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CORP-APPEND-0104A

Date: March 2015


Page: 1 of 5

Rev. 23

Critical Values List


Chemistry
Test
Bicarbonate (Total CO2)
Bilirubin, Total
Calcium, Ionized
Calcium, Total
Glucose
Iron
Glucose, WB POC
Glucose, WB, neonatal POC
Magnesium
Phosphorus
Potassium
Sodium

Value
<10 or >40 mmol/L
>15 mg/dL

Comments

0.78 or 1.58 mmol/L


<6.0 or >13.0 mg/dL
<40 or >450 mg/dL
>500 ug/dL
<60 or >450 mg/dL
<40 or >200 mg/dL
<1.0 or >9.0 mg/dL
<1.0 or >9.0 mg/dL
<3.0 or >6.1 mmol/L
<120 or >160 mmol/L

Coagulation
Test

Value

Prothrombin Time

44.7 seconds

INR

5.0

PTT

85 seconds

Fibrinogen

<100 mg/dL

Factors 2, 5, 8, 9, 11

5%

Factor 7
Factor 10
Factor 13, Activity

6%
7%
5%

Comments
When ordered as part of a panel
other criteria apply.
When ordered as part of a panel
other criteria apply.
When ordered as part of a panel
other criteria apply.

Infectious Disease
Test
Detection of any infectious
agent:
Blood
Bone Marrow

Value
By:

Comments

Positive Culture , Smear or Rapid


Antigen
Positive Culture or Smear

AFB, bacterial, fungal, parasitic


AFB, bacterial, fungal, viral,
parasitic

***Disclaimer*** Critical values defined in this document are based on a specific test methodology and/or specific reference
range study and are current as of the revision date. A critical value defined by a quantitative cut off range or a qualitative result
may change if a specific method or reference range is changed and this document may be out of date. Clients can check for
current testing reference ranges and methods on the ARUP Website, the ARUP Test Directory or ARUP Hotlines. All critical
values are evaluated and reviewed by the laboratory section medical director. This document may become out of date.

CORP-APPEND-0104A Rev. 23
Date: March 2015
Page: 2 of 5

Critical Values List


Infectious Disease
Test
Body Fluid
(Except gastrointestinal fluid or
urine sources)
CSF or other Central Nervous
System specimen
CSF or other Central Nervous
System specimen

Value
Positive Culture or Smear

Comments
AFB, bacterial, fungal, viral,
parasitic

Positive Culture, Smear, or


Antigen detection
Nucleic Acid Testing (NAT)

Eye / Ocular

Positive Culture, Smear, or NAT

Tissue

Positive Culture or Smear

Detection of specific
infectious agent
Mycobacterium sp., Acid Fast
Bacillus (AFB) (M.
tuberculosis)
Zygomycete
Select Agents and other highly
pathogenic organisms (Bacillus
anthracis, Brucella spp.,
Burkholderia mallei,
Burkholderia pseudomallei,
Coccidiodes immitis,
Francisella tularensis, Yersinia
pestis, and C. diphtheriae,
Salmonella typhi, Vibrio
cholera)
5- fluorocytosine

By

AFB, bacterial, fungal, viral


(except Enterovirus), parasitic
All pathogens except Enterovirus,
EBV, HIV, JC virus, and
Parvovirus.
AFB, bacterial, fungal, viral,
parasitic
AFB, bacterial, fungal, viral,
parasitic
In

Positive stain, culture, NAT,


and/or resistance to primary antituberculosis agents
Positive Culture
Positive Culture and/or positive
probe for C. immitis

Nasal, Sinus

100 g/mL

Toxicology
Test

Value

Acetone

>100 mg/dL
>150 g/mL
>40 g/mL
>3 g/mL
>30 g/mL

Acetaminophen
Amiodarone
Amikacin

>8 g/mL

Comments
@ 4 hours post ingestion
@12 hours post ingestion
Peak - draw 30 min post infusion.
Trough - draw 30 min before
infusion

***Disclaimer*** Critical values defined in this document are based on a specific test methodology and/or specific reference
range study and are current as of the revision date. A critical value defined by a quantitative cut off range or a qualitative result
may change if a specific method or reference range is changed and this document may be out of date. Clients can check for
current testing reference ranges and methods on the ARUP Website, the ARUP Test Directory or ARUP Hotlines. All critical
values are evaluated and reviewed by the laboratory section medical director. This document may become out of date.

