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- Regulate many brain functions but are also active in the peripheral
nervous system.
- Implicated in a large variety of functions (attention/homeostasis).
- Defects in biogenic amine functions are implicated in most
psychiatric disorders.
Norepinephrine (noradrenaline)
- influences sleep wakefulness, attention and feeding behavior
- locus coeruleus
Epinephrine (adrenaline)
- medullary epinephrine neurons
- fight and flight behaviour
- autonomous nervous system (heart rate, dilatation, sweat, saliva)
Dopamine:
- substantia nigra and ventral tegmental area
- Activation of certain dopamine receptors causes hyperactivity and
stereotyped behaviour.
- Reward, attention, motor behaviour
- Dopamine receptor antagonists can induce vomiting (Medulla).
- Dopamine receptor antagonists can elicit catalepsy (decreased
ability to initiate movement).
- Cocaine increases the amount of dopamine in the synaptic cleft
- 4 different pathways that dopamine is involved in
- Nigrostriatal pathway
- Substantia nigra to striatum.
- Involved in the production of movement.
- Tuberoinfundibular pathway
- Arcuate nucleus of the hypothalamus to the
pituitary gland.
- Influences secretion of hormones such as prolactin
(involved in lactation).
- Mesocortical pathway
- Ventral tegmentum to cerebral cortex (frontal
lobes).
- Involved in motivation and emotional response.
- Thought to be associated with the negative
symptoms of schizophrenia including apathy,
listlessness and poverty of speech
- Mesolimbic pathway
- Ventral tegmentum to the limbic system via
nucleus accumbens, the amygdala and
hippocampus and to the medial prefrontal cortex.
- Associated with feelings of reward and desire.
- Implicated in addiction and depression, associated
with the negative symptoms of Schizophrenia such
as delusions, disordered thoughts and speech or
hallucinations.
- Cocaine block the dopamine reuptake transporter
at the presynaptic neuron
In parkinsons: if the substantia nigra does not excite the caudate and
putamen (less inervation) less inervation/inhibition of globus pallidus
more inhibition of the thalamus decrease excitatory signal
What are the main biogenic amines, and what is special about
them?
The main biogenic amines are serotonin, dopamine, epinephrine and
norepinephrine. They are found in the brain and also in the
peripheral nervous system and are involved in a large variety of
functions (attention/homeostasis). They are also linked to most
psychiatric disorders.
What is Parkinsons disease and how are the basal ganglia involved?
Parkinsons disease is a disease in which movement is affected
because the neurons in the substantia nigra die. As the substantia
nigra cannot inervate the nigrostriatal pathway anymore, the frontal
cortex is less excited which leads to less movement.