HYDERABAD INSTITUTE OF EXCELLENCE

JEE MAINS : HIGH DEPENDENCY QUESTIONS

CHEMISTRY IN EVERYDAY LIFE
I - DRUG CLASSIFICATION & DRUG ACTION

01. Select the correct statements

(A) Drugs are chemical of low molecular mass (B) Drugs produce Biological response
(C) Drugs which are used to threat diseases are called medicines (D) All are correct
02. Substrates bind to the active sites of an enzyme by interactions like
(A) ionic bonding (B) H-bonding
(C) Vanderwaals interacting (D) All
03. Receptors are
(A) Proteins (B) Lipids (C) Carbohydrates (D) Nucleic acids
04. The source of receptor proteins is in
(A) Interior of a cell (B) Cell wall
(C) Out of cell wall
(D) Fixed in the cell wall partially inside and partially projected outward
05. Drugs which supplement (or) substitute for chemical messengers are
(A) Antagonists (B)Agonists
(C) Blocking chemicals (D) All
06. Drugs that bind to the receptor site and inhibits its natural function are called
(A) Agonists (B) Antagonists (C) Blocking chemicals (D) All
07. The most useful classification of drugs for medicinal chemists is _________.
(A) on the basis of chemical structure. (B) on the basis of drug action.
(C) on the basis of molecular targets. (D) on the basis of pharmacological effect.
08. Drugs are classified based on
(i) drug action (ii) molecular targets
(iii) chemical reactions (iv) chemical structures
(A) (i), (ii) and (iv) (B) (i), (ii) and (iii)
(C) (ii), (iii) and (iv) (D) (i), (iii) and (iv)
09. Select the correct statement
(A) Enzymes are proteins in Nature and are biological catalysts
(B) Proteins which help in communication system are called receptors
(C) Polar molecules across the cell membrane are called carrier (D) all are correct
10. In the body message between two neurons and that between neurons to muscles is communicated
through certain chemical substances. These chemical substances are called
(A) Receptors (B) Agonists
(C) Chemical messengers(D) Antagonists
11. Which of the following is not a target molecule for drug function in body?
(A) Carbohydrates (B) Lipids (C) Vitamins (D) Proteins
12. Which of the following statements is not true about enzyme inhibitors?
(A) Inhibit the catalytic activity of the enzyme.

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(B) Prevent the binding of substrate.

(C) Generally a strong covalent bond is formed between an inhibitor and an enzyme.

(D) Inhibitors can be competitive or non- competitive.

13. Match the class of compounds given in Column I with their functions given in Column II.

Column I Column II

(i) Antagonists (a) Communicate message between two neurons and that between neurons to
muscles

(ii) Agonists (b) Bind to the receptor site and inhibit its natural function

(iii) Chemical messenger (c) Crucial to bodys communication process

(iv) Inhibitors (d) Mimic the natural messenger

(v) Receptors (e) Inhibit activities of enzymes

14. Which of the following statements are incorrect about receptor proteins?

(A) Majority of receptor proteins are embedded in the cell membranes.

(B) The active site of receptor proteins opens on the inside region of the cell.

(C) Chemical messengers are received at the binding sites of receptor proteins.

(D) Shape of receptor doesnt change during attachment of messenger.

Assertion and Reason Type :

(i) Assertion and reason both are correct statement but reason does not explain assertion.

(ii) Assertion and reason both are correct and reason explains the assertion.

(iii) Both assertion and reason are wrong statement.

(iv) Assertion is correct statement reason is wrong statement.

(v) Assertion is wrong statement reason is correct statement.

15. Assertion : Receptors are crucial to bodys communication process.

Reason : Receptors are proteins.

16. Assertion : Enzymes have active sites that hold substrate molecule for a chemical reaction.

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Reason : Drugs compete with natural substrate by attaching covalently to the active site of enzyme.

17. Assertion : Chemical messengers are chemicals that enable communication of message between two
neurons or between neurons and muscles.

Reason : Chemicals enter the cell through receptor.

18. Assertion : Competitive inhibitors compete with natural substrate for their attachment on the active sites
of enzymes.

Reason : In competitive inhibition, inhibitor binds to the allosteric site of the enzyme.

