DAFTAR PUSTAKA

Abbas, A.K., Lichtman, A.H. and Pober, J.S., 1994. Antigen processing and
presentation to T lymphocytes. Cellular and Molecular Immunology, WB
Saunders Comp. USA,, pp.115-35.

Abul KA, Lichtman AH, Pober JS (2000) Cellular and Molecular Immunolgy, Fifth
Edition. Philadelphia: W.B. Saunders Company.

Alam, S.M., Kidwai, A.A., Jafri, S.R., Qureshi, B.M., Sami, A., Qureshi, H.H. and
Mirza, H., 2011. Epidemiology of rheumatoid arthritis in a tertiary care unit,
Karachi, Pakistan. Epidemiology.

Allen, M., Oberle, K., Grace, M., Russell, A. and Adewale, A.J., 2008. A randomized
clinical trial of elk velvet antler in rheumatoid arthritis. Biological research for
nursing, 9(3), pp.254-261.

American College of Rheumatology Ad Hoc Commitie on Clinical Guidelines.

Guidelines for the management of Rematoid arthritis. Arthritis Rheum 1996; 39:
713 31.
American College of Rheumatology Subcommittee on Rematoid Arthritis Guidelines.
Guidelines for the Management of Rematoid Arthritis 2002 Update. Arthrits
Rheum 2002; 46: 328-46.

Balbir-Gurman, A., Fuhrman, B., Braun-Moscovici, Y., Markovits, D. and Aviram, M.,
2011. Consumption of pomegranate decreases serum oxidative stress and
reduces disease activity in patients with active rheumatoid arthritis: a pilot study.
The Israel Medical Association journal: IMAJ, 13(8), pp.474-479.
50

Benito-Ruiz, P., Camacho-Zambrano, M.M., Carrillo-Arcentales, J.N., MestanzaPeralta, M.A., Vallejo-Flores, C.A., Vargas-Lpez, S.V., Villacs-Tamayo, R.A. and
Zurita-Gavilanes, L.A., 2009. A randomized controlled trial on the efficacy and
safety of a food ingredient, collagen hydrolysate, for improving joint comfort.
International journal of food sciences and nutrition,60(sup2), pp.99-113.

Begovich, A.B., Carlton, V.E., Honigberg, L.A., Schrodi, S.J., Chokkalingam, A.P.,
Alexander, H.C., Ardlie, K.G., Huang, Q., Smith, A.M., Spoerke, J.M. and Conn,
M.T., 2004. A missense single-nucleotide polymorphism in a gene encoding a
protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
The American Journal of Human Genetics, 75(2), pp.330-337.

Bevaart, L., Vervoordeldonk, M.J. and Tak, P.P., 2010. Evaluation of therapeutic
targets in animal models of arthritis: how does it relate to rheumatoid arthritis?.
Arthritis & Rheumatism, 62(8), pp.2192-2205.

Billiau, A. and Matthys, P., 2001. Modes of action of Freunds adjuvants in

experimental

models

of

autoimmune

diseases.

Journal

of

leukocyte

biology,70(6), pp.849-860.

Bureau JF, Bihl F, Brahic M, Le Paslier D (1995) The gene coding for interferongamma is linked to the D12S335 and D12S313 microsatellites and to the MDM2
gene. Genomics 28, 109-112.

Brennan, F.M. and McInnes, I.B., 2008. Evidence that cytokines play a role in
rheumatoid arthritis. The Journal of clinical investigation, 118(11), p.3537.

Bhowmik, D., Gopinath, H., Kumar, B.P. and Kumar, K., 2013. Medicinal uses of
Punica granatum and its health benefits. Journal of Pharmacognosy and
51

Phytochemistry, 1(5).

Bratawidjaja KG, dan Rengganis I. Imunologi Dasar. Ed. VII. Ba Jakarta: FKUI; 2009.
ISBN 978-979-496-590-0

BPOM, R., 2008. Taksonomi Koleksi Tanaman Obat Kebun Tanaman Obat Citeureup.

