1. Aurelia Nicoleta Cristea, Farmacologie generala, Ed. Didactica si Pedagogica, Bucuresti, 2009.

Aurelia Nicoleta Cristea, Tratat de Farmacologie, sub redactia, Ed. Medicala, Bucuresti, 2005
***Farmacopeea Romana, editia a X-a, Ed. Medicala, Bucuresti, 1993

Ordinul Ministrului Sntii Nr. 75/2010 cu privire la Regulile de bun

practic farmaceutic, Monitorul

Oficial al Romaniei, partea I, nr. 91/2010.13. Marius Bojita, Liviu Roman, Robert Sandulescu, Radu Oprean,
Analiza si Controlul Medicamentelor, vol. 1si 2, Ed. Interlcredo, Cluj-Napoca, 2002.14. Martian Cotrau, Teodor
Stan, Lidia Popa, I. Preda, Maria Kincsez-Ajtay, Toxicologie, Ed. Didactica siPedagogica, Bucuresti, 1991.15. Ion
Ciulei, Emanoil Grigorescu, Ursula Stanescu, Plante medicinale, fitochimie si fitoterapie, Ed.Medicala, Bucuresti,
1993.16. .
Aurelia Nicoleta Cristea, Farmacie Clinic, volumul I, Editura Medical, Bucureti 2006

Leucuta S., Biofarmacie si farmacocinetica, Editura Dacia, Cluj-Napoca, 2001.

"Vitamin B6 (Pyridoxine) deficiency may lead to anemia, depression, dermatitis, high blood
pressure (hypertension), water retention, and elevated levels of homocysteine."

http://en.wikipedia.org/wiki/B_vitamins#B_vitamins_deficiency

Those who do not take Vitamin suplements, do not get enough B Vitamins:
quote ".... only a fraction of U.S. adults currently get the recommended daily intake of all B
vitamins by diet alone" -Harvard.eduhttp://www.hsph.harvard.edu/nutritionsource/what-
should-you-eat/vitamin-b/index.html#bottom-line

Dr Shari Lieberman and Dr Andrew Weil both concur that the "recommended daily intake"
RDI (or older RDA) will keep you "Alive but Not Happy" Most people are not even getting
the RDI or RDA needed for survival. Dr Shari Lieberman's "Real Vitamin and Mineral Book"
suggests the Optimum dose for B Vitamins as 25mg to 300 mg daily. Andrew Weil MD
suggests 50mg/day for his brand http://www.drweil.com/drw/u/ART02763/vitamin-
b6.html (Medical staff with stressful jobs sometimes take up to 1000 mg of B Complex /day, I
used to but now more like 600 mg/day). ALSO: get a separate B-12 (in mcg not mg) at least
1000 mcg per day, I get at least 10,000 mcg /day of B-12 (mental physical coordination and
well being). Vitamin List RDI/RDA & Dr Shari Liebermans "Optimum daily
intake"http://www.archure.net/salus/vitamins.html So get a multivitamin and get a "B
Complex" or "B Stress Formula" or "B-100" in the 100 mg size, and get 25 to 300 mg per day
(600 up to 1000 mg is ok for an adult, but not 2000 mg daily), weight proportion for children,
good for happy children daily, good for better grades, and plenty in pre-natal vitamins
already

LACK OF B VITAMINS CAUSES DEPRESSION: quote "DON'T WORRY, B HAPPY: If your seriously
low on any of the B vitamins, depression is one of the earliest symptoms. In fact, studies
show....over three-quarters of all depressed patients have a pyridoxine (vitamin B-6)
deficiency. Giving these patients even small doses of pyridoxine (vitamin B-6) improves their
depression" - pg 54 "Idiots Guide to Vitamins & Minerals" by Alan H. Pressman, D.C., Ph.D.,
C.C.N. This page http://archure.net/salus/bhappy.html

VITAMIN MINIMU OPTIMUM your best bet, as per Dr Shari OVER

MINERAL M Liebermans "The Real Vitamin & Mineral Book" DOSE
B1 thiamin 1.5 mg 25 - 300 mg none
B2 riboflavin 1.7 mg 25 - 300 mg none
B3 niacin 20 mg 25 - 300 mg 3,200 mg
B6 pyridoxine : ) 2 mg 25 - 300 mg >2,000 mg
B12 cobalamin 6 mcg 25 - 300 mcg none
BIOTIN 300 mcg 300 mcg ?
Choline/Inostiol n/a 25 - 500 mg ?
FOLIC acid 400 mcg 400 - 1200 mcg ?
PABA n/a 25 - 500 mg ??
PANTOTHENIC
10 mg 25 - 500 mg ?
acid
http://archure.net/salus/vitamins.html

