PATHOPHYSIOLOGY

Modifiable
Stress
Lifestyle
Exercise
Hypertension
Obesity

Non modifiable
Age
Sex
Family history of
stroke
Race

Continuity of risk
factors
Increased vasoconstriction

Increased blood perfusion

Formation of fatty
plaque deposits
Angiotensin II

Arteriolar
Hardening and
vasoconstricti
narrowing of
arteries

Thrombus
formation

Occlusion of major
vessels

aldosterone

sodium
reabsorption
water
reabsorption

Increased blood
coagulation

Pontine
bleedin
g

peripheral
Plaque ruptures the
resistance
pons

oxygenated blood to
the brain
anasarca

blood
renal
pressure
perfusion

plasma
volume (ECF)

Hypertension

Changes in
arteriolar bed
systemic
vascular
resistance
afterload

blood flow to
the organs
oxygenation
in kidneys

hyponatremia
GFR
hypovolemia
Renin

Angiotensinog
en

ACE from
lungs

Angiotensin I

Beta receptor
activation