Академический Документы
Профессиональный Документы
Культура Документы
Page 1 of 8
Guideline for the use of Naloxone in adult patients
Background:
Page 2 of 8
TWO Indications:
The dose should be titrated against the respiratory function and not the
level of consciousness. Where possible the aim is to maintain adequate
analgesia.
Page 3 of 8
2. Deliberate acute opioid overdose or recreational
intoxication
The dose maybe given undiluted or further diluted to 10ml with sodium
chloride 0.9%
Monitoring:
Page 4 of 8
and/or CCOT nurse should remain with the patient until the patient
arrives on critical care and is handed over to the critical care team.
Naloxone Infusion
Infusion regimen
Infusion preparation
Page 5 of 8
Table 1
Abrupt reversal of opioid drugs in the context of chronic use has been
reported to precipitate acute withdrawal syndrome with symptoms of
restlessness, severe agitation, delirium, nausea and vomiting, sweating,
shivering, abdominal pain, tachycardia, hypertension and tachypnoea.
Rarely pulmonary oedema (usually in patients with pre-existing cardiac
disease), arrhythmias and cardiac arrest have been reported.
The possibility of pulmonary oedema should be considered particularly if
there is unexpected breathlessness and hypoxia after naloxone.
Page 6 of 8
Key References
Toxbase http://www.toxbase.org/Poisons-Index-A-Z/N-
Products/Naloxone-antidote/ accessed 8th April 2015
Page 7 of 8
Appendix 1:
Page 8 of 8