NitricOxide 1

Nitric Oxide:
the molecule of life
Noni
and the
Nitric
Oxide Link
By Dr. Abbas Qutab
Noni and the Nitric Oxide Link
Acknowledgments
Id like to thank Dr. Tom Burke, Dr. Harry O. Eidenier, Jr. and
Dick Simonian, Esq. for their ongoing support and friendship.
Also Brian Thayer of Dream Builders, for making this dream a
UHDOLW\$QGQDOO\WR'LDQH6RORPRQIRUKHUYDOXDEOHDVVLVWDQFH
ZLWKUHVHDUFKDQGHGLWLQJLQKHOSLQJPHSXWWKHQDOPDQXVFULSW
together.
Nitric Oxide: The Molecule of Life
Dedication
This book is dedicated to my medical staff at Elan Vital Medical
Center and our clients worldwide, who have allowed us to create
wellness strategies for achieving optimal health. It is a constant
joy for me to witness and be a part of their improvement and
well being.
Foreword
Studies of the effects of nitric oxide in people have been
accelerating since its discovery in the late 1980s. Its broad
range of biologic effects is hard to envision for a molecule with
so short a half-life. As a gas, its here and then its gone. Yet
Dr. Abbas Qutab has gracefully woven a tale showing where
nitric oxide is a participant in many different organ systems and
medical conditions. How he was able to gleam this information
from many thousands of medical research publications is, quite
frankly, amazing. This synopsis, remarkably, doesnt talk down
to the reader by using sophisticated, sometimes unintelligible
medical terms. Rather it takes the reader from commonly
understood conditions such as pain and coronary arteries, which
virtually everyone understands, to a simple explanation of how
the presence or absence of nitric oxide can make a difference
in peoples health. You have to be impressed that he was able
to capture the important, positive messages that sometimes are
buried in the medical literature.
I hope that those who read this book come away as
impressed as I was in this description of why Noni, via nitric
oxide, may be so helpful for so many different conditions.
By Dr. Thomas Burke
The WORLD should read this book. (all) at once!

Anonymous
Table of Contents
Acknowledgments......................................................................3
Dedication ..................................................................................4
Foreword ....................................................................................5
Introduction ................................................................................9
Extracts on Noni Create Nitric Oxide ......................................13
Nitric Oxide: The Molecule of Life .........................................17
What is nitric oxide? ....................................................18
What does nitric oxidedo in the body?.........................18
Where does nitric oxide come from? ............................18
Do nitrates/nitrites lead to peroxynitrites? ..................22
Health Benefits of Nitric Oxide ...............................................25
Nitric oxide and the heart ............................................25
Nitric oxide and blood pressure ...................................27
Nitric oxede and pain relief .........................................28
Nitric oxide and seual function ....................................32
Nitric oxide and fertility ...............................................33
Nitric oxide and weight loss.........................................33
Nitric oxide and energy ................................................34
Nitric oxide and exercise/sports ...................................36
Nitric oxide and inflammation .....................................36
Nitric oxide and digestion ............................................38
Nitric oxide and the immune system ............................39
Nitric oxide and the prevention of cancer ....................40
Nitric oxide and insomnia ............................................41
Nitric oxide and diabetes .............................................42
Nitric oxide and the brain ............................................44
Nitric oxide and wound and fracture healing ..............46
Nitric oxide and trauma ...............................................48
Final Thoughts .........................................................................51
End Notes .................................................................................54
Bibliography ............................................................................56
About the Author......................................................................59
INTRODUCTION
It must have been three or four years ago now, that one
of my favorite patients, whom I will call Sonny showed up in
my office for his regular checkup.
Ive stopped all my meds, Dr. Abbas, he said, a little
sheepishly, but with a determination in his eye. This big bear
of a man, charming and jovial, had fought a long-standing war
with high blood pressure. We were mostly winning this battle,
with the normal medications, and the contribution of his rigid
discipline (most of the time) when it came to diet and exercise.
Sonny always has a joke and a smile for us when he comes in to
the clinic, and often brings gifts of fresh fruit or vegetables -hes
a great guy.
As you can imagine, I was a bit appalled at this news that
he no longer took the drugs that I counted on to protect him, but
he eagerly told me what he was taking instead.
Nitric oxide, doc. Extracts of the Noni tree - its something
to do with creating nitric oxide in the body. I heard about it from
a friend of mine who takes it for
her arthritis- she hasnt felt this
well in years. So I gave it a try.
Go on, take my blood pressure.
He grinned and pulled up his
sleeve in anticipation.
To my surprise, his blood
pressure was normal. He hadnt
seen 120 over 80 for at least five
years without medication. Sonny
explained that he had now been
taking this Noni extract product
for three months, and had been off
his medications for one month. I insisted he come back monthly

for a while, so I could monitor this situation, and each time he
came into my office, his blood pressure remained normal. He
was taking no drugs at all, just this proprietary blend of extracts
of Noni fruit. He was thrilled and proud of his discovery. And I
was completely intrigued.
This launched my investigation into the humble Noni tree,
with its strange little ugly fruit. I read everything I could get my
hands on, and discussed it with many colleagues, many of whom
brushed it off as another scam or possible placebo effect. Now,
while it is true that placebo effects are powerful, they just dont
normalize blood pressure problems as severe as Sonnys. And
they dont reverse illnesses as crippling as the fibromyalgia that
had been plaguing Nancy, another
of my patients. The change in her
Nitric oxide has
wellbeing since she started to take
been
extensively
a proprietary blend of Noni extracts
proven in thousands
has been almost miraculous.
of studies to aid every system and cellin the body...
In my study, I learned this

proprietary nutraceutical creates
nitric oxide in the body. Nitric oxide,
known as NO, has been extensively
proven in thousands of studies to
aid every system and cell in the body, and has shown dramatic
results when used by patients suffering from a wide variety of
complaints. I have been recommending the proprietary blend
of Noni extracts to my patients for several years, now, with
wonderful results.
Nitric oxide, which has become a sort of celebrity
molecule, has been the subject of thousands of scientific papers
in the past decade. It is a small, simple molecule, composed of
10
one atom of oxygen and one of nitrogen. It was best known as

a toxic gas and an ingredient in air pollution until 1987, when it
was first shown to be produced by various cells throughout the
human body and to help cells communicate with each other.
I spoke at great length with scientists who were
researching Noni, its nitric oxide effect, and I found myself
wanting to help spread the word. I now travel extensively,
lecturing to both doctors and laypeople on the benefits of this
proprietary blend of Noni extracts that have such a high nitric
oxide effect.
I must emphasize that I make no money whatsoever
from the sale of any Noni extract or nitric oxide products. It is
simply that I have never before found a product that I could so
wholeheartedly endorse, and I wish to extend the benefits I see
so regularly in my practice to people all over the world.
11
EXTRACTS OF NONI
CREATE NITRIC OXIDE
By now there certainly arent many people interested in
health and healing who havent heard of Noni. Typing Noni into
Google brings up six or seven million websites where this topical
fruit tree is referenced. Since the middle of the 1990s, Noni, or
Morinda citrifolia, has catapulted onto the worldwide stage and
grown exponentially, with sales now estimated at about one billion
dollars annually. This shrubby evergreen tree, with its small, foulsmelling fruit has been called the Ancient Cure from Paradise, the
Painkiller Tree, and the Aspirin of the Ancients. In Australia
it has been called Cheesefruit from the overwhelming smell.
It grows wild throughout the Southeast Asian countries, but its
original home was Polynesia, Micronesia and the Hawaiian Islands.
Polynesians have successfully used this health-promoting plant and
its fruit for thousands of years, yet they readily admit to not knowing
how or why it works. Southeast Asians have always used all parts of
the Noni tree medicinally-the bark, root, leaf, fruit and flower.
Researchers have explored the Noni fruit, leaves, and roots
to try to ascertain the exact ingredient or ingredients that promote
health. Noni is high in Vitamin C and other vitamins, amino acids
(the building blocks of protein), minerals, and contains several
other compounds including the antioxidant carotenoids, and
bioflavonoids. It is also has potassium, which is a consideration for
anyone suffering from kidney disease or insufficiency. Although it
has less potassium content than orange juice or tomato juice, you
still may want to be aware of this.
This list of constituents alone do not adequately explain the
benefits patients all over the world are experiencing from taking
Noni, considering they naturally occur in many nutritious plant
foods.
13
Determined to solve this puzzle, scientists began to notice

