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Yohimbe bark extract comes from an evergreen tree native to Africa. It contains the active ingredient yohimbine and has traditionally been used as an aphrodisiac and to treat erectile dysfunction. While yohimbe bark extract has many drug, herb, and food interactions, research has not found it to be toxic. It was used for many years as a treatment for erectile dysfunction until being replaced by FDA-approved PDE5 inhibitors.
Yohimbe bark extract comes from an evergreen tree native to Africa. It contains the active ingredient yohimbine and has traditionally been used as an aphrodisiac and to treat erectile dysfunction. While yohimbe bark extract has many drug, herb, and food interactions, research has not found it to be toxic. It was used for many years as a treatment for erectile dysfunction until being replaced by FDA-approved PDE5 inhibitors.
Yohimbe bark extract comes from an evergreen tree native to Africa. It contains the active ingredient yohimbine and has traditionally been used as an aphrodisiac and to treat erectile dysfunction. While yohimbe bark extract has many drug, herb, and food interactions, research has not found it to be toxic. It was used for many years as a treatment for erectile dysfunction until being replaced by FDA-approved PDE5 inhibitors.
Yohimbine chemical structure Evolutionary.org Yohimbe
Before advanced medicine produced commercially available products to treat diseases,
people used many herbs and vegetation as remedies. Herbal remedies were used to treat any and every disease known, or at times unknown, to man. One of these herbals was Yohimbe bark extract which was used to treat a variety of illnesses and diseases. Through the mechanism of action, Yohimbe bark extract had varied outcomes. Yohimbe bark extract does have a variety of drug-herb, herb-herb, and food-herb interactions. Unlike the interactions, toxicity of Yohimbe bark extract is virtually non-existent. The Yohimbe herb has been known for many years and thus has many commercial preparations and Food and Drug Administration (FDA) approval as a drug. Yohimbe bark extract has an active ingredient called Yohimbine (Summary). Yohimbe bark extract is from the evergreen tree native to countries of central and western Africa and was used as an aphrodisiac and to enhance sexual performance (Yohimbe). Other uses of the Yohimbe bark extract include athletic performance, weight loss, exhaustion, angina, hypertension, diabetic neuropathy, and postural hypotension. (Yohimbe). Along with the many uses, Yohimbe bark extract works as an aphrodisiac by [g]enital blood vessel dilation, nerve impulse transmission to genital tissue and increased reflex excitability in the sacral region of the spinal cord (Yohimbe). Yohimbine has many interactions with medicinal drugs, herbs, and foods. Most interactions with medicinal drugs are mild except for the major interaction with monoamine oxidase inhibitors (MAOIs) (Yohimbe). Some of the herb-herb interactions with Yohimbe bark extract are: decreased blood pressure with Berberine, increased risk of hypertensive crisis with caffeine-containing herbs and ephedrine products (Yohimbe). Food-herb interactions were mainly due to risk of hypertensive crisis with tyramine-containing foods, such as aged cheeses, fermented meats, red wines, and vasopressor-containing foods, including overripe fava beans, coffee, tea, colas, and chocolate (Yohimbe). According to research, there are multiple interactions involving Yohimbine. Unlike the many interactions, toxicity was not found. The closest evidence to toxicity for Yohimbine was [t]he structurally related compound reserpine (Summary). [R]eserpine was carcinogenic in both mice and rats (Summary). No literature was found to indicate that Yohimbine was carcinogenic.
Robert G. Perez Yohimbe bark extract
The commercially available products of Yohimbe bark extract was supplied as capsules, tablets, and liquids (Summary). Today there are many over the counter Yohimbine- containing products. From a single search on the Natural Medicines database, 711 products containing Yohimbine were retrieved. In 1999 only Yohimbine hydrochloride [was] a(FDA) approved prescription drug for the treatment of impotence (Summary). In 2017 there are phosphodiesterase type-5 (PDE5) inhibitors that are used for erectile dysfunction and are FDA approved prescription medications. For many years, Yohimbe bark extract was a major aid for erectile dysfunction and other uses. Even though Yohimbine has many drug-herb, herb-herb, and food-herb interactions, most of the interactions are mild except for MAOIs. With no literature available to dispute, Yohimbine is non-toxic. Having a multitude of over the counter Yohimbe bark extract- containing products, only the Yohimbine hydrochloride was FDA approved as a therapeutic medication. Although not a first line product for erectile dysfunction, Yohimbine has been replaced by PDE5 inhibitors that are indicated primarily for erectile dysfunction by the FDA. With a plethora of Yohimbe bark extract-containing products available for consumption and the many ailments treated, it is wise to understand the Yohimbine product to be of assistance to the public with questions pertaining to the herb.
SUMMARY OF DATA FOR CHEMICAL SELECTION Yohimbe bark extract / Yohimbine. (n.d.). doi:https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/yohimbe_508.pdf