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150 mg
300 mg
175 mg
225 mg
175 mg
Pharmacology
Erdosteine pharmacologically acts as a bronchial mucus fluidifying agent.
Pharmaco-therapeutic
Erdosteine is classified under the mucolytic drugs.
Pharmacodynamic
Erdosteine besides its property of fluidifying bronchial mucus thus facilitating
expectorations, shows effects as antagonizing the formation in loco of free radicals and
ascontrasting the action of elastase enzyme.
From pharmacological studies results that Erdosteine, as such, does not posses these
properties but only after metabolization, into active metabolites which have the chemical
SH groups. These metabolits break the SH groups and bringing about a reduction in the
mucus elasticity and viscosity thus facilitating the expectoration.
The chemical SH groups, distinctive of this activity, are chemically blocked and become
Erdosteine is rapidly absorbed after oral administration, after a single oral dose,
the T max is 1.2 hours.
Erdosteine rapidly metabolized into at east 3 active metabolites containing free
thiol groups, which tentatively are : N-thioglycolyl-homocysteine (metabolite I), Nacetyl-homocysteine (metabolite II), and homocysteine (metabolite III). The
elimination half-life of erdosteine is 1.4 hours on the average, and that of the
Indications
Mucolytic, fluidifying agent in acute and chronic airways affections.
Dosage
Capsule 150 : 1 2 capsules, 2 3 times a day.
Capsule 300 : 1 capsule, 2 3 times a day.
Granule 175 : Children 15 19 kg : 1 sachet, 2 times a day.
Children 20 30 kg : 1 sachet, 3 times a day.
Children > 30 kg and adults : 2 sachets, 2 times a day.
Granule 225 : 1 sachet, 2 3 times a day.
Dry Syrup : Children 15 19 kg : 5 ml, 2 times a day.
Children 20 30 kg : 5 ml, 3 times a day.
Children > 30 kg and adults : 10 ml, 2 times a day.
Overdose :
With dosages exceeding the suggested ones (900 mg/die) : sweating, vertigo and flushing have
been observed.
Warnings and Precautions :
-
The product in granulates (sachet and suspensions) contains sucrose, keep this into
Phenylketonuria, due to the presence of aspartame, only for the granulate in sachets and
for suspension.
In patients with severe renal failure (creatinine clearance < 25 ml/min).
Drug Interaction
No interactions have been observed with other medicaments and the drug can be administered
together with antibiotics, bronchodilators (theophylline, 2 mimetics, cough sedatives, etc).
Packaging
VECTRINE Capsule 150 : Box, 2 blisters @ 10 capsules.
VECTRINE Capsule 300 : Box, 2 blisters @ 10 capsules.
VECTRINE Granule 175 : Box @ 30 sachets.
VECTRINE Granule 225 : Box @ 30 sachets.
VECTRINE Dry Syrup : Box, 1 bottle @ 60 ml.
Manufactured by :
DEXA MEDICA
Jl. Bambang Utoyo 138
Palembang - Indonesia