TETRASODIUM EDTA - National Library of Medicine HSDB Database

5/2/2017 TETRASODIUMEDTANationalLibraryofMedicineHSDBDatabase
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HSDB Env.Health&Toxicology TOXNET HSDB
TETRASODIUMEDTA
CASRN:64028
Formoreinformation,searchtheNLMHSDBdatabase.
HumanHealthEffects:
HumanToxicityExcerpts:
/HUMANEXPOSURESTUDIES/Tetrasodiumedetateusedindustassequesteringagentshouldnotbeappliedtoeyeunless
firstneutralized,becauseitformssolutionsufficientlyalkalinetobeinjurioustoeye.
[Grant,W.M.ToxicologyoftheEye.3rded.Springfield,IL:CharlesC.ThomasPublisher,1986.,p.390]**PEERREVIEWED**
/SIGNSANDSYMPTOMS/RapidintravenousadministrationofNa2EDTAcauseshypocalcemictetany.However,aslowinfusion
(15mgperminute)administeredtoanormalindividualelicitsnosymptomsofhypocalcemiabecauseofthereadyavailability
ofextracirculatorystoresofcalcium.
[Hardman,J.G.,L.E.Limbird,P.B.,A.G.Gilman.GoodmanandGilman'sThePharmacologicalBasisofTherapeutics.10thed.NewYork,NY:McGraw
Hill,2001.,p.1868]**PEERREVIEWED**
/CASEREPORTS/A75yearoldmanbeingtreatedforseveralmalignantepithelialtumorswasprescribedasunscreenUriage
SPF50+cream.After10monthsofusingtheproduct,thepatientpresentedwitheczematousareaswherethesunscreenhad
beenapplied(face,neckandbackofhands).PatchtestingwasperformedwithstandardseriesofGEIDAC(SpanishContact
DermatitisandCutaneousAllergyResearchGroup),sunscreenseries(ChemotechniqueDiagnostics,Malmo,Sweden)andthe
UriageSPF50+cream.After4days,apositivereactionwasobservedtothecream(++).Themanufacturersuppliedthe
individualingredientsoftheirproduct.Outofthe24componentsprovided,onlytetrasodiumethylenediaminetetraaceticacid
(EDTA)0.2%aquawaspositiveanditwasnegativeinfivecontrolssubjects....Inourpatient,therewasacloserelation
betweentheapplicationofthesunscreenandtheappearanceofeczema.Positivepatchtestwasonlyobtainedwith0.2%aqua
tetrasodiumEDTAasacomponentofthesunscreen,whereasethylenediaminewasnegative.Hiseczemaresolvedoncethe
sunscreenceasedtobeused.HeisnowusingamineralbasedproductwithoutEDTA.
[SanchezPedrenoPetal;ContactDermatitis61(2):125126(2009)]**PEERREVIEWED**
/OTHERTOXICITYINFORMATION/.../Edeticacid/andmanyofitssaltsbindmetalcationstightlyandsorenderthem
essentiallyinnocuous./EDTAanditssalts/
[Gosselin,R.E.,R.P.Smith,H.C.Hodge.ClinicalToxicologyofCommercialProducts.5thed.Baltimore:WilliamsandWilkins,1984.,p.II381]
**PEERREVIEWED**
/OTHERTOXICITYINFORMATION/AllknownpharmacologicaleffectsofEDTAresultfromformationofchelateswithdivalent
andtrivalentmetal/ions/inthebody.
[Hardman,J.G.,L.E.Limbird,P.B.,A.G.Gilman.GoodmanandGilman'sThePharmacologicalBasisofTherapeutics.10thed.NewYork,NY:McGraw
Hill,2001.,p.1868]**PEERREVIEWED**
/OTHERTOXICITYINFORMATION/...Regardinghumanhealthrelatedendpoints,thedocumentsonthefreeacidandthe
sodiumsaltarealmostidenticalandcrossreadingofdatafromdifferentsaltsofEDTAandthefreeacidhasbeenperformed
forhazardassessmentexceptfortheendpointsacutetoxicity,irritation,corrosivityandsensitization.Thecrossreadingis
justifiedbythedissociationofbothcompoundsinbiologicalmedia....
[EuropeanCommission;ScientificcommitteeonToxicity,EcotoxicityandtheEnvironment;OpinionontheresultsoftheRiskAssessmentof:
TetrasodiumEthylenediamineTetraacetate(64028)andEdeticAcid(60004)HumanHealthPart(September2003).Availablefrom,asofNovember
18,2011:http://ec.europa.eu/health/scientific_committees/environmental_risks/opinions/sctee/index_en.htm**PEERREVIEWED**
https://toxnet.nlm.nih.gov/cgibin/sis/search/a?dbs+hsdb:@term+@DOCNO+5003. 1/21
Skin,EyeandRespiratoryIrritations:
BothedeticacidandNa4EDTAaremildskinirritants,butcomparativelypotenteyeirritants.


ProbableRoutesofHumanExposure:
Accordingtothe2006TSCAInventoryUpdateReportingdata,thenumberofpersonsreasonablylikelytobeexposedinthe
industrialmanufacturing,processing,anduseoftetrasodiumEDTAis1000orgreaterthedatamaybegreatly
underestimated(1).
[(1)USEPA;InventoryUpdateReporting(IUR).Nonconfidential2006IURRecordsbyChemical,includingManufacturing,ProcessingandUse
Information.Washington,DC:U.S.EnvironmentalProtectionAgency.Availablefrom,asofNov4,2011:http://cfpub.epa.gov/iursearch/index.cfm
**PEERREVIEWED**

NIOSH(NOESSurvey19811983)hasstatisticallyestimatedthat1,388,281workers(611,582ofthesewerefemale)were
potentiallyexposedtotetrasodiumEDTAintheUS(1).

[(1)NIOSH;NOES.NationalOccupationalExposureSurveyconductedfrom19811983.Estimatednumbersofemployeespotentiallyexposedto
specificagentsby2digitstandardindustrialclassification(SIC).Availablefrom,asofNov4,2011:http://www.cdc.gov/noes/**PEER
REVIEWED**

EmergencyMedicalTreatment:

EmergencyMedicalTreatment:
EMTCopyrightDisclaimer:
TheinformationcontainedintheTruvenHealthAnalyticsInc.productsisintendedasan
educationalaidonly.Alltreatmentsorproceduresareintendedtoserveasaninformation
resourceforphysiciansorothercompetenthealthcareprofessionalsperformingthe
consultationorevaluationofpatientsandmustbeinterpretedinviewofallattendant
circumstances,indicationsandcontraindications.TheuseoftheTruvenHealthAnalytics
Inc.productsisatyoursolerisk.Theseproductsareprovided"asis"and"asavailable"
foruse,withoutwarrantiesofanykind,eitherexpressorimplied.TruvenHealthAnalytics
Inc.makesnorepresentationorwarrantyastotheaccuracy,reliability,timeliness,
usefulnessorcompletenessofanyoftheinformationcontainedinthe
productsAdditionally,TruvenHealthANALYTICSINC.makesnorepresentationor
warrantiesastotheopinionsorotherserviceordatayoumayaccess,downloadoruseas
aresultofuseoftheTruvenHealthANALYTICSINC.products.Allimpliedwarrantiesof
merchantabilityandfitnessforaparticularpurposeoruseareherebyexcluded.Truven
HealthAnalyticsInc.doesnotassumeanyresponsibilityorriskforyouruseoftheTruven
HealthAnalyticsInc.products.
ThefollowingOverview,***GENERALORUNKNOWN***,isrelevantforthisHSDB
recordchemical.
LifeSupport:
oThisoverviewassumesthatbasiclifesupportmeasures
havebeeninstituted.
ClinicalEffects:
0.2.1SUMMARYOFEXPOSURE
0.2.1.1ACUTEEXPOSURE
A)SUMMARYTreatthepatient,notthepoison.
Symptomaticandsupportivecareisthemainstayof
therapy.
B)Thegeneralapproachtothepoisonedpatientisto:
1)Firstassessthepatient.Supportvitalfunctionsas
needed,monitorcardiacstatus,vitalsigns,fluid
intakeandoutput,bodytemperature,andmental
status.