19. Assertion : Non-competitive inhibitor inhibits the catalyic activity of enzyme by binding with its

19. Assertion : Non-competitive inhibitor inhibits the catalyic activity of enzyme by binding with its active
site.
Reason : Non-competitive inhibitor changes the shape of the active site in such a way that substrate cant
recognise it.
20. Assertion : Chemical messenger gives message to the cell without entering the cell.
Reason : Chemical messenger is received at the binding site of receptor proteins.
21. Assertion : Receptor proteins show selectivity for one chemical messenger over the other.
Reason : Chemical messenger binds to the receptor site and inhibits its natural function.

II (ANT ACIDS & ANTIHISTAMINES)

01. The chemicals that remove excess acid in the stomach and maintain the pH to normal levels are
called
(A) antibiotics (B) antiseptics (C) antacids (D) analgesics
02. Which of the following is not used as antacid
(A) Ampicillin (B) Ranitidine (C) Cimetidine (D)
03. The compound that cannot acts as an antacid is
(A) (B) (C) NaOH (D)
04. Which of the following antacid is used to prevent the interaction of histamine with the receptors
present in the stomach wall, which results in release of lesser amount of acid.
(A) (B) Cimetidine
(C) Sodium hydrogen carbonate (D) All
05. Among the following which is not antacid ?
(A) Histamine (B) Cimetidine (C) Ranitidine (D) Zantac
06 Which one of the following stimulates the secretion of pepsin and HCl in the stomach ?
(A) Microbials (B) Histamine (C) Antibiotics (D) Antacids
07 Terfenadine is commonly used as a / an
(A) Antimicrobial (B) Antibiotic (C) Antihistamine (D) Tranquilizer
08. Which of the following compounds are administered as antacids ?
(A) Sodium carbonate (B) Sodium hydrogencarbonate

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(C) Aluminium carbonate (D) Magnesium hydroxide
09. Amongst the following antihistamines, which are antacids ?
(A) Ranitidine (B) Brompheniramine (C) Terfenadine (D) Cimetidine
III -NEUROLOGICAL ACTIVITY DRUGS

(Tranquilizers)

01. Hypnotics are sleep producing drugs. Among the following the hypnoticdrug(s) is/are
(A) Barbiturates (B) Valium (C) Serotonin (D) All of these
02. Among the following which is a Tranquilizer
(A) Nardil (B) Chlordiazepoxide (C) Equanil (D) All of these
03. The compounds such as Luminol and seconal, which act as tranquilizers are obtained from
(A) Salicylic acid (B) Opium poppy (C) Barbituric acid (D) P-Nitrophenol
04. Which of the following drug is used in controlling depression and hyper tension ?
(A) Chlorodiazepoxide (B) Mepro bamate (C) Equanil (D) Nardil
05. Which of the following statements is correct?
(A) Some tranquilisers function by inhibiting the enzymes which catalyse the
degradation of noradrenaline.
(B) Tranquilisers are narcotic drugs.
(C) Transquilisers are chemical compounds that do not affect the message transfer from nerve to
receptor.
(D) Tranquilisers are chemical compounds that can relieve pain and fever.
06. The compound that causes general antidepressant action on the central nervous system belongs to
the class of ______.
(A) analgesics (B) tranquilizers (C) narcotic analgesics (D) antihistamines
07. Which of the following are antidepressants?
(A) Iproniazid (B) Phenelzine (C) Equanil (D) Salvarsan
08. Veronal and luminal are derivatives of barbituric acid which are __________.
(A) Tranquilizers (B) Non-narcotic analgesic
(C) Antiallergic drugs (D) Neurologically active drugs
09. Which of the following statements are correct about barbiturates?
(A) Hypnotics or sleep producing agents. (B) These are tranquilizers.
(C) Non-narcotic analgesics.
(D) Pain reducing without disturbing the nervous system.

Analgesics)

01. Paracetamol is a/an

(A) Antibiotic (B) Analagesic (C) Transquiliser (D) Anti Histamine
02. A chemical that reduces (or) totally abolishes pain without causing disturbances of nervous system
is known as
(A) antibiotic (B) Tranquilizer (C) antiseptic (D) Analagesic

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03. Analagesics such as morphine, codene etc, are chiefly used for the relief of
(1) Post operative pain (2) Cardiac pain (3) Cancer pain (4) Headache
The correct one is
(A) 1, 2, 3 (B) 2, 3, 4 (C) 1, 3, 4 (D) 3, 4, 1
04. The set of the following drugs isolated from opium poppy is
(1) Morphene (2) Codeine (3) Aspirin (4) Papaverine
The correct one is
(A) 1, 2 and 3 (B) 2, 3 and 4 (C) 1, 3 and 4 (D) 1, 2 and 4
05. Which of the following is an antipyretic ?
(A) Quinine (B) Luminal (C) Paracetamol (D) Piperazine
06. A drug that is antipyratic as well as analgesic is
(A) Chloroquin (B) Pencillin (C) Paracetamol
(D) Chloro promazine hydrochloride
07. Which statement about aspirin is not true
(A) Aspirin belongs to narcotic analgesics. (B) It is effective in relieving pain.
(C) It has antiblood clotting action. (D) It is a neurologically active drug.