a correlation between the success stories of patients using Noni
and the benefits of having enough nitric oxide in the body. Due
to its importance in the human body, a vast amount of research
was being conducted on the properties of nitric oxide. It seemed
possible that nitric oxide (NO) was the mechanism at workperhaps Noni caused a nitric oxide effect in the people who took
it.
Research was undertaken in 1999 and 2000, by Dr. Thomas
Burke and his researchers at Integrated Systems Physiology, an
independent lab in Denver, Colorado. They conducted in-vitro
experiments which tested diluted Noni juice on endothelial
cells, the cells that line the inner surface
of blood vessels. That was the answer
for which everyone had been searchingthe Noni juice did indeed create nitric
oxide! This suddenly helped to explain
the enormous improvements patients
were having drinking this humble
tropical juice. The shrubby little tree
that had the weight of the collective
voice of generations was finally being
confirmed in the scientific arena.
In vitro testing yielded great
finds about nitric oxide
Having isolated at least one of the main

mechanisms by which Noni works in the body, this advanced
Noni product is now available on the market. This product has
been available internationally, now, for three years. And the
reports of health improvements are pouring in from around the
world.
There is now even a test that can show you how well the
proprietary blend of Noni extracts is generating NO in your own
14
system. Baltimore Laboratories in Monroe, CT, has created a

test which reliably indicates nitric oxide levels in the body. This
quick and easy saliva test measures within 30 seconds, and in
early trials, showed increases in nitric oxide by-products of up
to 400% in people who had taken two droppers-full three times
a day for only four days.
So what is nitric oxide anyway? What does it do for us,
and where does it come from?
15
NITRIC OXIDE:
THE MOLECULE OF LIFE
Nitric oxide (NO) helps maintain, defend, and repair every
cell of the body. Thats quite a statement. But the fact that it is one
of the most important molecules to human life is, without a doubt,
one of the major discoveries of this century. Scientists knew that
NO was produced in bacteria, but no one realized its importance
in higher animals such as mammals. This discovery caused quite a
sensation in the late 1980s.
By 1992 it was named The Molecule of the Year by
Science magazine. In 1998 it brought the Nobel Prize for Physiology
or Medicine to three scientists, Robert Furdhgott, Luis Ignarro
and Ferid Murad, for their discovery of the signaling properties
of NO. The scientific literature on NO is growing exponentially,
and to date, in 2006, there are more than 70,000 scientific papers
published regarding some aspect of nitric oxide and its beneficial
role in patient care. But the most important fact in all this is that it
brings better health to millions around the world.
Most people have never even heard of nitric oxide, known as
NO. NO is not nitrous oxide, the laughing gas that some dentists use
to sedate their patients. It is not nitric acid, a highly corrosive acid
which is used in the making of explosives and fertilizers. And it is
not nitrogen dioxide, a poisonous air pollutant, a component of acid
rain. Nitric oxide may be a simple molecule, made up of one part
nitrogen, and one part oxygen, but scientists and researchers around
the globe have been astonished by the seemingly limitless list of
functions of nitric oxide in the body. In my 25 years of research,
I have never seen a molecule [NO] that so pervasively influences
normal and abnormal body functions, said Dr. Solomon Snyder,
the director of neuroscience at Johns Hopkins Medical School. 1
17
WHAT DOES NO DO IN THE BODY?
Although it is a highly reactive gas, NO is however the

most important signaling or messenger molecule in our body.
This means that although it has only a short life of a few seconds,
in that time it instigates processes involving an extensive array of
physiological functions that control blood circulation, inflammation,
learning and memory, digestion, and penile erection.
One of NOs broadest functions is in controlling blood
pressure by dilating (relaxing and widening) blood vessels, which
improves blood flow and helps prevents the clotting of the blood.
This holds profound implications for the treatment of cardiovascular
disease. It may have been what led Sonny to my office three years
ago.
It is also a powerful tool to help patients with impotence
problems, as it can initiate and maintain erection by dilating blood
vessels. This explains the mechanism of Viagra. Plentiful studies in
the laboratory have shown that nitric oxide is also vitally important
to the immune system. It fights and kills bacteria, viruses, fungi,
parasites, and cancer cells, or stops their ability to multiply. It also
acts like a neurotransmitter, relaying messages between nerve
cells.
More of its roles are continually being isolated and identified,
and research into the potential clinical applications of nitric oxide is
still in its infancy. The possibilities seem endless.
Across the board it is truly an important and busy
molecule!
WHERE DOES NO COME FROM?
Let me tell you a little about where NO comes from. The

primary way that nitric oxide is created is from L-arginine, one of
18
the essential amino acids, which are building blocks of protein. The
essential amino acids are called that because the body cannot create
them from other compounds, but must get them from food, such
as meat and fish. Then various enzymes are needed, plus oxygen,
to release nitric oxide from L-arginine. The biochemistry depends
on the action of one of a family of enzymes, called nitric oxide
synthases or NOS, which converts L-arginine to another amino
acid, L-citrulline, forming nitric oxide in the process.
But nitric oxide is also created from substances known as
nitrates and nitrites found in plants such as green leafy vegetables,
and Noni, as we now know, has proven to be high in these
substances. Proprietary extracts of
the Noni tree contain large amounts
...Nitric oxide is
of nitrates and nitrites, which are
the most important
then converted into nitric oxide by
signaling or mesnormal stomach acid. 2 3 This NO
senger molecule
protects us by killing almost all the
in our body.
bacteria that have been swallowed in
our food. But in addition, the nitric
oxide diffuses through the stomach
wall and enters the red blood cells, or
binds to proteins and is carried to all
parts of the body.
For thousands of years, humans have used nitrates to
preserve meat from bacterial spoilage. Now, you may think of
nitrates and nitrites in a negative way, having heard that they seem
to be harmful chemicals added to foods such as bacon, sausage, and
smoked meats. But strangely enough, it appears that nitrates may
have been blamed incorrectly. Recent research shows that there
is a healing potential instead; nitrates are an aid to cardiovascular
health through their conversion into nitric oxide. A study published
in Harvards Heart Letter in 2004 found that nitrates and nitrites
19
(through nitric oxides action) keep arteries relaxed and more

