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Ribonucleic
acid (RNA)
implicated
in
is
a polymeric molecule
various
biological
roles
RNA
acids,
and,
constitute
the
along
three
to
denote
the
nitrogenous
biological
reactions,
controlling gene
RNA (tRNA)
molecules
to
deliver amino
complementary
base
pairing,
form
intrastrand
While
DNA
contains deoxyribose,
RNA
The
complementary
base
to adenine in
DNA
DNA,
most
biologically
active
and
RNAs,
othernon-
In
this
chemical catalysis,
fashion,
like
RNAs
can
enzymes.[6] For
achieve
instance,
STRUCTURED
RNA
contains
a ribose sugar,
with
position,
in
deaminated
adenine
base
whose nucleoside is
modifications
pseudouridine
can
be
and
found
in tRNA,[18] while
nucleosides
with 2'-O-
ribosomal
RNA,
many
of
the
post-transcriptional
proteins,
frequently
requires
specific tertiary
of
secondary
structure
like hairpin
loops,
naturally
occurring enantiomer of
RNA
is D-RNA
The
DNA
sequence
also
dictates
where
added
to
are
also
number
of RNA-dependent
RNA
(A)
2. Guanine (G)
3. Cytosine (C)
4. Thymine (T)
X-Ray Evidence
There were 2 strands
Strands were twisted around each other (helix)
The nitrogen bases are in the middle
The Double Helix
Francis Crick & James Watson
Trying to understand the structure of DNA by building
models
Unsuccessful until early 1953, Watson was shown a
copy of Franklins X-ray pattern
The instant I saw the picture my mouth fell open
and my pulse began to race.
James Watson
Within weeks Watson and Crick had figured out the
structure of DNA
9
Histones
Proteins that coil up DNA
DNA + histone molecules form a bead-like structure
called a nucleosome
Nucleosomes pack together to form thick fibers that
loop and coil together to form chromosomes
10
DNA Replication
When Watson and Crick discovered the double helix
structure of DNA they recognized immediately how
DNA could copy itself
The strands are complementary
If you could separate the two strands, the rules of
base pairing would allow you to reconstruct the base
sequence of the other strand
Replication
When the DNA splits into 2 strands, then produces 2
new strands following the rules of base pairing
How Replication Occurs
Replication is carried out by enzymes
Before DNA replicates, the double helix must unwind
and unzip
There
are
many
regulatory
replication
DNA polymerase
11
molecules
used
in
Joins
individual
nucleotides
to
produce
DNA
14
Translation
The sequence of nucleotide bases in an mRNA
molecule serves as instructions for the order in which
amino acids are joined to make a protein
Proteins are put together on ribosomes
Translation
Decoding mRNA into a protein
Steps of Translation
1. mRNA is transcribed from DNA in the nucleus and
released into the cytoplasm
2. mRNA attaches to a ribosome
3.
copies
of
the
master
plan
called
defective
proteins
that
disrupt
normal
biological activities
Mutations are also a source of genetic variability
which can be beneficial
Polyploidy
16
17