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Introduction:

Now a days,the synthesis of mesoporous particles has been of great interest due to
its uses, ranging from drug delivery to chemical sensors.among various mesoporous
particles, silica has ever-expanding list of uses,because it is chemically inert,
harmless, thermally stable, and inexpensive(Nandiyanto, Kim et al. 2009).
Mesoporous silica materials with pore size250 nm(Heikkil, Salonen et al. 2007),
offer several attractive features, such as a large surface area, easily modified pore
size and volume,excellent biocompatibility as well as allowing easier chemical
functionalization of their surface(Zhang, Zhi et al. 2010, Yuan, Tang et al. 2011). the
most often used mesoporous silica material based drug carrier has been the ordered
hexagonal molecular sieve MCM-41(Heikkil, Salonen et al. 2007).they have many
traditional applications such as catalysis and chromatography but new biomedical
applications include cell imaging, diagnosis and bioanalysis and drug/gene/protein
delivery.for this purpose,morphology, controlled pore size and ordered particle size
of mesoporous silica is required(Lu, Wu et al. 2009).thwre are several methods of
preparation of mesoporous material with different morphologies, from thin film,
sphere, fiber, as well as bulk form,such as the MCM series and the SBA
series(Nandiyanto, Kim et al. 2009).MSN is composed of highly ordered mesoporous
structure along with uniform but adjacent pore size,through its ordered structure, it
can accommodate the loaded drug molecule and protect the entrapped drug from
any type of degradation (Yuan, Tang et al. 2011).
The simplist way of drug administration is oral drug delivery.through new drug
development,various kind of innovative drugs are developed but most of these
show poorly aqueos solubility,resulting in poor oral bioavaillibility and efficacy dur to
insufficient dissolution in gastrointestinal tract(Zhang, Zhi et al. 2010). Among a
variety of drug-delivery systems, mesoporous silica materials have several
attractive features for use in the delivery of water-insoluble drugs. These particles
have large surface areas and porous interiors that can be used as reservoirs for
storing hydrophobic drugs. Silica-based materials have been successfully used as
drug-delivery vectors, gene transfection reagents,cell markers, and carriers of
molecules(Lu, Liong et al. 2007)

Uncategorized References
Heikkil, T., et al. (2007). "Mesoporous silica material TUD-1 as a drug delivery
system." International journal of pharmaceutics 331(1): 133-138.

Lu, F., et al. (2009). "Size effect on cell uptake in wellsuspended, uniform
mesoporous silica nanoparticles." Small 5(12): 1408-1413.
Lu, J., et al. (2007). "Mesoporous silica nanoparticles as a delivery system for
hydrophobic anticancer drugs." Small 3(8): 1341-1346.
Nandiyanto, A. B. D., et al. (2009). "Synthesis of spherical mesoporous silica
nanoparticles with nanometer-size controllable pores and outer diameters."
Microporous and Mesoporous Materials 120(3): 447-453.
Yuan, L., et al. (2011). "Preparation of pH-responsive mesoporous silica
nanoparticles and their application in controlled drug delivery." The Journal of
Physical Chemistry C 115(20): 9926-9932.
Zhang, Y., et al. (2010). "Spherical mesoporous silica nanoparticles for loading and
release of the poorly water-soluble drug telmisartan." Journal of Controlled Release
145(3): 257-263.