flexible, which in turn keeps blood pressure low, and prevents
strokes and heart attacks. 4 Other studies carried out by the National
Institutes of Health, the University of Alabama and Wake Forest
University 5 have confirmed these findings, that nitrate, a common
salt, can dilate blood vessels and improve blood flow. In an article
published in the November 2003 issue of Nature Medicine,
researchers reported that nitrite is easily converted into nitric oxide,
suggesting that nitrates and nitrites may in fact be a source of nitric
oxide for the bodys needs. 6
Since nitric oxide, from nitrates and nitrates, dilates blood
vessels, this may help to explain why some people feel a bit faint, or
get headaches after eating smoked meats with nitrates. But I dont
suggest you start eating lots of hot dogs- those high fat little guys
made from questionable meats will never be a health food! There
is a much better source of nitric oxide, and it is from a proprietary
blend of Noni extracts.
So, since nitric oxide is released from arginine, why not
just eat lots of protein that is high in L-arginine, or take arginine
supplements? Internet ads and gyms across America are abuzz with
the arginine - nitric oxide link. And the truth is L-arginine is indeed
a good source of nitric oxide, and most Americans probably get
enough in the protein that we regularly eat to make our own nitric
oxide.
But there are a few good reasons why taking a substance
which releases nitric oxide directly, from nitrates and nitrates, is
preferable. First, there are several co-factors that are necessary in
order to form nitric oxide in your cells. Secondly, the environment
around the cells making nitric oxide must not be too acidic or too
alkaline. If one or more co-factors is missing or not in adequate
supply, and/or the cell environment is too acidic or too alkaline, then
20
nitric oxide will not be created, or

not at optimum levels.
Exercise also plays a part
in creating the optimum amount
of nitric oxide from L-arginine.
In people who are sedentary,
or those whose chronic illness
or overweight issues limit their
ability to exercise, nitric oxide
is not produced in optimal
quantities.
Another
factor
to
consider when ensuring a good
supply of NO is the fact that Exercise is key in creating nitric oxide
L-arginine has other roles to play
in the body besides its ability to generate nitric oxide, primarily in
the metabolism of protein, for muscle growth. Its other functions
include detoxifying ammonia in the body (a by-product of energy
production) and promoting the secretion of several hormones,
including insulin, and growth hormone. Since creating NO is not
L-arginines only job, it seems preferable to take a plant substance
that directly generates NO.
And finally, there is the herpes link. People who suffer from
either herpes Type 1, the oral form that causes cold sores, or herpes
Type 2, the genital form, need to be aware that L-arginine can actually
feed the herpes virus, which needs arginine to replicate. Those
patients are regularly urged to avoid the L-arginine-rich foods, and
to eat L-lysine foods or take lysine supplements, which may reduce
herpes outbreaks, or limit them. This is due to the fact that L-lysine
competes with L-arginine in the body, so the supplementation
of L-lysine can tip the balance in its own favor. This ameliorates
herpes outbreaks, especially the oral form. L-arginine has not been
21
conclusively proven to worsen herpes Type 2 symptoms, but its

general connection to herpes has been shown in many trials.
And further, with regard to the herpes issue, recent detailed
studies have shown that nitric oxide actually inhibits the replication
of the herpes virus7, which is good news for those who take the
proprietary blend of Noni extracts..
This herpes link may seem small to those of you who have
never had cold sores, or arent familiar with this nasty virus. But
unfortunately herpes is especially prevalent in humans. In fact,
over 100 million people here in the U.S. alone are afflicted with the
virus, in conditions such as cold sores, genital herpes, and shingles,
its painful cousin.
So, eating a big steak or downing L-arginine capsules isnt
always the answer. However, the
proprietary blend of Noni has a large
...The proprietary
amount of nitrates and nitrites which
blend of noni has
can be converted into nitric oxide
a large amount of
when they reach the hydrochloric
nitrates and nitrites
acid in the stomach. This nitric oxide
that can be concan then pass through the stomach
verted into
wall, rapidly diffusing through the
nitric
body. This method of getting nitric
oxide...
oxide is faster and relies on no other
conditions for its creation, giving you
nitric oxide quickly when and if it is needed.
DONITRATES/NITRITESLEADTOPEROXYNITRITES,
THE DAMAGING FREE RADICALS?
In my lectures I am often asked if taking a product high in
nitrates and nitrites might lead to damaging levels of peroxynitrites,
22
which are a type of free radical. In a nutshell, no. This is because

the amount of nitrates and nitrites in the proprietary blend of Noni
extracts, while high, is not immediately converted to nitric oxide.
Contents of the stomach break down fairly slowly.
Also, the NO diffuses through the stomach lining and enters
the blood vessels where it attaches to amino acids and proteins, and
while attached to these proteins the nitric oxide cannot react with
oxygen to form peroxynitrite. Peroxynitrite is only created when
nitric oxide is released as a gas from the proteins and then interacts
with oxygen.
Finally, the body, through an additional mechanism of
NO, has a safety valve to protect it from peroxynitrites. There is a
powerful antioxidant molecule, called glutathione, also generated
by NO, which can mop up peroxynitrites. There is absolutely no
way that ingestion of plant substances such as the proprietary blend
of Noni extracts would lead to the formation of peroxynitrites.
23
HEALTH BENEFITS
OF NITRIC OXIDE
Now that you know a little about the many functions
nitric oxide has in the body, lets talk a little about what nitric
oxide can do for specific health problems that you or someone
in your family may be experiencing.
NO AND THE HEART
NO helps to prevents heart disease. Heart attacks happen
when blood cant circulate through the coronary arteries in the heart
resulting in the death of a part of the heart muscle- it simply dies and
scars over from a lack of oxygen. This happens partially because of
narrowing of the arteries caused by cholesterol build-up.
But heart attacks can also be due to blood clots forming
in these narrowed arteries caused by inflammation, leading the
artery to clog up just like plumbing in the sink. Dr. Robert Vogel,
professor of medicine at the University of Maryland Medical
Center described this condition in a very picturesque way;
that the clogged endothelial lining had the texture of Velcro,
promoting this condition called atherosclerosis. Atherosclerosis
consists of plaques containing cholesterol and lipids on the
walls of the arteries. To some degree it naturally occurs with
aging, but there are many other risk factors; high blood pressure,
smoking, diabetes, high cholesterol, and/or a family history of
heart disease. As well as a heart attack, atherosclerosis can lead
to stroke, and eye and kidney problems.
With this build up of plaque lining the artery walls, the
endothelial cells lose their capacity to produce nitric oxide.
Inactivity and poor diet also weaken the endothelial cells, as can
high blood sugar from diabetes. When these fragile endothelial
25
cells are damaged, they can not create as much nitric oxide.8
By taking a substance high in nitrates and nitrates such as the
proprietary blend of Noni extracts, nitric oxide helps to prevent
heart disease in several ways. It dilates the arteries, making
them wider, so more blood, more oxygen and nutrients can get
through to the heart muscle. It also helps prevent clotting by
preventing the platelets in the blood from sticking together, as
well as preventing them from sticking to the vessel wall. NO has
also been shown to reduce arterial plaque once formed.
Nitroglycerin, that well-known under the tongue
medication, works to ease chest pain by the release of nitric
oxide. This drug has been in use for well over 100 years, but
until researchers in 1988 discovered nitric oxides function
with regard to dilating dilate blood vessels, no one knew how it
worked.
Interestingly, Alfred Nobel, of the Nobel Prize fame, made
his fortune in nitroglycerine, which is also involved in the creation
of dynamite. When he died, his heirs were astounded to learn that
he had left the bulk of his fortune to create the Nobel prizes that
are have become so prestigious. Ironically, the man whose name
became synonymous with the most destructive weapon the world
had yet seen, dynamite, went on to establish these coveted awards
for intellectual achievement and peace. Furthering this irony, in
Nobels later years he suffered a heart condition which caused
him to have severe angina pain, and his doctor recommended
he take small doses of nitroglycerine! He refused, unwilling or
unable to believe that the explosive substance he knew so well
could help, not harm, the human body.
John P. Cooke, M.D., director of vascular medicine at
Stanford Universitys medical school, states, NO is the bodys
own form of nitroglycerin. In fact, heart patients would not need
to take nitroglycerin if their vessels were making enough NO. I
26
sometimes tell heart patients to think of a healthy endothelium