2)Patientswithcomaoralteredmetalstatusshould
receiveoxygen,naloxone(Narcan(R)),thiamine(in
adults),andhaveglucoselevelmeasuredimmediately
orreceiveD50.
3)Assessthesubstanceinquestionandtherouteof
administrationforpotentialtoxicity.
4)Preventfurtherabsorption:
a)Oral:usevariouscombinationsoflavage,cathartics,
andadsorbentsasindicatedbytheingestedsubstance
andclinicalstatus.
b)Dermal:Removecontaminatedclothing,washskin,hair
andnailsthoroughly.
c)Pulmonary:Removefromexposureandadministerhigh
flowhumidifiedoxygenasneeded.
d)Ocular:irrigatethoroughlywithtepidwateror
normalsalineforatleast15minutes.
5)Appropriatelaboratorytestsshouldbeordered.
C)Symptomsseenduetounknownpoisonsmayoccurtoany
ofthebodysystems,andathoroughdiagnostic
evaluationshouldbeperformedonanypatientinvolved
inexposuretoanunknownagent.
Laboratory:
A)Appropriatelaboratoryevaluationisdeterminedinpart
bytheclinicalconditionofthepatient.Initialhistory
isofteninaccurateandmostdeliberateingestionsin
adultsandadolescentsinvolvemorethanonedrug.
1)Serumelectrolytestoevaluateformetabolicacidosis
andafourhouracetaminophenlevelshouldbeobtained
ifthereisanypossibilityofmixedoverdoseor
uncertainhistory.
2)Testsofhepaticandrenalfunction,arterialblood
gases,pulseoximetry,andchestradiographsshouldbe
performedifclinicallyindicated.
3)A12leadelectrocardiogramshouldbeperformedto
evaluateforarrhythmia,tachycardia,orinterval
prolongation.
4)Pregnancytestingshouldbeconsideredinwomenof
childbearingpotentialaspregnancymayprecipitate
suicidalgesturesandoverdosemaycomplicatethe
pregnancy.
B)Toxicologyscreensanddruglevelsshouldbeperformedas
indicatedbyhistoryandclinicalsignsandsymptoms.
1)Avarietyoftestsareavailable.Generaltoxicology
screensrarelyprovideinformationthataltersthe
managementoftheasymptomatic,stablepatient(an
exceptiontothisisanacetaminophenlevel).
2)Blood,urineandgastriccontentsarepotential
analyticalsamplesandshouldbesaved.
3)Consulttheclinicaltoxicologylaboratoryearlysothat
thecorrectspecimensareobtainedforthesuspected
poison.
TreatmentOverview:
0.4.2ORALEXPOSURE
A)Thismanagementisintendedforuseintheabsenceofa
specifictreatmentprotocolforaproduct,drugor
chemicalwhensomeguidelinesmaybeneededforpatient
care.Itmayalsobehelpfulwhenanexperimentalagent
hasbeeningestedandtherearenodataavailableonits
toxicity.
B)Thegoalistoremove,detoxify,orpreventabsorption
ofingestedsubstances.Whichofthefollowingmeasures
areappropriatewilldependonthepatient's
symptomatologyandthepossibleingestantsinvolved.
C)Upto50%ofallinitialhistoriesareincorrect;
historyshouldbeobtainedfromseveralindividualsif
possible.Importantinformationtobeobtainedfrom
productsincludesthetypeofpackaging,theamountin
thepackage,andtheamountremainingafteringestion.
Insuspectedmixedingestions,havingafamilymember
bringinallmedicationsavailableinthehomemaybe
useful.
D)ACTIVATEDCHARCOAL:Administercharcoalasaslurry(240
mLwater/30gcharcoal).Usualdose:25to100gin
adults/adolescents,25to50ginchildren(1to12
years),and1g/kgininfantslessthan1yearold.
E)GASTRICLAVAGE:Considerafteringestionofa
potentiallylifethreateningamountofpoisonifitcan
beperformedsoonafteringestion(generallywithin1
hour).Protectairwaybyplacementintheheaddownleft
lateraldecubituspositionorbyendotracheal
intubation.Controlanyseizuresfirst.
1)CONTRAINDICATIONS:Lossofairwayprotectivereflexes
ordecreasedlevelofconsciousnessinunintubated
patients;followingingestionofcorrosives;
hydrocarbons(highaspirationpotential);patientsat
riskofhemorrhageorgastrointestinalperforation;and
trivialornontoxicingestion.
F)WHOLEGUTLAVAGEHasbeenutilizedasalternative
methodforGIdecontamination.Theuseofwholegut
lavageinthemanagementofpoisonedpatientsis
currentlycontroversial.Potentialsolutionsforuse
includeColyte(R)andGolytely(R).
G)INTRAVENOUSENVENOMATIONPROCEDURES:Thereislittle
thatcanbedonetoeliminateexposuretotoxins
administeredintravenouslyorbyenvenomation.
Proceduressuchasfasciotomyandfasciotomyare
recommendedwhendocumentedpressuremyolysisis
functionthreatening.
H)GENERALTREATMENT
1)Establishrespirationandcreateanartificialairway,
ifneeded.
2)Treathypotensionwithfluidsavoidvasopressorsif
possible.
3)Pulmonaryarterycatheterizationshouldbeconsidered
inpatientswithpersistenthypotensiontooptimize
utilizationoffluidsandvasopressors.
4)HYPOTENSION:Infuse10to20mL/kgisotonicfluid.If
hypotensionpersists,administerdopamine(5to20
mcg/kg/min)ornorepinephrine(ADULT:begininfusionat
0.5to1mcg/min;CHILD:begininfusionat0.1
mcg/kg/min);titratetodesiredresponse.
5)Aggressivelytreatandevaluatecomaregardlessof
suspectedcause.Intubateandventilateasneeded.
Comatosepatientsshouldreceiveoxygen,naloxone
(Narcan(R)),thiamine(adults)andeitherD50orrapid
determinationofglucoselevel.Checkcoretemperature
toevaluateforhypoorhyperthermia.Consider
evaluationforCNSlesionorinfectionwithCTand
lumbarpuncture.
6)Performserialexaminationstodeterminewhetherthe
patientisimprovingordeteriorating.
0.4.3INHALATIONEXPOSURE
A)INHALATION:Movepatienttofreshair.Monitorfor
respiratorydistress.Ifcoughordifficultybreathing
develops,evaluateforrespiratorytractirritation,
bronchitis,orpneumonitis.Administeroxygenandassist
ventilationasrequired.Treatbronchospasmwithan
inhaledbeta2adrenergicagonist.Considersystemic
corticosteroidsinpatientswithsignificant
bronchospasm.
B)Carefullyobservepatientswithinhalationexposurefor
thedevelopmentofanysystemicsignsorsymptomsand
administersymptomatictreatmentasnecessary.
0.4.4EYEEXPOSURE
A)DECONTAMINATION:Removecontactlensesandirrigate
exposedeyeswithcopiousamountsofroomtemperature
0.9%salineorwaterforatleast15minutes.If
irritation,pain,swelling,lacrimation,orphotophobia
persistafter15minutesofirrigation,thepatient
shouldbeseeninahealthcarefacility.
0.4.5DERMALEXPOSURE
A)OVERVIEW
1)DECONTAMINATION:Removecontaminatedclothingand
jewelryandplacetheminplasticbags.Washexposed
areaswithsoapandwaterfor10to15minuteswith
gentlespongingtoavoidskinbreakdown.Aphysician
mayneedtoexaminetheareaifirritationorpain
persists(Burgessetal,1999).
RangeofToxicity:
A)Inmanycasestheamountoftoxiningestedwillbe
unknown,orthemilligram/kilogramtoxicityoftheagent
itselfwillbeuncertain.Itisthepatient,notthe
poison,whichshouldbetreatedinthesecases,anduntil
thetoxicsubstanceorthesubstance'stoxicityhasbeen
moreaccuratelydeterminedtheamountingestedwillhave
lessrelevancethanthepatient'sclinicalcondition.
