Вы находитесь на странице: 1из 167

- ..

14.04.03

:
,

..

- 2016


.......................................................................
...................................................................................................

1.

.............
1.1 ......
1.2
..................................................................................
1.3
..........................................................
1.4
.................................................................
1.5

..................................................................................
1..................................................................................
2.

..........................
2.1 -

..................................
2.2

......................................
2.3 -
...............................................................................................
2.4

.....................................................
2...................................................................................

3.

..........................
3.1 ,
()
................................................
3.2
.................................

.
2
6
14
14
20
26
33

35
39

41

41

49

56

62
71

72

72
76

3.3
-


.................................................................................
3.4


...................................................................................
3...................................................................................
4. -


4.1 ,
.........................................................
4.2
,
()
.........................................................................
4.3

......................................................................................................
4................................................................................
.......................................................................................
...............................................................................................
.............................................................................................

82

92
103

105
105

109

112
113
114
117
135

- ()

()


( )

()

()


.
[156].
, ,
(, 50%
),
, 25%
[15,121,138].

,
[9].

.. ,

..

.. ,

..

..

..
..

,
,

.. , .. , .. , .. , ..
.

, 2015 . 79 ,

. ,
,


,
,
,

.

,
: .. , .. , .. , .. ,
.. , .. .
,
,
[138].

.
-
.
.
:

,
;

() ;

;
7

.
, -
.


- ()
20122014 . (-
() 14/ 83 ;
3/ 210 ),

(64 ).
.
.
,
, , , ,
, ,

, .
:
: , ,
-,

-,

, , -, PEST-, SWOT-,
, .
. ,
:

- ,

;

, ,
,
;

,
() ,
.
.
,

() .
:

, 5-

( 1 2013 .);

( 25
2014 .);

( 21
2014 .);

(
9

10 2015 .);

,
( 21
2014 .);

,
( 09
2015 .);

, ()
- (
29 2015 .);

, (
19 2015 .);

,
(
29 2015 .);

,
(
29 2015 .).

10


-
:

- ;


-
.

, () (-)
, -
.. .
, :

,
;

(5- );

,
.);
11

() .
. ( 95% )

, ,
, ,
.

-

-
(-, 2013 .);

(-, 2012 ., 2013 ., 2014 ., 2015 .);
- ,

(-,

2013

.);

() (, 2013 .); -

(-,

2013

.);

(, 2014 .), 3-
(, 2014 .) -
: ,
,

(,

2014

.),

()
(-, 2014 .), -

(, 2014 .),
XXI . (-, 2015 .),
- , 150-
12

-
- ..
(-,
2015 .), II ,
... ,
.. .
, (-, 2015 .),
-
(-, 2015 .),
-2015:
(-, 2015 .).
. 45
, 6 ,
,
,
.

.

2020 .,
- -
.. 1 .
.
, , , 116
, 17 ; 27 , 10 .
167 , 47
.

13

1.

1.1

30- . .
,
,

.

[127].
-
,
[129]. 1939 .
,

[129].


.
1949 . 70- . ,
,

,
. ,
, 1981 .
6 ,
70 [130]

14

2005 .
, ,
,
, , ,
, [129].


. 60- . .


. 2002 .

[140].
(Prontuario Farmaceutico
Nazionale) ,
, .
[139].
, : , , ,
, , , , , , ,
,
, ,
[143].
, ,
()
, . ,

, ,
[132].

,
15

.
23- ,
[126].

1940- .,

1950-


[123,124]. 1965 .

[159,167],

[147]. 1970- - 1980- .

, 1986 .

[149].
1994 .
,
[122].
,

, ,
[125].

1994 . -
[2,25,89,96,109,120].
,
,
-
.. ,
16

.. [110]. 2000 .,

( ) [98],
. ,
15 , 2005 .
[99], 2006. ,
[100].


.
,
,
,
[8,47,83].

1999 . 23
1999 . 328 ,

, .2.2.1.

,



[46].
12 2007 . 110,

, ,
17

,
, [43].
1992 .
,

[119].
, c 1977 .
2 . ,
208 340, 2015
. 19- [166].

, 2782- [57],
[82]
7, 5% 562 604.

[58] ,

[53].



28 2014 .
871

, [67],
,
,

- .,
. ,
18

,
. ,

.
:
- ();
- ( );
- ( ).
1997 .

, 2000 .

[48]
[45]. 2006 .
,
.
09 2014. 498
,
,
() [61].

2014 .
[61,67], , 02 2000 . 304
[48]. ,
.

;
19

, ;
[79].

,
: ,
,
,

[15].

1.2


[138,161]:
1.

;
2.

3.

4.

;
5.


;
6.

() ;
7.

;
8.

;
20

9.

10.

;
11.

;
12.

.
,
3 () [156]:
1.

,

;
2.


, ,
,

;
3.


.
,

.
:

;
21

( );

[91,142].
-

[142].
, :

( , EML, EDL),

, , ,
,
;

[142].


[142].

.
, [9].

22


, ,
,
, .

, ,
,
[125].

,

[125].
.. . (1999 .), , [107,108].
.. (2004 .) :
,
, .. ,

, ,
[15]. ..
(2007 .) ,
,
[120]. .. .
(2009 .), ,

[93]. .. (2015 .)
-
23

, ,
[26].
, ,
,
[41].

[49].

, ,
. -
, ,
,
,
.
, ,
, ,

.
,
.

( ) [15,142].
,


,

[142].
,

24

[142], ,
:

, ;

,

, , ,

[106,142].
,
,
[41,142].
.., ,
[108].

,
[142].

[15,142],

,
, [106].
25


, , ,
,
, , : ,
, , .


[142]. ,
,
, 26
2001 . 88
. [41].

, ,
, .
,
: - , ,
[41].

() [15].
1.3


, -



26

-
[21, 30, 118].

2000- ., ,

,
, , ..

()
() [30].
[27].

16 - 17 .
, , , , , .
,
, ,
.
,
I XVIII .,
, . 18
,
,
,
[37].

[30].

.. :

27

,
[84].

,
, 1920-1930 .

[94].

,

. , 1942 .
, .. , [16,31].



.

() ,

.

,
, ,
I ; II
( ) ;
III
(.1) [10].

28

..


..

2-


..

3-


..

II

( )

III

()

1
,
.
,
:
I .
.
,
,




.
:
, ,
;
29


, ;
/ ;

;


/ ;


,
;

;
,
[34];
;
-

, ;
.

:
1.

;
2.

, ;
3.

,
30

;
4.

.
()

.