IV (Anti microbials)

Antibiotics

01. The chemical compounds which are produced by micro organism like bacteria, fungi and mould
and inhibit the growth of micro organisms are called
(A) Antipyratics (B) Antiseptics (C) Antibiotics (D) Tranquilizers
02. Which of the following is an antibiotic ?
(A) Tetramycin (B) Aspirin (C) Paracetamol (D) Zantac
03. Ampicillin is
(A) an analagesics (B) an antibiotic (C) an antipyretic (D) an anti histamine
04. Arsenic containing medicine used for the treatment of syphilis is
(A) Erythromycin (B) Ofloxacin (C) Salvarsan (D) Penicillin
05. Antiseptic chloroxylenol is
(A) 4-chloro-3, 5-dimethyl phenol (B) 3-chloro-4, 5-dimethyl phenol
(C) 4-chloro-2, 5-dimethyl phenol (D) 5-chloro-3, 4-dimethyl phenol
06. Which one of the following is not a broad spectrum antibiotic ?
(A) Tetracycline (B) Chloram pheniol (C) Pencillin (D) All of these
07. Which of the following is a Bacterostatic ?
(A) Pencillin (B) Erythromycin (C) Amino glycoside (D) Ofloxacin
08. Which of the following is not true for antibiotic ?
(A) Tetracycline is one of the broad spectrum antibiotics which is effective against a large number of
harmful micro organisms
(B) Streptomycin is highly effective against micro organisms which cause Tuberculosis
(C) Penicillin has a narrow spectrum and certain persons are sensitive to it
(D) Pencillin, may be administered without testing the patients for sensitivity to it

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09. Select the incorrect statement.
(A) Bactericidal antibiotics are those which kill the microbes
(B) Bacterio static antibiotics are those which inhibits the growth of microbes
(C) Ofloxacin is the bactereostatic antibiotic (D) Pencillin is bactericidal
10. Which of the following are showing structural similarities with Salvarsan
(A) Prontosil (B) azodye (C) sulphanilamide (D) both (A) & (B)
11. Salvarsan is arsenic containing drug which was first used for the treatment of ________ .
(A) syphilis (B) typhoid (C) meningitis (D) dysentry
12. A narrow spectrum antibiotic is active against ____ .
(A) gram positive or gram negative bacteria (B) gram negative bacteria only.
(C) single organism or one disease. (D) both gram positive and gram negative bacteria.
13. Which of the following are sulpha drugs?
(A) Sulphapyridine (B) Prontosil (C) Salvarsan (D) Nardil
14. Assertion : Penicillin (G) is an antihistamine
Reason : Penicillin (G) is effective against gram positive as well as gram negative bacteria.
15. Assertion : Sulpha drug contain sulphonamide group.
Reason : Salvarsan is a sulpha drug.
16. Which of the following statements are incorrect about penicillin?
(A) An antibacterial fungus (B) Ampicillin is its synthetic modification.
(C) It has bacteriostatic effect (D) It is a broad spectrum antibiotic

Antiseptics and disinfectant)

01. The chemical compound that kill (or) prevent the growth of microorganisms are called
(A) Antipyretics (B) Analagesics (C) Antiseptics (D) Antacids
02. Antiseptic dettol is a mixture of
(A) Chloroxylenon and Terpeneol (B) Bithionol and Terpineol
(C) Chloroxylenon and Bithionol (D) Terpineol and formaldehyde
03. Phenol can be used as
(A) Anitmicrobial (B) An antiseptic (C) A disinfectant (D) All of these
04. Bithionol is an example of
(A) Disinfectant (B) Antiseptic (C) Antibiotic (D) Analgesic
05. Which of the following statements is not true ?
(A) Some disinfectants can be used as antiseptic at low concentration
(B) Sulphadiazine is a synthetic anti bacterial
(C) Aqueons solution of boric acid is used as disinfectent
(D) Aspirin is analgesic and antipyratics
06. Tincture of Iodine is
(A) Aqueous solution of (B) Alcoholic solution of
(C) Solution of in aqueous KI (D) Aqueous solution of
07. Which of the following statements is not correct ?

