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Chien-Chun Yang

5113 Whitman Way Apt 201 Carlsbad, CA 92008 | 562-338-6525 | chien.yang1984@gmail.com

1.2 years experience in Medical/BioMedical equipment/device company; responsible for hardware
and circuit design, testing and verification, FPGA testing/verification, ElectroOptic testing and
signal analysis and algorithm development for flow cytometry and cell sorter.
2.3 years experience in FDA regulated medical device company; responsible for hardware and
circuit testing and verification, developing DSP and feature extraction/analysis, machine learning
algorithms, mathematical modeling, regression and optimization to analyze/modeling/diagnose
diseases from biosignals.
Experience using hardware, circuit knowledge, LabVIEW and C/C++ to design HMI and build
working console station for industrial grade automation machine and cell sorter.
Embedded projects using microcontroller and bandpass filter design using FPGA.
3 years experience in Medical Image Processing/Analysis, pattern recognition, features
extraction/analysis, image descriptors, computer vision and machine learning techniques.
3 years experience with ultrasound and high resolution DICOM medical images (CT and MRI)
analysis using computer vision and machine learning techniques.
Experience of operating high power uCT to acquire high resolution breast cancer tissue and DCIS
Familiar with Medical Imaging Modalities such as Ultrasound, CT, MRI, fMRI and uCT.
Background in Electrical Engineering with experiences in electronic circuits, hardware
testing/verification, DSP, Digital Image Processing, Digital Logic Design and FPGA.
Familiar with Digital Filter Design and experiences with Texas Instrument DSP chip and FPGA.
Completed Pre-Med and advanced Human Physiology and Pathology courses.
Technical abilities including:
Program/Design Skills/Languages: VHDL, Verilog, C/C++/C#/Java/AForge.NET, MATLAB,
LabVIEW, OpenCV, OpenGL, Python, Assembly
Electrical Engineering Software: Xilinx ISE and System Generator, Altera Quartus II,
ModelSim, SPICE, Texas Instrument CCStudio, MATLAB/Simulink, LabVIEW, Keil uVision, Electronics
Workbench Multisim, CodeBlock, Eclipse
Precise/Accurate communication, solid skills for testing, verification and detailed documentation.
Strong scientific/research attitudes and logical thinking and professional at experiment
Languages: English, Mandarin Chinese, Basic German and Japanese

FPGA testing and verification using VHDL and ModelSim. Digital Logic Design, Digital Signal
Processing, Filter Design, Texas Instrument DSP chip.
Digital Image Processing, filtering, compression, image reconstruction, segmentation, edge
detection, 2D wavelet transform, image features/descriptors extraction.
Computer Vision, machine learning (SVD, PCA, Decision Tree, SVM, k-NN, feature selection,
regularization, lasso and elastic net), pattern recognition, feature extraction/analysis,
clustering, classification, and mix-effect, panel regression modeling.
Mathematical modeling (fix-effects and mixed-effects), regression and optimization with linear
& nonlinear constraints.
Analog circuits, passive and active filters, OpAmp Circuit testing and verification.
Medical Imaging: Computer Tomography, MRI, Acoustic Ultrasound and Ultrasound Imaging.


University of Rochester Rochester, NY
Master of Science in Biomedical Engineering May 2013
Interdisciplinary with Electrical Engineering in DSP and Digital Logic Design using FPGA
Concentration in Medical Imaging, Medical Image Analysis using Machine Learning and
Computer Vision
Tuition Scholarship (Merit-Based) Recipient
National Tsing Hua University Hsinchu, Taiwan
Graduate Education in Biomedical Engineering August 2009
Bio-Optics, Laser Tweezers, Total Internal Reflection Fluorescence (TIRF) Microscopy
California State University, Long Beach Long Beach, CA
Bachelor of Science, Dual Major in Electrical Engineering and Biomedical and Clinical
Engineering December 2008
Concentration in DSP, Medical Instrumentation and Pre-Medical
Presidents Honor List for Excellence High Scholastic Achievement
Deans Honor List for Excellence High Scholastic Achievement
Who's Who Among Students In American Universities and Colleges
Henry Pettus Randall Scholarship