,
,
[10].
II
, ( ), :
;

;

;

,
;
.
III () .
:
( ) (-)
, , () ,
,

:

31


;

.

70- . .
,

() [12].

2000 .
614 , 1391 ,
:

.

,
620 1145 .
12% .
, ,
2003 ., . ,
,
, ()

. ..

, ()
-

(). ,
, 20%
, 557 1117 .
2009-2010 . ,
32

. 4-
, 588

- ,

().


,
, ,
[10,31].
:
. ,

1.4

(TRICARE)
, ,
. 9,2 .
,

[158,162].

TRICARE
- [163,164].
,
,
33

,
.
(U.S. Department of Defense
Pharmacy and Therapeutics Committee, DoD P&T),

,
(),
, [134,158].
,
. 1998 .,
2005 .
(.1)
(Basic Core Formulary, BCF) (Extended
Core Formulary, ECF) [162,164].


,
15 ,
- [151].


[134,165].
1 -

( 1)

( 2)

0$
3$
3$
0$
9$
9$

3$
9$

22$

22$
34

22$

( 3, )

90 30

30

90

, ,
.
.
, 3
() ,
( ,
), ()

1 2 [154].
,
,
.
,

;
,
. ( )
-
;
- (,
, )
, 1 2 ,
.

3-

,
, [158].

35

1.5


, ,

[5].
. 29 21 2011 . 323-
[50]
, ,
2009 . .
25 2009 . 267-

22 1993 . 5487-1 19.1 ,
. 39 c

[81]. 21 2011 .
323-
. 31 [50], 2
04 2012 . 477
, ,


[60].
.
( 5
2011 . 169) [71],
36

, ,

,
, ,
.

. . 31
21 2011 . 323-


,
.

.
5.2.12 ,

, ,
[62].
,
04 2012 . 477:

( 5
2012 . 498) [73];
,
( - ) ,
( 5 2012 . 499)
[66];

(
10 2011 . 905) [72];
37


( 10 2012 . 408) [76];

- (
15 2013 . 70) [74];

( 8 2013 . 61) [77].

,
()
[ 40,51,52,56,78,86, 87].
,

,

. ,
,

,

, ,
, ,
, .35 21
2011 . 323-
,

.

38

. 32 21 2011 . 323-

, . 2
,
, .. .
,


- [50,63,64,65].
,
, , ,
, , ..
[65,75].


.


,

.

30 2002 .

[39],
01 2014 . 590 2013 .
,

39

[54] ,

,
, 1010, 1020, 1030, 1040,
1050,
.
,
[54].
1
1. ,
, ,

.
2.
,
,
- .
3.
,

.
4. ,


.
5.

40

2.


2.1 -



:

, ,
- .

.
4- ,
,
(.2).

.
, .

II ,
.
III

, ,

.

, ,
,
.
III
:

,
;

()
.
IV
.

42

2 -


, ,

(.. ),
[90].

.
( )
, ,
, .



(.3).

:
1.

,
, ;
2.

;
3.

, .
4.

, ,

:
1.

;
2.


;
3.

, ;
45

4.

5.

6.

7.

;
8.

, -


;
9.

, ..

(-, .);
10.

, ,
;
11.

(PEST-, SWOT-, )

PEST-
,
. Political (), Economical (), Social
() Technological () .
,
- ,
. ,

.

SWOT-

,
,
(SWOT- Strengths (), Weaknesses
(), Opportunities ( ), Threats () [23].
46



.
(Balanced Scorecard),
. . [92].
: ,
; ;
, .
, ,
,

(. 2) [1], ,
-

.
69 , 32 ,
33 .

47

2
, .

, .

()

<10

10 - 15

15 - 20

>20

12

12

12

12

10

69

65

33

32

24

36

2.2



,
.

, [105].
- ,
,
, ..
.
,
,

, :

(CURE Model) [146],


(SOJA) [144]
(PPDDEM) [145].

, :
, , ,
-, VEN- XYZ-,
[4,21].

[142].


.
,
, ,


(-), /
( ). ,

(),

(),


, --.
,
,
.

, , : ,
, ,
, ,
( , ),
.

,
.
,
, ,
,
.

.

,
- . ,
50

,
,
, .
PubMed, MEDLINE, Cochrane library,

.. ,

[22,135,150,152,155,160].
,
,
-
( ). ,
- ,
, :
1.

),
2.

3.

, .

, , .
,
, , Cochrane Database [160], -,
, ,

. , - ,


[153].
51

, ,

[137,157],

, [137,148].
,
[128].

,
. ,
,
,

, , . , ,

.

: , -,
[137].

.
.
,
,
[117,137].

,
,
. ,
52


[114,115,117,137,157].
-

, .
- [137, 115]:
CER= Cost/ Ef,
CER -;
Cost , .;
Ef .
-

. ,

, ,
[157,115].
(Direct Costs) ,
,
.

,

, .

, ..
(Indirect Costs)
/ , .
,

..
53

(Intangible

Costs)

,
, : , ,
. ,
,
[114,115, 117,157].


.

, : ,
, .
[112].

CER,
, .

, -, [115,137,157].


.
,
[137].

, ,
. .

.
54

,
,
,
.

[117,131,137].
, ,
,
, ,
,
,
.
.

.
,
(
) .

, , ,
(..,
,
), . ,
[113,116]:
BIA= Sx S,
BIA , ;
Sx ,
;
S ,
.
55

BIA ,
.
, , ,
,
[131,113,116].

. ISPOR
, , ,

[131].
:
,
, .. , [24].

.
, ,
,
2-3-
.
2.3 -


,
, , ,
, , ,
56

,
[13].
-
[6].

, ,
, , ..,

, , , .., ,
[6].
, .. .

[95].

, ,
[13].
:
,
, ,
,
, , , ;
,
,
, ,
-, ,
[6].
,
,
[7].
57

:
) ,

, , ; )

) ,

[13].

, ,
. ,
, ..

,

: () ,
[6,7,13,95].
3 ,
.
3


( )



58

D1, D2, , Dk :
D = D1 D2 Dk ,
D1= (d11, d12, , d1i, , d1m1 )
D2= (d21, d22, , d2i, , d2m2)
Dk= (dk1, dk2, , dki, , dkmn)
, .
R :
R D = D1 D2 Dk .
k
:

k ;

) ;

(1, 2, , k);

[133].

,
.

[13].
, - .

, , ,
. ,
59

,
, .. [13].
.

,
, , ,
..

, ,

,

.
, ,
,
[13].

.

: , , ,
[20].
,
:
1.

- ;
2.

3.

.
4.

() ;
60

5.