CORP-APPEND-0104A Rev. 23
Date: March 2015
Page: 3 of 5

Critical Values List


Toxicology
Test

Value

Amitriptyline+Nortriptyline
Bupropion
Caffeine (Neonate)
Carbamazepine Epoxide
Carbamazepine, Total
Carbamazepine, Free
Choramphenicol
Chlorpromazine (12 and older)
Chlorpromazine (0-12 years)
Clomipramine+Norclomipramine
Clozapine
Cyanide
Desipramine
Cyclosporine A
Digitoxin

>500 ng/mL
>400 ng/mL
>40 g/mL
>15 g/mL
>20 g/mL
>3.8 g/mL
>25 g/mL
>750 ng/mL
>200 ng/mL
>900 ng/mL
>2000 ng/mL
>100 g/mL
>500 ng/mL
>700 ng/mL
>35 ng/mL

Digoxin

>2.4 ng/mL

Disopyramide
Doxepin+Nordoxepin
Ethanol
Ethosuximide
Ethylene Glycol
Everolimus
Felbamate

>7 g/mL
>500 ng/mL
>250 mg/dL
>150 g/mL
>20 mg/dL
>15 ng/mL
>200 g/mL
>12 g/mL

Gentamicin

>2 g/mL

Flecainide
Imipramine+Desipramine
Isopropanol
Methanol

>1.5 g/mL
>500 ng/mL
>50 mg/dL
>20 mg/dL

Lidocaine

>9 g/mL

Lithium

1.6 mmol/L

Comments

Trough

Trough - draw 8-12 hr. post dose.


Minimum post dose 6 hours

Peak - draw 30 min. post infusion.


Trough - draw 30 min. before
infusion.

> 30 min. post IV dose after steady


state (5-10 hours)
Trough

***Disclaimer*** Critical values defined in this document are based on a specific test methodology and/or specific reference
range study and are current as of the revision date. A critical value defined by a quantitative cut off range or a qualitative result
may change if a specific method or reference range is changed and this document may be out of date. Clients can check for
current testing reference ranges and methods on the ARUP Website, the ARUP Test Directory or ARUP Hotlines. All critical
values are evaluated and reviewed by the laboratory section medical director. This document may become out of date.

CORP-APPEND-0104A Rev. 23
Date: March 2015
Page: 4 of 5

Critical Values List


Toxicology
Test

Value

Comments

Mexiletine
Mycophenolic Acid (MPA)
Nortriptyline
Pentobarbital

>2 g/mL
>25 g/mL
>500 ng/mL
>10 g/mL
>30 g/mL
>14 g/mL
>50 g/mL
>40 g/mL
>3.0 g/mL
> 15 g/mL
>2 g/mL
>400 ng/mL

Trough, 3 months adult


Trough, 0 - 3 months
Trough, 3 months adult
Trough, 0 -3 months

Phenytoin, Total
Phenobarbital
Phenytoin, Free
Primidone
Propafenone
Protriptyline
Procainamide
NAPA
Quinidine
Salicylate
Sirolimus
Theophylline
TCA - Tricyclics
Tobramycin
Valproic Acid (VPA), Free
Valproic Acid (VPA), Total
Voriconazole
Vancomycin
Zonisamide

>12 g/mL
>35 g/mL
>10 g/mL
>300 g/mL or >30 mg/dL
>25 ng/mL
>25 g/mL
>20 g/mL
>400 ng/mL
>12 g/mL
>2 ug/mL
>30 g/mL
>150 g/mL
>6.0 g/mL
>80 g/mL
>80 g/mL
>80 g/mL

Trough
Trough

Trough, 6 months adult


Trough, 0 - 6 months
Peak draw 30 min post infusion.
Trough draw 30 min. before
infusion
Trough
Trough
Peak (not recommended)

Trace and Toxic Elements


Test
Lead

Value
45 g/dL (birth thru 18 yr)
70 g/dL (>19 years)

Comments
Blood
Blood

***Disclaimer*** Critical values defined in this document are based on a specific test methodology and/or specific reference
range study and are current as of the revision date. A critical value defined by a quantitative cut off range or a qualitative result
may change if a specific method or reference range is changed and this document may be out of date. Clients can check for
current testing reference ranges and methods on the ARUP Website, the ARUP Test Directory or ARUP Hotlines. All critical
values are evaluated and reviewed by the laboratory section medical director. This document may become out of date.

CORP-APPEND-0104A Rev. 23
Date: March 2015
Page: 5 of 5

Critical Values List


Arterial Blood Gases
Test
pH
PCO2
PO2
Hemoglobin

Value
7.25 or 7.6
20 or 60 mm Hg
40 mm Hg
7.0g/dL

Comments

Test

Value

Comments

Antibody Screen
DAT (Direct Coombs)

Positive
Positive

Transfusion Service

Hematology
Test
Hematocrit
Hemoglobin
Platelet Count
White Blood Cell Count

Value
21% or 65%
7 or >21.0 g/dL
20 or 1000 x 103/L
2.0 or 40 x 103/L

Comments

***Disclaimer*** Critical values defined in this document are based on a specific test methodology and/or specific reference
range study and are current as of the revision date. A critical value defined by a quantitative cut off range or a qualitative result
may change if a specific method or reference range is changed and this document may be out of date. Clients can check for
current testing reference ranges and methods on the ARUP Website, the ARUP Test Directory or ARUP Hotlines. All critical
values are evaluated and reviewed by the laboratory section medical director. This document may become out of date.