as a lifelong supply of nitroglycerin.9
Large efforts are currently being made in the
pharmaceutical industry, to find more powerful and selective
heart drugs based on this new awareness of nitric oxide and
its role in blood vessel maintenance and health. However, it
seems that a natural substance, such as the proprietary blend of
Noni extracts is the superior answer, without the side effects so
common to pharmaceutical drugs.
NO HELPS TO REDUCES HIGH BLOOD PRESSURE
According to recent figures supplied by the American
Heart Association, about 65 million Americans age 20 and older
have high blood pressure, or nearly 30%. Of these, 63% are
unaware of the condition.
High blood pressure or hypertension means that the heart
has to pump harder to push blood through narrowed vessels. High
blood pressure is also a frequent cause of, and risk factor for,
stroke, heart disease (including heart attack), and kidney failure.
Once again, nitric oxide helps relax the muscles in the
walls of the vessels, thereby helping to lower blood pressure. NO,
via the extracts of the Noni tree, can be a useful adjunct to help
these millions of people in normalizing their blood pressure along
with, of course, the diet and exercise of a healthy lifestyle.
Remember my patient, Sonny,
who had struggled with high
blood pressure for so long? He
is one of thousands around the
world who have discovered
that a proprietary blend of
Noni extracts can achieve what
27
drugs, diet and exercise could not.

NITRIC OXIDE AND PAIN RELIEF
An enormous number of people regularly suffer from pain,
dramatically reducing their quality of life. A 2005 USA Today/
ABC News/Stanford University Medical Center poll showed that
19% of American adults, or almost 1 in 5, suffer from chronic pain
and 44% have acute or short-term pain. These were attributed to
medical injury or to joint pain, heart disease or cancer.10
When you are in pain, it is hard to think about anything
else. Nothing else seems to matter much- all you can think about
is being pain-free. Or finding a way to live with it somehow.
So how does pain work and what happens in the body?
Pain may be anything from unpleasant to agonizing, but it does
have a function; it is actually a necessary survival instinct. It is
the reflex that makes you whip your hand away from that hot
stove in a reaction that seems faster than thought. It is the instinct
that forces you to avoid using a muscle that needs to rest after
an injury. In this regard, pain has a positive outcome. But when
chronic pain from inflammation or an injury continues unabated,
it seems to have no rhyme or reason. We just want it to stop.
All pain, indeed all sensation, results from the functioning
of the nervous system, that incredibly complicated web of nerves
and cells and messengers that communicates sensory information.
From the brain to every cell in the body, the nervous system
handles the messages for such sensations such as cold, touch,
and heat, and of course pain, from bruises, sprains, and from
other more chronic sources such the inflammation of arthritis.
Many drugs are prescribed for pain relief. Scientific
research shows that the pain relieving effects of the medications
like morphine, aspirin, and oxycontin are due to the release of
Nitric Oxide.11 Take tennis elbow, for example. An interesting
28
Australian study recently

proved that the pain of Taking a proprietary blend
chronic
tennis
elbow of noni extracts, or even
is relieved by topical applying it topically, can
application of nitric oxide.12 help pain sufferers without
This is great news for all the the harmful side effects
and possible addiction so
people who have suffered
often caused by
from this difficult-to-treat
pain killers.
injury.
Taking a proprietary
blend of Noni extracts, or
even applying it topically, can help pain sufferers without the
harmful side effects and possible addiction so often caused by pain
killers.
During my lectures I ask that people email me with
the results of taking the proprietary blend of Noni extracts.
Cassandra, an Australian model, wrote me of her experience of
pain from an injury.
I am a black belt martial arts champion and I had a bad
fall training for the Olympics about eight years ago, she wrote.
I damaged my neck and teeth and I have to say I have had no
neck or back pain since I started using a proprietary blend of
Noni extracts! I am feeling so great. Today I dont know what to
do with out this product.
Then there is the case of Lene Jensen of Scandinavia.
She told me that her ex-fiance gave her a spray bottle of the
proprietary blend of Noni extracts early in 2006. He had told her
that it could help all kinds of conditions, and had pain relieving
qualities. She reported, The next morning when I should start
on the product I woke up with a very bad toothache. I dont know
why but I grabbed the spray and sprayed it on my bad tooth. In
2-3 minutes the pain disappeared 100%. This is WILD!
29
Eric Mortensen, of Denmark, wrote me the following

email:
Hello, my name is Eric Mortensen: In two days the
proprietary bland of Noni extracts cured me of terrible stress, a
bad headache migraine and sleeplessness. In five to nine days it
helped my back pains, eczema on two fingers that no doctors or
other health specialists had been able to cure for several years.
During the last 3 years I have taken 12 strong headache pills
each day to relieve awful headache pains and pressure in my
forehead.
To sleep I have had to take one or two sleeping pills.
Without these pills I could not sleep. Since day two on the
proprietary blend of Noni extracts I have not taken one single
pill, and all the above mentioned pains and problems are gone by
the wind. Now 14 days later I feel much younger in every part of
my body. I focus much better, I remember much better and it is
easier to concentrate.
I need to say that my sex life has improved a lot. I feel
that I have got much more energy here, and have become more
sensitive. My fianc has exactly the same experience.
Beside this I can really feel that my legs have much
better blood circulation and today and I can walk and walk where
I before got acid in my legs when I walked too fast.
Another wonderful testimonial came in at the last minute,
and almost didnt make the book. But it was so exciting I held up
the presses to get it in. Listen to this, sent in an email to me from
Claus B. Henriksen, of Denmark:
I realize that I may be too late for a testimonial for
Dr. Qutabs book, but I find my wifes personal experience so
interesting that I want to tell you about it.
My wife has MS and the past six months she has
encountered increasing spasms in her legs, particularly in her
30
right leg, from the thigh to under her foot. These spasms are
either involuntary, or triggered by movement, touching, laughter
or coughing. Three times a day she takes three full droppers full
of the proprietary blend of Noni extracts. It has improved her
circulation and her lower extremities are not as cold as they used
to be. But it has made no different to the violent pain caused by
the spasms.
About three weeks ago she decided to distribute/rub
some drops of the extract on the muscles that spasms and the
result is staggering. For up to three hours she experiences almost
no spasms.
Because of her experience a dear friend of ours, who
also has great pain, but in connection with her menstruation,
decided to rub some drops on her lower abdomen, which gave
her great pain relief.
Furthermore she was very unfortunate two days ago,
getting a second degree burn on two fingertips, touching a very
hot plate on our electric stove. Obviously she experienced a
violent pain and skin on her fingers turned white. For five hours
she kept the fingers in ice cold water, but the pain continued. I
suggested that she tried the proprietary blend of Noni extracts.
And guess what. The pain disappeared almost completely. Again
for about three hours. She kept applying it regularly and today,
her fingers almost look as if nothing had happened. No visible
scars, though the affected area is a little reddish and the skin a
little tight.
This information may not be new to you or the doctors on
the medical board, but I find it significant and would like to make
a comment. I believe that the above gives basis for considerations
of a special lotion with a much stronger concentration. Whether
this would bring relief for a period longer that three hours I do
not know, but maybe it is possible to produce a lotions that has a
31
slower and long term release of the active ingredient.

