant,
shouldnothandlecrushedorbrokentablets

Protonix
PROzacWeekly
Qdall
QdallAR
Ranexa

pantoprazole
FLUoxetine
combination
combination
ranolazine

Tablet
Tablet
Capsule
Capsule
Tablet

Slowrelease
Entericcoated
Extendedrelease
Extendedrelease
Slowrelease

Page 11 of 16

Reasons/Comments3
Extendedrelease
Slowrelease(a)
Note:bioavailabilityincreasesby75%whenthe
pelletsaretakenwithoutthecapsuleshell
Extendedrelease(h)
Extendedrelease
Delayedrelease
Note:orallydisintegratingdonotswallow;
dissolveinwateronlyanddispense
viadosingsyringeorNGtube
Slowrelease
Note:containsentericcoatedgranules;mixwith
wateronly;notforNGuse
Delayedrelease(a)
Delayedrelease
Extendedrelease
Extendedrelease
Note:womenwhoare,ormaybecome,pregnant,
shouldnothandlecrushedorbrokentablets

DrugProduct
Rapamune

ActiveIngredient(s)2
sirolimus

DosageForm(s)
Tablet

Rayos

predniSONE

Tablet

RazadyneER
Renagel
Renvela

galantamine
sevelamer
sevelamercarbonate

Capsule
Tablet
Tablet

RequipXL
Rescon
ResconJR
ResconMX
Respahist
RespaireSR
Revlimid

rOPINIRole
combination
combination
combination
combination
combination
lenalidomide

Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Capsule

RitalinLa
RitalinSR
RTanna
RythmolSR
Ryzolt

methylphenidate
methylphenidate
combination
propafenone
traMADol

Capsule
Tablet
Tablet
Capsule
Tablet

Sensipar

cinacalcet

Tablet

SEROquelXR
SinemetCR
SinuventPE
SloNiacin
Solodyn

QUEtiapine
levo/carbidopa
combination
nicotinicacid
minocycline

Tablet
Tablet
Tablet
Tablet
Tablet

Page 12 of 16

Reasons/Comments3
Note:pharmacokineticNanoCrystaltechnology
maybeaffected(b)
Delayedrelease
Note:releaseisdependentuponintactcoating
Extendedrelease
Note:tabletsexpandinliquidifbrokenorcrushed
Note:tabletsexpandinliquidifbrokenor
crushed(b)
Extendedrelease
Slowrelease(h)
Slowrelease(h)
Slowrelease(h)
Extendedrelease(a)
Extendedrelease
Note:teratogenicpotential;healthcareworkers
shouldavoidcontactwithcapsulecontents/body
fluids
Extendedrelease(a)
Extendedrelease
Slowrelease
Extendedrelease
Extendedrelease
Note:crushingmaycauseoverdose
Note:tabletsarenotscoredandcutting
maycausevariabledosageaccuracy
Extendedrelease
Extendedrelease(h)
Extendedrelease(h)
Slowrelease(h)
Extendedrelease

DrugProduct
Somnote
Sprycel

ActiveIngredient(s)2
chloralhydrate
dasatinib

DosageForm(s)
Capsule
Tablet

Reasons/Comments3
Liquidfilled
Filmcoated
Note:activeingredientsaresurroundedbyawax
matrixtopreventhealthcareexposure;women
whoare,ormaybecome,pregnant,shouldnot
handlecrushedorbrokentablets

Strattera

atomoxetine

Capsule

Note:capsulecontentscancauseocularirritation

Sudafed12hour
Sudafed24hour
Sular
SymaxDuotab
SymaxSR
Tasigna

combination
combination
nisoldipine
hyoscyamine
hyoscyamine
nilotinib

Capsule
Capsule
Tablet
Tablet
Tablet
Capsule

TaztiaXT
Tecfidera
TEGretolXR
Temodar

diltiazem
dimethylfumarate
carBAMazepine
temozolomide

Capsule
Capsule
Tablet
Capsule

Extendedrelease(b)
Extendedrelease(b)
Extendedrelease
Controlledrelease
Extendedrelease
Note:disruptionofcapsulemayyieldhighblood
levelscausingenhancedtoxicity
Extendedrelease(a)
Delayedrelease
Extendedrelease(b)
Note:accidentallyopenedordamagedcapsules
requirerigorousprecautionstoavoidinhalationor
contactwiththeskinormucousmembranes(i)

TessalonPerles

benzonatate

Capsule

Note:swallowwhole;localanesthesiaoftheoral
mucosa;chokingcouldoccur

Theo24

theophylline

Capsule

Theochron
Tiazac
Topamax

theophylline
diltiazem
topiramate

Tablet
Capsule
Tablet;Capsule

Extendedrelease
Note:containsbeadsthatdissolvethroughoutthe
GItract
Extendedrelease
Extendedrelease(a)
Taste;Taste(a)

Page 13 of 16

DrugProduct
ToprolXL
TouroCCLD
TouroLALD
Toviaz
Tracleer

ActiveIngredient(s)2
metoprolol
combination
combination
fesoterodine
bosentan

DosageForm(s)
Tablet
Tablet
Tablet
Tablet
Tablet

Reasons/Comments3
Extendedrelease(h)
Extendedrelease(h)
Extendedrelease(h)
Extendedrelease
Note:womenwhoare,ormaybecome,pregnant,
shouldnothandlecrushedorbrokentablets

