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ManagementstrategiesforhyperemesisBestPractice&ResearchClinicalObstetrics&Gynaecology

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August2009 Volume23,Issue4,Pages549564

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Managementstrategiesforhyperemesis
CeciliaBottomley,MRCOG(SpecialistRegistrarinObstetricsandGynaecology)
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,TomBourne,PhD,

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DOI:http://dx.doi.org/10.1016/j.bpobgyn.2008.12.012

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Nauseaandvomitingoccurinupto80%ofnormalpregnancies.Hyperemesisgravidarum,resultingin
dehydrationandketonuria,isamoresevere,disablingandpotentiallylifethreateningconditionaffectingup
to1.5%ofpregnancies.Treatmentissupportivewithintravenousrehydration,antiemeticsandcorrectionof
vitamindeficiencytominimizecomplications.Therearegoodsafetydatatosupporttheuseof
antihistamines,phenothiazinesandmetoclopromideinhyperemesisgravidarum,thoughtrialsofefficacy
arelackingandthereislittleevidenceonwhichtochosetheoptimumtherapy.Thisreviewdiscussesthe
diagnosisandmanagementofhyperemesisgravidarumandtheprevention,recognitionandtreatmentof
theseriouscomplicationsofWernickeencephalopathy,osmoticdemyelinationsyndromeand
thromboembolism.

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BestPractice&ResearchClinicalObstetrics
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ManagementstrategiesforhyperemesisBestPractice&ResearchClinicalObstetrics&Gynaecology

2009ElsevierLtd.PublishedbyElsevierInc.Allrightsreserved.

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