NanoCellect Biomedical, Inc., Electrical/Software Engineer Nov 2015 Present
Work with Senior Engineers to research and develop flow cytometry and cell sorter machine. Job
duty includes but not limit to:
Review, Test and Verify VHDL for FPGA applications for cell sorter machine.
Review, Test and Verify Analog Circuitry for Photon Multiplier Tube (PMT) signal detection
including 24-Bit AD7768 ADC, Active LPF, HPF, BPF, transimpedance/transconductance
amplifier, Voltage-Controlled Oscillator, Sallen Key Filter, Darlington Pair, Sziklai Pair, Baseline
Restore Circuit, Envelop and Peak Detector for cell sorter machine.
Supervise/mentor interns and junior engineers to develop signal/data analysis protocols and
image processing algorithms (sobel filter, laplacian filter, edge detection, etc) to achieve
microfluidic chip auto alignment and laser alignment.
Implement optic spillover/crossover compensation and verifications algorithms in JAVA.
Use optic devices/components to verify LASER spec: Beam Profiler, Power Meter, PMTs, dichroic
mirrors, lens, neutral density filters, etc.
Use statistic modeling (e.g. Poisson) methods for cell sorter and electro-optic signal analysis
and verification, and mentor coworkers for data analysis and unsupervised learning.
Design/Maintain, Test/Verify the protocol/procedures for the design and workflow of cytometry
and cell sorter during R&D phases.
Introduce and establish the standard operation procedure/protocol to the company to manage
the R&D phase, progress and ensure the smoothness and seamless workflow.

Intersection Medical, Inc., Product Development R&D Electrical EngineerAug 2013 Oct
Work with Senior Engineers and Research Scientists to research and develop medical device
monitoring and detecting pulmonary edema and congestive heart failure. Job duty includes but not
limit to:
Simulate and construct bioimpedance/bioelectrical resistivity mathematical model,
Bioimpedance Image and Electrical Resistivity Tomography, using Wenner-Schlumberger array
technique and perform biosignal analysis.
Simulate and verify the tetrapolar in-phase/in-quadrature sine correlator for bioimpedance
measurement in both hardware and software.
Design and verify Analog Filters (Passive, Active, LPF and HPF) and simulate Multi-Stage/Multi-
rate Digital Filters (LPF, BPF, CIC, Half-Band, Moving Average and DC Removal Filters).
Test and verify the designed medical device, the associated electronic circuitry (Howland
Current Source), signal integrity and GUI. Board Bring-up, writing and maintaining detailed V&V
procedures, protocol and documentation.
Tremendous data mining, high dimensional feature extraction, selection and analysis from raw
human biosignal data.
Develop Algorithms using but not limit to: 3D interpolation, regression, fix-effect and mixed-
effect modeling, SVD, PCA, feature selection, Lasso and Elastic Net regularization, k-means
clustering, Decision Tree, SVM, Logistic Regression, linear and non-linear constrained
optimization to solve ill-posed inverse problem.
Process and analyze the acquired bioimpedance signals using machine learning techniques to
construct mathematic models to aid clinical/diagnostic interpretation.
Help setup the medical device testing protocols, Safety Protocol Compliance (IEC 60601-1 and
IEC-60601-2 for Medical Electrical Equipment regulation), Quality Collaboration by Design
Design and perform in-vivo experiments to acquire bioimpedance signals from human subjects.