Most people don't take vitamins, most people are depressed (and hide it)
20% to 30% of people take vitamins "Daily" ///// 50 % to 80% never take
vitamins http://www.crnusa.org/benpdfs/CRN011benefits_whovms.pdf

!! Vitamin and Mineral Safety 3rd Edition by John N. Hathcock, Ph.D. with a
foreword by James C. Griffiths, Ph.D. edited by Douglas MacKay, N.D. Andrea Wong,
Ph.D. Haiuyen Nguyen

Even those who take a multi vitamin (good to do) do not get enough B vitamins to keep
them happy, as the official RDI is enough to keep you alive but not
happyhttp://en.wikipedia.org/wiki/Reference_Daily_Intake
Question:
Can taking too much vitamin B-12 be dangerous? The label on my B-complex states it contains
50,000% the Daily Value!

Answer:
If your B-complex contains 50,000% of the Daily Value (DV), which is 6 mcg for adults, then it has 3,000
mcg of B-12. For people without a severe B-12 deficiency, this is certainly more than necessary.

Taking some B-12 is advisable for people over the age of 50 (when you're less able to extract B-12 from
food), as well as for those taking medications that interfere with B-12 absorption, strict vegetarians,
alcohol and drug abusers, people recovering from surgery or burns, and those with bowel or pancreatic
cancer.

Although vitamin B-12 is generally considered to be safe, and no "Upper Tolerable Intake Level" has been
established, there are some reports of doses of 20 mcg per day or higher causing outbreaks of acne and
rosacea. There is also a study which showed that a high-dose B complex supplement (with 1,000 mcg of
B-12) hurt, rather than helped, people with diabetes and advanced kidney disease.

In general, it's best to avoid excessive doses of any vitamin if it is not needed.

Get more information, including the Recommended Daily Allowance for B-12 (by age and gender),
differences in the forms of B-12, potential side-effects and drug interactions, plus ConsumerLab.com's
tests of popular products, in the B Vitamin Supplements Review >>

https://www.consumerlab.com/answers/Can+taking+too+much+vitamin+B-
12+be+dangerous%3F+The+label+on+my+B-
complex+states+it+contains+50,000%25+the+Daily+Value!+/too_much_b12/

Vitamin and Mineral Recommendations

Micronutrient Current DV1 UL2

Vitamin A 5,000 IU 3,000 mcg (10,000 IU)

Vitamin C 60 mg 2000 mg

Calcium 1,000 mg 2,000 mga

Iron 18 mg 45 mg
 Vitamin D 400 IU 100 mcg (4,000 IU)

Vitamin E 30 IU 1000 mg

Vitamin K 80 mcg ND

Thiamin 1.5 mg ND

Riboflavin 1.7 mg ND

Niacin 20 mg 35 mg

Vitamin B6 2 mg 100 mg

Folate 400 mcg 1,000 mcg

Vitamin B12 6 mcg ND

Biotin 300 mcg ND

Pantothenic acid 10 mg ND

Phosphorus 1,000 mg 4g

Iodine 150 mcg 1,100 mcg

350 mg (non-food sources) /

Magnesium 400 mg
400 mg incl. supplemental
 Zinc 15 mg 40 mg

Selenium 70 mcg 400 mcg

Copper 2 mg 10,000 mcg

Manganese 2 mg 11 mg

Chromium 120 mcg ND

Molybdenum 75 mcg 2,000 mcg

Chloride 3,400 mg 3.6 g

1
The table lists the Daily Values (DVs) based on a caloric intake of 2,000 calories, for adults and children four or
more years of age. The nutrients in the table above are listed in the order in which they are required to appear on a
dietary supplement label. This list includes only those nutrients for which a DRV has been established.

2
The Tolerable Upper Intake Level (UL) is the highest level of daily nutrient intake that is likely to pose no risk of
adverse health effects to almost all individuals in the general population. The UL values listed above pertain to adult
( 19 y) men and women, excluding pregnant and/or lactating women

a
The UL for calcium is 2,500 mg for men and women 19-50 y and 2,000 mg for those individuals 51 y.

ND = not determined

http://www.crnusa.org/about_recs.html