Tutor: Kevin Phan

Bio 93- O'Dowd, Warrior

OH: Fri. 1-3 PM, Nat Sci I 2108
phankt@uci.edu

Week 6 Worksheet

1. Piebald spotting is a condition found in humans in which there are patches of skin that lack
pigmentation. The condition results from the inability of pigment-producing cells to migrate
properly during development. Two adults with piebald spotting have one child who has the trait
and a second child with normal skin pigmentation.
a) Is the piebald spotting trait dominant or recessive? What information led you to this answer?

b) What are the genotypes of the parents?

2. The pedigree below traces the inheritance of alkaptonuria, a biochemical disorder. Affected
individuals, indicated here by the colored circles and squares, are unable to break down a
substance called alkapton, which colors the urine and stains body tissues. Does alkaptonuria
appear to be caused by a dominant allele or a recessive allele? Fill in the genotypes of the
individuals whose genotypes can be deduced. What are possible for each of the other
individuals?

Week 6 Worksheet

Tutor: Kevin Phan

Bio 93- O'Dowd, Warrior
OH: Fri. 1-3 PM, Nat Sci I 2108
phankt@uci.edu

3. Pseudohypertrophic muscular dystrophy is an inherited disorder that causes gradual

deterioration of the muscles. It is seen almost exclusively in boys born to apparently normal
parents and usually results in death in early teens.
a) Is this disorder caused by a dominant or a recessive allele? Is its inheritance sex-linked or
autosomal? How do you know?

b) Explain why this disorder is almost never seen in girls.

4. A wild-type fruit fly (heterozygous for gray body color and normal wings) was mated with a
black fly with vestigial wings. The offspring have the following phenotypic distribution shown
in Figure 1.

Figure 1: In the following chart, indicate which flies are the parental-type offspring and which
are recombinant type offspring.
Phenotype
Wild-type
Black vestigial
Black normal
Gray vestigial

# Offspring
778
785
158
162

Type of Offspring

a) What is the recombination frequency between these genes for body color and wing type?

b) How many map units apart are these two genes?

Tutor: Kevin Phan

Bio 93- O'Dowd, Warrior
OH: Fri. 1-3 PM, Nat Sci I 2108
phankt@uci.edu

Week 6 Worksheet

5. Genes A, B and C are located on the same chromosome. Testcrosses show that the recombination
frequency between A and B is 28% and between A and C is 12%. Can you determine the linear order of
these gene? Explain.

6. Given the following recombination frequencies, what is the correct order of genes on the
chromosome? A-C = 10%, B-C = 6%, A-B = 15%
a. ACB
b. ABC
c. CAB
d. BAC
e. CBA
7. A man who carries an X-linked allele will pass it on to
a. all of his daughters.
b. half of his daughters.
c. all of his sons.
d. half of his sons.
e. all of his children.
8. Colorblindness is a recessive, sex-linked, trait in humans. A colorblind woman marries a
normal man. What percentage of their children will likely be colorblind?
a. 0%
b. 25%
c. 50%
d. 100%
e. 75%

9. In humans, male-pattern baldness is controlled by a gene that occurs in two allelic forms.
Allele Hn determines nonbaldness, and allele Hb determines pattern baldness. In males, because
of the presence of testosterone, allele Hb is dominant over Hn. If a man and woman both with
genotype HnHb have a son, what is the chance that he will eventually be bald?
a. 0%
b. 25%
c. 33%
d. 50%
e. 75%