Академический Документы
Профессиональный Документы
Культура Документы
HEART FAILURE
Clinical syndrome that can result from a structural or functional cardiac disorder
that impairs the ability of the ventricle to fill with or eject blood.
The syndrome may result from disorders of the pericardium, myocardium,
endocardium or great vessels, but majority of patients with HF have symptoms due to
LV dysfunction
The abnormality in cardiac function causes the failures of the heart to pump the
blood at a rate that is satisfactory for the requirements of metabolizing tissues.
Presentation of patients with HF
Decreased exercise tolerance
- dyspnea and fatique occurring at rest or during exercise
Fluid retention
- complaint of leg or abdominal swelling as primary symptoms
- impaired exercise tolerance not noticed by patient as it occurs gradually
No symptoms of symptoms of another disease
- cardiac enlargement or dysfunction may noted on usual routine evaluation or that
for another disease
Development stages of HF
Stage A
at risk for HF but without structural heart disease or symptoms of HF
- hypertension,atherosclerotic disease, diabetes, obesity, metabolic syndrome
- use of cardiotoxins
- family history of cardiomyopathies
Stage B
Structural heart disease but without signs or symptoms of HF
- previous myocardial infarction (MI), LV remodeling including LVH and low
fraction (EF), asymptomatic valvular disease.
Stage C
Structural heart disease with prior or current symptoms of HF
- known structural disease
- shortness of breath (SOB), fatique and reduced exercise tolerance
Stage D
Refractory HF
- marked symptoms at rest despite maximal medical therapy
- required specialized interventions
DIAGNOSIS
The full evaluation of HF requires consideration of the underlying abnormality of the
heart, the severity of the syndrome, the etiology, precipitating and exacerbating factors,
identification of concomitant diseases relative to the management and estimation of
prognosis.
History
determine predisposition to risk factors especially in lifestyle (eg smoking, diet,
alcohol comsumption, substance abuse etc)
prior or current evidence of MI, valvular disease or congenital heart disease
Review patients history of hypertension, DM, dyslipidemia, valvular, coronary or
peripheral artery disease (PAD), exposure to cardiotoxic agents, rheumatic fever,
chest irradiation, illicit drug use, STDs, malignancies etc.
Detailed family history to determine familial predisposition to atherosclerotic
disease or cardiomyopathy.
Possible causes of HF that need to be investigated:
- coronary artery disease (CAD)
- cardiomyopathies (alcoholic and idiopathic)
- congenital heart disease
- chronic arrhythmias
- endocrine disorders (esp thyrotoxicosis)
- inflammatory/immunological
- genetic conditions
- HIV
- Hypertension
- Infections
- Malignancies
- Valvular heart disease
Identify and treat precipitating or exacerbating factors of HF:
- anemia
- arrhythmias, esp A-fib
- drugs (eg NSAIDs, calcium antagonists, corticosteroids, liquorice)
- excess salt intake
- infection
- pulmonary embolism
- renal dysfunction, renal artery stenosis
- silent MI
Physical exam
Abnormal physical findings in HF :
- presence of 3rd heart sound, S1<S2
- elevated jugular venous pressure
- irregular pulse, tachycardia
- positive hepato-jugular reflex
peripheral edema
pulmonary rales that do not clear with coughing
laterally displaced apical impulse
- ECG
- ECG changes are frequently found in HF patients
- will detect A-fib or flutter and ventricular arrhythmias as the cause or contributing factor of HF
- normal ECG suggests that HF may not be the cause of the patients symptoms
- Chest x-ray
- useful to detect cardiac enlargement and pulmonary congestion
Class II
- patient has slight limitation of physical activity
- they are comfortable at rest but ordinary physical activity results in discomfort
Class III
- patient has a marked limitation of physical activity
- they are comfortable at rest but less than ordinary activity leads to discomfort
Class IV
- the patient is unable to carry out any physical activity without discomfort
- symptoms are present at rest and any physical activity will cause an increase in
discomfort
ASSES PROGNOSIS
Prognostic Parameters
- decreasing LVEF
- worsening NYHA functional status
- degree of hyponatremia
- decreasing peak exercise oxygen uptake
- decreasing hematocrit
- widened QRS on 12-lead ECG
- chronic hypertension
- resting tachycardia
- renal insufficiency of failure
- intolerance to therapy
- refractory volume overload
- changes in sensorium
Once HF is advanced, estimated survival guide is useful for the timing of transplantation,
other treatments reserved for severe disease, or hospice care.
Medications
dosing, side effects and precautions should be discussed along with the
importance of compliance
assist patients in dealing with complicated drug regimens
patients should be counseled to avoid taking NSAIDs
- emphasize that NSAIDs should not be taken to suppress cough caused by ACE
inhibitors
NSAIDs can cause Na retention, peripheral vasoconstriction and can decrease the
efficacy and increase the toxicity of ACE inhibitors and diuretics
Activity
- if in a stable condition, patients should be encouraged to carry out daily physical
activity and leisure time activities that do not induce symptoms
- strenuous exercises, competitive and tiring sports should be discouraged
- discuss patients concern about sexual activity
- advice, if appropriate, concerning use of sublingual nitrates prior to sexual
intercourse
Lifestyle Modification
Diet modification
salt restriction
- moderate Na restriction is indicated to permit effective use of lower doses of
diuretics
- if possible, dietary Na should be restricted to 2g (-1/2tsp)
- advise patient to restrict adding salt and soya sauce to cooking, not to add extra
salt or soya sauce at the table and to avoid foods which are very high in salt
- controlling the amount of Na intake is more relevant in advanced HF
- salt substitutes may contain K and when used in large quantities can lead
tohyperkalemia
Weight control
obesity
- if patient is obese or overweight, then treatment should include weight loss
- goal BMI for Asian adult : 18.4 22.9 kg/m2, BMI for European adults : 18.5
24.9 kg/m2
- minimum reduction in overweight individuals is 5% reduction in body weight
Smoking cessation
assess patients tobacco use and strongly urge patient and family to stop
smoking
Prolonged therapy with Ramipril has been shown to lower the likelihood
of CV death, MI and HF
ACE inhibitors and beta-blocker should be used and maintained even once
the patient responds to the diuretic. Diuretics can cause activation of the renninangiotensin-aldosterone systemn in patients with mild symptoms of HF and
combination with ACE inhibitors counteract this neuro-hormonal activation.
Actions : increase urinary Na excretion and decrease physical signs of fluid retention
Effects : reduced jugular venous pressure, pulmonary congestion, peripheral edema and
body weight.
They are the only medications that can adequately control fluid retention of HF.
Thiazide Diuretics
thiazide diuretics may be sufficient for patients with mild HF
may be used in combination with loop diuretics for resistant edema
Loop diuretics :
*loop diuretics are usually necessary when HF worsens and as HF progresses higher
doses will be necessary especially if patient failed to respond to thiazide diuretics
Combinations
in patients with sinus rhythm digoxin may be used to improved status and
relieve symptoms in patients whose symptoms are not relieved with diuretics, ACE
inhibitors and beta-blockers.