What an incredible story.
NITRIC OXIDE AND SEXUAL FUNCTION
One of the hottest topics surrounding nitric oxide and
its uses in the body is with regard to sexual health. Research is
beginning to show that smokers, or those with atherosclerosis,
high blood pressure, or diabetes may have less nitric oxide in
their bodies, which can lead to impotence. Since the discovery
that it is nitric oxide which dilates blood vessels in the penis to
initiate and maintain erections, pharmaceutical companies have
jumped to create drugs to make use of this fact. Prolonging the
vasodilation effect of nitric oxide is the mechanism by which
medications like Viagra, Levitra and Cialis help millions of men
with erectile dysfunction or impotence. However, the proprietary
blend of Noni extract releases nitric oxide to aid in sexual health
without the side effects related with those medications.
On a recent lecture tour in the UK, I again asked for
peoples experience of using the proprietary blend of Noni
extracts. Marjorie Beauchamp, from England sent me a short,
amusing email:
This product, the blend of Noni extracts that I have been
taking its a powerful Aphrodisiac ... I wont reveal more ...
my husband and I can only say WOW, WOW, WOW!
I think her point is well made.
32
NO IMPROVES FERTILITY
Nitric oxide has other
beneficial effects in the sexual arena- it
holds important functions with regard
to fertility. After the sperm reaches
the egg, it releases nitric oxide, killing
and preventing the other competing
sperm from entering the egg. Nitric
oxide also helps the womens fertility
by keeping their ovaries youthful and
extending the reproductive age.
Taking a substance that
Fertility improves with
increases the nitric oxide effect such
nitric oxide
as the proprietary blend of Noni
extracts can help maintain reproductive health and vitality in
both sexes.
NO AND WEIGHT LOSS
Within the cells of your body are the tiny mitochondria,
the sites where food and oxygen is miraculously turned into
energy for you. These microscopic parts of cells are actually major
powerhouses. In addition
to generating almost all
of the energy you use,
and controlling your
cellular
metabolism,
the mitochondria are
where all your fat is
burned- both dietary fat
and stored fat. Research
suggests that nitric oxide
not only stimulates
33
the creation of new mitochondria13, but also may make each

individual mitochondrion larger, which helps them to burn even
more fat and therefore, could help you to lose weight.
Many of my patients and the people who come to hear
my lectures on the effects and benefits of nitric oxide have told
me about the weight they have lost on the proprietary blend of
Noni extracts. Many of them were taking it for other complaints,
but noticed the weight loss as a side bonus!
Beverly Morrison, one of my patients in my clinic in
Massachusetts, had been trying for years to lose some weight,
but could never get it off, or keep it off. She wrote of her
experience:
After a five-year struggle with excess weight I lost
15 pounds in 60 days. I decided to have a mini-body cleanse
supervised by Dr. Abbas Qutab, followed by a daily regimen of
Noni juice and a nitric oxide supplement (the proprietary blend
of Noni extracts). I took two droppers full three times a day and
also two tablespoons of Noni juice.
The mini cleanse provided the metabolic boost that my
system needed and the nitric oxide gave me the sustained energy
to increase physical activity. Months later, I am delighted that
I have kept the weight off and exercise daily for at least 30
minutes.
NO AND ENERGY
I just have so much more energy. I hear this statement
more than any other from the folks who approach me after
lectures, or write to me, after trying the proprietary blend of Noni
extracts. With our lives getting busier and busier, and everyone
pushing to achieve more in each day, more energy seems to be a
great gift.
You know how you usually feel so much better after
34
a brisk walk? This is due to the generation of nitric oxide in

your body. Exercise increases NO, and taking a substance that
increases NO increases your energy to exercise, and so forth.
Taking the proprietary blend of Noni extracts to increase NO
and exercising is a great combination!
NO, as we have seen on the section regarding
cardiovascular health, causes blood vessels to dilate, which
keeps blood flowing to all tissues. Blood carries oxygen, glucose
(a type of sugar) and other nutrients. Once oxygen, glucose
and nutrients enter the cells, the highly efficient mitochondria
generate energy for all bodily functions. A deficiency of NO of
course then leads to less than normal blood flow, which then
decreases the delivery of glucose and oxygen to cells and organs.
So by that same reckoning, the optimum availability of NO can
lead to higher energy levels for normal daily activity, plus more
specifically for exercise regimes and sportsmen.
Frazer Goodman, a jazz musician in Australia wrote to
me with these comments:
Wow, for me the proprietary blend of Noni extracts has
given me much more energy and also I feel strengthening in
my legs and a sense of wellbeing. I notice also that my stress
level especially under the heat has been more tolerable. Its been
amazing.
Bryan Prettyman, here in the US, said the following:
My daughter has more energy and is not falling asleep
in class and getting all of her homework done now in school.
She has more energy during basketball games as well and is
healing from a sprained ankle much faster. Rachael, a friend of
mine, said she felt more energy within two days, less stress and a
better overall mood. She has also noticed her skin tone changing.
Another friend, Mark, tells me he lost 5 lbs in a week and has
more energy.
35
As for me, I have way more energy, less stress, better

mood, and think I am much more clear and focused. My back
hurts less as well. I have also noticed a stronger sexual drive.
Lots of good things happening.
NO AND EXERCISE/SPORTS
Lasse Rouhiainen, from Finland, really noticed the
effects on his exercise routine and sports:
Im normally quite healthy, but I have noticed some
amazing effects that the proprietary blend of Noni extracts gives
me. I sleep better and less hours than before. I take it before and
after going to the gym or doing sports and it really helps a great
deal! I truly believe this product will help make peoples lives
better.
NITRIC OXIDE REDUCES INFLAMMATION
There is an extraordinary number of people globally
who suffer from inflammatory disorders: In the USA alone the
figures are:
Inflammatory Diseases in the United States

Arthritis (all types) - 70 million
Allergies - 39 million
Asthma - 17 million
Cardiovascular Disorders - 60 million
Nitric oxide inhibits inflammation in blood vessels by
blocking the inflammation that occurs in damaged endothelial
cells. If these cells become damaged or dysfunctional NO
production is impaired which leads to more inflammation and
36
tissue damage- a very vicious cycle. From there it is an easy step

to the many other inflammatory diseases that haunt our society
today; hypertension, obesity, high cholesterol, diabetes, arthritis,
lupus, and many other syndromes.
For these millions of people who suffer from inflammatory
disorders, a heightened nitric oxide effect from a substance such
as the proprietary blend of Noni extracts could be extremely
beneficial.
Henrik Lundin, an ice hockey player in Sweden, wrote
to me that he feels stronger, and his inflammation from previous
injuries has been reduced, since regularly taking the proprietary
blend of Noni extracts. This is what he said:
When I used to play ice hockey, (I stopped playing as
professional in 2002) I always had problems with the upper
part of my feet, especially in the beginning of every ice hockey
season. I always tied my skates hard on the upper part of the
skates to balancing better on the ice. I always got inflammation
after a few days of training, causing me to try everything from
warm feet baths, using Tiger Balm and various drugs a lot.
Sometimes it was so bad that I could not train with my team for
many days.
In November 2005 I spoke to a friend who was playing
ice hockey in my hometown who invited me to come and train
with a 2nd league team in Sweden. I continued the training with
this team and of course inflammation hit my feet again. At the
same time a friend sent me the proprietary blend of Noni extracts
which I took for two days and my feet were cured. It must be
that product that cured my inflammation- that this product
helped me with my inflammation is great, but even better is that
I feel stronger, full of energy and more clear-minded than I did
before.
Eczema, that itchy unpleasant skin disorder, is also
37
considered an inflammatory disease. Martin Florian Toby, from