,
.
4

S1
S2

()
2
3
..
B2
B3
F12
F13
F22
F23

1
B1
F11
F21

n
Bn

Sm

i- - j- (),
Bi j- ().
,
:

Fij i- j- (
).
, ,

Microsoft Excel, ,
.
,
,
,
IBM SPSS Statistics 23 [14].

61

2.4




,
.

PEST-
.
PEST- ,
, 5.
5 PEST- ,

P
1

2 2


3
3
4 4


( , , ),
..


5 5


(100% )
6 6

62

1
2
3
4
5

T

1


3

4

5


6

,
, .

, ,
.

SWOT-
.
,
,
. ,
,
,
.

, :
,
,
, -
() 2012-2014 .
63

, ,

6,

SWOT

, SWOT.
6 SWOT-
, SWOT-

(Strengths)
(Weaknesses)


,
,




(Threats)
(Opportunities)


,

, ..


( )

64

7 SWOT

I.
II.
III.
IV.

i.
ii.
iii.

A.
a)

,
)

B.
, ..

b)
C.


c)

IC
Ia)

IIA
Ib)

IIIA
Ic)

IVA
IIIa)

IVB
IIIb)

IIIc)

IVc)



iC

iiB

iiiC



(.. )

.

,
,
.
:
,
( ),
, :
1.

1.1.

;
2.

2.1.

;
2.2.

;
3.

3.1.

3.2.

3.3.

;
4.

4.1.

, .,
-
.

(.8).
8


100
%


60%

60%


67

-100%



-100%

-100%

,
:
,

60%


,
68

,
,
50%

(,
..)

(
)


:
1. , ,

,
;
2.


- .
3.

69

2
1.
-
, 4- ,
,
.
2.

,
.
3. -
-

- ,
.
4.

,
.

3.


3.1 ,
()


,
. 7,3 . .,
5% (.9).
9 ,
(. .)

2004

4,9

1,7

2,0

1,0

0,2

2009

6,96

1,1

4,15

0,91

0,8

2014

7,3

1,0

4,3

1,0

1,0

2010 .
10 18 ,
,
16 . . .


20122014 .
72


210 3/ 2012-2014 .,
.

10.
,
, 855,
(87,6% ) :
1. (57,9%).
, ,
-
();
2. (14,5%);
3. (5,7%);
4. (4,8%);
5. - 94,6%);
6. ,
.

: () 5,7%;
0,5%; 1,5%;
6,1%; 0,8%, 0,7%,
6,2%; 5%;
11,3%; 27,9%; 34,3%.
:
2,7%; 7,1%;
57,3%; 4,7%;
6,6%;
1,6%; 0,1% .

73

12,5%
4,6%
4,8%
5,7%

57,9%
14,5%




-

10
2012-2014 .
11 ,
2012-2014 .
: 48%, -
11,7%, 7,2%, 6,5%,
5,7%, 3,8%.
,
,
.


- ,
, ,
323-
96 19
74

(-10) [42], ..: XII


17 (18%), 7
; IX ,
15 (16%);
I 13 , 46%
; VI
11 , X 10 (10%)
. , ,
,
, 1. ,
,
,
.
13,4%
3,8%
3,8%
48,0%

5,7%

6,5%
7,2%

11,7%

-



11
2012-2014 .
75

3.2

2721
14 -,

.
(B05BA
).
,

,
.
(, , ,

, ,
- ,
,

.
, ,
, ,
, (
).
,
, ,
,
.
76

(A.Wretlind,

1957

.),

: (15-20%), (4045%) (40-55%),


.
.

: (1+1+1),
.


. parenteral nutrition PubMed
29305 , Cochrane 2940, Cochrane 52,
83, 2741,
3, 49.

Nutrition Day
2011 .,
-
[85].
963
,
APACHE II 3 : ,
.

,
()

77

(.12) [85].
12

8
16
26

, %

12
21
28

95,2
85,1
64,8

93,3
80,4
52,5



(.13).
.

- . .. (
01.04.2015 .), , :

,
,
,
(, , ,

), ,

-,

78

13

52800
105600
171600

79200
138600
184800

()* ()*
(//).
Nutrition Day
80 (79,8 ), 7
[85],
(ESPEN)
25-30 // [111].

, 2400
, 16800 .
,
(, ) (. 14) ,
15%, 30%, 55%
.
14

2400

88
79

77

322

16800

615

542

2254

-
/ 14- 2012 2014 .
,
,
, ,
(. 15)
(. 16).
15 ,

(1+1+1)


- 10% 500
/ 10% 250
5% 500
40/80 1000
/ 10% 250
2053


,
8654

17247
12049

16

(1+1+1)

61454
114254
180254

70047
122847
188847

64849
117649
183649

79200
138600
184800


[114,115, 116,117]:
CER=DC/Ef,
CER -, /%;
DC , ;
80

Ef , %.
-

(.17).
17 -

- CER, /%

(1+1+1)

64553
134259
278170

73579
144356
291431

68119
138248
283409

84887
172388
352000

,
31,
., 1 000
,
.

[113,116,117]:
Ec = (cost(x) cost)1 000,
Ec ., ;
Cost(x)
;
Cost
7 , ;
18 ,
.,
,
[117].
81


,
,
,
(1+1+1),

.
18

( 1000 ),



(1+1+1)

20334939
11308678
16768762
38129540
28032008
34140116
73830247
60569444
68591049

3.3



,
,

.

,
82

, ,
( -44) (. 19).
19

:
1.

1.

2.

2.

3.
:

1.

1.

2.

2.

, ..

5-
:
1.

- ,

.

-


, 35
5- (724 ),

(-
),
83

( ), -
.. , -

.. ,

.. ,

.. , 9 - [104];
2.

- ,

.

-
,
,

5-

(264

)
,
,
[103];
3.

, - ,
.
,
, -
-

,
,

(96 ),
[97].
84

,
, ,
,
(.4).

4


(. 20),
,
( ).
20
( )


/
1


3
4

f11

f12

f13

f14

R11

R12

R13

R14

f21

f22

f23

f24

85

R21

R22

R23

R24

f31

f32

f33

f34

R31

R32

333

R34

n= ;
i ;
fi .
( ) 0,0-1,0
0,1.
,

.

- .
- , ,
19 2013 . 2427-

2014 . [82], 18 2006 . 665
,
,
- ,

()
[58], 15 2010 . 805

,
[53], 30 1998 . 681
,
86

[59],

29 2007 . 964
234 [70],

31 2014 . 14-
034-2014 ( 2008) [80],
, 12
2013 . 590
,
[54], 18 2012
. 3740
,
[55], 3 2010
. -29

[68],

12 2011 . 77


[69].
41
, 25 , 16

33 .
,
.

