Clinical Toxi Commercial cology of Products Fifth Edition 4 SECTION I. INGREDIENTS INDEX Table 11-1 Numerical Toxicity Rating Definitions Probable Oral LETHAL Dose (Human) Toxicity Rating ‘or Clans Dose For 70 ke. pervon (180 Ib.) 6 Supertoxic | Less than —mg./kg. | A taste (less than 7 droy 5 Extremely — | 5-50 mg/kg. | Between 7 drops and 1 toxie : teaspoonful (tsp.) 4 Very toxie | 50-500 mg/kg, | Between 1 tsp, and 1 ounce 3. Moderately | 05-5 gmi/kg. | Between 1 oz. and 1 pint toric (or 11b) 2 Slightly toxic | 6-15 am/kg, | Between 1 pt. and 1 quart 1 Practically | Above 15 gm./kg. | More than 1 quart (2.2 Ib.) nontoxic 100 Fluoride i.e, Sodium, barium, zine Toxicity Rating: 4. Clinical data indicate that the sodium salt Tes near the borderline between tox- ¢ rat oral LDso is 60 mg./kg. ‘Although Tess toxic in animals, barium fluoride be as toxic in man as the sodium salt (or perhaps slightly more toxic). Celeium fuoride is, ‘Comparatively benign (toxicity rating 3?) because ‘See also: Fluoride, Reference Congener in Section Il Ref: Lewis and Tatken, 1978, ofits low solubility and low ionization. In terms of acute toxicity, most fluorides presumably lie be- tween the sodium and calcium salts. In terms of the acute oral LDso in rats (75 mg./kg.), sodium monofluorophosphate (MFP) is as toxic as sodium Auoride and ean produce systemic fluoride poison- ing. 188 Arsenic Grey arsenic Toxicity Rating: 5(2). Elemental arsenic, also known as grey arsenic or metallic arsenic, is insol- Sre also: Arsenic, Reference Congener in Section II. 245 Most lead compounds lie in toxicity lasses 3 or ‘See also: Lead, Reference Congener in Section IIT. Ref: Fairhall and Sayers, 1940. uble in water and dilute acids. It is less toxic than arsenous and arsenic acids and their soluble salts. Lead