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(A) Some antiseptics can be added to soaps.
(B) Dilute solutions of some disinfectants can be used as antiseptic.
(C) Disinfectants are antimicrobial drugs.
(D) Antiseptic medicines can be ingested.
08. Match the classes of drugs given in Column I with their action given in Column II.
Column I Column II
(i) Analgesics (a) Inhibit the growth of microorganisms can be given orally
(ii) Antiseptics (b) Treatment of stress
(iii) Antihistamines (c) Applied to inanimate objects
(iv) Antacids (d) Prevents the interaction of histamine with its receptor
(v) Tranquilisers (e) Pain killing effect
(vi) Antibiotics (f) Applied to diseased skin surfaces
(vii) Disinfectants (g) Treatment of acidity
09. Compounds with antiseptic properties are _________.

(A)
CHCl3 (B)
CHI3 (C) Boric acid (D) 0.3 ppm aqueous solution of

ANTIFERTILITY DRUGS)

01. Estrogen and progestrerone are ___________

02. The hormones that suppresses ovulation is ___________
03. Norenthindrone is _______________
04. Norestrol is ____________
05. Which is the correct statement about birth control pills?
(A) Contain estrogen only.
(B) Contain progesterone only.
(C) Contain a mixture of estrogen and progesterone derivatives.
(D) Progesterone enhances ovulation.
06. Which of the following are anti-fertility drugs ?
(A) Estrogen (B) Norenthindrone (C) Ethynylestradiol (D) Furacine

VI CHEMICALS IN FOOD

01. Which one of the following sweeteners cannot controll the taste in food ?
(A) Saccharin (B) Alitame (C) Sucralose (D) Asparatome
02. The most sweetener of the following is
(A) Alitame (B) Saccharin (C) Sucrolose (D) Aspartame
03. Among the following sweeteners the compound that contains group is
(A) Saccharin (B) Alitame (C) sucralose (D) Aspertame

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04. The artificial sweetener containing chlorine that has the appearance and taste as that of sugar and
is stable at cooking temperture is
(A) Aspartame (B) Saccharin (C) Sucrolose (D) Alitame
05. Salts of sorbic acid and propionic acid are used as
(A) food preservatives (B) antioxidants
(C) flavouring agents (D) all of these
06. Choose the correct statement.
(A) Saccharin is 650 times sweeter than sugar
(B) Alitame is 2000 times sweeter than sugar
(C) Sucralose is 160 times sweeter than sugar
(D) Aspartame is 550 times sweeter than sugar
07. Which of the following chemicals can be added for sweetening of food items at cooking temperature
and does not provide calories ?
(A) Sucrose (B) Glucose (C) Aspartame (D) Sucrolose
08. Which of the following will not enhance nutritional value of food?
(A) Minerals (B) Artificial sweeteners (C) Vitamins (D) Aminoacids
09. Which of the following are not used as food preservatives?
(A) Table salt (B) Sodium hydrogencarbonate
(C) Cane sugar (D) Benzoic acid
10. Assertion : Preservative are added to food items.
Reason : Preservatives inhibit the growth of microorganisms.
11. Assertion : Artificial sweeteners are added to the food to control the intake of calories.
Reason : Most of the artificial sweeteners are inert and do not metabolise in the body.
12. Name two -amino acids which form a dipeptide which is 100 times more sweet than cane sugar?

VII - CLEANING AGENTS

01. Bithional is added to soap as an additive to function as a / an

(A) Softener (B) Buffering agent (C) Antiseptic (D) Hardeness
02. Which of the following enhances leathering property of soap?
(A) Sodium carbonate (B) Sodium rosinate
(C) Sodium stearate (D) Trisodium phosphate
03. Why Glycerol is added to soap ?
(A) to act as a filler. (B) to increase lathering.
(C) to prevent rapid drying. (D) to make soap granules.
04. Match the soaps given in Column I with items given in Column II.
Column I Column II
(i) Soap chips (a) dried miniature soap bubbles
(ii) Soap granules (b) small broken pieces of soap formed from melted soaps

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(iii) Soap powder (c) soap powder + abrasives + builders
(iv) Scouring soap (d) soap powder + builders like and
05. Assertion : Sodium chloride is added to precipitate soap after saponification.
Reason : Hydrolysis of esters of long chain fatty acids by alkali produces soap in colloidal form.
06. Which of the following is an example of liquid dishwashing detergent?

