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Pathophysiology in
Status epilepticus
Surat Tanprawate, MD, FRCPT, MSc(Lond.)
The Northern Neuroscience Center,
Division of Neurology, Chaing Mai University
status epilepticus
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Definition
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Why 30 minutes?
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Typical seizure in adults
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Term and use
Type of SE
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Status epilepticus
Mortality 7.6-39%
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Predictive factors
Epilepsy with provoked seizure or low AEDs level lowest mortality (4-6%)
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A comparison of
survival by duration
in status epileptics
shows a marked
increase in mortality
for patients in
prolonged status
epileptics (Towne et
al. 1994)
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Receptor tracking
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Receptor trafficking
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Liu H,et al. Natl Acad Sci USA 1999; 96: 528691.
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Transforming
growth factor
receptor 2
(TGFR2)
Within hours following BBB breakdown albumin diffuses into the brains extracellular
space, binds to astrocytic TGF receptors and induces transcriptional change
Pathophysiologi
cal cascade of
inflammatory
events in
epilepsy
Nat Rev Neurol
2011;7(1):31-40
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