, IBM SPSS Statistics 23,
.
87

()
2,4,6.

(
3,5,7)

-.

: 16
, 17
15 ,
.

(. 21).
21



.
22

88




()




,



- ,

()

, ,

590 13.08.13
3740 18.12.12
-29 03.04.10
77 12.07.11
(
)



31 2014 . 14

034-2014 (
2008)







( 2013 . 590)

( 2012 . 3740)
- (
2010 . -29)

( 2011 . 77)
(
)

034-2014 ( 2008)

89


, ,


.
:
1.

2.

: , , ,
, , , ;
034-2014 (
2008);
3.

. ,
; , ,
: , ()
, , ( 2013
. 590), ( 2012 . 3740), -
( 2010 . -29),
( 2011 . 77).
4.

), .

.
:
, , ,
;
90

( 2013 . 590),
( 2012 . 3740), - (
2010 . -29), (
2011 . 77) , ;
, , ,
, ( ),
() [11].
-,

.

,
.
,
( 1), 64

, .
:
1.

2.

10;
;
3.

, , 1
5- , ;

1
5- .
91

,
1 5- :
1.

2.

, : ,

, , ,
, , , ,
( ), ,
, , , , ,
, .
:
;
, ,
, , ;
[11].

3.4.

, ,
( ,
,
.).

, ,
, (),
() (, ).

92

, :

, , (),
,
- ;
() -

, (
), , ,

( ) [50].
()
-
() - ()
[36].

, [60].
: ; ;
; ;
; , ,
; ;
. ,
, , ,
(

),
.

,


93

,
, [60,71].
,
() :
, -
.

23.
23


,

-

(,
.)
-
(

)

-
(

)

-
(

)

-


94


()


-
()

,


- (
) -
( ). , ,
-

(,

.) 10 18
, .
-
(-)
.
,
,
24.
24 ,
95

, .
- - - - -

11

11

12

12

11

4
19

4
21

4
25

4
24

4
23

3
17

, ,
,
, ,
1 ( )
(5- ) [54,102].
,
,
. ,
() [44,88].

,
.
,

.
3/ 20122014 .,
, .
,

, : -
96

(); () ,
, ;
(),
; (),
, , ,
; ()

()
; ()
;
() .

,
, 1000
, 5.
;
; 12%

; ;
9%
;
; 10%

;
; 23%
;
; 18%

; ;
5%
; ;

;
; 20%

3%

5 ,
,
,
97

, .

,

60
). ,
( -
), -,
-, -

-.

6 [28].

,
[32, 38].
,

, 25.
25 ,


, .
-
-
- -

52
32

37
32

30
24

8
7

12

12

13

2
98

2
83

2
69

2
22

98

, ,

6

25 ,
-


,
.
,
-, , ,
7 1417 , ,
.
99

-
: (N05)

(N05)

() ; (N06)
; (N06)
- ;
(R06) ()
; (05)
.

.

, .


.

,
..
.

26 [18].
26

-

,

(
,
,
() )

100

--

,
(
, ,
() )

--

,
(
, ,
() )


, [18]:

,

;

,
, ,
;


, ;

101

( )
, , ,
,
, ;
( )
,
( , ),
( ) (, ) [44].


,
( , ,
, .).

, -
.

.

. 27 [17].
27
(, )

102

, ,

-
(


()


()


(
)

3
1.
,
57,9% 48%, 14,5% 7,2% .
2.
-
103


.
3.
,
, ,
.
4.
,
,
,
,
, ()
.

104

4. -

4.1

2010 . ,
: -,
,

, :
1

;
2
(, ) ;
3
-
.. , , (
-) .
588 ,
1 215, 2 322,
3 588 .

, ,

., 2011 . ,
637 [101].
105


[102]:
1

;
2

;
3

) (-
);
4

(- );
5
-
.. ,

.. , .. , 3

.. ,

9 - .
727
( 14% ).
6% ( N
) 113% ( S ). 53
, 4- , ,
5- 183 .
,

. 7.
106

-,

120
112
107

100

94

101

80

83

67

71

76

71
60

55
46

51

28
36

24

40
20

22

5- 2013 .

16

14

17

32

36
17

18

35

22

30

37

42

4- 2010 .

7
-
, .7,
,
,

[29].
, 5- , 65 %
, 7%
, 18%
, 4%
, 35% .

,
107


( ,
). ,

.
, 4- 5-
, , 14,8%,
, 4- ,
,
, 2015 . 2010 .
.8.
4- . (2010 .)

5- . (2013 .)

1 200 000
1 051 296
1 000 000

890 845

800 000
600 000

450 868
496 775

400 000
179 959 232 482
54 313
86 498
171 831
97 831 114 593
10 834
18 584
200 000 101 769
107
785
81
946
11
907
13 83778 260
76 344
61 102 81 526
25 039
31 848
8 125
4 63027 152
3 876
0

D
G

J
L

R
S
V

8
-

108

4.2 ,

()

,
:
,
;

.
2002 2014 . . ,

17 25 .
( (), ,

14
12
10
8
6
4
2
0

14

8
5

1
3

(2002 .)

4
0

.) . 9 [19].

(2014 .)
(2002 .)

(2014 .)

9

109


-
()
,
.

, ()
, - ,


. ,

-, -

.)

- -.
-,
(-)

- [19].

( 78 ),
,
.
2002 2014 .
.
.10.

110

76

56
37
32
32

11
11

1
1

16

2
2

(2002.)

-
-
(2002.)

80
70
60
50
40
30
20
10
0

10


(, )
.
2015 2002 . ,
39% ( 13 21 ).

- 18% ( 69 57 ),
- 44% ( 39 ).
,
30 2002 . 2014-2015 .,
() .

111

4.3


-

,
.
:
1.

- ;
2.

, ,

;
3.

,
,
);
4.

( - .
.. ) , ;
5.

;
6.

( 14/)
.
7.

.
112

4
1.

, 5-
14%, 14,8%.
2.

113


1.

- ,

,
. -


, .
2.

, PEST-,
SWOT-
.


.
3.

, ..

,
,
.
4.

10 : X 57,9% 48%;
XII 14,5% 7,2%
;
I
114

5,7%,
,
XIII - 13,4%.

,
,
, -
.
5.

. 5- 5
: ,
, ()
( ), .
6.

,

.


- ,

.
7.

- ,
,

.
115

,
264 , (705 )

96 ,
.
8.

,
()
,

, ,
()
.

116


, .. :

1.

