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OVERLAPPING
PATHOMECHANISM
Laratta et al.2014.
MARKERS: COPD & CAD
CRP
Circulating CRP levels are associated with increased mortality in both COPD patients
& in the general population.
Systemic inflammation
Hyperinflation
15-fold higher mortality at 30 days VS with normal values for both markers.
Dransfield MT, Rowe SM, Johnson JE, Bailey W, Gerald L. Thorax 2008;63:3015.
Packard KA, Wurdeman RL, and Arouni AJ. Ann Pharmacother 2002;36:1058-67
ACE-I INDUCED COUGH
20% or more of px who receive ACE-I dry cough
Kathleen A Packard, Richard L Wurdeman, and Amy J Arouni Ann Pharmacother 2002;36:1058-67.
ARB IN COPD
ARBs confer many of the same hemodynamic
benefits as ACE-I, but act more distally
Kathleen A Packard, Richard L Wurdeman, and Amy J Arouni Ann Pharmacother 2002;36:1058-67.
ARB in COPD
Kathleen A Packard, Richard L Wurdeman, and Amy J Arouni Ann Pharmacother 2002;36:1058-67.
RATE CONTROL AGENTS FOR COPD
Resting heart rate was associated with both cardiovascular and
all-cause mortality across all stages of COPD (p<0.001)
inhibiting the pacemaker current, If (an the sino-atrial node) without affecting cardiac
contractility, repolarization, or atrioventricular conduction
Majewski S, Slomka S, Wyderkiewicz EW, Ciebiada M et al. 2012. Am J Cardiovasc Drugs 2012
In patients with asthma and COPD, Ivabradine produced an effective reduction in HR and did
not alter respiratory function and symptoms over the short term.
Majewski S, Slomka S, Wyderkiewicz EW, Ciebiada M et al. 2012. Am J Cardiovasc Drugs 2012
SUMMARY
COPD is a complex lung and systemic disease that has
a critical influence on severity and prognosis &
associated with a variety of CV diseases including
CAD