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Compi-Clox Dry Syrup 100ml (Ampicillin

Trihydrate 125 mg + Cloxacillin Sodium 125


mg/5ml)

COMPI-CLOX
Brand of Ampicilin + Cloxacillin for Oral usage

COMPI-CLOX is a combination of Ampicillin as Trihydrate and Penicillinase resistant


Cloxacillin as sodium salt to form broad spectrum antibiotic preparation. COMPI-CLOX
exhibits bactericidal activity against a broad range of Gram-positive and Gram-negative
organisms such as Streptococcus species, staphylococcus species, Salmonella species,
Haemophilus influenza, Eshericia-coli, Proteus mirabilis and Neisseria species.
ABSORPTION AND EXCRETION
Ampicillin and Cloxacillin are both acid stable and are easily absorbed, producing good serum
and urine concentrations. COMPI-CLOX is mainly excreted by glomerular filtration and renal
tubular secretion.
INDICATIONS
COMPI-CLOX is effective in the treatment of respiratory tract infections, Ear, Nose and throat
infections. Uniary tract infections, Gastro- intestinal infections, skin and soft tissue infections.
Pelvic infections, Septicaemia, Endocarditis, Orthopaedic infections. COMPI-CLOX Neonatal
Oral drops is indicated for the prophylaxis or treatment of bacterial infections in premature
babies or neonates.

DOSAGE AND ADMINISTRATION


Administer COMPI-CLOX hour-1hour before meals or feeding.
DROPS- Neonates: 0.5ml (90mg) - 4 times daily or as by the physician. See 0.5ml mark on the
dropper
SYRUP- Children: 1 month-2years- - 1 teaspoonful 4times daily
2-10 years-1-2 teaspoonful 4times daily.
CAPSULE-Adult: one or two capsules 4times daily or as directed by a physician.
CONTRAINDICATIONS
Hypersensitivity to Penicillin
SIDE EFFECTS:
The side effects of COMPI-CLOX as with other Penicillin are usually of mild and transitory
nature. They may include Diarhoea, indigestion or occasionally rash-either utrticaria which
suggest penicillin hypersensitivity or erythematous.
PREPARATION OF THE SUSPENSION
To make 100ml of the suspension, add 80ml of boiled and cooled water, while 10ml (two
teaspoonful) of the water is added to Neonatal Oral drops to make 12ml suspension. Invert and
shake the bottle until all powder is dispersed. Alternstively for 100ml suspension, add boiled and
cooled water to half of the bottle, shake well and slowly add more water up to the mark on the
label.
SHAKE WELL BEFORE TAKING EACH DOSE
STORAGE
All COMPI-CLOX containers should be kept tightly closed and stored in a cool dry place
below 25 0C. The suspension should be used within 7 days of preparation and stored in a cool
place preferably a refrigerator.
PRECAUTION:
Reduced dosage is required in patients with impaired functions e.g. renal failure, neonates and
pre-mature infants.
KEEP OUT OF THE REACH OF CHILDREN
COMPOSITION AND AVAILABILITY
NEONATAL ORAL DROPS: 90mg drops: When reconstituted each 0.5ml contains 60mg
Ampicillin as Ampicillin Trihydrate B.P. and 30mg Cloxacillin as the Sodium Salt B.P.
SUSPENSION: 250mg Dry Syrup: When reconstituted each 5ml contains 125mg Ampicillin as
the Trihydrate B.P. plus 125mg Cloxacillin as the Sodium Salt B.P.
CAPSULES: 500mg: 250mg Ampicillin as Ampicillin Trihydrate B.P. and 250mg Cloxacillin as
Cloxacillin Sodium Salt B.P. in Blister and 500's packs.
NAFDAC REGISTRATON NUMBER:
Compi-Clox Dry Syrup x 100ml -04-2350

Compi-Clox Neo-natal Drops -04-2128


Compi-Clox Capsules x 500s, x 100s, x 20s -04-3403
Manufactured by
DRUGFIELD PHARMACEUTICALS LIMITED
Lynson Chemical Avenue,
KM 38, Lagos-Abeokuta Expressway,
Sango-Otta, Nigeria