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BatchFermentationvsContinuousFermentationProcess:
SimilaritiesandDifferencesAComparisonTable

BatchFermentationvsContinuousFermentationProcess
 BatchFermentationvsContinuousFermentationProcess
Home AboutUs BiologyExams CSIRJRF/NET
(SimilaritiesanddifferencebetweenBatchFermentationandContinuousFermentation
Process)
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BatchFermentationandContinuousFermentationarethetwocommonlyadoptedIndustrial
Fermentationmethodsforthescaleproductionofmicrobialbiomassormetabolites.

Batch Fermentation: Here the fermenter is first filled with the raw material (carbon
source).Thenthemicrobesareaddedandallowedtofermenttherawmaterialunderoptimum
pHandaeration.Theproductsremaininthefermenteruntilthecompletionoffermentation.
After fermentation, the products are extracted and the fermenter is cleaned and sterilized
beforenextround.Thusherethefermentationisdoneasseparatebatches.

Continuous Fermentation: Here the exponential growth rate of the microbes is

maintained in the fermenter for prolonged periods of time in by the addition of fresh media
are regular intervals. The metabolite or the product of fermentation is extracted for the
overflowfromthefermenter.Thusunlikebatchfermentation,incontinuousfermentation,the
fermentationprocessneverstopsinbetweenanditcontinuestorunforalongperiodoftime
withtheadditionofnutrientsandharvestingthemetabolitesatregularintervals.

ThepresentpostdescribestheSimilaritiesandDifferencesbetweenBatchFermentationand
ContinuousFermentationProcessasaComparisonTable.

Similarities between Batch Culture and Continuous Culture Fermentation

Methods

Bothareindustrialfermentationmethodsforthelargescaleproduction.

Bothmethodscanbeusedfortheproductionofmicrobialbiomassorproducts.

Bothrunundercontrolledenvironmentalconditions

Themechanicalcomponentsoffermenterisalmostsimilarinbothtypes

DifferencebetweenBatchFermentationandContinuousFermentationProcess

Sl.
BatchFermentation ContinuousFermentation
No.

1 Itisaclosedsystem. Itisanopensystem.

2 Setupisnotchangedfromoutsideonce Setupischangedfromoutsideduringthe

thefermentationisstarted. fermentationprocess.

Sl. Home AboutUs BiologyExams CSIRJRF/NET
BatchFermentation ContinuousFermentation
No.

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3 Theprocessisstoppedoncetheproductis Theprocessisnotstoppedforthe

formed. collectionoftheproducts,butitis
continuouslytakenoutfromthe

fermenter.

4 Nutrientsareaddedonlyonce(inthe Nutrientsareaddedmanytimes(inthe

beginning)andnotaddedinbetweenthe beginningandinbetweenthe

fermentationprocess. fermentationprocess).

5 Lesscontroloverthegrowthofthe Morecontrolonthegrowthand

microbesandtheproductionofdesired production.

products.

6 Environmentalconditionsinthe Environmentalconditioninthe

fermenterwillnotbeconstant. fermenterwillbekeptconstant.

7 Turnoverrate(conversionofthesubstance Turnoverratewillbehigh.
todesiredproduct)isless.

8 Nutrientsinthefermenterareutilizedin Nutrientsinthefermenterareutilizedin

relativelyslowrate. relativelyfastrate.

9 Microbesinthefermentershowlag,log Optimumorexponentialgrowthrateof

andstationaryphases. microbesismaintainedinthefermenter.

10 Contentsofthefermenterareremoved ContentsofthefermenterareNOT
afterthefermentationprocessforthe removedfortheisolationofproducts.

isolationofproducts. Productsareextractedfromtheoverflow
fromthefermenter.

Sl. Home AboutUs BiologyExams CSIRJRF/NET
BatchFermentation ContinuousFermentation
No.

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11 Thefermenteriswashedandcleaned Nosuchwashingsteprequiredsince
beforethenextstepoffermentation. continuousadditionofnutrientsand

microbesareperformed.

12 Relativelylargersizefermentersareused. Smallersizefermenterisrequired,since

theyieldisveryhigh.

13 Lessclosetothenaturalenvironment. Moreclosertothenaturalenvironment.

14 Hugeapplicationintheindustrial Limitedapplicationintheindustrial
production. production.

15 Suitablefortheproductionofsecondary Suitablefortheprimarymetabolites

metaboliteswhoseproductionisnot whoseproductionisassociatedwiththe
associatedwiththegrowthofthe growthoftheorganism.Example:
microbes.Example:antibiotics. organicacids,aminoacids.

16 Morecommonmethodforthelargescale Lesscommonlyusedforlargescale
productionofcellbiomassandproducts. production.

17 Easytosetupandrunthancontinuous Noteasytosetup.Requiresophisticated

culture. instrumentation.

18 Lessinitialinvestmentrequired. Initialinvestmentwillbemore.

19 Lesssuitablefortheproductionof Moresuitablefortheproductionof
biomasssuchasSingleCellProteins biomass(SCP).

(SCP).

20 Labourdemandisless. Labourdemandismore.

21 Chanceofcontaminationisless. Chanceofcontaminationismore
Sl. Home AboutUs BiologyExams CSIRJRF/NET
BatchFermentation ContinuousFermentation
No.

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22 EasyandQuickcontrolmethods. Controlmethodsaremorecomplicated.

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