Denmark, wrote me an email after taking the proprietary blend of
Noni extracts, very pleased that his eczema was so improved:
I was introduced to this proprietary product by a friend.
After using it for two weeks twice a day, the eczema on my face
disappeared. For six years I had suffered from this eczema so
today Im very happy. My children also had a very bad cold and
flu that also disappeared in the same period.
Fibromyalgia is another painful inflammatory illness that
you may have heard of. It involves widespread pain, especially
in specific tender points in muscles, plus a long list of symptoms
including fatigue, irritable bowel syndrome (constipation or
diarrhea), chronic headaches, sleep disorder, and dizziness.
I recently received an email from a woman in Sweden, Karin
Clizbe, who has found great relief using the proprietary blend of
Noni extracts. Heres what she said;
I have fibromyalgia and also Morbus Dercum [a rare
syndrome which includes fatigue and painful swellings of the
fatty tissue] and have lots of pain and other problems. I have
started to take the proprietary blend of Noni extracts and am
sleeping in a better way. I start to feel an inner peace combined
with more and new energy! With my best regards from Sweden,
Karin Clizbe.
NITRIC OXIDE IMPROVES DIGESTION
NO is heavily involved in the processes of your digestive
tract. It regulates blood flow to the gut, which helps you digest
your food, and keeps the lining of the gut whole and undamaged
to protect you from invaders such as bacteria, viruses, fungi, and
parasites. It also actively is able to kill off those invaders by its
action.
NO also helps to keep the intestines moving properly.
38
This is called peristalsis, and is what makes food move smoothly

along the intestinal tract being absorbed as nutrients, and finally
being expelled as waste.
It also helps to control the relaxation of muscle along the
intestinal walls, and the function of the valves, called sphincters at
the bottom of the esophagus, at the bottom of the stomach where
it joins the duodenum, and the ileocecal valve where the small
intestine meets the large. So people who suffer from spasms of
these valves, or those with IBS, Irritable Bowel Syndrome, may
benefit from a heightened level of NO in the body.
Once again, many of the people taking the proprietary
blend of Noni extracts find that they have improved digestion
reduced constipation. It seems to be one of the first things to
improve, along with a general sense of wellbeing and improved
energy.
NO AND THE IMMUNE SYSTEM
Another main function
of nitric oxide in the body is
Nitric oxide acts as
its contribution to the immune
a powerful weapon
response. NO acts as a powerful
against infections. It
weapon against infections. It acts as a
acts as a signaling
molecule between
signaling molecule between immune
immune
cells, and is produced in white
cells.
blood cells, such as macrophages,
which are large cells which destroy
invaders. Macrophages use the toxic
effects of NO, in large quantities, to
kill invading viruses, bacteria, fungi, and parasites. Studies show
that viruses, including HIV, multiply less rapidly when exposed
to nitric oxide, and that NO can destroy invading organisms that
are hard to kill by any other method.
39
As we saw earlier in the section on NO and digestion,

various pathogens (bacteria and viruses) can enter our bodies
through the digestive tract with our food intake. By taking the
proprietary blend of Noni extracts, nitric oxide is released in the
stomach which can kill the bacteria and other pathogens that
may have been swallowed in our food.
NO AND THE PREVENTION OF CANCER
Key players of your immune system, your white blood

cells, use nitric oxide to defend against cancerous tumors.
Several scientific studies show that nitric oxide can inhibit
cancer cells, and there is much research being conducted with
an eye to creating drugs that will release nitric oxide releasing
agents as a tumor defense mechanism.14 15 16
An exciting study was conducted by researchers from
the University of Hawaii led by Annie Hirazumi. Mice with the
deadly Lewis Lung Carcinoma were treated with Noni extract, and
subsequently their life span was significantly increased between
105%-123%. The experiment was repeated on a different lot of
mice with similar results. The researchers concluded that the
Noni juice ...seems to act indirectly by enhancing host immune
system involving macrophages and/or lymphocytes.17 18
Another cancer trial published in the cancer journal,
Angiogenesis, looked at the effects of Noni juice on tumors; it
was found that Noni was highly effective in reducing both the
growth rate and the proliferation of malignant tumors.19
Cancer is one of the leading causes of death in America
today, and one in four Americans will have some form of cancer
in his or her lifetime. So logically it makes sense to increase
nitric oxide in our bodies to help prevent various cancers. And
we can do that by taking the proprietary blend of Noni extracts.
40
NO AND INSOMNIA
Insomnia
is
an
increasingly common and
debilitating problem for
many people. They may have
difficulty falling asleep, may
wake up often during the night,
wake too early, or feel that their
sleep is just not refreshing.
Unfortunately, according to the
National Sleep Foundations
nationwide polls, 58% of Nitric oxide is important for good sleep
adults experience symptoms
of insomnia a few nights or more per week, 29% experience it
every night or almost every night, and 68% report that sleepiness
interferes with their concentration and makes handling stress on
the job more difficult. Frighteningly, 19% report that they have
dozed off while driving during the past year.
So insomnia is becoming a chronic problem that has a
major impact on how people function during the day. It can cause
irritability, poor judgment, and as you can see, can increase the
risk of accidents. It can also worsen existing medical problems and
lead to new ones, since so much physical and mental rejuvenation
takes place when we are sleeping.
Once again, adequate levels of nitric oxide may help- it has
been shown that nitric oxide plays an important part in the initiation
and continuation of good sleep. Various studies have concluded
that when nitric oxide formation is suppressed or interfered with,
normal sleep mechanisms are also suppressed.20 21
Tony Ejem, a fashion photographer from Canada, found
relief from his insomnia within days of taking the proprietary blend
of Noni extracts, and he emailed me about his experience.
41
When I was introduced to the proprietary blend of Noni

extracts by a friend, I was very excited. After my first two bottles
arrived I started to take the recommended dose right away. I had
suffered for many years with severe insomnia -not being able to
sleep without taking strong sleeping pills every night.
I have been involved in sports for all my life (martial
arts, tennis, downhill skiing, windsurfing etc.) on the competitive
level. I was injured many times over the years and had to deal
with a lot of pain in my lower back and my neck. In the last five
years I have had to take some strong painkillers to be able to
function on a daily basis.
Lately I started to experience even more stiffness in
my neck along with very painful migraine headaches as a result
of long hours I have to spend working on the computer as a
professional photographer. I went through a body cleansing for
the first three days on the product. I went to bed on day four and
slept for very first time without any pills. This has not changed
since then. My back and neck pain decreased 60% in three weeks
and my headaches are gone.
I started to share the product with some of my friends
and heard many wonderful testimonials in almost every case. I
believe I will get stronger and get even better quality of life as I
continue to use this product every day.
NO AND DIABETES
According to the American Diabetes Association, there
are approximately 20 million Americans who have diabetes,
which is around 7% of the population. And the percentage has
been growing, unfortunately, in parallel with the increase in
obesity which plagues our society.
Research has consistently shown that people suffering
diabetes have a reduced amount of nitric oxide in their bodies.
42
In both Type 1 and Type 2 diabetes blood and urine tests show
reduced levels of nitrates and nitrites, which indicate a lessened
ability to generate NO. This leads to poor circulation, including
heart disease, kidney problems, damage to the retinas of the
eyes, loss of feeling in fingers and toes (peripheral neuropathy),
and slower or otherwise impaired wound healing.
The reason why NO is under produced in diabetics is not
completely understood by scientists and researchers at this point.
One possibility may be that diabetes leads to an accumulation of
acid molecules, which is called acidosis, in the body. This is due
to the fact that the main dysfunction in diabetes is a reduced
ability to process sugar into energy. The result is too much acid
in the body. Acid cells tend to suppress the production of nitric
oxide, or use up available stores of nitric oxide.22
Another possibility for NO underproduction is that
diabetics may have less NO in their systems due to a destructive
process caused by the diabetes itself, which causes oxygen
radicals to destroy or inactivate NO at an accelerated rate.23 Or it
may be the fact that those with diabetes seem to be less able to
generate nitric oxide from L-arginine. It may even be that low
L-arginine intake in the diet or lack of exercise leading to low
oxygen in the body may contribute to the diabetics reduced NO
state. Or it may be all of the above factors combined.
In any event, many people with diabetes struggle with
many health issues. One is relating to the nervous system.
Diabetics tend to experience a loss of sensation, a phenomena
that is caused directly by an abnormality in nerve function. The
damage to nerves, leading to a loss of nerve function, is in great
part due to poor circulation caused by decreased production of,
or loss of, NO.
One example of this is in the diabetic patients digestive
track. NOs role as an important signaling molecule makes it vital
43
to the messaging system which controls