Casco, R., Vidal, B., Raquel, H., Neves-Costa, A., Figueiredo, N., Gupta, V.,
Fonseca, J.E. and Ferreira Moita, L., 2014. Potent anti-inflammatory and
antiproliferative effects of gambogic acid in a rat model of antigen-induced
arthritis. Mediators of inflammation, 2014.

Choudhary, M., Kumar, V., Malhotra, H. and Singh, S., 2015. Medicinal plants with
potential anti-arthritic activity. Journal of Intercultural Ethnopharmacology, 4(2),
p.147.

Chu, C.Q., Swart, D., Alcorn, D., Tocker, J. and Elkon, K.B., 2007. Interferon
regulates susceptibility to collageninduced arthritis through suppression of
interleukin17. Arthritis & Rheumatism, 56(4), pp.1145-1151.

Darmawan J. Rheumatic condition in the northern part of Central Java. An

epidemiological survey. 1988:97-111.
Dixon, W.G., Hyrich, K.L., Watson, K.D., Lunt, M., Galloway, J., Ustianowski, A.,
Symmons, D.P.M. and BSRBR Control Centre Consortium, 2010. Drug-specific
risk of tuberculosis in patients with rheumatoid arthritis treated with anti-TNF
therapy: results from the British Society for Rheumatology Biologics Register
(BSRBR). Annals of the rheumatic diseases, 69(3), pp.522-528.
Doodes, P.D., Cao, Y., Hamel, K.M., Wang, Y., Rodeghero, R.L., Mikecz, K., Glant,

52

T.T., Iwakura, Y. and Finnegan, A., 2010. IFN- regulates the requirement for IL17 in proteoglycan-induced arthritis. The journal of immunology, 184(3), pp.15521559.

Dvorak, A.M. and Dvorak, H.F., 1974. Structure of Freund's complete and incomplete
adjuvants: Relation of adjuvanticity to structure. Immunology,27(1), p.99.

Ealick, S.E., Cook, W.J., Vijay-Kumar, S., Carson, M., Nagabhushan, T.L., Trotta, P.P.
and Bugg, C.E., 1991. Three-dimensional structure of recombinant human
interferon-gamma. Science, 252(5006), pp.698-702.

Firestein, G.S., Panayi, G.S. and Wollheim, F.A. eds., 2006. Rheumatoid arthritis.
Oxford University Press.

Fina-Aviles, F., Medina-Peralta, M., Mendez-Boo, L., Hermosilla, E., Elorza, J.M.,
Garcia-Gil, M., Ramos, R., Bolibar, B., Javaid, M.K., Edwards, C.J. and Cooper,
C., 2014. The descriptive epidemiology of rheumatoid arthritis in Catalonia: a
retrospective study using routinely collected data. Clinical rheumatology, pp.1-7.

Feldmann, M., Brennan, F. M. & Maini, R. N. Role of cytokines in rheumatoid arthritis.

Annu. Rev. Immunol. 14, 397440 (1996)

Flesch, I.E., Hess, J.H., Huang, S., Aguet, M., Rothe, J., Bluethmann, H. and
Kaufmann, S.H., 1995. Early interleukin 12 production by macrophages in
response to mycobacterial infection depends on interferon gamma and tumor
necrosis factor alpha. The Journal of experimental medicine, 181(5), pp.16151621.

Furst, D.E., Keystone, E.C., Fleischmann, R., Mease, P., Breedveld, F.C., Smolen,
53

J.S., Kalden, J.R., Braun, J., Bresnihan, B., Burmester, G.R. and De Benedetti,
F., 2010. Updated consensus statement on biological agents for the treatment of
rheumatic diseases, 2009. Annals of the Rheumatic Diseases, 69(Suppl 1), pp.i2i29.

Freund, J., 1956. The mode of action of immunologic adjuvants. Bibliotheca

tuberculosea, (10), p.130.

Gabriel, S.E. and Michaud, K., 2009. Epidemiological studies in incidence,

prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res
Ther, 11(3), p.229.

Ghayur, T., Banerjee, S., Hugunin, M., Butler, D., Herzog, L., Carter, A., Quintal, L.,
Sekut, L., Talanian, R., Paskind, M. and Wong, W., 1997. Caspase-1 processes
IFN--inducing factor and regulates LPS-induced IFN- production.

