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Delivery Technology
Capsugel Dosage Form Solutions developed enTRinsic drug delivery
technology to provide oral delivery with full enteric protection and
rapid release in the upper gastrointestinal (GI) tract without the use
of coatings. Tailored capsules utilized with enTRinsic technology
are manufactured using pharmaceutical grades of cellulosic enteric
derivatives (100%). This novel and proprietary technology has proven in
vitro and in vivo performance, and is finding application in several areas:
Enabling the oral delivery of sensitive molecules, such as nucleotides and peptides, vaccines and live
biotherapeutic products (LBPs).
A product development tool enabling rapid prototype development and accelerated in vivo testing.
A novel enteric dosage form for market differentiation and/or intellectual property.
Nucleotides
Peptides
Vaccines
Live Biotherapeutic Products
Regulatory Status:
Active Pharma/
Nutritional Ingredient
Target Product Profile
Commercial Goals
Product
Design
Develop
Technology Breadth
Formulation Capabilities
Rapid Advancement Process C
linical Manufacture
Tech Selection Methodology
Scale-up
Technology Platforms
Capsugel Dosage Form Solutions utilizes
a premier breadth of technologies, used
alone or in combination, to address key
formulation challenges and meet target
product profiles. Specialized development
and manufacturing capability is in place to
handle highly potent, controlled substance,
hormonal and oncology compounds.
Manufacture
Facilities & Equipment
Global Footprint
Quality & S
upply Chain
Claims & IP
R
obust &
Well Understood
Bioavailability Enhancement
Spray-dried dispersions Hot-melt extrusion Lipid/liquid-based formulations
Nano-crystal technology Salt forms Particle size reduction/micronization
Specialized Applications
Lipid multiparticulate technology Inhalation formulations Abuse deterrent technology
Taste-masking High potency APIs
Capsugel will use reasonable efforts to include accurate and up-to-date information on this brochure but makes no warranties or representations of any kind as to its accuracy or completeness. The entire contents of this brochure are subject to
copyright protection. Copyright 2015 Capsugel Belgium NV. All rights reserved. GMCN 201510005