[RumackBHPOISINDEX(R)InformationSystemMicromedex,Inc.,Englewood,CO,2017;CCISVolume172,editionexpiresMay,2017.HallAH&Rumack
BH(Eds):TOMES(R)InformationSystemMicromedex,Inc.,Englewood,CO,2017;CCISVolume172,editionexpiresMay,2017.]**PEERREVIEWED**
EMTCopyrightDisclaimer:
TheinformationcontainedintheTruvenHealthAnalyticsInc.productsisintendedasan
educationalaidonly.Alltreatmentsorproceduresareintendedtoserveasaninformation
resourceforphysiciansorothercompetenthealthcareprofessionalsperformingthe
consultationorevaluationofpatientsandmustbeinterpretedinviewofallattendant
circumstances,indicationsandcontraindications.TheuseoftheTruvenHealthAnalytics
Inc.productsisatyoursolerisk.Theseproductsareprovided"asis"and"asavailable"
foruse,withoutwarrantiesofanykind,eitherexpressorimplied.TruvenHealthAnalytics
Inc.makesnorepresentationorwarrantyastotheaccuracy,reliability,timeliness,
usefulnessorcompletenessofanyoftheinformationcontainedinthe
productsAdditionally,TruvenHealthANALYTICSINC.makesnorepresentationor
warrantiesastotheopinionsorotherserviceordatayoumayaccess,downloadoruseas
aresultofuseoftheTruvenHealthANALYTICSINC.products.Allimpliedwarrantiesof
merchantabilityandfitnessforaparticularpurposeoruseareherebyexcluded.Truven
HealthAnalyticsInc.doesnotassumeanyresponsibilityorriskforyouruseoftheTruven
HealthAnalyticsInc.products.
ThefollowingOverview,***EDETATECALCIUMDISODIUM***,isrelevantforthisHSDB
recordchemical.
LifeSupport:
oThisoverviewassumesthatbasiclifesupportmeasures
havebeeninstituted.
ClinicalEffects:
0.2.1SUMMARYOFEXPOSURE
A)WITHTHERAPEUTICUSE
1)Thefollowingadverseeffectshavebeenreportedwith
theuseofedetatecalciumdisodium:InvertedTwaves
andcardiacrhythmirregularities,transientdecreases
inbloodpressure,acutenecrosisoftheproximal
tubules,microscopichematuria,glycosuria,
proteinuria,nephrotoxicity,acuterenalfailure,
dermatitisandexfoliativedermatitisofthescrotum,
injectionsitepainfollowingintramuscularinjection,
hypocalcemia,hypercalcemia,nausea,vomiting,
abdominalpain,diarrhea,mildelevationsinSGOTand
SGPT,anemia,bonemarrowdepression,fatigue,
myalgia,zincdeficiency,headache,tremors,numbness,
andtingling.
2)Inpatientswithleadencephalopathy,edetatecalcium
disodiummayworsencerebraledema.Forpatientswith
leadencephalopathy,edetatecalciumdisodiumshould
bebegun4hoursafteradministrationofdimercaprol.
B)WITHPOISONING/EXPOSURE
1)Noilleffectswereobservedfollowinginadvertent
administrationof5timestherecommendeddose,
infusedintravenouslyovera24hourperiodoftime,
toanasymptomatic16montholdwithabloodlead
levelof56mcg/dL
0.2.3VITALSIGNS
A)WITHTHERAPEUTICUSE
1)Atransientdecreaseinbloodpressure,rangingfrom5
to20mmHgwasreportedinoverhalfofpatientsin
onestudy.
0.2.20REPRODUCTIVEHAZARDS
A)Therearenoadequatewellcontrolledstudiesoftheuse
ofedetatecalciumdisodiuminpregnantwomen.Edetate
calciumdisodiumisinpregnancycategoryB.Itisnot
knownifedetatecalciumdisodiumisexcretedinhuman
breastmilk.Areproductionstudyinratsatdosesupto
about25to40timesthehumandoserevealedevidenceof
fetalmalformations.Theseteratogeniceffectswere
preventedbysimultaneoussupplementationofdietary
zinc.
0.2.21CARCINOGENICITY
0.2.21.1IARCCATEGORY
A)IARCCarcinogenicityRatingsforCAS62339
(InternationalAgencyforResearchonCancer(IARC),
2016;InternationalAgencyforResearchonCancer,
2015;IARCWorkingGroupontheEvaluationof
CarcinogenicRiskstoHumans,2010;IARCWorkingGroup
ontheEvaluationofCarcinogenicRiskstoHumans,
2010a;IARCWorkingGroupontheEvaluationof
CarcinogenicRiskstoHumans,2008;IARCWorkingGroup
ontheEvaluationofCarcinogenicRiskstoHumans,
2007;IARCWorkingGroupontheEvaluationof
CarcinogenicRiskstoHumans,2006;IARC,2004):
1)NotListed
0.2.21.3ANIMALOVERVIEW
A)Longtermanimalstudieshavenotbeenconductedto
evaluatethecarcinogenicpotentialofedetatecalcium
disodium.
0.2.22GENOTOXICITY
A)Longtermanimalstudieshavenotbeenconductedto
evaluatethemutagenicpotentialofedetatecalcium
disodium(ProdInfoCalciumdisodiumversenate,2004).
Laboratory:
A)Monitorrenalandhepaticfunction,serumelectrolytes,
urinalysis,urinesediment,andECG.Levelsshouldbe
checkedbeforeeachcourseoftherapyandmonitoreddaily
duringtherapyinseverecasesandafterthesecondand
fifthdayoftherapyinlessseriouscases.Monitorblood
leadandzinclevels.
B)Refertothe"Lead"documentforadditionalinformation.
RangeofToxicity:
A)Noilleffectswereobservedfollowinginadvertent
administrationof5timestherecommendeddose,infused
intravenouslyovera24hourperiodoftime,toan
asymptomatic16montholdwithabloodleadlevelof56
mcg/dL
[RumackBHPOISINDEX(R)InformationSystemMicromedex,Inc.,Englewood,CO,2017;CCISVolume172,editionexpiresMay,2017.HallAH&Rumack
BH(Eds):TOMES(R)InformationSystemMicromedex,Inc.,Englewood,CO,2017;CCISVolume172,editionexpiresMay,2017.]**PEERREVIEWED**
AntidoteandEmergencyTreatment:
Give...calciumgluconate...or...calciumchlorideslowlyiv.Repeatasneededevery5to10minutes.
[Olson,K.R.(Ed.);Poisoning&DrugOverdose.4thed.LangeMedicalBooks/McGrawHill.NewYork,N.Y.2004.,p.425]**PEERREVIEWED**
/SRP:/Immediatefirstaid:Ensurethatadequatedecontaminationhasbeencarriedout.Ifpatientisnotbreathing,start
artificialrespiration,preferablywithademandvalveresuscitator,bagvalvemaskdevice,orpocketmask,astrained.Perform
CPRifnecessary.Immediatelyflushcontaminatedeyeswithgentlyflowingwater.Donotinducevomiting.Ifvomitingoccurs,
leanpatientforwardorplaceontheleftside(headdownposition,ifpossible)tomaintainanopenairwayandprevent
aspiration.Keeppatientquietandmaintainnormalbodytemperature.Obtainmedicalattention./PoisonsAandB/
[Currance,P.L.Clements,B.,Bronstein,A.C.(Eds).;EmergencyCareForHazardousMaterialsExposure.3Rdedition,ElsevierMosby,St.Louis,
MO2005,p.160]**PEERREVIEWED**
/SRP:/Basictreatment:Establishapatentairway(oropharyngealornasopharyngealairway,ifneeded).Suctionifnecessary.