Ghelani, H.S., Rachchh, M.A. and Gokani, R.H., 2013. Evaluation of Anti-arthritic
Activity of Polyherbal Formulation in Freunds Adjuvant Induced Arthritic Rat
Model. Inventi Rapid: Ethnopharmacology.

Gregersen, P.K., Silver, J. and Winchester, R.J., 1987. The shared epitope
hypothesis.

An

approach

to

understanding

the

molecular

genetics

of

susceptibility to rheumatoid arthritis. Arthritis & Rheumatism, 30(11), pp.12051213.

Handayani, L., Riau, U.S., Widyanto, M.R., Kodariah, R. and Handayani, P.W., 2011,
FUZZY CELLS EXTRACTION AND CELL MORPHOLOGY FOR THE ANTIGEN
POSITIVITY DETERMINATION OF IMMUNOHISTOCHEMICAL IMAGE.

54

Jahromi, S.B., Pourshafie, M.R., Mirabzadeh, E., Tavasoli, A., Katiraee, F., Mostafavi,
E. and Abbasian, S., 2015. Punica granatum Peel Extract Toxicity in Mice.
Jundishapur Journal of Natural Pharmaceutical Products,10(4).

Janeway, C.A., Travers, P. and Walport, M., 1999. Immunobiology: the immune
system in health and disease (Vol. 157, pp. 174-176). New York, NY;: Current
Biology Publications.

Johnson, H.M., Bazer, F.W., Szente, B.E. and Jarpe, M.A., 1994. How interferons fight
disease. Scientific American, 270(5), p.68.

Jurenka, J., 2008. Therapeutic applications of pomegranate (Punica granatum L.): a

review. Alternative medicine review, 13(2), p.128.

Kalim H. Pengembangan reumatologi dalam menjawab tantangan masalah

kesehatan pada pembangunan jangka panjang tahap II. Pidato pengukuhan.
1994 : 4-6.

Kim, E.Y. and Moudgil, K.D., 2009. The determinants of susceptibility/resistance to

adjuvant arthritis in rats. Arthritis research & therapy, 11(4), pp.1-9.

Kim, E.Y., Chi, H.H., Rajaiah, R. and Moudgil, K.D., 2008. Exogenous tumour
necrosis factor alpha induces suppression of autoimmune arthritis.Arthritis Res
Ther, 10(1), p.R38.

Kim, J.M. and Weisman, M.H., 2000. When does rheumatoid arthritis begin and why
do we need to know?. Arthritis & Rheumatism, 43(3), pp.473-484.
Kothari, A., 2012. Evaluation of anti-inflammatory effect of Punica granatum (Linn)
seed extract against different mediators of inflammation in albino rats.Journal of
55

Pharmacy Research, 5(1).

Lahiri, M., Morgan, C., Symmons, D.P. and Bruce, I.N., 2011. Modifiable risk factors
for RA: prevention, better than cure?. Rheumatology, p.ker299.

Lindblad, E.B., 2000. Freund's adjuvants. In Vaccine Adjuvants (pp. 49-63). Springer
New York.

Luqmani, R., Hennell, S., Estrach, C., Birrell, F., Bosworth, A., Davenport, G., Fokke,
C., Goodson, N., Jeffreson, P., Lamb, E. and Mohammed, R., 2006. British
Society for Rheumatology and British Health Professionals in Rheumatology
guideline for the management of rheumatoid arthritis (the first two years).
Rheumatology, 45(9), pp.1167-1169.
Mathers, D.S.C. and Pfleger, B., The global burden of rheumatoid arthritis in the year
2000. Criterion, 1(2).

Meron, M.K., Amital, H., Shepshelovich, D., Barzilai, O., Ram, M., Anaya, J.M., Gerli,
R., Nicola,

B. and Shoenfeld, Y., 2010. Infectious aspects and the

etiopathogenesis

of rheumatoid arthritis.

Clinical

reviews

in allergy

&

immunology, 38(2-3), pp.287-291.

McInnes, I.B. and Schett, G., 2007. Cytokines in the pathogenesis of rheumatoid
arthritis. Nature Reviews Immunology, 7(6), pp.429-442.

