1-All of the following statements regarding verapamil are true EXCEPT:

Ans -It increases heart rate

2-All of the following statements regarding cardiac glycosides are true EXCEPT:
Ans -They decrease intracellular concentrations of calcium in myocytes
Or
Digoxin has a longer half-life than digitoxin
Or
They cause a decrease in vagal tone
Or
Amrinone

3-This drug is a selective beta-1 agonist:

Ans dobutamine
4-All of the following drugs are used in the treatment of severe congestive heart failure EXCEPT:
Ans verapamil
5-This drug is a Class IA antiarrhythmic drug:
Ans-Quinidine
6-This drug is an effective bronchodilator:
Ansnone of the above
7-All of the following are common adverse effects of calcium channel blockers EXCEPT:
Ans-Skeletal muscle weakness
8-This drug group useful in angina increase myocardial oxygen delivery (by reversing coronary
arterial spasm) and does not decrease myocardial oxygen requirement (by decreasing the
determinations of oxygen demand):
Ans-Myotropic coronary dilators (Dipyridamole
9-The following statements concerning mechanism of nitrate beneficial clinical effect are true,
EXCEPT?
Ans-Increased myocardial oxygen consumption
10-Which of the following antianginal agents is a myotropic coronary dilator:
Ans-Dipyridamole
11-This drug blocks alpha-1 adrenergic receptors:
Ans-Prazosin
12-This drug is a non-peptide angiotensin II receptor antagonist:
Ans-Losartan

13-Which of the following statements concerning nitrate mechanism of action is True?

Ans-All of the above
14-Duration of nitroglycerin action (sublingual) is:
Ans-10-30 minutes

15-Side effect of nitrates and nitrite drugs are, EXCEPT:

Ans-GI disturbance
16-Main clinical use of calcium channel blockers is:
Ans-a) Angina pectoris
b) Hypertension
c) Supraventricular tachyarrhythmias
d) All of the above

17-Which of the following statements concerning beta-adrenoceptor-blocking drugs are true:

Ans-Beneficial effects of these agents are related primarily to their hemodynamic effects
decreased heart rate,
blood pressure, and contractility which decrease myocardial oxygen requirements at rest
and during
exercise

18-All of the following are central acting antihypertensive drugs EXCEPT:

Ans=Minoxidil
19-This drug inhibits the angiotensin-converting enzyme:
Ans- Captopril
b) Enalapril
c) Ramipril
d) All of the above

20- All of the following are normally involved in the pathogenesis of heart failure EXCEPT:
Ans- A decrease in preload

21-The non-glycoside positive inotropic drug is:

Ans-Dobutamine

22-Choose the derivative of the plant Foxglove (Digitalis):

Ans-Digoxin

23-All of the following agents belong to cardiac glycosides EXCEPT:

Ans- They decrease intracellular concentrations of calcium in myocytes
Or
Digoxin has a longer half-life than digitoxin
Or
They cause a decrease in vagal tone
Or
Amrinone

24-All of the following statements regarding cardiac glycosides are true EXCEPT:
Ans- They cause a decrease in vagal tone

25-Compare the half-life of digoxin and the half-life of digitoxin:

Ans- Digitoxin is greater than digoxin

26=The manifestations of glycosides intoxication are:

Ans- Atrioventricular junctional rhythm
Second-degree atrioventricular blockade
Ventricular tachycardia
All the above

27=Drugs most commonly used in chronic heart failure are:

Ans- Cardiac glycosides
b) Diuretics
c) Angiotensin-converting enzyme inhibitors
d) All the above

28=This drug is a Class II antiarrhythmic drug:

AnsPropranolol

29-This drug is associated with Torsades de pointes.

Asn-Sotalol

30-This is a drug of choice for acute treatment of ventricular tachycardias:

Ans-Lidocaine

31-The calcium channel blockers have direct negative inotropic effects because they reduce the
inward movement of calcium during the action potential.
Ans- True

32-All of the following statements regarding verapamil are true EXCEPT:

AnsI already wrote in stating question (see ans)

33-Angina pectoris is:

Ans-Severe constricting chest pain, often radiating from the precordium to the left

shoulder and down the arm,

due to insufficient blood supply to the heart that is usually caused by coronary disease

34-This drug group useful in angina decreases myocardial oxygen requirement (by decreasing the
determinations of oxygen demand) and does not increase myocardial oxygen delivery (by reversing
coronary arterial spasm):
Ans-Beta-adrenoceptor-blocking drugs (Atenolol, Metoprolol

35-Pick out the diuretic agent for hypertension treatment:

ans- Dichlothiazide
36-This drug activates alpha-2 adrenergic receptors:
Ans-Clonidine
37-All of the following statements regarding angiotensin II are true EXCEPT:

Ans-Angiotensin I is almost as potent as angiotensin II

38- For increasing blood pressure in case of low cardiac output the following agents must be used:
Ans- Positive inotropic drugs
39-A 65-year-old woman has been admitted to the coronary care unit with a left ventricular myocardial
infarction. She develops acute severe heart failure with marked pulmonary edema, but no evidence of
peripheral edema or weight gain Which one of the following drugs would be most useful?
Ans- Furosemide

A.
B.
C.
D.
E.

Digoxin
Furosemide
Minoxidil
Propranolol
Spironolactone

40-A 60-year-old man presents to his primary care physician with a complaint of severe chest pain when
he walks uphill to his home in cold weather. The pain disappears when he rests. After evaluation and
discussion of treatment options, a decision is made to treat him with nitroglycerin. In advising the patient
about the adverse effects he may notice, you point out that nitroglycerin in moderate doses often produces
certain symptoms. Which of the following effects might occur due to the mechanism listed?
Ans-(D) Increased cardiac force
A.
B.
C.
D.
E.

Apnea due to cranial vasodilation

aDizziness due to reduced cardiac force of contraction
Diuresis due to sympathetic discharge
Headache due to meningeal vasodilation
Hypertension due to reflex tachycardia

41-A 45-year-old woman with hyperlipidemia and frequent migraine headaches develops angina of effort.
Which of the following is relatively contraindicated because of her migraines?
Ans-) Nitroglycerin
A. Amlodipine
B. Diltiazem
C. Metoprolol
D. Nitroglycerin
E. Verapamil
42A 5-year-old child is brought to the emergency department with sinus arrest and a ventricular rate of 35
bpm. An empty bottle of his uncles digoxin was found where he was playing.Which of the following is
the drug of choice in treating a severe overdose of digoxin?
Ans- Digoxin antibodies

A.
B.
C.
D.
E.

Digoxin antibodies
Lidocaine infusion
Magnesium infusion
Phenytoin by mouth
Potassium by mouth

43-A 73-year-old man with a history of falling at home is found to have moderately severe hypertension.
Which of the following drug groups is most likely to cause postural hypotension and thus an increased
risk of falls?
Ans- Alpha1-selective receptor blockers
A.
B.
C.
D.
E.

ACE inhibitors
ansAlpha-receptor blockers
Arteriolar dilators
Beta1-selective receptor blockers
Nonselective blockers