University of Rochester Medical Center: Department of Radiology and Imaging Sciences

Rochester Center for Brain Imaging Rochester, NY
M.S. and Research Associate under Dr. Axel Wismueller Radiologist, M.D., PhDSept
2010 Aug 2013
Develop computational visualization methods for the exploratory analysis of high-dimensional data
from biomedical imaging. Research to develop robust and adaptive systems for computer-aided
analysis and visualization with pattern recognition, machine learning and image
processing/computer vision approaches. Application areas range from fMRI, MRI mammography
and Computer Tomography. Use computational radiology to help bridge the gap between
fundamental engineering research and clinical practice.
Development of Pseudo (Virtual) Mammography from Breast MRI: Utilize image
processing techniques such as 3D Perspective Reconstruction, Filtering, Region Growing,
Segmentation, Otsu's Method, K-means, Edge Detection and Morphological methods to develop
algorithms transforming Breast MRI to Pseudo (Virtual) Mammography.
Segmentation MRI Breast Lesion using Fuzzy C-Means: Experience with Fuzzy C-Means
clustering and Connected Components labeling to segment MRI Breast Lesion regions.
Scalogram and Sonoelastography: Application of 2D wavelet transform and scalogram to
create sonoelastography to detect stiff region of ultrasound images.
Predicting Biomechanical Strength of Proximal Femur with Bone Mineral Density
Features and Support Vector Regression: Predicting Femur bone strength using Multiple
Detector Computer Tomography and Feature Extraction/Analysis with Machine Learning/Vision
techniques to improve Computer-Aided Diagnosis.
Clinical Implementation of Micro-CT for Intra-Operative Guidance in Oncoplastic
Resections of Breast Cancer: To provide intraoperative feedback to breast surgeon on
locations of the positive/close margins in the lump of tissue excised during lumpectomy, thus
allowing for prompt re-excision during the same procedure and prevent additional surgery
(presently in 3050% range), we designed, constructed and started testing a device for micro-
CT and micro-MRI imaging of lumpectomy specimens. We performed micro-CT imaging of
lumpectomy specimen phantom and determined the positive/close margin localization errors.
We conclude that it could be possible to provide intraoperative feedback to surgeon allowing
immediate correction of the problem without the need for an additional surgery days later.

Department of Biomedical Engineering, University of Rochester, Teaching Assistant

Fall 2012
BME SIGNALS, SYSTEMS AND IMAGING. Help and provide guidance to students building electronic
circuit and use sensors, transducers and Op-Amp to measure vital signs and bio-signals.

Industrial Technology Research Institute, Engineer, Research & Development2009

ITRI is a national research organization, with a mission of conducting technological research,
promoting industrial development, creating economic value and improving social welfare for
Taiwan. ITRI is Taiwan's largest applied technology R&D institution and also a pioneer in creating
Taiwan's high tech industry.
Develop and Integrate HMI, remote thermal sensor, 6-axis servo motors, hardware and
communication protocols to control and monitor Injecting Molding/Automation Machine.
Designed/assembled Working Console station and Human Machine Interface for Industrial Level
Automation Machine/Injection Molding Machine using LabVIEW and C/C++.
Utilized Motion Control Chip to control multi-axes Servo Motors and Azbil(Yamatake) Single-Loop
Controller to control and monitor thermocouples.
Conducted research on RS-232, RS-485, Ethernet, EtherCAT communication interface and
protocols, as well as IEEE 802.3 and IEEE 1588 Standards.

Department of Electrical Engineering, California State University, Long Beach, Teaching

Assistant Fall 2008
Digital Signal Processing for Multimedia Communication. Help and provide guidance to students to
design a Bandpass filter using FPGA with Xilinx System Generator and to achieve
software/hardware co-simulation using Simulink.


