ABSTRACT

EFFECT OF GIVING LEMON.) PEEL EXTRACT [(Citrus Limon (L) Burm. f] ON LEVELS
TG, HDL-C, and APO-A1 SERUM LEVELS MALE WHITE RAT (Rattus novergicus)
WISTAR STRAIN
Riyadatus Solihah
Dyslipidemia is a disorder of lipid metabolism characterized by increased levels of total
cholesterol, triglycerides (TG), low density lipoprotein (LDL-C) or a decrease in high-density
lipoprotein (HDL-C) in the blood, while hyperlipidemia is a condition where there are elevated
levels of lipids in ie blood triglycerides, kolersterol or both. This state tehadap high risk of
cardiovascular disease (CVD) (Price, 2012; Stapleton et al., 2010).
This research uses experimental research design pure (True Experimental) and the study design
used was the randomized post test only control group design, sample number 32 strain Wistar
rats (RattusnovergicusWistar strain) 3-4 month old male weighing approximately 100-120 grams
were divided into 4 groups, consisting of 1 control group were only given a high-fat diet feed for
28 days, and 3 treatment groups were given a high-fat diet feeding and lemon peel extract with 3
different doses of 2250 mg / kg bw , 3000 mg / kg, 3750 mg / kg for 14 days.
Data analysis with inferensial analysis include analysis of normality test with Shapiro and its
homogeneity analysis with test Levene Test. If normal and homogeneous data is then continued
by annova test one way with a level of significance of the test, at variance 0.05 . the test variance
be obtained levels of TG were not significant with P = 0.125 means that there is no effect of
extract of lemon peel to decreased levels of TG in rats, while the value of HDL-C and Apo A1
obtain P = 0.001, both data have p <0.05, which means there is a significant effect of extract of
lemon peel to the decreased levels of HDL-C and Apo A1 in the rat
Lemon peel extract contains d-limonene that can decrease cholesterol levels by inhibiting the
activity of HMG-Coa reductase, and d-limonene activate PPAR can increase the levels of
serum Apo-A1 in circulation which is the main and largest of protein fractions HDL-C role in
cholesterol transport.
Keywords: peel lemon extract, TG, HDL-C and Apo-A1, dyslipidemia