Watchforsignsofrespiratoryinsufficiencyandassistventilationsifneeded.Administeroxygenbynonrebreathermaskat10
to15L/min.Monitorforpulmonaryedemaandtreatifnecessary....Monitorforshockandtreatifnecessary....Anticipate
seizuresandtreatifnecessary....Foreyecontamination,flusheyesimmediatelywithwater.Irrigateeacheyecontinuously
with0.9%saline(NS)duringtransport....Donotuseemetics.Foringestion,rinsemouthandadminister5mL/kgupto200
mLofwaterfordilutionifthepatientcanswallow,hasastronggagreflex,anddoesnotdrool....Coverskinburnswithdry
steriledressingsafterdecontamination..../PoisonsAandB/
/SRP:/Advancedtreatment:Considerorotrachealornasotrachealintubationforairwaycontrolinthepatientwhois
unconscious,hasseverepulmonaryedema,orisinsevererespiratorydistress.Positivepressureventilationtechniqueswitha
bagvalvemaskdevicemaybebeneficial.Considerdrugtherapyforpulmonaryedema....Consideradministeringabeta
agonistsuchasalbuterolforseverebronchospasm....Monitorcardiacrhythmandtreatarrhythmiasasnecessary....Start
IVadministrationofD5W/SRP:"Tokeepopen",minimalflowrate/.Use0.9%saline(NS)orlactatedRinger'sifsignsof
hypovolemiaarepresent.Forhypotensionwithsignsofhypovolemia,administerfluidcautiously.Watchforsignsoffluid
overload....Treatseizureswithdiazepamorlorazepam....Useproparacainehydrochloridetoassisteyeirrigation....
/PoisonsAandB/
AnimalToxicityStudies:
NonHumanToxicityExcerpts:
/LABORATORYANIMALS:AcuteExposure/Basedonlimitedexperimentaldataandlackofreportsofskinandrespiratory
sensitisationduringindustrialuseofedeticacidandNa4EDTA,the/investigators/concludethatbothedeticacidandNa4EDTA
donotcausesensitisationbyskincontactorbyinhalation.BasedonthepositiveresultswiththeMagnussonKlingmantest,
theCSTEEconcludesthatedeticacidsaltsmaybeweakskinsensitizers.
/LABORATORYANIMALS:AcuteExposure/Notirritatingtoskinofrabbits.Irritatingtorabbiteyes.
[EuropeanChemicalsBureau;IUCLIDDataset,Tetrasodiumethylenediaminetetraacetate(64028)(2000CDROMedition).Availablefrom,asof
February18,2004:http://esis.jrc.ec.europa.eu/**PEERREVIEWED**
/LABORATORYANIMALS:AcuteExposure/Trilonbat200400mg/kgcausedtetanicconvulsionsanddeathofrabbitsandmice.
[SamoilovNetal;BYULLEKSPBIOLMED74(8):46(1972)]**PEERREVIEWED**
/LABORATORYANIMALS:SubchronicorPrechronicExposure/Whenadministeredindrinkingwatertowhitemice,EDTA...and,
TetrasodiumEDTA...producedchangesinthemineralcontentofthetissues.EDTAwasadministeredataconcentrationof3.4
mM(duetoitslowsolubilityinwater)andthesaltswereadministeredatconcentrationsof25mM.Themineralcontentof
bones,kidneys,liver,andmuscleswasdeterminedusingatomicabsorptionspectrophotometry....Aftertreatmentwith
TetrasodiumEDTA,calciumwasreducedinbone,liver,andmusclezincwasreducedinthekidneys,muscle,andliverand
magnesiumwasreducedinboneandliver....MicegivenEDTAhadincreasedmusclecalciumandmicetreatedwith
TetrasodiumEDTAhadincreasedrenalmagnesium.Similarresultswere/previously/reportedafteroraladministrationof1
mmol/kg/dayEDTAfor35daysinastudyusing42maleWistarrats.
[CosmeticIngredientExpertReviewPanel;FinalReportontheSafetyAssessmentofEDTA,Calcium,DisodiumEDTA,DiammoniumEDTA,Dipotassium
EDTA,DisodiumEDTA,TEAEDTA,TetrasodiumEDTA,TripotassiumEDTA,TrisodiumEDTA,HEDTA,andTrisodiumHEDTA.InternationalJournalof
Toxicology21(S2):95142(2002)]**PEERREVIEWED**
/LABORATORYANIMALS:ChronicExposureorCarcinogenicity/Basedonatwoyearstudyafterdietaryexposure,aNOAELof
500mg/kg/dayisderivedforNa3EDTA.Basedonthisstudyandalimitednumberoffurthernonstandardrepeateddose
toxicitystudies,itisconcludedthatbothedeticacidandNa4EDTAhaveonlyalowpotentialfortoxicityafterrepeatedoral
administration./TrisodiumEDTA/
/LABORATORYANIMALS:DevelopmentalorReproductiveToxicity//Investigators/evaluatedtheteratogenicityofEDTAandits
...tetrasodiumsaltusingCDalbinorats.Twentyinseminatedratswereintubatedwith2.3to2.4mLofthetestcompounds
(equivalentto1000mg/kgEDTA),equallydivided,twicedailyonGD57to14.Theratsofthevehiclecontrolgroupreceived
1.0mL/kgdosesofphosphatebuffertwicedaily.Anadditionaluntreatedgroupservedasthecontrolgroup.Femalesofall
treatmentgroupshaddiarrheatheincidenceswere80%(EDTA)...and90%(TetrasodiumEDTA).Onthefirstdayofdosing,
threefemalesoftheEDTAgroup...hadtransientepisodesofdecreasedactivity....ThefemaleswerekilledonGD21,and
eachfetuswasexaminedforexternalanomalies.Thetestcompoundsdidnotsignificantlyaffectlittersize,postimplantation
loss,orthesexratiocomparedtocontrols.Onethirdofthefetuseswereinspectedforvisceralabnormalitiesandtwothirds
wereexaminedforskeletalabnormalities.Nopatternwasobservedregardingtreatmentwithaparticularcompoundorthe
incidenceofanomalies.TheinvestigatorsconcludedthatEDTAanditssaltswerenotteratogenicundertheconditionsofthis
study,evenatmaternallytoxicdoses.
/GENOTOXICITY/TetrasodiumEDTAinducedcationdeficiencydidnotcauseaberrationsinChinesehamsterovarycellsor
murinegermcellsbutthechelatingagentshadeffectsonmitosisandmeiosis.
/GENOTOXICITY/NegativeintheAmestestforSalmonellatyphimuriumTA98,TA100,TA1535,TA1537,TA1538,Escherichia
coliWP2uvrAwithandwithoutactivation.
/ALTERNATIVEandINVITROTESTS/Atconcentrations<100mM,TetrasodiumEDTAandCuEDTAcausedcellnecrosisand
reducedthecolonyformingabilityofnormalratkidneycellsinculture.Cytotoxicitywasnotobservedwhenthecellswere
exposedto100mMZnEDTAorFeEDTA,orto5mMTetrasodiumEDTAorZnEDTAforaslongas7weeks.
/ALTERNATIVEandINVITROTESTS/After24hoursoftreatment,aconcentrationof5.3mMTetrasodiumEDTAinduceda50%
reductionincellproteincontentofculturedHepG2cells.
/ALTERNATIVEandINVITROTESTS/...TheNaEDTAconcentrationsupto20uMshowednomeasurableeffect.Severecell
damagewasnotedfollowingexposureto66uMNaEDTA.Thenumberofadherentcellsshowedthesameeffect.Plating
efficiencyshowedaslightdecreaseevenat0.1uMandwasonly75%ofthecontrolvalueat20uMand48%at66uM.
[HugenschmidtSetal;ArchToxicol67(1):768(1993)]**PEERREVIEWED**PubMedAbstract
NonHumanToxicityValues:
LD50Mouseip330mg/kg
[Lewis,R.J.Sr.(ed)Sax'sDangerousPropertiesofIndustrialMaterials.11thEdition.WileyInterscience,Wiley&Sons,Inc.Hoboken,NJ.