Nasution, A.R Sumariyono. 2014. Introduksi Reumatologi Dalam :Buku Ajar Ilmu
Penyakit Dalam Jilid III Edisi V. Sudoyo, A.W., Setiyohadi, B., Alwi, Idrus, et al.
Interna Publishing. Jakarta.

Nazrun Shuid, A. and Naina Mohamed, I., 2013. Pomegranate use to attenuate bone
56

loss in major musculoskeletal diseases: an evidence-based review. Current drug

targets, 14(13), pp.1565-1578.

Okamura, H., Tsutsui, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., Torigoe,
K., Okura, T., Nukada, Y., Hattori, K. and Akita, K., 1995. Cloning of a new
cytokine that induces IFN- production by T cells. Nature,378(6552), pp.88-91.

Pearson, C.M., 1956. Development of arthritis, periarthritis and periostitis in rats given
adjuvants. Experimental Biology and Medicine, 91(1), pp.95-101

Perhimpuan Reumatologi Indonesia. Diagnosis dan Pengelolaan Artritis Reumatoid.

Rekomendasi Perhimpuan Reumatologi Indonesia 2014

Plenge, R.M., Seielstad, M., Padyukov, L., Lee, A.T., Remmers, E.F., Ding, B., Liew,
A., Khalili, H., Chandrasekaran, A., Davies, L.R. and Li, W., 2007. TRAF1C5 as
a risk locus for rheumatoid arthritisa genomewide study.New England Journal
of Medicine, 357(12), pp.1199-1209.

Priharjo, R., 1995. Teknik Dasar Pemberian Obat Bagi Perawat.

Prayoga, Elza Prima. 2013. Efek Ekstrak Kloroformik Herba Lengkuas (Alpinia
Gangala L) Varietas Batu terhadap Volume Edema Plantaris Tikus (Rattus
Norvegicus) Yang diiinduksi Karagenan. Skripsi Fakultas Kedokteran Universitas
Islam Malang. Halaman 45-59.
Plotnikoff NP, Ed.(1999) Cytokines: stress and immunity. Boca Raton: CRC Press.

Rudolf, M., Deighton, C., Bosworth, A., Hall, J., Hammond, A. and Hennel, S., 2009.
Rheumatoid Arthritis. National clinical guideline for management and treatment in
adults. NICE Clinical Guidelines. Royal College of Physicians, London, (79).

57

Ragno, S., Colston, M.J., Lowrie, D.B., Winrow, V.R., Blake, D.R. and Tascon, R.,
1997. Protection of rats from adjuvant arthritis by immunization with naked DNA
encoding for mycobacterial heat shock protein 65. Abstracts Arthritis &
Rheumatism, 40(2), pp.277-283.
Rahman, A. and Abdalla, R.A., 2014. Phytochemical Study of the Major Flavonoid
from Punica granatum (Doctoral dissertation, Sudan University of Science and
Technology).
Sabeh, F., Fox, D. and Weiss, S.J., 2010. Membrane-type I matrix metalloproteinasedependent regulation of rheumatoid arthritis synoviocyte function. The Journal of
Immunology, 184(11), pp.6396-6406.

Scott, D.L., Wolfe, F. and Huizinga, T.W., 2010. Rheumatoid arthritis. The Lancet,
376(9746), pp.1094-1108.

Spindler, A., Bellomio, V., Berman, A., Lucero, E., Baigorria, M., Paz, S., Garrone, N.,
Torres, A.I., Romano, O., Carraccio, A. and Leal, O., 2002. Prevalence of
rheumatoid arthritis in Tucuman, Argentina. The Journal of rheumatology, 29(6),
pp.1166-1170.

Silman AJ, Hochberg MC. Descriptive epidemiology of Rematoid arthritis. Dalam:

Hochberg MC,Silman AJ, Smolen JS, Weinblatt ME, Weisman MH (eds).
Rematoid Arthritis. Mosby: Philadelphia.2009; 15-22

Sung, Y.K., Cho, S.K., Choi, C.B. and Bae, S.C., 2013. Prevalence and incidence of
rheumatoid arthritis in South Korea. Rheumatology international,33(6), pp.15251532.