smooth muscle cells. This regulates
the movement of food through the
digestive track, called intestinal
motility, or peristalsis. It is the reduced
levels of NO in these patients that may
be the cause of nerve dysfunction in
the stomach, called gastroparesis, that
delays or stops stomach emptying. The
unpleasant and uncomfortable result
for the diabetic is nausea, vomiting,
bloating, and weight loss. They
need increased levels of available
NO to bring greater blood flow, with
Noni extracts can supply nitric
essential oxygen and nutrients, to those
oxide to diabetics
vulnerable nerve cells.
Since diabetics have a lessened ability to generate
NO from L-arginine, simply adding more arginine-rich foods
to the diet does not help. It is powerful new knowledge that
the proprietary extracts of Noni can, without depending on
L-arginine, directly supply high levels of nitric oxide to the
diabetic patient.
Finally, if that wasnt enough for the diabetic patient,
nitric oxide also mimics insulin action in moving glucose out of
the blood and into cells.24 One could speculate that perhaps nitric
oxide intake via the proprietary blend of Noni extracts might
lead to a lessened need for as much drug usage for the control
of blood sugars. I look forward to hearing from more diabetic
patients in the future.
NO AND THE BRAIN
Research on nitric oxides role in the brain is currently
44
revealing some of the most exciting advances of knowledge in

biology. NO is distributed everywhere throughout the brain, and
may have an involvement in almost all of its normal physiological
functions. It is unlike any known neurotransmitter; unstable, and
seems to be produced when needed by neurons. As we have seen
earlier, acting as a messenger between cells is one of its primary
functions throughout the body, but this is especially true in the
brain, where there is more of the enzyme that creates NO, nitric
oxide synthase, than in any other organ of the body.25
Many studies are being conducted with regard to NOs
brain and nervous system connection, and researchers are
suspecting that NO may turn out to be the molecule that is at the
basis of learning and memory. Simply put, a cell in the brain is
responsible for releasing a chemical messenger called glutamate,
which stimulates another cell, a receptor cell, with this chemical
to release nitric oxide. If it is strongly stimulated, the receptor
sends back an NO molecule to tell the sender that the message
was received, and asks it to send an even stronger message
next time. This cycle is known as long term potentization, a
fascinating and normal path that creates memory.
NO is also certainly involved in behavior, as it is the
neurotransmitter found in a number of nerve pathways within
brain regions that regulate the emotions. In a very interesting
study conducted at Johns Hopkins University, mice were specially
bred without the gene that enables them to make nitric oxide in
the brain cells. These mice turned out to exhibit dramatically
more sexual and aggressive behavior than normal mice. Because
this behavior was heightened, it appears that removing the gene
causes a loss of social inhibition. One of the co-researchers of
this study, Dr. Solomon Snyder, director of the Department of
Neuroscience at Johns Hopkins, said, nitric oxide may be
the neurotransmitter that puts a brake on our social behavior.
45
The highly aggressive behavior in mice whose brains cannot

make nitric oxide appears to be the most pronounced change in
aggression ever associated with a neurotransmitter.26 27
In this same study, it was noted that there were emotional
changes to these altered mice, with regard to fear. When
confronted with a situation that would cause a normal mouse to
be hesitant, the study mice acted fearlessly. The findings could,
of course, have significant implications for studying human
aggressive and violent behavior, but much more research is
needed.
As well as looking at NOs involvement in normal
brain function, scientists are also investigating its involvement
in pathology or disease. Problems in the brain that seem to be
related in some way to nitric acid production are schizophrenia,
multiple sclerosis, and strokes. Since nitric oxide can prolong
cell life, it may be an effective way to treat certain diseases
where cells die prematurely, such as Parkinsons disease and
Alzheimers disease.
I regularly recommend that my patients take the
proprietary blend of Noni extracts, and it is wonderful for me
to see them feeling better. I often see improvements in brain
function such as learning and memory. How exciting it is that
this source of beneficial nitric oxide has been discovered and
made available to all of us.
NO AND WOUND AND FRACTURE HEALING
For wounds or fractures to heal properly, there must be
an adequate supply of NO, which regulates cell division and
proliferation necessary for tissue repair, as well as ensures that
cells mature, and collagen is synthesized.28
Let me explain just a little of how this works. When NO
stimulates cell division, one cell becomes two, two cells become
46
four, etc. There are 10 to 20 growth factors that are involved in

this process, and several of these simply can not complete their
function with out nitric oxide. Besides NOs importance to cell
proliferation, it is also involved in making sure that each new
cell is identical to its parent.
As cells proliferate, they must
become
mature cells capable of
Work with nitric oxide
responding to external signals. If
is creating promising
there is not an adequate supply of
methods of treating
NO for these processes, normal
bone fractures and
maturation does not occur, so a
also bone diseases
cell cannot recognize, process
such as
and transmit information from
osteoporosis.
outside of the cell to the cell
interior. The bottom line is that
wound healing cannot occur.
Nitric oxide also protects the wound while it is healing,
by effectively reducing the number of dangerous cells including
bacteria and fungi which may infect the wound. In this way nitric
oxide may promote the health of certain cells and tissue.
An interesting study with wounds of diabetic patients
found not only that nitric oxide production is reduced in those
with non-healing wounds, but that healing would only occur
when that deficiency of NO was corrected. There proved to
a critical level of nitric oxide production that is essential for
healing.29
NO is also involved in the healing of bones. Researchers
at the Orthopedic Research Institute, at the University of New
South Wales in Australia found that after a fracture, NO activity
was found in the broken area, rising to a peak on the 15th day
after the break. They double checked this finding, wishing to
ascertain the dependence of healing on the nitric oxide, by
47
using an inhibitor of NO. A significant decrease in healing was