2004.,p.1659]**PEERREVIEWED**
LD50Ratip>2.0g/kg
LD50Ratip4000mg/kgbw
EcotoxicityValues:
LC50Species:Lepomismacrochirus(Bluegill)Conditions:static,pH8.9Concentration:486mg/Lfor96hr/Versenepowder/
[Verschueren,K.HandbookofEnvironmentalDataonOrganicChemicals.Volumes12.4thed.JohnWiley&Sons.NewYork,NY.2001,p.1099]
**PEERREVIEWED**
LC50Species:Lepomismacrochirus(Bluegill)0.74(0.621.28)g,34(2838)mmConditions:staticConcentration:1,030
mg/Lfor96hr(95%confidenceinterval:9801,080mg/L)/39.00%a.i.,Versene100/
[BatchelderTLetal;BullEnvironContamToxicol24(4):543549(1980)]**PEERREVIEWED**PubMedAbstract
LC50Species:Lepomismacrochirus(Bluegill)weight0.74(0.621.28)g,length34(2838)mmConditions:static
Concentration:3,092mg/Lfor96hr(95%confidenceinterval:2,3203,540mg/L)/41.10%a.i.,VerseneFE3/
[BatchelderTLetal;BullEnvironContamToxicol24(4):543549(1980)]**PEERREVIEWED**PubMedAbstract
LC50Species:Daphniamagna(WaterFlea)age<or=24hrConditions:freshwater,static,2022degC,pH7.67.7
Concentration:625000ug/Lfor24hr/formulation/
[BringmannG,KuhnR;ZWasserAbwasserForsch10(5):161166(1977)ascitedintheECOTOXdatabase.Availablefrom,asofNovember19,2011:
http://cfpub.epa.gov/ecotox/**PEERREVIEWED**
Metabolism/Pharmacokinetics:
Interactions:
TetracyclineHClabsorptioninman,givenconcomitantlywithtetraNaEDTAandmilk,showedinhibitoryeffectofmilk
counteractedbysimultaneousingestionofEDTA.
[PoigerHetal;EURJCLINPHARMACOL14(2):129(1978)]**PEERREVIEWED**PubMedAbstract
CortisolreduceddegreeofvasculardamagetoadrenalectomizedratirrigatedwithNa4EDTAsaltifadministeredwithin16hr
priortoEDTA,noprotectionifdelayeduntil15minpriortoEDTA.
[ZaremHetal;PROCSOCEXPBIOLMED118(3):602(1965)]**PEERREVIEWED**PubMedAbstract
Pharmacology:
TherapeuticUses:
Tetrasodiumedetateusedindustassequesteringagentshouldnotbeappliedtoeyeunlessfirstneutralized,becauseitforms
solutionsufficientlyalkalinetobeinjurioustoeye.
[Grant,W.M.ToxicologyoftheEye.3rded.Springfield,IL:CharlesC.ThomasPublisher,1986.,p.390]**PEERREVIEWED**
/Investigators/examinedtheefficacyoftetrasodiumEDTAineradicatingbiofilmsderivedfromsalivaryinoculaorpurecultures
ofCandidaalbicansondiscsofpolymethylmethacrylate(PMMA)denturebaseorontoothbrushesthathadbeenusednormally
for48weeks.Itsefficiencyinvirusneutralizationwasalsodetermined.Overnight(16hr)treatmentwith4%(w/v)
tetrasodiumEDTAsolutionreducedsalivaryandC.albicansbiofilmviablecountsby>or=99%.Biofilmremovalwasconfirmed
usingconfocallaserscanningmicroscopy.Presence/absenceofsucroseduringbiofilmformationhadnoeffectonkillingefficacy.
ProlongedtreatmentofPMMAwithtetrasodiumEDTAdidnotinfluencesubsequentformationofC.albicansbiofilmsoraffect
surfaceroughnessofthePMMA,butitreducedsubsequentbiofilmformationfromasalivaryinoculum.Infectivitiesofherpes
simplexvirusandpoliovirussuspensionswerereducedby>99.99%bytreatmentfor1and2hr,respectively.Tetrasodium
EDTAsolutionefficientlydisinfectedtoothbrushesandPMMAdiscs,withthedetachmentofbiofilms,andrapidlyneutralized
bothnonenvelopedandenvelopedviruses.Denturesandtoothbrushesbecomecontaminatedbybacterialbiofilmsandby
viruses.Thereisaneedfordisinfectionmethodsthatarerapidlyeffective,costeffective,nontoxicandeasilyimplemented.
ThesestudiesindicatethattetrasodiumEDTAsolutionhasdisinfectionapplicationsintheoralcarefield.
[DevineDAetal;JApplMicrobiol103(6):251624(2007)]**PEERREVIEWED**PubMedAbstract
Centralvenouscatheter(CVC)relatedbloodstreaminfections(BSIs)areknowntoincreaseratesofmorbidityandmortalityin
bothinpatientsandoutpatients,includinghematologyoncologypatientsandthoseundergoinghemodialysisorhomeinfusion
therapy.Biofilmassociatedorganismsonthelumensofthesecathetershavereducedsusceptibilitytoantimicrobial
chemotherapy.ThisstudytestedtheefficacyoftetrasodiumEDTAasacatheterlocksolutiononbiofilmsofseveralclinically
relevantmicroorganisms.BiofilmsofStaphylococcusepidermidis,methicillinresistantS.aureus,Pseudomonasaeruginosa,
Escherichiacoli,Klebsiellapneumoniae,andCandidaalbicansweregrowntolevelsofapproximately1x10+5colonyforming
units(CFU)cm(1)onCVCsegmentsinamodelsystem,thensubjectedtothetetrasodiumEDTAlocktreatment.Comparisons
ofbiofilmsbeforeandafterexposuretothe40mgmL(1)tetrasodiumEDTAlockfor21hoursshowedthatthebiofilmviable
cellcountsofallorganismstestedweresignificantlyreduced(P<0.05)afterexposuretothetreatment.Antimicrobiallock
treatmentusing40mgmL(1)oftetrasodiumEDTAforatleast21hourscouldsignificantlyreduceorpotentiallyeradicate
CVCassociatedbiofilmsofclinicallyrelevantmicroorganisms.
[PercivalSLetal;InfectControlHospEpidemiol26(6):5159(2005)]**PEERREVIEWED**PubMedAbstract
Exptluse:trilonbhadsignificanttherapeuticeffectwheninjectedivat50mg/kgintorabbitsand150175mg/kgipintomice
poisonedwithlithiumchloride.
[SamilovNetal;BYULLEKSPBIOLMED74(8):46(1972)]**PEERREVIEWED**
...Tetrasodiumedtaiseffectivefortreatinglimeburnsofcorneaand/aschelatingagent/fortreatinghypercalcemiapatients
byremovingbloodcalcium.
[Luckey,T.D.andB.Venugopal.MetalToxicityinMammals,1.NewYork:PlenumPress,1977.,p.119]**PEERREVIEWED**
Interactions:
TetracyclineHClabsorptioninman,givenconcomitantlywithtetraNaEDTAandmilk,showedinhibitoryeffectofmilk
counteractedbysimultaneousingestionofEDTA.
[PoigerHetal;EURJCLINPHARMACOL14(2):129(1978)]**PEERREVIEWED**PubMedAbstract
CortisolreduceddegreeofvasculardamagetoadrenalectomizedratirrigatedwithNa4EDTAsaltifadministeredwithin16hr
priortoEDTA,noprotectionifdelayeduntil15minpriortoEDTA.
[ZaremHetal;PROCSOCEXPBIOLMED118(3):602(1965)]**PEERREVIEWED**PubMedAbstract
EnvironmentalFate&Exposure:
ProbableRoutesofHumanExposure:
Accordingtothe2006TSCAInventoryUpdateReportingdata,thenumberofpersonsreasonablylikelytobeexposedinthe
industrialmanufacturing,processing,anduseoftetrasodiumEDTAis1000orgreaterthedatamaybegreatly
underestimated(1).
[(1)USEPA;InventoryUpdateReporting(IUR).Nonconfidential2006IURRecordsbyChemical,includingManufacturing,ProcessingandUse
Information.Washington,DC:U.S.EnvironmentalProtectionAgency.Availablefrom,asofNov4,2011:http://cfpub.epa.gov/iursearch/index.cfm
**PEERREVIEWED**
NIOSH(NOESSurvey19811983)hasstatisticallyestimatedthat1,388,281workers(611,582ofthesewerefemale)were
potentiallyexposedtotetrasodiumEDTAintheUS(1).
