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Viruses(notes)
Viruses
Propertiesofviruses
nomembranes,cytoplasm,ribosomes,orothercellularcomponents
theycannotmoveorgrow
theycanonlyreproduceinsideahostcell
2majorpartsaproteincoat,andDNAorRNA
theyareextremelytiny,smallerthancellsandonlyvisiblewithelectronmicroscopes
ReviewthestructureofDNA
RNAissimilartoDNA
Shapeofadoublehelix,repeatingunitsofnucleotides
Basepairsheldtogetherbyhydrogenbonds(weak)
Adenine|Thymine
Guanine|Cytosine
Insteadofthymine,ithasuracil
Ithasthesugarribose,insteadofdeoxyribose
Itissinglestranded
ThesidesoftheDNAmadeofalternatingdeoxyribose(5ringsugar)and
phosphates
VirusStructure
Virushasacoveringthathasacapsidandsometimesanenvelope
Innercorecontainsanucleicacidmolecule(DNAorRNA)andvariousproteins
Virusesareusuallyveryspecifictotheirhostandtothecellstheycaninfect.
ViralReproduction
SeeVideoonHowaVirusInvadesYourBody(NPR)
Lyticcycle=reproductionoccurs,cellsburst
Lysogeniccycle=reproductiondoesnotimmediatelyoccur(dormancy)
1.Attachmentspecificproteinsoncellsurfaceattachtothevirus(SeeAnimation:EntryofViruses)
2.Penetrationthevirusisengulfedbythecell(CellcanenterLysogenicorLyticCycle)
3.Biosynthesisviralcomponentsaremade(proteincoat,capsid,DNA/RNA)
4.Maturationassemblyofviralcomponents
5.Releasevirusesleavehostcelltoinfectnewcells(oftendestroyshost)
(See:AnimationatMcGrawLambaPhageReplicationCycle)
TypesofViruses
Bacteriophagevirusesthatinfectbacteria.
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Viruses(notes)
RetrovirusesRNAvirusesthathaveaDNAstage
HowAreVirusesNamed
Historicallytheyhavebeennamedforavarietyoffactors,including
theassociateddiseases(poliovirus,rabies)thetypeofdiseasecaused(murineleukemiavirus)
thesitesinthebodyaffectedorfromwhichtheviruswasfirstisolated(rhinovirus,adenovirus)
wheretheywerefirstisolated(Ebolavirus,Hantavirus)
theanimalthatcarriesthevirus(birdflu,swineflu)
forthewaypeopleimaginedtheywerecontracted(dengue=evilspiritinfluenza=influenceofbadair).
NewerConventions
ExampleofanInfluenzaVirusNaming
FocusonHumanImmunodeficiencyVirus
CausesthediseaseAIDS(AcquiredImmuneDeficiencySyndrome)
HIVInfectionCycle(animation)|HIVLifeCycledrugstargetspecificviralprocesses
HIVColoringAssignment*Makesureyouunderstandthestepsinvolvedininfectionandhowdrugstreatthedisease.
RelatedtoViruses
Viroidsevensmallerthanviruses,consistofRNAstrandsthatlackaproteincoat
Prions"rogueprotein",believedtobethecauseofMadCowDisease,alsomaycauseKuruincannibaltribes
TreatmentofViruses
Vaccines
AntiviralDrugs
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