Вы находитесь на странице: 1из 34

Human Cell Biology

2016-2017
(1e stage MA Biomedical Engineering
and many other MA programmes)

Truncus Communis Basic Medical Sciences

30-09-2016

Teachers:

Anton Roebroek
Department of Human Genetics
Herestraat 49, bus 602
B-3000 Leuven
e-mail: anton.roebroek@med.kuleuven.be
tel.: 016 33 07 51
Georg Halder
Department of Human Genetics
Herestraat 49, bus 602
B-3000 Leuven
e-mail: georg.halder@cme.vib-kuleuven.be
tel.:
016 37 32 51

30-09-2016

Objectives
Acquirement of basic knowledge and insight
in Cell Biology (= understanding cells in terms of their
molecular components).
Cell biology is a scientific discipline that studies cells:

their physiological properties


their structure
the organelles they contain
the interactions with their environment
their life cycle, division and death.

This is done both on a microscopic and molecular level.


30-09-2016

Course textbook
Molecular Biology of the Cell (6th ed, new, 2015)
Alberts, Johnson, Lewis, Morgan, Raff, Roberts, Walter
Garland Science

ISBN 978-0-8153-4464-3 (paperback)


(75.00, Garland Science)
( 93.85, Bol.com)
ISBN 978-0-8153-4432-2 (hardcover)
(125.00, Garland Science, more expensive!!)
( 150.15, Bol.com)

30-09-2016

Content part I (taught by Anton Roebroek)


(September 30 to November 4, 6 lectures)
PART I INTRODUCTION TO THE CELL
1. Cells and Genomes
2. Cell Chemistry and Bioenergetics
3. Proteins
PART II BASIC GENETIC MECHANISMS
4. DNA, Chromosomes, and Genomes
5. DNA Replication, Repair, and Recombination
6. How Cells Read the Genome: From DNA to Protein
7. Control of Gene Expression
PART III WAYS OF WORKING WITH CELLS
8. Analyzing Cells, Molecules, and Systems
9. Visualizing Cells
PART IV INTERNAL ORGANIZATION OF THE CELL
10. Membrane Structure
11. Membrane Transport of Small Molecules and the Electrical Properties of Membranes
12. Intracellular Compartments and Protein Sorting
13. Intracellular Membrane Traffic
14. Energy Conversion: Mitochondria and Chloroplasts

30-09-2016

Content part II (taught by Georg Halder)


(November 18 to December 23, 6 lectures)

PART IV INTERNAL ORGANIZATION OF THE CELL


15. Cell Signaling
16. The Cytoskeleton
17. The Cell Cycle
18. Cell Death
19. Cell Junctions and the Extracellular Matrix
PART V CELLS IN THEIR SOCIAL CONTEXT
20. Cancer
21. Development of Multicellular Organisms
22. Stem Cells and Tissue Renewal
23. Pathogens and Infection
24. The Innate and Adaptive Immune System

30-09-2016

Evaluation
Oral examination (with written preparation)
In the exam period in January 2017

Both teachers will examine their part


Both parts have an equal weight (max. 10 + 10 = 20)

Additional information:
https://onderwijsaanbod.kuleuven.be/syllabi/e/H03H0BE.htm#activetab=doelstellingen_idp3067264

30-09-2016

Alberts Johnson Lewis Morgan Raff Roberts Walter

Molecular Biology
of the Cell
Sixth Edition

Chapter 1
Cells and Genomes

30-09-2016

Copyright Garland Science 2015

UNIVERSAL FEATURES OF CELLS ON EARTH

30-09-2016

The hereditary information in the fertilized egg


determines the nature of the whole multicellular organism

sea urchin
30-09-2016

mouse

seaweed
10

DNA and it building blocks

30-09-2016

11

The copying of genetic information by DNA replication

30-09-2016

12

From DNA to
protein

30-09-2016

13

How genetic information is broadcast


for use inside the cell

30-09-2016

14

The conformation of an RNA molecule

30-09-2016

15

How a protein molecule acts as an catalist for a


chemical reaction

30-09-2016

16

Life as an autocatalytic process

30-09-2016

17

Formation of a membrane
by amphiphilic phospholipid
molecules
(simple physico-chemical
properties of the molecules
that form the plasma
membrane

30-09-2016

18

THE DIVERSITY OF GENOMES AND THREE OF LIFE

19

30-09-2016

19

Mycoplasma genitalium
A. Outside view (scanning
electron micrograph)
B. Cross section
(transmission electron
micrograph)

30-09-2016

20

Geology of a hot
hydrothermal vent
in the ocean floor

30-09-2016

21

Organisms living
at a depth of 2500
meters near a vent
in the ocean floor

30-09-2016

22

Shape and sizes of some bacteria

30-09-2016

23

The structure of bacterium

Vibrio cholerae
Escherichia coli
(E. coli)
30-09-2016

24

Three major divisions (domains) of the living world

Procaryotes:
Eukaryotes:

30-09-2016

bacteria and archaea (no nucleus)


nucleus (membrane-enclosed intracellular
compartment containing the genome)
25

Genetic information conserved since the days of the


last common ancestor of all living things

Sequence alignment of the RNA sequence of a ribosomal RNA component

30-09-2016

26

Four modes of
genetic
innovation and
their effects in
the DNA
sequence of an
organism

30-09-2016

27

Families of evolutionary related genes in the


genome of Bacillus subtilis

30-09-2016

28

30-09-2016

29

The genome of
Escherichia coli
(E. coli)

30-09-2016

30

GENETIC INFORMATION IN EUKARYOTES

30-09-2016

31

The major features of eukaryotic cells

NB:
30-09-2016

plant cells have a cell wall


(a thicker, more rigid and stronger extracellular matrix)
32

A mitochondrion (power house of the cell)

30-09-2016

33

30-09-2016

34

Вам также может понравиться