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Mobile phase A
(per cent V/V)
92 50
Mobile phase B
(per cent V/V)
8 50
15 - 20
50 92
50 8
20 - 25
92
B. (1R)-2-amino-1-(3,4-dihydroxyphenyl)ethanol (noradrenaline),
C. 1-(3,4-dihydroxyphenyl)-2-(methylamino)ethanone
(adrenalone),
D. 4-[(1R)-2-(benzylmethylamino)-1-hydroxyethyl]benzene-1,2diol,
E. 2-(benzylmethylamino)-1-(3,4-dihydroxyphenyl)ethanone.
01/2009:1238
AIR, MEDICINAL
Aer medicinalis
DEFINITION
Compressed ambient air.
Content : 20.4 per cent V/V to 21.4 per cent V/V of oxygen (O2).
CHARACTERS
Appearance: colourless gas.
Solubility : at 20 C at a pressure of 101 kPa, 1 volume dissolves
in about 50 volumes of water.
1331
Air, medicinal
PRODUCTION
Carbon dioxide : maximum 500 ppm V/V, determined using
an infrared analyser (2.5.24).
Gas to be examined. Filter the substance to be examined to
avoid stray light phenomena.
Reference gas (a). Use a mixture of 21 per cent V/V of oxygen R
and 79 per cent V/V of nitrogen R1, containing less than
1 ppm V/V of carbon dioxide R1.
Reference gas (b). Use a mixture of 21 per cent V/V of oxygen R
and 79 per cent V/V of nitrogen R1, containing 500 ppm V/V
of carbon dioxide R1.
Calibrate the apparatus and set the sensitivity using reference
gases (a) and (b). Measure the content of carbon dioxide in the
gas to be examined.
Carbon monoxide : maximum 5 ppm V/V, determined using
an infrared analyser (2.5.25).
Gas to be examined. Filter the substance to be examined to
avoid stray light phenomena.
Reference gas (a). Use a mixture of 21 per cent V/V of oxygen R
and 79 per cent V/V of nitrogen R1, containing less than
1 ppm V/V of carbon monoxide R.
Reference gas (b). Use a mixture of 21 per cent V/V of oxygen R
and 79 per cent V/V of nitrogen R1, containing 5 ppm V/V of
carbon monoxide R.
Calibrate the apparatus and set the sensitivity using reference
gases (a) and (b). Measure the content of carbon monoxide in
the gas to be examined.
Sulfur dioxide : maximum 1 ppm V/V, determined using an
ultraviolet fluorescence analyser (Figure 1238.-1).
The apparatus consists of the following :
a system generating ultraviolet radiation with a wavelength
of 210 nm, made up of an ultraviolet lamp, a collimator, and a
selective filter; the beam is blocked periodically by a chopper
rotating at high speeds ;
a reaction chamber, through which flows the gas to be
examined ;
a system that detects radiation emitted at a wavelength of
350 nm, made up of a selective filter, a photomultiplier tube
and an amplifier.
Gas to be examined. Filter the substance to be examined.
Reference gas (a). Use a mixture of 21 per cent V/V of oxygen R
and 79 per cent V/V of nitrogen R1.
dry. Open the 2 taps. Connect the nozzle to the source of the
gas to be examined and set the flow rate to 1 L/min. Flush
the burette by passing the gas to be examined through it for
1 min. Close the lower tap of the burette and immediately
afterwards the upper tap. Rapidly disconnect the burette
from the source of the gas to be examined. Rapidly give a
half turn to the upper tap to eliminate any excess pressure in
the burette. Keeping the burette vertical, fill the funnel with
a freshly prepared mixture of 21 mL of a 560 g/L solution of
potassium hydroxide R and 130 mL of a 200 g/L solution
of sodium dithionite R. Open the upper tap slowly. The
solution absorbs the oxygen and enters the burette. Allow
to stand for 10 min without shaking. Read the level of the
liquid meniscus on the graduated part of the burette. This
figure represents the percentage V/V of oxygen. The value
read is 20.4 to 21.4.
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