Sari, R.P., Amin, J. and Sari, S.P., 2010. UJI EFEK ANTIARTRITIS EKSTRAK
ETANOL 80% KULIT BUAH DELIMA MERAH (PUNICA GRANATUM L.)

58

TERHADAP UDEM PADA TELAPAK KAKI TIKUS. Majalah Ilmu Kefarmasian,

7(1), pp.34-48.

Shukla, M., Gupta, K., Rasheed, Z., Khan, K.A. and Haqqi, T.M., 2008. Consumption
of hydrolyzable tannins-rich pomegranate extract suppresses inflammation and
joint damage in rheumatoid arthritis. Nutrition, 24(7), pp.733-743.

Scott, D.L., Wolfe, F. and Huizinga, T.W., 2010. Rheumatoid arthritis. The Lancet,
376(9746), pp.1094-1108.

Tripathi, S.M. and Singh, D.K., 2000. Molluscicidal activity of Punica granatum bark
and Canna indica root. Brazilian Journal of Medical and Biological Research,
33(11), pp.1351-1355

Tobn, G.J., Youinou, P. and Saraux, A., 2010. The environment, geo-epidemiology,
and autoimmune disease: rheumatoid arthritis. Journal of autoimmunity, 35(1),
pp.10-14.

Takayanagi, H., Ogasawara, K., Hida, S., Chiba, T., Murata, S., Sato, K., Takaoka, A.,
Yokochi, T., Oda, H., Tanaka, K. and Nakamura, K., 2000. T-cell-mediated
regulation of osteoclastogenesis by signalling cross-talk between RANKL and
IFN-. Nature, 408(6812), pp.600-605.

Tobn, G.J., Youinou, P. and Saraux, A., 2010. The environment, geo-epidemiology,
and autoimmune disease: rheumatoid arthritis. Journal of autoimmunity, 35(1),
pp.10-14.

Udagawa, N., Horwood, N.J., Elliott, J., Mackay, A., Owens, J., Okamura, H.,
Kurimoto, M., Chambers, T.J., Martin, T.J. and Gillespie, M.T., 1997. Interleukin59

18 (interferon-inducing factor) is produced by osteoblasts and acts via

granulocyte/macrophage colony-stimulating factor and not via interferon- to
inhibit osteoclast formation. The Journal of experimental medicine, 185(6),
pp.1005-1012.

Vidal, A., Fallarero, A., Pea, B.R., Medina, M.E., Gra, B., Rivera, F., Gutierrez, Y. and
Vuorela, P.M., 2003. Studies on the toxicity of Punica granatum L.(Punicaceae)
whole fruit extracts. Journal of ethnopharmacology,89(2), pp.295-300

van Eden, W., Thole, J.E.R., van der Zee, R., Noordzij, A., van Embden, J.D.,
Hensen, E.J. and Cohen, I.R., 1988. Cloning of the mycobacterial epitope
recognized by T lymphocytes in adjuvant arthritis. Nature, 331(6152), pp.171173.

Weichman, B.M., 1989. Rat adjuvant arthritis: a model of chronic inflammation. JY

Chang & AJ Lewis, Eds, pp.363-380.

Yazici, Yusuf, and Ismail Simsek. "Treatment options for rheumatoid arthritis beyond
TNF- inhibitors." (2010): 663-666.

Yoon, C.H., Chung, S.J., Lee, S.W., Park, Y.B., Lee, S.K. and Park, M.C., 2013. Gallic
acid, a natural polyphenolic acid, induces apoptosis and inhibits proinflammatory
gene expressions in rheumatoid arthritis fibroblast-like synoviocytes. Joint Bone
Spine, 80(3), pp.274-279.

Yuniarti, T., 2008. Ensiklopedia tanaman obat tradisional. MedPress.

Zurier, R.B., Rossetti, R.G., Jacobson, E.W., Demarco, D.M., Liu, N.Y., Temming,
J.E., White, B.M. and Laposata, M., 1996. Gammalinolenic acid treatment of
60

rheumatoid

arthritis.

randomized,

Rheumatism, 39(11), pp.1808-1817.

61

placebocontrolled

trial.Arthritis

&