DIFFERENTIAL

EQUATIONS AND CELL

GROWTH (PART 1)
By:Katherine Lea Butler
 CONCEPTS FOR
UNDERSTANDING
 dm/dt

Image from: https://www.softmath.com/ -d is basically a Delta

tutorials-3/algebra-formulas/fractions- Image from: https://play.google.com/
store/apps/details?
and-decimals-and.html
-Represents change id=com.EnrikeDev11.logaritmo

-Irrational number
-t is time -Inversion of an
-Properties used for
-m is a total increase exponential rate
exponential
functions and -Base of a natural log is e
natural logarithms
-Like Pi

MATHEMATIC CONCEPTS
 BIOLOGY CONCEPTS
Critical Mass: The size a cell reaches before Mitosis
Mitosis: The process in which the cell replicates its DNA
and separates into two new cells
Daughter cell: The two new cells produced from Mitosis
S6: A compound responsible for growth in a cell

Image from: https://sites.google.com/a/mca.org.tw/benbiology/Home/mitosis

THE ARTICLE
MY BASIS
Image from: http://events.embo.org/17-cell-org/

Title: Coordination of cell growth and cell division: a

mathematical modeling study
Published in 2004
Major crossover to biology
Contains 16 dierential equations
My main source
Modeled Yeast cells, HeLa, and Xenopus laevis
Bulk of information
Article Link: http://jcs.biologists.org/content/117/18/4199
BASIC DIFFERENTIAL
EQUATIONS
MATHEMATICS IS
PREDICTIVE AND
DESCRIPTIVE
Differential Equations do both
 Variable, Total
Constant that represents Ribosome content
total increases

dm/dt =k1[S6]R-k2m,

Constant Constant times

variable

Equation from: http://jcs.biologists.org/content/117/18/4199

 S6 is the main factor that creates
total increase in cell growth

d[S6]/dt=k3A/V-k4[S6]

Equation from: http://jcs.biologists.org/content/117/18/4199

THE DATA
 EQUATION 9 AND VALUES EXPLAINED
k1=1
-Can be any constant value
k3=25
-S6 production in relation to area and volume of cell, values I found were around 30
k4=3
-Degradation of S6
P= m/V several values for m
P=349.027 P=2,482.8 P=19,552.8 Total Ribosome content

dr = k1k3[R] =
dt k 4P
Placeholder

Equation from: http://jcs.biologists.org/content/117/18/4199

 THREE SOLUTIONS TO EQUATION 9 FOR EQUATION 10
0.711= 0.100= 0.013=
-P -P -P

Radius of cell at critical size Radius of cell at birth

T=T0 + r c - r B

Time from critical size to cell division

Equation from: http://jcs.biologists.org/content/117/18/4199

 P P P rB

32.70 49.208 177.74 1.55

32.34 46.728 158.68 1.798

32.11 45.008 145.45 1.97

31.87 43.408 133.14 2.13

31.67 41.948 121.906 2.276

31.505 40.708 112.37 2.4

31.35 39.608 103.906 2.51

31.21 38.6 96.14 2.61

CONCLUSION
 -P is not viable
-P gives the best data for
-Smaller cell birth radius
means more time needed
-Data is assumed to be
mostly accurate, despite true
values missing
-rB Predictive to get the
descriptive T

Graph create by Katherine Butler

WHY P ISNT VIABLE

Can be graphed, however it

presents challenges
Doesnt show enough change
Doesnt show enough description
Linked back to its actually value
Value is too big
Which creates too little of a
change
Graph create by Katherine Butler
CITES USED
https://www.softmath.com/tutorials-3/algebra-formulas/fractions-and-decimals-and.html
http://events.embo.org/17-cell-org/
http://jcs.biologists.org/content/117/18/4199
https://www.softmath.com/tutorials-3/algebra-formulas/fractions-and-decimals-and.html
https://play.google.com/store/apps/details?id=com.EnrikeDev11.logaritmo
https://sites.google.com/a/mca.org.tw/benbiology/Home/mitosis
http://book.bionumbers.org/how-big-is-a-budding-yeast-cell/
http://www.pnas.org/content/107/3/999.full
https://books.google.com/books?id=0WfH6uhnZqkC&pg=PA166&lpg=PA166&dq=total+average+biomass+of+a+yeast
+cell&source=bl&ots=OF9Eh89WqT&sig=jq5OXFodcxVjnGQCTKd3JD2lA2s&hl=en&sa=X&ved=0ahUKEwist43WgbPR
AhWihFQKHYLvBhAQ6AEILjAD#v=onepage&q=total%20average%20biomass%20of%20a%20yeast%20cell&f=false
http://book.bionumbers.org/how-many-ribosomes-are-in-a-cell/
http://www.nature.com/articles/ncomms2015