Transmitting IP Camera Image captured by VGA from FPGA through Ethernet
incorporated with OpenCV Face Detection: Integrate FPGA's Ethernet and VGA modules
with IP Camera to achieve Human Face Detection.
FPGA Design Projects: Use FPGA to interface with LCD, RS-232, PS/2, VGA, AD9980, DVI,
Chrontel and BRAM.
DSP Chip Design using TI CCStudio: Simulate FIR and IIR filters and implement Complex
Number operation.
DSP Design using FPGA: Use Simulink and Xilinx FPGA as software/hardware co-simulation
to design Bandpass Filter.
Filter Design: FIR Filter, Windowed Filter, Smooth Filter and Butterworth Filter.
ECG Amplifier and Audiometer: Use electronic components to build ECG Amplifier and
Three-Step Polygraph/Lie Detector: Integrate ECG Monitor, Pulse Rate Monitor, Galvanic
Skin Resistance Monitor.
Design of a Modular Thermal Cautery Surgical Equipment: Use electronic components to
build Thermal Cautery Surgical Equipment.
Atmel T89C51AC2 microprocessor Route-tracking Vehicle: Build an IR sensors route-
tracking vehicle using microcontroller.
Comparison of Parallel MRI Reconstruction Methods for Accelerated 3D Fast Spin-
Echo Imaging: Literature review and presentation of accelerated pulse sequences patterns
that benefits 3D MRI Reconstruction.
Microbubble-Aided Focus Ultrasound Disruption of the BloodBrain Barrier in
Assisting Drug Delivery for Alzheimer Treatment: Analysis of Secure Ultrasound field
configurations for stable cavitation with microbubble to achieve Alzheimer drug delivery.
Local Frequency Estimation of Ultrasound Shear Wave Phantom with Different
Methods Approach: Use Short-Time Fourier Transform and 2D Wavelet Transform, Time-
Frequency Analysis, Time-Scale Analysis and Elastogram to detect stiff region of ultrasound
Brain fMRI and DTI-MRI Analysis: Used FSL, Diffusion Tensor Tool Kit and TrackVis to analyze
brain fMRI images.


Predicting the Biomechanical Strength of Proximal Femur Specimens with Minkowski Functionals
and Support Vector Regression. SPIE Medical Imaging, February 2014, San Diego, CA.

Method and device for intraoperative imaging of lumpectomy specimens to provide feedback to
breast surgeon for prompt re-excision during the same procedure. SPIE Medical Imaging, February
2014, San Diego, CA.

Improving bone strength prediction in human proximal femur specimens through geometrical
characterization of trabecular bone microarchitecture and support vector regression. Journal of
Electronic Imaging. February 2014.

Evaluating Proximal Femur Bone Strength Prediction by Advanced Characterization of Trabecular

Microarchitecture Using Scaling Index Computation and Support Vector Regression. RSNA
Conference, December 2013, Chicago, IL.

Predicting the Biomechanical Strength of Proximal Femur Specimens through High Dimensional
Geometric Features and Support Vector Regression. SPIE Medical Imaging, February 2013, Orlando,

Biomechanical Strength Prediction of Proximal Femur Specimens through Bone Mineral Density
Characterization Combined with Support Vector Regression. RSNA Conference, November 2012,
Chicago, IL.
Phase Contrast Computed Tomography: Classification of Osteoarthritic and Healthy Chondrocyte
Patterns in Human Patella Cartilage through Local Scaling Properties. (Presenter) RSNA Conference,
November 2012, Chicago, IL.

Bone Mineral Density Features and Support Vector Regression for Predicting the Biomechanical
Strength of Proximal Femur Specimens. Center for Emerging Innovative Science Conference, April
2012, Rochester, NY.

Predicting the Biomechanical Strength of Proximal Femur Specimens with Bone Mineral Density
Features and Support Vector Regression. SPIE Medical Imaging, February 2012, San Diego, CA.

Characterization of healthy and osteoarthritic chondrocyte cell patterns on phase contrast CT

images of the knee cartilage matrix. SPIE Medical Imaging, February 2012, San Diego, CA.

Design of a Modular Thermal Cautery Surgical Equipment. 11th IEEE BME Bio-Tech Contests. Spring
2009, Long Beach, CA. (1st Place Award)

Application of Pressure and Humidity Sensors in Prevention of Pressure Ulcers for Wheelchair
Users. 11th IEEE BME Bio-Tech Contests. Spring 2009, Long Beach, CA. (4th Place Award)

Principles and Applications of Synchrotron Radiation. High School Scientific Contest Exhibition.
1998 Taipei, Taiwan. Honorable Research Award.