Obat

5-FU/FA
Folinic Acid/ Leucovorin
Capecitabine

Oxaliplatin

Irinotecan

Bevacizumab

ESO

Diare, mua, limfopenia, hand and foot

syndrome, edema, kelelahan, demam,
sakit kepala, sakit, parestesia, alopecia,
nyeri abdomen, anorexia, nafsu makan
berkurang, konstipasi, dispepsia,
syomatitis, muntah, neutropenia,
trombositopenia, dipsnea, peningkatan
bilirubin, iritasi mata
Neuropati perifer
Anemia, mual
Kelelahan
Diare
Muntah
Nyeri abdomen, konstipasi
Trombositopenia
Demam, anoreksia, leukopenia,
dipsnea, batuk
Edema, neutropenia
Anemia, leukopenia, trombasitopenia,
peningkatan bilirubin, diare, mual,
astenia, nyeri abnomen, muntah
alopecia, demam, konstipasi, anoreksia
mukositis, nyeri, dispnea, batuk,
pusing, infeksi, ruam
Kelemahan, hipertensi, nyeri,
Nyeri abdomen, muntah, URI,
konstipasi, leukopenia, proteinuria,
Epistaxis (32-35%)
Ovarian failure (with mFolfox) (34%)
Diarrhea (grades 3/4: 2-34%)
Stomatitis (30-32%)
Alopecia (6-32%)
Neutropenia (grades 3/4: 6-27%)
Headache (26%; grades 3/4: 2-4%)
Dyspnea (25-26%)
Dizziness (19-26%)
GI hemorrhage (19-24%)
Dyspepsia (17-24%)
Taste alteration (14-21%)
Dry skin (7-20%)
Exfoliative dermatitis (3-19%)
Fatigue (grades 3/4: 5-19%)
Flatulence (11-19%)
Lacrimation disorder (6-18%)

Neuropathy (grades 3/4: 1-17%)

Weight loss (15-16%)
Hypokalemia (12-16%)
Skin discoloration (2-16%)
Thromboembolic events (grades 3/4:
15%)
Myalgia (8-15%)
Hypotension (7-15%)
Nausea (grades 3/4: 4-12%)
Back pain (undefined)
Ramucirumab

GI cancer (plus paclitaxel)

Fatigue/asthenia (57%)
Neutropenia (54%)
Diarrhea (32%)
Epistaxis (31%)
Peripheral edema (25%)
Stomatitis (20%)
Proteinuria (17%)
Hypertension (25%)
Infusion-related reactions (16%)
Hypertension grade 3-4 (15%)
Thrombocytopenia (13%)
Hypoalbuminemia (11%)
NSCLC (plus docetaxel)
Neutropenia (55%)
Fatigue/asthenia (55%)
Stomatitis/mucosal inflammation
(37%)
Epistaxis (19%)
Febrile neutropenia (16%)
Peripheral edema (16%)
Thrombocytopenia (13%)
Lacrimation increased (13%)
Hypertension (11%)

Cetuximab

Acneform rash (90%)

Fatigue (89%)
Hypomagnesemia (55%)
Asthenia/malaise (49%)
Fever (33%)
Nausea (29%)
Constipation (28%)
Diarrhea (28%)
Abdominal pain (25%)
Anorexia (25%)
Headache (25%)

Infusion reaction (25%)

Vomiting (25%)
Dyspnea (20%)
Pain (19%)
Nail disorder (16%)
Back pain (11%)
Stomatitis (11%)
Anemia (10%)
Cough increased (10%)
Infection (11%)
1-10%
Insomnia (10%)
Peripheral edema (10%)
Pruritus (10%)
Dehydration (9%)
Depression (9%)
Weight loss (9%)
Conjunctivitis (7%)
Dyspepsia (7%)
Alopecia (5%)
Skin disorder (5%)
Leukopenia (1%)
Panitumumab

Erythema (65%)
Acneiform dermatitis (57%)
Pruritus (57%)
Hypomagnesemia (39%)
Fatigue (26%)
Abdominal pain (25%)
Paronychia (25%)
Skin exfoliation (25%)
Nausea (23%)
Rash (22%)
Constipation (21%)
Diarrhea (21%)
Vomiting (21%)
Skin fissures (20%)
Cough (14%)
Dermatologic toxicity, Grade 3 and 4
(14% )
Acne (13%)
Peripheral edema (12%)

Regorafenib

Anemia (79%)
Increased AST (65%)
Asthenia (64%)
Proteinuria (60%)

Hypocalcemia (59%)
Hypophosphatemia (57%)
Lymphopenia (54%)
Decreased appetite and food intake
(47%)
Increased lipase (46%)
Hand-foot skin reaction (HFSR) [palmarplantar erythrodysesthesia] (45%)
Hyperbilirubinemia (45%)
Increased ALT (45%)
Diarrhea (43%)
Thrombocytopenia (41%)
Mucositis (33%)
Weight loss (32%)
Infection (31%)
Hypertension (30%)
Dysphonia (30%)
Hyponatremia (30%)
Pain (29%)
Fever (28%)
Rash (26%)
Hypokalemia (26%)
Increased amylase (26%)
Increased INR (24%)
Hemorrhage (21%)
Nausea (20%)
Trifluridine/ Tipiracil

Anemia, all grades (77%)

Neutropenia, all grades (67%)
Asthenia/fatigue, all grades (52%)
Nausea, all grades (48%)
Thrombocytopenia, all grades (42%)
Decreased appetite, all grades (39%)
Diarrhea, all grades (32%)
Vomiting, all grades (28%)
Neutropenia, grades 3-4 (11-27%)
Abdominal pain, all grades (21%)
Pyrexia, all grades (19%)
Anemia, grade 3 (18%)
1-10%
Stomatitis, all grades (8%)
Dysgeusia (7%)
Alopecia (7%)
Asthenia/fatigue, grades 3-4 (7%)
Thrombocytopenia, grades 3-4 (1-5%)
Decreased appetite, grades 3-4 (4%)
Diarrhea, grades 3-4 (3%)

Vomiting, grades 3-4 (2%)

Abdominal pain, grades 3-4 (2%)
Nausea, grades 3-4 (2%)
Pyrexia, grades 3-4 (1%)