Medicina

Tema: PATOLOGIA SISTEMULUI NERVOS CENTRAL

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PREPARATE MACROSCOPICE

Hematom cerebral
Tumor cerebral (glioblastom)
Hidrocefalie
Leptomeningit purulent

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PIESE MICROSCOPICE

68. Infarct ischemic cerebral (ramolisment cenuiu). Coloraie H-E

Indicaii:
1. Focar de necroz cu rarefierea esutului cerebral.
2. esutul cerebral adiacent cu edem i modificri distrofice.
45. Glioblastom multiform (coloraie H-E)
Indicaii:
1. Celule tumorale atipice i polimorfe.
2. Focare de necroz i hemoragii.
3. Stroma tumorii.
123. Meningiom fibroblastic (coloraie H-E)
Indicaii:
1. Fascicule de celule tumorale de tip fibroblastic.
2. Fascicule de fibre colagene.
225. Metastaze de melanom n creier (coloraie H-E)
Indicaii:
1. Nodulul metastatic constituit din celule tumorale bogate n melanin.
2. esutul cerebral adiacent cu ramolisment ischemic.

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PATHOLOGY OF THE CENTRAL NERVOUS SYSTEM

Microspecimens
68. Ischemic infarction in the brain (gray softening) (H.E. stain).
The earliest definitive microscopic signs of irreversible ischemic injury in the infract are
eosinophilic (red) neurons. It shows the loss basophilic staining (nucleic acids) and the
indistinctive cellular features. This process continues with increasing time so that all
distinct intracellular features are lost. One of the first changes after neuronal death (pink
neruons), is the pathy infiltration of inflammatory cells (green arrows), neurtrophils and
macrophages into the infarcted tissue.
45. Glioblastoma. (H.E. stain).
Histologically, it is formed by pleomorphic fusiform, polygonal or round cells, of
variable sizes, bizarre eosinophilic cells. The tumor is intensely cellularized. Giant cells
can be sporadically found. In some neoplasms, numerous mitoses have been detected, as
well as a certain tendency of perivascular palisade arrangement. Necrosis, hemorrhage,
cysts and edema are frequently found. At the periphery of necrosis, cells tend to arrange
in a palisade pattern. The tumor is well vascularised
123. Fibroplastic meningioma. (H.E. stain).
Microscopically, the tumor is characterized by an uneven structure, having a complex
appearance of endotheliomatous and fibromatous areas that can predominate
alternatively, from one case to another. The tumor can be dominated by polygonal
meningothelial cells, fusiform fibroblasts or a mixture of the two. These structures can be
whorled or fasciculate, with the presence of small aggregates and calcified cellular
remnants, psammoma bodies. Reticulin and collagen are in variable amounts, and
cartilaginous and/or bony metaplasias are not excluded
225. Metastases of melanoma in the brain (H.E. stain).
Microscopically, metastatic neoplastic nodule consists of large polygonal cells (or spindle
cells) that have very pleomorphic nuclei, irregularly shaped and has abundant
cytopolasmic melanin pigment. Adjacent surrounding tissue is softened because of
ischemia.

Macrospecimens

121) Brain hematoma

122) Brain tumor - glioblastoma
123) Hydrocephaly.
124) Purulent leptominengitis.