/ .. , .. , .. , .. , ..
, .. , .. , .. //
. 2012. 10-1. . 11-15

2.

.,

/ ., . // . 2000
1 . 2.
3.

..

/ .. , .. // . 2003. 3 (66). . 10
12.
4.

..

-, VEN- / ..
, .. // . 2014. 6. .
15.
5.

, ..

- / .. ,
.. , .. , .. , .. , .. . //
. , 22015 .114-118.
6.

. ., . .

http://technomag.edu.ru/doc/425220.html
7.

.. .

. LAP LAMBERT Academic Publishing GmbH & Co.


KG Dudweiler, rbr, 66123 Saarbrucken, Germany. 2011. 394 c.
8.

.. / ..

// . 1999. 1. . 40 56.

117

9.
/

, .. - , ,

..

..

..

//

. . 2005.
10. . 48.
10.

, ..

() / .. , .. , .. ; . .. .
.: - . -, 2010. 128 .
11.

. [

]. : http://grls.rosminzdrav.ru/grls.aspx
12.

, ..

/ ..,
.., .. // .-. . 2008. 4. . 47-53.
13.

. . . 8- .: . . -

.: , 2008. 1328 .
14.

IBM SPSS Statistics V23.0 [ ].

http://www-

01.ibm.com/support/knowledgecenter/SSLVMB_23.0.0/spss/product_landing.dita
15.

..

/ .. // . 2004. 4. . 30-35.
16.

(1942 .).
17.

()
- : . . 29 2015 . ,
2015. 77 .
18.

, ,
/
. . 2015. 40 .
19.


118

,
: . .
21 2014 . .: . . , 2014. 76 .
20.

.. / ..

. .: , 2005. 304.
21.

..


/ .. // . 2008. 3. . 46-50.
22.

. .. [ ]. :
http://www.mma.ru/science/nii/pharm/otlab/lfe.html
23.

.-.

. .: , 2007. 800 c.
24.

, ..


/ .., .., ..., ..,
.. // . : .
2013. 2. . 20-26.
25.

..

/ .. , .. , ..
// : . . .,1997. .3. .29 31.
26.

, ..

..

//

. 2015. 1-2. . 36-42.


27.

.., .., ..

// .
(1; 2010; ): . ... : .
. . , 2010. . 66.
119

28.

..,

..,

..

,

// . II .-. . .

, , 26 2014 . . : -, 2014. . 121122.
29.

..

/ ..
[ .] // . . 2014. . 2.
1. . 54.
30.

, ..

/ .., .. //
. 2011. 1. . 25-31.
31.

, ..

/ ..
, .. , .. // .-. . 2010. 6. .
6672.
32.

, ..

, /
.. , .. , .. // .-. . 2009.
5. . 1217.
33.

, ..

/ .. , .. ,
.. // I 8-11.06.2010.
.: , 2010. .
6667.
34.

, ..

/
.. [ .] // .-. . 2014. 2. . 5257.
35.

, ..
120

/ .. [ .] // .-. .
2014. 9. . 5964.
36.

, ..

.. , .. , .. // . II .. . .
. .: -, 2014. . 121122.
37.

, ..

( ) / .. [ .] // . . .. . 2008. 2 (22). . 179184.


38.

..

/
.. [ .] // . . 2014. .
2. 1. . 54.
39.

: .
22 2002 . 30.
40.

"

":
18 1995 . 191.
41.

"

. :
26 2001 . 88.
42.


, 10 : 27
1997 . 170.

121

43.


: 12.02.2007. 110.
44.

: . 31 2009 . 1148.
45.

2510/1684-32 18.02.2000 .
46.


(): 23.08.1999 328 (. 13.06.2006)
47.

()

:
16 1992 . 277.
48.

: 304 2 2000 (.

17.04.2002 .).
49.

: . 12.04.2010

61- (. 29.12.2015).
50.

: . 21

2011 . 323-.
51.

, : 23
1997 . 321.
52.

: 15 2002
. 583 ( . 09.08.2010 377).
53.

:
15 2010 . 805.
122

54.

, :
13 2013 . 590.
55.

,
:
18 2012 . 3740.
56.

:
20 2003 . 27.
57.

2015 ,

, :
. 30.12.2014 2782- ( . 26.12.2015)
58.


()
: 18 2006 .
665.
59.

, :
. 30 1998 . 681.
60.

, :
4 2012 . 477.
61.

123

: 09.09.2014 498.
62.

: . 19 2012 . 608.
63.

- :
15 2012 . 543.
64.


-

,
,

23 2012 . 252
65.

, :
20.06.2013 388.
66.

, (
- ) ,
: 5 2012 . 499.
67.


, :
. 28.08.2014 871
68.

:
3 2010 . -29.
124

69.


: 12
2011 . 77.
70.

234 ,
234
: . 29
2007 . 964.
71.

:
5 2011 . 169.
72.

11 2011 . 905.
73.


:
5 2012 . 498.
74.

-
: 15 2013 . 70.
75.


: 07 2013 . 549.

125

76.


: 10 2012 . 408.
77.

: 8
2013 . 61
78.

"


": - 15
2003 . 165.
79.

- 18.02.1997 59.
80.

034-2014 ( 2008):
31 2014 . 14-.
81.

: 22 1993 . 5487-1 (.
07 2011 . 420-).

82.

2014 : . . 19 2013
. 2427-.
83.

.. , ,

: /
.., .. , .. ; . . .. .
.: - , 2006. 456.
84.

, .. -

18771878 .. ., 1879. .
1. 416 .
126

85.

.., .., .., ..,

.. Nutrition Day .
. . 2011.
86.

09.01.1996 2.
87.

17.09.1991 (. 18.04.1995).
88.

23 2010 . 706.
89.

/ . [ .]. (); .(), 1997.


100 .
90.

. .

, 1959. 432 .
91.

, .. -

/ .. //
XXI . 2010. . 12.
4. . 414-416.
92.

. .

/ . . , . . // . -. 2006. 304 .
93.

..

/ .. , .. , .. , .. , .. //
- .
.. . 2009. . 1. 2. . 7275.
94.

) / .. [ .] // . . .-. . 2008. 2
(22). . 179184.
95.

( ) / .. , .. , ..
. : - . 2005. 255 .
127

96.

..

/ .. // .
. 1998. 4. .8081.
97.


/ . . 2015. 480 .
98.

( ). .: ,
2000. .I. 975.
99.

( ). .: , 2005. .VI.
968.
100.