[(1)NIOSH;NOES.NationalOccupationalExposureSurveyconductedfrom19811983.Estimatednumbersofemployeespotentiallyexposedto
specificagentsby2digitstandardindustrialclassification(SIC).Availablefrom,asofNov4,2011:http://www.cdc.gov/noes/**PEER
REVIEWED**
EnvironmentalStandards&Regulations:
FIFRARequirements:
Residuesofethylenediaminetetraaceticacid,tetrasodiumsaltareexemptedfromtherequirementofatolerancewhenusedin
accordancewithgoodagriculturalpracticeasinert(oroccasionallyactive)ingredientsinpesticideformulationsappliedto
growingcropsortorawagriculturalcommoditiesafterharvest.Use:sequestrant.Limit:5%ofpesticideformulation.
[40CFR180.910(USEPA);U.S.NationalArchivesandRecordsAdministration'sElectronicCodeofFederalRegulations.Availablefrom,asof
October18,2011:http://www.ecfr.gov**PEERREVIEWED**
Residuesofthefollowingchemicalsubstancesareexemptedfromtherequirementofatolerancewhenusedinaccordancewith
goodmanufacturingpracticeasingredientsinanantimicrobialpesticideformulation,providedthatthesubstanceisappliedon
asemipermanentorpermanentfoodcontactsurface(otherthanbeingappliedonfoodpackaging)withadequatedraining
beforecontactwithfood.(a)Thefollowingchemicalsubstanceswhenusedasingredientsinanantimicrobialpesticide
formulationmaybeappliedto:Foodcontactsurfacesinpubliceatingplaces,dairyprocessingequipment,andfoodprocessing
equipmentandutensils.Ethylenediaminetetraaceticacid(EDTA),tetrasodiumsaltisincludedonthislist.
[40CFR180.940(a)(USEPA);U.S.NationalArchivesandRecordsAdministration'sElectronicCodeofFederalRegulations.Availablefrom,asof
beforecontactwithfood....(c)Thefollowingchemicalsubstanceswhenusedasingredientsinanantimicrobialpesticide
formulationmaybeappliedto:Foodprocessingequipmentandutensils.Ethylenediaminetetraaceticacid(EDTA),tetrasodium
saltisincludedonthislist.
[40CFR180.940(c)(USEPA);U.S.NationalArchivesandRecordsAdministration'sElectronicCodeofFederalRegulations.Availablefrom,asof
AsthefederalpesticidelawFIFRAdirects,EPAisconductingacomprehensivereviewofolderpesticidestoconsidertheir
healthandenvironmentaleffectsandmakedecisionsabouttheircontinueduse.Underthispesticidereregistrationprogram,
EPAexaminesnewerhealthandsafetydataforpesticideactiveingredientsinitiallyregisteredbeforeNovember1,1984,and
determineswhethertheuseofthepesticidedoesnotposeunreasonableriskinaccordancetonewersafteystandards,suchas
thosedescribedintheFoodQualityProtectionActof1996.PesticidesforwhichEPAhadnotissuedRegistrationStandards
priortotheeffectivedateofFIFRA'88weredividedintothreelistsbasedupontheirpotentialforhumanexposureandother
factors,withListBcontainingpesticidesofgreaterconcernthanthoseonListC,andwithListCcontainingpesticidesof
greaterconcernthanthoseonListD.TetrasodiumethylenediaminetetraacetateisfoundonListD.CaseNo:4036Pesticide
type:insecticide,fungicide,herbicide,antimicrobialCaseStatus:Noneoftheactiveingredientsinthecasearebeing
supportedforreregistrationbytheirregistrants.Allareunsupported,orsomeareunsupportedandsomearecancelled.Cases
describedas"unsupported"generallyarebeingprocessedforcancellation.Activeingredient(AI):tetrasodium
ethylenediaminetetraacetateAIStatus:Registrantsofthepesticidehavenotmadeorhonoredacommitmenttoseek
reregistration,conductthenecessarystudies,orpaytherequisitefees,ortheyhaveaskedEPAtocanceltheirproduct
registrations.Unlesssomeotherinterestedpartysupportsthem,productscontainingthepesticidewillbecancelled.
[UnitedStatesEnvironmentalProtectionAgency/Prevention,PesticidesandToxicSubstances;StatusofPesticidesinRegistration,
Reregistration,andSpecialReview.(1998)EPA738R98002,p.310]**PEERREVIEWED**
FDARequirements:
Indirectfoodadditives:Substancesforuseascomponentsofcoatings.Resinousandpolymericcoatings.TetrasodiumEDTAis
includedonthislist.
[21CFR175.300;U.S.NationalArchivesandRecordsAdministration'sElectronicCodeofFederalRegulations.Availablefrom,asofSeptember7,
2004:http://www.ecfr.gov**PEERREVIEWED**
AllowableTolerances:
Residuesofethylenediaminetetraaceticacid,tetrasodiumsaltareexemptedfromtherequirementofatolerancewhenusedin
accordancewithgoodagriculturalpracticeasinert(oroccasionallyactive)ingredientsinpesticideformulationsappliedto
growingcropsortorawagriculturalcommoditiesafterharvest.Use:sequestrant.Limit:5%ofpesticideformulation.
[40CFR180.910(USEPA);U.S.NationalArchivesandRecordsAdministration'sElectronicCodeofFederalRegulations.Availablefrom,asof
beforecontactwithfood.(a)Thefollowingchemicalsubstanceswhenusedasingredientsinanantimicrobialpesticide
formulationmaybeappliedto:Foodcontactsurfacesinpubliceatingplaces,dairyprocessingequipment,andfoodprocessing
equipmentandutensils.Ethylenediaminetetraaceticacid(EDTA),tetrasodiumsaltisincludedonthislist.
[40CFR180.940(a)(USEPA);U.S.NationalArchivesandRecordsAdministration'sElectronicCodeofFederalRegulations.Availablefrom,asof
beforecontactwithfood....(c)Thefollowingchemicalsubstanceswhenusedasingredientsinanantimicrobialpesticide
formulationmaybeappliedto:Foodprocessingequipmentandutensils.Ethylenediaminetetraaceticacid(EDTA),tetrasodium
saltisincludedonthislist.
[40CFR180.940(c)(USEPA);U.S.NationalArchivesandRecordsAdministration'sElectronicCodeofFederalRegulations.Availablefrom,asof
Chemical/PhysicalProperties:
MolecularFormula:
C10H16N2O8.4Na
**PEERREVIEWED**
MolecularWeight:
380.17
[O'Neil,M.J.(ed.).TheMerckIndexAnEncyclopediaofChemicals,Drugs,andBiologicals.WhitehouseStation,NJ:MerckandCo.,Inc.,
Color/Form:
Whitepowder
[Lewis,R.J.Sr.;Hawley'sCondensedChemicalDictionary15thEdition.JohnWiley&Sons,Inc.NewYork,NY2007.,p.1228]**PEERREVIEWED**
MeltingPoint:
300degC(decomposes)
Density/SpecificGravity:
6.9lb/gal/Apparentdensity/
pH:
pHof1%soln:11.3
Solubilities:
Slightlysolubleinethanol
[Lide,D.R.CRCHandbookofChemistryandPhysics88THEdition20072008.CRCPress,Taylor&Francis,BocaRaton,FL2007,p.3482]**PEER
REVIEWED**
Lesssolubleinalcoholthanthepotassiumsalt
Freelysolubleinwater
Inwater,500g/Lat20degC
[Gerhartz,W.(execed.).Ullmann'sEncyclopediaofIndustrialChemistry.5thed.VolA1:DeerfieldBeach,FL:VCHPublishers,1985toPresent.,
p.VA10:96]**PEERREVIEWED**
OtherChemical/PhysicalProperties:
Amorphous
2004.,p.V2:1659]**PEERREVIEWED**
ChemicalSafety&Handling:
Skin,EyeandRespiratoryIrritations:
BothedeticacidandNa4EDTAaremildskinirritants,butcomparativelypotenteyeirritants.
FireFightingProcedures:
Nonflammable.Useextinguisherappropriatetootherburningmaterial....
