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12/8/2015

Viruses(notes)

Viruses
Propertiesofviruses
nomembranes,cytoplasm,ribosomes,orothercellularcomponents
theycannotmoveorgrow
theycanonlyreproduceinsideahostcell
2majorpartsaproteincoat,andDNAorRNA
theyareextremelytiny,smallerthancellsandonlyvisiblewithelectronmicroscopes

ReviewthestructureofDNA
RNAissimilartoDNA

Shapeofadoublehelix,repeatingunitsofnucleotides
Basepairsheldtogetherbyhydrogenbonds(weak)
Adenine|Thymine
Guanine|Cytosine

Insteadofthymine,ithasuracil
Ithasthesugarribose,insteadofdeoxyribose
Itissinglestranded

ThesidesoftheDNAmadeofalternatingdeoxyribose(5ringsugar)and
phosphates

VirusStructure
Virushasacoveringthathasacapsidandsometimesanenvelope
Innercorecontainsanucleicacidmolecule(DNAorRNA)andvariousproteins
Virusesareusuallyveryspecifictotheirhostandtothecellstheycaninfect.

ViralReproduction
SeeVideoonHowaVirusInvadesYourBody(NPR)
Lyticcycle=reproductionoccurs,cellsburst
Lysogeniccycle=reproductiondoesnotimmediatelyoccur(dormancy)
1.Attachmentspecificproteinsoncellsurfaceattachtothevirus(SeeAnimation:EntryofViruses)
2.Penetrationthevirusisengulfedbythecell(CellcanenterLysogenicorLyticCycle)
3.Biosynthesisviralcomponentsaremade(proteincoat,capsid,DNA/RNA)
4.Maturationassemblyofviralcomponents
5.Releasevirusesleavehostcelltoinfectnewcells(oftendestroyshost)
(See:AnimationatMcGrawLambaPhageReplicationCycle)

TypesofViruses
Bacteriophagevirusesthatinfectbacteria.
http://www.biologycorner.com/APbiology/pathology/virus.html

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12/8/2015

Viruses(notes)

RetrovirusesRNAvirusesthathaveaDNAstage

HowAreVirusesNamed
Historicallytheyhavebeennamedforavarietyoffactors,including
theassociateddiseases(poliovirus,rabies)thetypeofdiseasecaused(murineleukemiavirus)
thesitesinthebodyaffectedorfromwhichtheviruswasfirstisolated(rhinovirus,adenovirus)
wheretheywerefirstisolated(Ebolavirus,Hantavirus)
theanimalthatcarriesthevirus(birdflu,swineflu)
forthewaypeopleimaginedtheywerecontracted(dengue=evilspiritinfluenza=influenceofbadair).
NewerConventions
ExampleofanInfluenzaVirusNaming

FocusonHumanImmunodeficiencyVirus
CausesthediseaseAIDS(AcquiredImmuneDeficiencySyndrome)
HIVInfectionCycle(animation)|HIVLifeCycledrugstargetspecificviralprocesses
HIVColoringAssignment*Makesureyouunderstandthestepsinvolvedininfectionandhowdrugstreatthedisease.
RelatedtoViruses
Viroidsevensmallerthanviruses,consistofRNAstrandsthatlackaproteincoat
Prions"rogueprotein",believedtobethecauseofMadCowDisease,alsomaycauseKuruincannibaltribes

TreatmentofViruses
Vaccines
AntiviralDrugs

http://www.biologycorner.com/APbiology/pathology/virus.html

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