( ). .: , 2006. .VII.
1000.
101.
( ). : . ..
. 2010. 148 .
102. (5-
.). .: .. , 2013. 178 .
103.
) / .
.. .., . . 2014.
244.
104.
/
. . 2015. 324 .
105. , .. .
/ .. , .. . .: , 2003. 221 .
128

106. .. / .. ;
.. .. . ., 2000. C. 316 348.
107. .., .., .. :
// . . . 1999. . 7. 15.
108. ,

..

/ .. , .. , .. // . 1999. 12
. 535
109. , .. -
/ .. , .. , . , .. , . // .
1999. 7 . 1
110. ..
/ .. , .. // . 1998. 5.
.610.
111. .., ..
(ESPEN)
. . 2009.
112. .., ..
. . 2010. . 2
.12-18.
113. , ..
/ .., .., .. // :
. 2015. . 3. 4. . 7-14.
114. , ..
/
.., .. // : . 2015. . 1.
3. . 7-16.
115. , .. -
/ .., ..,
.. // .
. 2012. . 5. 4. . 3-8.
129

116. , .. :
/ .., .. // .
. 2011. 2. . 912.
117. ,

..

..,

..,

..

//

: . 2014. . 2. 1. . 5-20.
118. ,

..

/ .., .. // . 2007. 9. .
73-78.
119. , .. : / ..
// - . ..
. 2008. 1. . 130137.
120. , .. : / ..
// - . ..
. 2007. 3. . 182189.
121. Adherence to longterm therapies. Evidence for action. Geneva, World
Health

Organization,

2003.

].

http://www.who.int/chp/knowledge/publications/adherence_report/en/
122. American Medical Association. AMA policy on drug formularies and
therapeutic interchange in inpatient and ambulatory patient care settings. Am J Hosp
Pharm. 1994; 51:180810.
123. American Society of Hospital Pharmacists, American Hospital Association,
American Pharmaceutical Association et al. Statement of guiding principles on the
operation of hospital formularies. Am J Hosp Pharm. 1964; 21:401.
124.

American Society of Hospital Pharmacists. Minimum standard for

pharmacies in hospitals. Am J Hosp Pharm. 1958; 15:9924.

130

125. ASHP Guidelines on the Pharmacy and Therapeutics Committee and the
Formulary

System

].

http://www.ashp.org/doclibrary/bestpractices/formgdlptcommformsyst.pdf
126. Australian pharmaceutical formulary 23rd edition available [
]. :

https://ajp.com.au/news/australian-pharmaceutical-

formulary-23rd-edition-available/
127. Base des Medicaments et Informations Tarifaires [ ].
: http://www.codage.ext.cnamts.fr/codif/bdm_it
128. Briggs

AH.

Handling

uncertainty

in

cost-effectiveness

models.

Pharmacoeconomics. 2000;17(5):479-500.
129. British National Formulary [ ]. :
http://www.bnf.org/about/
130. British National Formulary: The Essential Reference Books [
]. : http://www.bnf.org/products/books/
131. Budget Impact Analysis Good Practices [ ].
: http://www.ispor.org/budget-impact-health-study-guideline.asp
132. Canadian Agency for Drugs and Technology in Health. Health Technology
Assessment.

].

www.cadth.ca/index.php/en/hta..
133. Codd E.F. The Relational Model for Database Management Version 2.
Reading, Mass.: Addison-Wesley, 1990.
134. Department of Veterans Affairs National Acquisition Center. Federal
supply schedule service pharmaceuticals. [ ]. :
www1.va.gov/oamm/oa/nac/fsss/pharmfss.cfm.
135. Drug Effectiveness Review Project. Home page. [ ].
: www.ohsu.edu/ohsuedu/research/policycenter/DERP/index.cfm
136. Drug promotion: what we know, what we have yet to learn [
]. : http://apps.who.int/medicinedocs/pdf/s8109e/s8109e.pdf

131

137. Drummond MF, Sculpher MJ, Torrance GW, OBrian BJ, Stoddart GL.
Methods for the economic evaluation of health care programmes. 3rd Ed. Oxford:
Oxford University Press; 2005.
138. Essential medicines and health products [ ].
: http://www.who.int/medicines/areas/rational_use/en/
139. France G, Taroni F, Donatini A. The Italian health-care system. Health
Econ. 2005 Sep;14(Suppl 1): S187-202.
140. German

Institute

of

Medical

Documentation

and

Information

[ ]. : http://www.dimdi.de/static/en/index.html
141. Health Affairs Policy 04-032. TRICARE Pharmacy Benefit Program
Formulary

Management.

].

www.ha.osd.mil/policies/2004/04-032.pdf.
142. Holloway, K. editor. (2003) Drug and therapeutics committees: a practical
guide. Geneva: World Health Organization. Department of Essential Drugs and
Medicines

Policy.

].

http://apps.who.int/medicinedocs/pdf/s4882e/s4882e.pdf
143. Home of Common European Drug Database [ ].
: http://cedd.oep.hu/
144. Janknegt R., Steenhoek A. The System of Objectified Judgment Analysis
(SOJA): a tool in rational drug selection for formulary inclusion. Drugs. 1997; 53:550
562.
145. Karr A. Improving the drug evaluation process. Pharm J. 1994; 252:576
577.
146. Karr A. The Comparative Utilisation of Resources Evaluation Model-a
CURE for all disease. Pharm J.2000; 265:610621.
147. Lammy PP, Flack HL. Pharmacy and therapeutics committee, consent, and
the hospital formulary. Am J Hosp Pharm. 1966; 23:66272.
148. Mauskopf J, Earnshaw S, Mullins CD. Budget impact analysis: review of
the state of the art. Expert Rev Pharmacoeconomics Outcomes Res. 2005;5(1):65-79.
132

149. May JR. Formulary systems. In: DiPiro JT, ed.Encyclopedia of clinical
pharmacy. New York: Marcel Dekker; 2002.
150. MEDLINE/PubMed Resources Guide [ ].
: https://www.nlm.nih.gov/bsd/pmresources.html
151. Ministry of Defense Pharmacoeconomic Center. Future meetings of the
DoD

P&T

Committee.

].

www.pec.ha.osd.mil/PT_Committee.html.
152. Oxford Centre for Evidence-based Medicine. Levels of evidence.
[ ]. : www.cebm.net.
153. Pettiti DB. Meta-analysis, decision analysis, and cost-effectiveness
analysis. Oxford: Oxford University Press; 2000: 264-71.
154. Promoting Quality and Efficient Health Care in Federal Government
Administered or Sponsored Health Care Programs. Presidential Executive Order No.
13410,

C.F.R.

].