[Sittig,M.HandbookofToxicandHazardousChemicalsandCarcinogens,2002.4thed.Vol1AHNorwich,NY:NoyesPublications,2002.,p.2187]
**PEERREVIEWED**
HazardousReactivities&Incompatibilities:
Incompatiblewithstrongacids,nitrates,oxidizers.Cansolubilizemetals.
**PEERREVIEWED**
Reactswithmostdivalentandtrivalentmetallicionsformingsolublemetalchelates.
HazardousDecomposition:
Whenheatedtodecompositionitemitstoxicfumesof/nitrogenoxidesandsodiumoxides/
PreventiveMeasures:
SRP:Thescientificliteraturefortheuseofcontactlensesbyindustrialworkersisinconsistent.Thebenefitsordetrimental
effectsofwearingcontactlensesdependnotonlyuponthesubstance,butalsoonfactorsincludingtheformofthesubstance,
characteristicsanddurationoftheexposure,theusesofothereyeprotectionequipment,andthehygieneofthelenses.
However,theremaybeindividualsubstanceswhoseirritatingorcorrosivepropertiesaresuchthatthewearingofcontact
lenseswouldbeharmfultotheeye.Inthosespecificcases,contactlensesshouldnotbeworn.Inanyevent,theusualeye
protectionequipmentshouldbewornevenwhencontactlensesareinplace.
**PEERREVIEWED**
StorageConditions:
...Storeinawellventilatedareaawayfromsourcesofheat....
**PEERREVIEWED**
CleanupMethods:
...Removeallignitionsources.Collectpowderedmaterialintheconvenientandsafemanneranddepositinsealedcontainers.
Ventilateareaaftercleanupiscomplete....
**PEERREVIEWED**
DisposalMethods:
SRP:Themostfavorablecourseofactionistouseanalternativechemicalproductwithlessinherentpropensityfor
occupationalexposureorenvironmentalcontamination.Recycleanyunusedportionofthematerialforitsapproveduseor
returnittothemanufacturerorsupplier.Ultimatedisposalofthechemicalmustconsider:thematerial'simpactonairquality
potentialmigrationinsoilorwatereffectsonanimal,aquatic,andplantlifeandconformancewithenvironmentalandpublic
healthregulations.
**PEERREVIEWED**
OccupationalExposureStandards:
Manufacturing/UseInformation:
Uses:
ForEDTAtetrasodiumsalt(USEPA/OPPPesticideCode:039107)thereare0labelsmatch./SRP:Notregisteredforcurrentuse
intheU.S.,butapprovedpesticideusesmaychangeperiodicallyandsofederal,stateandlocalauthoritiesmustbeconsulted
forcurrentlyapproveduses./
[NationalPesticideInformationRetrievalSystem'sUSEPA/OPPChemicalIngredientsDatabaseonEDTATetrasodiumSalt(64028).Availablefrom,
asofOctober19,2011:http://npirspublic.ceris.purdue.edu/ppis/**PEERREVIEWED**
Generalpurposechelatingagent.
TetrasodiumEDTAcanbeusedinsanitizingsolutionsforuseonfoodprocessingequipmentandutensilsandonfoodcontact
surfacesinpubliceatingplaces.
[USEPA,OfficeofPrevention,Pesticides,andToxicSubstances;ScienceAssessmentforEDTAChemicals(January2004).EPADocumentID:EPAHQ
OPP200503250002.Availablefrom,asofApril18,2012:http://www.regulations.gov/#!home**PEERREVIEWED**
EthylenediamineTetraaceticAcid(EDTA)anditssaltsaresubstituteddiamines....Theseingredientsfunctionaschelating
agentsincosmeticformulationsbycombiningwithpolyvalentmetalcationsinsolutiontoformsolubleringstructures.
TheuseofEDTAanditssaltsasstabilizingandchelatingagentshasbeendescribedas"ubiquitous".Originally,EDTAandthe
Edetatesweredevelopedtocounteracttheeffectsofhardwaterandheavymetalionsondyestuffsusedintextile
manufacture.Currently,theseingredientsareusedinawidenumberofapplications.EDTA,HEDTA,andtheirsaltsmaintain
clarity,protectfragrancecomponents,stabilizepolymericthickenersandcoloradditives,preventrancidity,andincrease
preservativeeffectiveness,amongothereffects.
ExperimentallyEDTAiseffectiveindetachingbiofilminwaterpurificationprocesses./EthylenediaminetetraaceticAcid/
[NationalResearchCouncil.DrinkingWater&Health,Volume4.Washington,DC:NationalAcademyPress,1981.,p.117]**PEERREVIEWED**
Sequesterant/fromtable/
[PohlSetal;HairPreparations.KirkOthmerEncyclopediaofChemicalTechnology(19992011).JohnWiley&Sons,Inc.OnlinePostingDate:
September18,2009]**PEERREVIEWED**
Manufacturers:
TheDowChemicalCo.,2030DowCenter,Midland,MI48642,(989)6361000Productionsite:2301N.BrazosportBlvd.,
Freeport,TX77541
[SRIConsulting,2010DirectoryofChemicalProducers.MenloPark,CA.2010,p.491]**PEERREVIEWED**
EasternColor&ChemicalCo.,35LivingstonSt.,P.O.Box6161,Providence,RI02904,(401)3319000Productionsite:
Providence,RI02904
FortAmandaSpecialties,LLC,1747FortAmandaRoad,Lima,OH45804,(419)9962000Productionsite:Lima,OH45804
TetrasodiumEDTAProducers(2009)
Company Address CityStateCountry
Calle5y4,ParqueIndustrialGral. 7600MardelPlata
QuimicosEssiodS.A.
Savio (BA),Argentina
CibaSpecialtyChemicals Mississauga,ONL5N
2626ArgentiaRoad
CanadaInc. 5N2,Canada
Shanghai200070,
3WIndustryCo.,Ltd. Room5C.5B,TianMuRoad749/71
China
GuangdongShantouSecondCross Guangdong515041
SandChemicalCo.,Ltd
Roadonthe7th China
ShantouXilongChemical 2XiLongMiddleStreet,ChaoShan Shantou,Guangdong
Co.,Ltd. Road Province515064,China
35DingzishanRoad,Huaiyin JinanCity,Shandong
JinanReagentGeneralWorks
District 250022,China
ChangzhouCity,
ChangzhouShanfeng
28CailingRoad JiangsuProvince
ChemicalCo.,Ltd.
213004,China
ShijiazhuangCity,
HebeiChengxinCo.,Ltd. YuanzhaoRoad,YuanshiCounty
Hebei051130,China
CangzhouGoldlion 4021,5thBuilding,Chaoyang CangzhouCity,Hebei
ChemicalsCo.,Ltd. HuayuanArea,32,YuheRoad Province061001,China
GuangzhouChemical 882GongyeDadaoSouthAvenue, Guangzhou510288,
ReagentFactory HaizhuDistrict China
ShanghaiJixiangChemical 5879NantingRoad,Tinglin Shanghai201505,
ReagentCo.,Ltd. IndustryPark,JinshanArea China
ShanghaiChemicalReagent
MansionofHualun,560XuJiaHui Shanghai200062,
Co.,Ltd.,(ShanghaiHuayi
Road China
Group)
92305LevalloisParis
SynthronB.P. 177
Cedex,France
BASFAktiengesellschaft
67056Ludwigshafen,
AromaChemicals/Cosmetic CarlBoschStrasse38
Germany
Ingredients
64293Darmstadt,
MerckKGaA Frankfurterstrasse250
Germany
83209Prienam
ChensegEuropeGmbH JosephvonFraunhoferStrasse9
Chiemsee,Germany
CibaSpecialtyChemicals BradfordBD120JZ,
P.O.Box38
WaterTreatments GreatBritain
GEHealthcare(Formerly LittleChalfront
AmershamBiosciencesUK AmershamPlace BuckinghamshireHP7
Ltd.) 9NA,GreatBritain
AVAChemicals(P)Ltd. 1/20B,NarayanPlaza,26A Mumbai400.072,India
ChandiviliRoad,Andheri(East)
CantonLaboratoriesPrivate MakarpuraVadodara
110A&BG.I.D.C.