TRENtal
Treximet

pentoxifylline
combination

Tablet
Tablet

Trilpix
TylenolArthritis
Uceris

fenofibric
acetaminophen
budesonide

Capsule
Tablet
Tablet

UltramER

traMADol

Tablet

Ultrase
Uniphyl
UrocitK
Uroxatral
Valcyte
VerapamilSR
Verelan
VerelanPM
VidexEC
Vimovo
ViramuneXR
VoltarenXR
VoSpireER

pancrealipase
theophylline
potassiumcitrate
alfuzosin
valGANCiclovir

verapamil
verapamil
didanosine
naproxen/esomeprazole
nevirapine
diclofenac
albuterol

Capsule
Tablet
Tablet
Tablet
Tablet
Tablet
Capsule
Capsule
Capsule
Tablet`
Tablet
Tablet
Tablet

Extendedrelease
Note:uniquedrugmatrixenhancesrapiddrug
absorption
Extendedrelease
Controlledrelease
Note:coatingontabletisdesignedtobreakdown
atpHof7.0orabove
Extendedrelease
Note:tabletdisruptionmaycauseapotentially
fataloverdoseofdrug
Entericcoated
Slowrelease
Waxcoated;preventsupperGIrelease
Extendedrelease
Teratogenicandirritantpotential(i,b)
Extendedrelease(h)
Sustainedrelease(a)
Extendedrelease(a)
Delayedrelease
Delayedrelease
Extendedrelease(b)
Extendedrelease
Extendedrelease

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DrugProduct
Votrient

ActiveIngredient(s)2
pazopanib

DosageForm(s)
Tablet

WellbutrinSR,XL

buPROPion

Tablet

XanaxXR
Xarelto
ZegeridOTC
Zenpep
ZohydroER
Zolinza

ALPRAZolam
rivaroxaban
omeprazole/NaHCO3
pancrealipase
HYDROcodone
vorinostat

Tablet
Tablet
Capsule
Capsule
Capsule
Capsule

Zortress

everolimus

Tablet

Zyban
ZyfloCR

buPROPion
zileuton

Tablet
Tablet

Page 15 of 16

Reasons/Comments3
Note:crushingsignificantlyincreasestheAUCand
Tmax;crushedorbrokentabletsmaycause
dangerousskinproblems
Extendedrelease
Extendedrelease
Crushedtabletmustbegivenwithin4hours
Delayedrelease(b)
Delayedrelease(a)
Extendedrelease
Note:irritant;avoidcontactwithskinormucous
membranes;avoidcontactwithcrushedorbroken
tablets
Note:crushedpowdermaycause
dangerouseffectstomucusmembranes
Slowrelease
Extendedrelease


(a)

Capsulemaybeopenedandthecontentstakenwithoutcrushingorchewing;softfoodsuchasapplesauceorpuddingmayfacilitateadministration;contentsmay
generallybeadministeredvianasogastrictubeusinganappropriatefluidprovidedentirecontentsarewasheddownthetube.

(b)

Liquiddosageformsoftheproductareavailable;however,dose,frequencyofadministrationandmanufacturersmaydifferfromthatofthesoliddosageform.

(c)

Antacidsand/ormilkmayprematurelydissolvethecoatingofthetablet.

(d)

Capsulemaybeopenedandtheliquidcontentsremovedforadministration.

(e)

Thetasteofthisproductformwouldlikelybeunacceptabletothepatient;administrationvianasogastrictubeshouldbeacceptable.

(f)

Effervescenttabletsmustbedissolvedintheamountofdiluentrecommendedbythemanufacturer.

(g)

Tabletsaremadetodisintegrateunderthetongue.

(h)

Tabletisscoredandmaybebrokeninhalfwithoutaffectingreleasecharacteristics.

(i)

Skincontactmayenhancetumorproduction;avoiddirectcontact.

Disclaimer:Thislistingisnotmeanttorepresentallproducts,eitherbygenericortradename.Theauthorencouragesmanufacturers,pharmacists,nurses,andotherhealth
professionalstonotifyhimofanychangesorupdates.

1.Correspondenceregardingthislistmaybeaddressedto:
JohnF.Mitchell,PharmD,FASHP
Email:rxmitchell@att.net
2.Thegenericnameisprovidedmerelyasareferencepointandisonlylistedforsingleingredientmedications;itshouldnotbeassumedthatdrugswiththesamegenericare
equivalenttothespecificbrandnamelistedrelativetocrushingorchewing.Ifquestionsarise,pleasecheckwithyourpharmacist.
3.TwoofficialUSPtermsareusedtodesignatespecialreleasemedicationforms:"extendedrelease"and"delayedrelease".Otherssuchas"sustainedrelease",controlled
release",etc.arecommonlyusedonpackagelabeling.Theterm"Slowrelease"isbeingusedheretosignifyallsuchdrugswithaspecialreleasemechanism.

Copyright2011,2012,2013,2014.Nopartofthislistmaybereproducedinanyformatwithouttheexpressedpermissionoftheauthor.

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