:http://edocket.access.gpo.gov/cfr_2007/janqtr/pdf/3CFR13410.pdf.
155. Pubmed

search

].

www.ncbi.nlm.nih.gov/pubmed
156. Rational Use of Medicines: Activities [ ].
: http://www.who.int/medicines/areas/rational_use/rud_activities/en/
157. Russell LB, Siegel JE, Daniels N, Gold MR, Luce BR, Mandelblatt JS.
Cost-effectiveness analysis as a guide to resource allocation in health: roles and
limitations. In: Gold MR, Siegel JE, Russell LB, Weinstein MC, editors. CostEffectiveness in Health and Medicine. New York: Oxford University Press; 1996:3-24.
158. Shana Trice, Joshua Devine, Harsha Mistry, Eugene Moore, Andrea
Linton. Formulary Management in the Department of Defense. JMCP March 2009 Vol.
15, No. 2
159. Social Security Administration. Conditions of participation for hospitals.
Am J Hosp Pharm. 1966; 23:179 180.
160. The Cochrane Collaboration. Home page. [ ].
: www.cochrane.org.
133

161. The Pursuit of Responsible Use of Medicines: Sharing and Learning from
Country

Experiences

].

http://apps.who.int/iris/bitstream/10665/75828/1/WHO_EMP_MAR_2012.3_eng.pdf?u
a=1
162. TRICARE Management Activity. Homepage of the Uniform Formulary
Beneficiary

Advisory

Panel.

].

www.tricare.mil/pharmacy/BAP/.
163. TRICARE Management Activity. TRICARE Pharmacy web site.
[ ]. : www.tricare.mil/pharmacy.
164. U.S. Code of Federal Regulations. Civilian health and medical program of
the Uniformed Services: pharmacy benefits program (32 C.F.R.Sect. 199.21).
[

].

http://edocket.access.gpo.gov/cfr_2007/julqtr/32cfr199.21.htm.
165. Veterans Health Care Act of 1992, Pub. L. No. 102-585, Sect. 603.
[ ]. : www.hrsa.gov/opa/pl102585.html.
166. WHO Model Lists of Essential Medicines [ ].
: http://www.who.int/medicines/publications/essentialmedicines/en/
167. Willcox AM. The legal basis of the formulary system.Am J Hosp Pharm.
1960; 17:6038.

134

1
2
3
4

10

11

12

,
,

,
,

( , )

( )


-10

() ()

() ()


()
,

13

14

15

16

I.
A41.9
+
+
+
+
+
+
+
+
+
+
00
+
+
+
+
+
02.9
+
+
+
08.1

22.11.2007 232

28.12.2012 1617

2
5
6

3
B35
B36

+
+

+
+

+
+

10

11

+
+

+
+

+
+

12

13

14

15
+
+

7
8

B37.0
B37.2

+
+

+
+

+
+

10

11
: ,
,
, ,

12

B37.3

B37.8

13

14

15

16

B50.0

16

18.12.2007 777

28.12.2012 1586

11.12.2007 752

86
+
+
+
+
+

11.12.2007 751
IV. ,

E10.1
+
+
+
+
+
+
+
+
+
+

E11.1
E12.1

E13.0
+
+
+
+
+
+
+
+
+
+


E14.0
24.12.2012 1428
E12.0
E11.0
E10.0

E15
+
+
+
+
+
+
+
+
+
+


E16.1
20.12.2012 1280
E16.2
B85

136

17

18
19

20
21

10

11

E05.5

12

13

14

15

16

9.11.2012 872

E27.2
+
+
+
+
+
+
+
+
+
+
V.
F45.3
+
+
+
+
+
+
+

22


23
24
25

26

27

28


29

30

31
32

F48.0
F99

G40

+
+

+
+

+
+

+
+

VI.
+
+
+
+
+
+
+

+
+


24.12.2012 1517


24.12.2012 1439

G43.0
G43.1

+
+

+
+

+
+

+
+

+
+

+
+

+
+

G44.2

G50

G51

G54
G59

G56.0

G57.5

+
+

+
+

+
+

G58.0
G90

+
+

137

+
+

+
+


24.12.2012 1550

24.12.2012 1551

33

10

11

12

13

14

34

66

VIII.
+
+

35

I10

IX.
+
+
+
+
+
+

36
:
( ,
)
,

37

( ,
,
,
)
38

39
40

41

15

VII.
10
+
+
+

16

13.10.2006 704

24.04.2006 314

I20.0
I21


9.11.2012 708

24.12.2012 1387

24.12.2012 1383

I50


20.12.2012 1283

I44I49

I10I15

I63


09.11.2012 711;

09.11.2012 787

09.11.2012 708

20.12.2012 1282

G93.2

138

10

11

42

I26

43

J01

44

J03

45
,

46

J03

J10J11

47

J12J18

48

J20-21

49
, ..
,

50

J34

51

52
(,
)