(A)
CH3 (CH 2 )10 CH 2OSO3 Na

C9H19 O CH 2 CH 2 O CH 2CH 2OH

5
(B)

CH3 SO3 Na
(C)

CH3
|
CH3 (CH 2 )15 N CH3 Br
|
CH3
(D)
07. Polyethyleneglycols are used in the preparation of which type of detergents?
(A) Cationic detergents (B) Anionic detergents
(C) Non-ionic detergents (D) Soaps
08. The role of phosphate in detergent powder is to
(A) Control pH level of the detergents water mixture
(B) remove and ions from the water that causes the hardness of water
(C) provide whiteness to the fabrics
(D) make the soaps act more rapidly
09. The cationic detergent that is used in hair conditioner is
(A) Sodium dodeyl benzene sulphonate (B) Sodium carbyl sulphate
(C) Tetra methyl ammonium chloride (D) Cetyl trimethyl ammonium bromide
10. Sodium alkyl benzene sulphonate is used as
(A) Soap (B) Fertilizer (C) Detergent (D) Pesticide
11. Match structures given in Column I with the type of detergents given in Column II.
Column I Column II

(i)
CH3 (CH 2 )16 COO(CH 2CH 2O) n CH 2CH 2OH (a) Cationic detergent

(ii)
C17 H35COO Na (b) Anionic detergent

(iii)
CH3 (CH 2 )10 CH 2 SO3 Na (c) Nonionic detergent

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CH3
|
CH3 (CH 2 )15 N CH3 Br
|
CH3
(iv) (d) Soap
12. Match the detergents given in Column I with their uses given in Column II.
Column I Column II

CH3
|
CH3 (CH 2 )15 N CH3 Br
|
CH3
(i) (a) Dishwashing powder

CH3 (CH 2 )11 SO3 Na

(ii) (b) Laundry soap

(iii)
C17 H35COO N a Na 2CO3 + Rosin (c) Hair conditioners

(iv)
CH (CH ) COO(CH CH O) CH CH OH
3 2 16 2 2 n 2 2 (d) Toothpaste
13. Which of the following are anionic detergents?
(A) Sodium salts of sulphonated long chain alcohol.
(B) Ester of stearic acid and polyethylene glycol.
(C) Quarternary ammonium salt of amine with acetate ion.
(D) Sodium salts of sulphonated long chain hydrocarbons.
14. Which of the following statements are correct?
(A) Cationic detergents have germicidal properties
(B) Bacteria can degrade the detergents containing highly branched chains.
(C) Some synthetic detergents can give foam even in ice cold water.
(D) Synthetic detergents are not soaps.

ASSIGNMENT-1

01.D 02.D 03.A 04.D 05.B 06.B 07.C 08.A 09.D 10.C 11.C 12.C
13. (i)(b) (ii)(d) (iii)(a) (iv)(e) (v)(c)
14. BD 15.A 16.D 17.D 18.D 19.E 20.B 21.D

ASSIGNMENT-2

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01.C 02.A 03.C 04.B 05.A 06.B 07.C 08.BD 09.A

ASSIGNMENT-3
Tranquilizers

01.D 02.D 03.C 04.C 05.A 06.B 07.ABC 08.AD 09.A

Analgesics
01.B 02.D 03.A 04.D 05.C 06. 07.A

ASSIGNMENT-4
Antibiotics
01.C 02.A 03.B 04.C 05.A 06.C 07.B 08.D 09.C 10.D 11.A 12.A 13.AB
14.C 15.D 16.C
Antiseptics and disinfectant
01.C 02.A 03.D 04.B 05.C 06. B 07.D
08.(i)(e) (ii)(f)(iii)(d) (iv)(g) (v)(b) (vi)(a) (vii)(c)
09.BC

ASSIGNMENT-V
01. 02. 03. 04. 05.C 06. BC

ASSIGNMENT-VI
01.B 02.A 03.A 04.C 05.A 06.B 07.D 08.B 09.BD 10.B 11.B
12. Aspartic acid and phenylalanine

ASSIGNMENT-VII
01.C 02. B 03. C 04.(i)(b) (ii)(a) (iii)(d) (iv)(c)
05.B 06. B 07.C 08.D 09.D 10.D 11.(i)(c) (ii)(d) (iii)(b) (iv) (a)
12.(i)(c) (ii)(d) (iii)(b) (iv) (a)
13.AD 14.ACD

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