observed in the rats that had been given the inhibitor. These
results show for the first time that NO is generated in the body
when a fracture takes place and that supplementation of NO can
reverse the slowness or inhibition of healing produced by NO
inhibitors.30
Studies testing substances that increase the amount of NO
have shown an increase in bone mass in experimental animals,
and early evidence suggests that the same applies in humans.
Work with NO is creating promising methods of treating bone
fractures, and also bone diseases such as osteoporosis.31 32
NO AND TRAUMA
As youve seen throughout this book, nitric oxide has
powerful benefits for many chronic disease conditions common
to man. But it also offers benefits for acute problems such as
trauma treatment, as well. NO is used in the intensive care
hospital setting to give significant improvement to patients in
respiratory distress, and it even saves lives. In another example,
treating Downs syndrome babies with nitric oxide before and
after cardiac surgery gives much better results than using simple
oxygen.
48
FINAL THOUGHTS
Research into all the potential clinical applications of
nitric oxide is still in early days, but is extremely promising,
and has come a long way in a relatively short time. With NOs
involvement in so many aspects of physiological function,
everything from blood pressure to sexual health, this unstable
gas, this tiny simple molecule, is one of the bright stars on the
horizon for drug companies around the world. They are in a race
to create drugs that will treat a whole gamut of human disease.
Some of these will hopefully be useful and indeed beneficial in
extreme circumstances. But unfortunately, in too many instances
pharmaceutical companies look for a synthetic drug that they
can patent, which usually comes with a host of side effects, some
dangerous, as I am sure you are only too aware.
But those of us who know about Noni, and its proprietary
blend of extracts, are in a fortunate position. We can ingest a
natural, gentle plant substance which generates healthful levels
of nitric oxide in our bodies, to benefit from the numerous
protective and healing qualities of NO.
Research is essential for the ongoing understanding of
nitric oxides functions in the body, but for our purposes, as
consumers, sometimes it is more powerful to hear the accounts of
other peoples experiences with a product. As I plowed through
the hundreds of testimonials that I have received, one stands out
in particular. Anita Granoe of Norway praises the nitric oxide
effect in so many health areas that I couldnt decide where to put
it in this book! So here it is:
I cant praise the proprietary blend of Noni extracts
enough. After I started on these drops I have got my inner peace
back, I feel much more fresh and with much more energy, but in
a relaxed way.
51
Many hours in front of a PC screen each day means

that I often feel dizzy and have headache, but this has almost
disappeared now. I have not needed to take any pain relief pills
since I started on the drops.
Besides this I feel that my quality of sleep has been
much, much better.
Before I almost never felt rested but now I wake up fresh and fit
each day. I sleep more hours in a deep sleep. Before I had a light
sleep and often woke up.
When my daughter became ill with a very high fever, I
gave her the drops, and the day after, believe it or not, she was
free from fever.
I have tried a lot of health products before but NEVER
discovered an effect that comes near to the proprietary blend of
Noni extracts. At last a product that really keeps what it promises.
I can give my warmest recommendations!
As a busy doctor working with health problems every
day, so can I!
52
53
END NOTES
Talan, Jamie. The healing powers of nitric oxide. Montreal Gazette. Sep 26, 1993, C5.
Ruddell, WSJ, et al. Nitrite and thiocyanate in gastric juice. Gut. May, 1976;17(5):401.
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Morinda citrifolia (Noni) with anti tumor activity. Phytother Res.(5), 8/13/1999; 380-7.
Zaragoza, Saura, et al. An antiviral mechanism of nitric oxide: inhibition of a viral protease.
Immunity(1), 1/1999, 21-8.
Sanders, SP. Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication
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Moncada, S, et al. The discovery of nitric oxide as the endogenous nitrovasodilator.
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Ignarro, LJ. Nitric oxide as a unique signaling molecule in the vascular system: a historical
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BOOKS
Ignarro, Louis. NO More Heart Disease: How Nitric Oxide Can Prevent--Even Reverse-- Heart
Disease and Stroke. St. Martins Press. 2005, New York.
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Energy and Revitalize Your Health. Woodland Publishing. 2002, Salt Lake City, Utah.
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Byrd, Edward. The Nitric Oxide Revolution: Transform Your Physique in 21 Days. Medical
Research Institute. 2005, San Francisco.
Butler AR, Nicholson, R. Life, Death and Nitric Oxide. Royal Society of Chemistry. 2003,
Cambridge, UK.
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Vincent, Steven. Nitric oxide in the Nervous System Academic Press. 1995, London.
58
About the Author

Dr. Abbas Qutab is the founder of Elan Vital Medical Centers located in Boston and
Worcester, Massachuetts. Since they first
opened in 1989, these clinics have been the
choice of many thousands of people around
the world seeking complementary and
alternative medicine treatments.
Dr. Qutab holds degrees in medicine, oriental medicine and
chiropractic, and has a Ph.D. in Ayurvedic medicine. He is one of
the very few physicians in the United Sates who has been awarded
an honorary Sc.D. from the World Health Organization Charted
University for his work in promoting alternative medicine. Dr
Qutab travels extensively and has taught thousands of physicians
in the United States and Europe on how to integrate alternative
medicine into their practices.
Dr. Qutab is board-certified in naturopathic medicine and has
received several leadership awards for promoting complementary
medicine. He is on the advisory board of the Congressional
Health Care Reforms Committee in Washington, D.C. and in
2003 received the Physician of the Year award.
Dr. Qutab has also extensively researched nitric oxide and all of
its functions in the body. He has co-authored several books on
Ayurvedic medicine.
59

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Nitric Oxide:

the molecule of life

By Dr. Abbas Qutab

Noni and the Nitric Oxide Link

Nitric Oxide: The Molecule of Life

Nitric Oxide: The Molecule of Life

The WORLD should read this book. (all) at once!

Nitric Oxide: The Molecule of Life

Noni and the Nitric Oxide Link

Nitric Oxide: The Molecule of Life

his medications for one month. I insisted he come back monthly

In my study, I learned this

Noni and the Nitric Oxide Link

one atom of oxygen and one of nitrogen. It was best known as

Nitric Oxide: The Molecule of Life

Noni and the Nitric Oxide Link

Nitric Oxide: The Molecule of Life

Determined to solve this puzzle, scientists began to notice

Having isolated at least one of the main

Noni and the Nitric Oxide Link

system. Baltimore Laboratories in Monroe, CT, has created a

Nitric Oxide: The Molecule of Life

Noni and the Nitric Oxide Link

Nitric Oxide: The Molecule of Life

WHAT DOES NO DO IN THE BODY?

Although it is a highly reactive gas, NO is however the

WHERE DOES NO COME FROM?

Let me tell you a little about where NO comes from. The

Noni and the Nitric Oxide Link

Nitric Oxide: The Molecule of Life

(through nitric oxides action) keep arteries relaxed and more

Noni and the Nitric Oxide Link

nitric oxide will not be created, or

Nitric Oxide: The Molecule of Life

conclusively proven to worsen herpes Type 2 symptoms, but its

Noni and the Nitric Oxide Link

which are a type of free radical. In a nutshell, no. This is because

Nitric Oxide: The Molecule of Life

Noni and the Nitric Oxide Link

Nitric Oxide: The Molecule of Life

Noni and the Nitric Oxide Link

sometimes tell heart patients to think of a healthy endothelium

Nitric Oxide: The Molecule of Life

drugs, diet and exercise could not.

Noni and the Nitric Oxide Link

Australian study recently

Nitric Oxide: The Molecule of Life

Eric Mortensen, of Denmark, wrote me the following

Noni and the Nitric Oxide Link

Nitric Oxide: The Molecule of Life

slower and long term release of the active ingredient.

Noni and the Nitric Oxide Link

Nitric Oxide: The Molecule of Life

the creation of new mitochondria13, but also may make each

Noni and the Nitric Oxide Link

a brisk walk? This is due to the generation of nitric oxide in

Nitric Oxide: The Molecule of Life

As for me, I have way more energy, less stress, better

Inflammatory Diseases in the United States

Noni and the Nitric Oxide Link

tissue damage- a very vicious cycle. From there it is an easy step

Nitric Oxide: The Molecule of Life

considered an inflammatory disease. Martin Florian Toby, from