J4142

53

30

13

14


20.12.2012 1126


20.12.2012 1201

20.12.2012 1205

20.12.2012 1205

X.
+
+
+

J36

J4546

12

15

+
+

+
+

XI.
+
+

139

28.02.2005 170

20.12.2012 1213,

12.02.2007 108

16


20.12.2012 1207

24.12.2012 1455

20.12.2012 1087

20.12.2012 1086

54 ,

,

55 ,

10

11

12

13

14

15

16
22.11.2004 247

22.11.2004 247

2022

29

22.11.2004 248

4.09.2006 636


24.12.2012 1479

18.12.2007 774

18.12.2007 774

29.07.2005 477

56

K35

57

72

58

+
+
+
+
+
+
+
+
+
XII.
L01
+
+
+
+
+
+
+

59

L02

60 ,

L02

61

L03

62


63
64

L08

65

66

L24

L25

+
+

L21
L23

+
+

+
+

140

9.11.2012 781

67 ,
,
()
68
69

L27

L30.1
L50

+
+

10

11
+

+
+

+
+

12

13

14

15

+
+

16

24.12.2012 1481

24.12.2012 1430

70
L51
+
+
+
+
+
71 ,
L51.9
+
+
+
+
+
+
+
+
+
+

72
L55
+
+
+
+
+
+
+
+
73
L70.0
+
+
+
74
L75
+
+
+

XIII. -
75
M54.1
+
+
+
+
+
+
+
76
50
+
+
+
+
+
+
+
+
+
54
77
M60.6
+
+
+
+
+
+
+
+
+
XIV.
78
N17
+
+
+
+
+
+
+
+
+
+

79
N19
+
+
+
+
+
+
+
+
+
+
XVIII. , ,
,
80 ,
R55
+
+
+
+
+
+
+
+
+
+

24.12.2012 1398
81
R57.1
+
+
+
+
+
+
+
+
+
+

24.12.2012 1445
XIX. ,
82
S06
+
+
+
+
+
+
+
+
+
+

24.12.2012 1390

141

83

84

85
,

86 ,

87 ,

88 ,

-


89

90
91

92


93

3
S27.0

4
+

5
+

6
+

10

11

12

13
+

14
+

15

16

7.11.2012 635

5.09.2006 644

24.12.2012 1405

24.12.2012 1384

S62

S82

S83

S92

S93


24.12.2012 1384

15.0


24.12.2012 1451

24.12.2012 1375

36
65
T66
W88
T66
W90

T67.0

142


20.12.2012 1253,
20.12.2012 1261,
24.12.2012 1467,
24.12.2012 1384

24.12.2012 1384

10

11

12

13

14

94

68.0

95

78.2

96

T78.3

143

15

16
20.12.2012 1115

20.12.2012 1278

20.12.2012 1079

24.12.2012 1430

I.
IV. ,

13

V.
VI.
VII.
VIII.
IX.
X.
XI.
XII.
XIII. -

XIV.

11
1
1
8
10
5
17

3
1
1
7
9
4
7

15

13

96

57

XVIII. , ,
,

XIX. ,

144

2




.

69

,0

1,0

,068

,1440

69

,8

1,0

,955

,0738

69

,7

1,0

,849

,0851

69

,1

,5

,135

,0724

69

,0

,1

,057

,0499

69

,0

,2

,030

,0577

()




;




- ,


()
;

(

);

,

(

69

,0

,2

,101

,0813

69

,0

,1

,009

,0284

69

,1

,3

,188

,0777

69

,0

,1

,051

,0504

69

,0

,1

,084

,0369

69

,0

,2

,093

,0734

69

,0

,7

,170

,1275

69

,1

,3

,180

,0815

69

,1

,4

,161

,1060

69

,0

,3

,123

,1139

69

,7

,8

,741

,0495


);
,


,

;


;


,
,
,
,

, ,

.;


;


;

;




;

;



;
, ,

;

146

69

,0

,9

,078

,1870

69

,0

,0

,000

,0000

69

,8

1,0

,886

,0772

69

,7

1,0

,946

,1008

69

,7

1,0

,814

,1115

69

,0

,3

,083

,1137

69

,3

1,0

,836

,1618

69

,1

,9

,623

,3598

69

,7

,8

,739

,0492

69

,9

1,0

,971

,0457

69

,9

1,0

,981

,0394

69

,8

1,0

,962

,0666

69

,8

1,0

,919

,0912

69

,0

,0

,000

,0000

69

,8

1,0

,970

,0649

69

,9

1,0

,984

,0369

.

;
,

;

( );

77
12.07.11
3740
18.12.12
590
13.08.13
-29
03.04.10



31 2014 . 14-



034-2014
( 2008)
30 1998 .
681

,
,


29 2007 .
964


234
N ( )

69

147

4




.

69

,0

1,0

,068

,1440

69

,8

1,0

,955

,0738

69

,7

1,0

,849

,0851

69

,1

,5

,135

,0724

69

,0

,1

,057

,0499

()




;




- ,


()
;

69

,0

,2

,030

,0577

69

,0

,2

,101

,0813

69

,0

,1

,009

,0284

69

,1

,3

,188

,0777

69

,0

,1

,051

,0504

69

,0

,1

,084

,0369

69

,0

,2

,093

,0734

69

,0

,7

,170

,1275

69

,1

,3

,180

,0815

(

);
,

(

);
,


,

;


;


,
,
,
,

, ,

.;


;


;

;




;

150

69

,1

,4

,161

,1060

69

,0

,3

,123

,1139

69

,7

,8

,741

,0495

69

,0

,9

,078

,1870

69

,0

,0

,000

,0000

69

,8

1,0

,886

,0772

69

,7

1,0

,946

,1008

69

,7

1,0

,814

,1115

69

,0

,3

,083

,1137

69

,3

1,0

,836

,1618

69

,1

,9

,623

,3598

69

,7

,8

,739

,0492

69

,9

1,0

,971

,0457

69

,9

1,0

,981

,0394

69

,8

1,0

,962

,0666

69

,8

1,0

,919

,0912

69

,8

1,0

,955

,0718

;



;
, ,

;

.

;
,

;

( );

77
12.07.11
3740
18.12.12
590
13.08.13
-29
03.04.10



31 2014 . 14-



034-2014
( 2008)

151

30 1998 .
681

,

69

,8

1,0

,970

,0649

69

,9

1,0

,984

,0369

,


29 2007 .
964


234
N ( )

69

152

6





.

69

,0

1,0

,068

,1440

69

,8

1,0

,955

,0738

69

,7

1,0

,849

,0851

69

,1

,5

,135

,0724

69

,0

,1

,057

,0499

69

,0

,2

,030

,0577

()




;




- ,


()
;

(

);

,

(

69

,0

,2

,101

,0813

69

,0

,1

,009

,0284

69

,9

1,0

,932

,0469

69

,0

,1

,051

,0504

69

,9

1,0

,988

,0323

69

,8

1,0

,993

,0356

69

,5

,9

,890

,0598

69

,1

,3

,180

,0815

69

,1

,4

,161

,1060

69

,0

,3

,123

,1139

69

,7

,8

,741

,0495


);
,


,

;


;


,
,
,
,

, ,
.;


;


;

;




;

;



;
, ,

;

155

69

,0

,9

,078

,1870

69

,0

,0

,000

,0000

69

,8

1,0

,886

,0772

69

,7

1,0

,946

,1008

69

,7

1,0

,814

,1115

69

,9

1,0

,999

,0120

69

,3

1,0

,836

,1618

69

,1

,9

,623

,3598

69

,7

,8

,739

,0492

69

,0

,0

,000

,0000

69

,0

,0

,000

,0000

69

,0

,0

,000

,0000

69

,0

,0

,000

,0000

69

,0

,0

,000

,0000

69

,0

,1

,010

,0304

69

,0

,2

,012

,0365

.

;
,

;

( );

77
12.07.11
3740
18.12.12
590
13.08.13
-29
03.04.10



31 2014 . 14-



034-2014
( 2008)
30 1998 .
681

,
,


29 2007 .
964


234
N ( )

69

156

-



-



( )

-

-
.

159

10

160

11

-

.

161

12

-


-
.

- 2014

162

13

- 2015
163

14


()

-

2015

164

15

- 2015

165

16

- 2015

166

17

167

Оценить