Ltd. 390.010,Gujarat,India
SuvidhaShoppingCentre,7/8,2/F, PaldiAhmedabad,
UnitedChemicalIndustries
NR.NutanSociety Gujarat380.007,India
135,PancharatnaCharRasta, Vapi,Gujarat396.195,
TriveniChemicals
G.I.D.C. India
UniversalSpecialty
502/A,BezzolaComplex,Sion Mumbai,Maharashtra
ChemicalsPvt.(Formerly
TrombayRoad,Chembur 400.071,India
UniversalEnterprise)
NewAllianceDyeChemPvt. RamKrishnaNiwas,Prarthana
Mumbai400.057,India
Ltd. SamajRoad
PlotA713,T.T.C.IndustrialArea,
SatyajitChemicalsPvt.Ltd. Mumbai400.613,India
M.I.D.C.MahapeNavi
184G.I.D.C.Estate,Behind
BromofineChemPvt.Ltd. GujaratChlorides,Nandesar Gujarat391.340,India
Vadodara
ACIIndustrialOrganicPvt.
NandesariVadodara
Ltd.(FormerlyAssociated A1/47/4&5,G.I.D.C.
391.340,India
ChemicalInd.)
128HindustanKohinoorIndustrial
BlueDipOrganicIndustries Complex,L.B.S.Marg,Vikhroli Mumbai400.083,India
West
EnvironSpecialtyChemicals A305KempPlaza,Chincholi, Malad(West),400.064
Pvt.Ltd. BunderRoad Mumbai,India
CIB,1307/9&10,PhaseIV, Ahmedabad382.330,
ShivChemIndustries
G.I.D.C.Estate,Naroda IndiaNARODA
Jerusalem91340,
BioLabLtd. P.O.Box34038
Israel
261Shobumachi,Minamisaitama Saitama3460100,
UedaKaseiKogyoK.K.
gun Japan
KumamotoTechnoResearchPark,
Kumamoto8612202,
DojindoLaboratories 20255TabaruMashikimachi,
Japan
Kamimashikigun
TongsuhPetrochemical 8/F,KTPBuilding272Yoidodong,
Seoul150742,Korea
CorporationLtd. Youngdungpogu
ComplexQuimica,S.A.de 66144SantaCatarina,
Cuauhtemoc700Nte.
C.V. N.L.,Mexico
Insurgentes06430
Polaquimia,S.A.deC.V. Azahares26,ColoniaSantaMaria
Mexico,D.F.,Mexico
ExperimentalPlantof
450029Ufa,
BashkortostanAcademyof ul.Ulyanovykh65
Bashkortostan,Russia
Sciences
CalleFornal35,PoligonoIndustrial 08292Esparreguera
QualityChemicalsS.L.
CanComellesSud (Barcelona),Spain
PanreacQuimica,S.A.U. C/Garraf,2,PoligonoPladela 08211Castellardel

Bruguera Valles(Barcelona),
Spain
AkzoNobel RexolinABKvarntorp 69292Kumla,Sweden
ImperialChemical 3HsingKungRoad,TaShe KaohsiungHsien815,
Corporation IndustrialPark Taiwan
SanDiego,CA92121,
EMDBiosciences,Inc. 10394PacificCenterCourt
U.S.A.
Powell,OH43065,
GFSChemicals,Inc. P.O.Box245
U.S.A.
LynxChemicalGroup
Atlanta,GA30328,
(FormerlyVulcan 2000RiveredgeParkway,Suite750
U.S.A.
PerformanceChemicals)
Midland,MI48642,
TheDowChemicalCompany P.O.Box1206
U.S.A.
Vernon,CA90058,
Norman,Fox&Co. 5511SouthBoyleAvenue
U.S.A.
EasternColor&Chemical Providence,R.I.02904,
P.O.Box6161
Co. U.S.A.
[DirectoryofWorldChemicalProducers,ChemicalInformationServices,9101LBJFrwy.,Suite310,Dallas,TX75243,(214)3496200.Date
downloaded:September2009.Availablefrom,asofNov4,2011:http://www.chemicalinfo.com/dwcp**PEERREVIEWED**
TetrasodiumEDTAProducerandManufactureData(2006)
Company Site CityStateZip Manufacture Import
TeterboroNJ
AgfaCorporation AgfaCorpTeterboro
07608
AkzoNobel
AkzoNobelFunctional ChicagoIL
FunctionalChemicals No Yes
ChemsChicago 606073823
LLC
BASFCorpCorporate FlorhamPark
BASFCorporation No Yes
Headquarters NJ07932
PasadenaTX
ChemQuest,Inc. ChemQuest,Inc. Yes No
77507
EastmanKodak RochesterNY
EastmanKodakPark Yes No
Company 14650
SturtevantWI
JohnsonDiversey,Inc JohnsonDiversey,Inc No Yes
531770902
Huntington
LosAngelesChemical LosAngelesChemicalCo.
BeachCA No Yes
Company HuntingtonBeach,CA
92649
TheDowChemical DowChemicalFreeport, FreeportTX
Yes No
Company TX 77541
TheDowChemical DowChemical MidlandMI
No Yes
Company Headquarters 48674
[USEPA;InventoryUpdateReporting(IUR).Nonconfidential2006IURRecordsbyChemical,includingManufacturing,ProcessingandUse
Information.Washington,DC:U.S.EnvironmentalProtectionAgency.Availablefrom,asofMov4,2011:http://cfpub.epa.gov/iursearch/index.cfm
**PEERREVIEWED**
MethodsofManufacturing:
TetrasodiumEDTAwasformedbyreactingabasicsolutionofethylenediaminewithformaldehydeandsodiumorhydrogen
cyanide,followedbyhydrolysistoformthesalt.Itcanalsobeproducedbyusingexcesssodiumhydroxideinthereaction.The
intermediateethylenediaminetetracetonitrilecanbeisolatedandhydrolyzed...inaseparatestep.Itwassuppliedeitherin
anhydrousformorhydratedwithtwomoleculesofwaterpermoleculeofthesalt.
GeneralManufacturingInformation:
AnumberofsaltsofEDTAareavailablewithusesidenticalorsimilartotheacid.TheUSPsaltsarecallededetates(calcium
disodium,disodiumedetates)othersareusuallyabbreviatedtoEDTA(tetrasodium,trisodiumEDTA).Othersalts,known
chieflyundertrademarknames,arethesodiumferric,dihydrogenferrousandarangeofdisodiumsaltswithmagnesium,
divalentcobalt,manganese,copper,zinc,andnickel.
Historicaldata(datasubmittedtotheFDAin1984)indicatedthatEDTAandTetrasodiumEDTAwereusedtypicallyat
concentrationsupto1%,butoneformulationeachcontainedconcentrationsof25%.
IthasbeenestimatedthatdailyhumanconsumptionofEDTAsaltsare1.5x104forTetrasodiumEDTA.
Odorandtasteevaluationsindicatedthat1%dipoftetrasodiumEDTAincreasedshelflifeoffishfrom59to10daysand
significantlydecreaseddevelopmentoftrimethylamineandvolatile,basicnitrogencompounds.
[Furia,T.E.(ed.).CRCHandbookofFoodAdditives.2nded.Cleveland:TheChemicalRubberCo.,1972.,p.737]**PEERREVIEWED**
TetrasodiumEDTAshowedincreaseof14%waterretentionat0degCwhen1.0%solutionwasaddedtomincedporkmixture
havingpHof6.6./FromTable/
[Furia,T.E.(ed.).CRCHandbookofFoodAdditives.2nded.Cleveland:TheChemicalRubberCo.,1972.,p.695]**PEERREVIEWED**
EDTAtetraNasalthadweakestantimicrobialeffectoncuttingfluidpreservatives.
[IZZATIN,BENNETTEO;DEVINDMICROB20:683(1979)]**PEERREVIEWED**
Formulations/Preparations:
Thecosmeticgradematerialcontainsaminimumof99.0%TetrasodiumEDTAasNa4EDTA.2H2O
Anhydrousordihydrate.
[Lewis,R.J.,Sr(Ed.).Hawley'sCondensedChemicalDictionary.13thed.NewYork,NY:JohnWiley&Sons,Inc.1997.,p.1092]**PEER
REVIEWED**
Impurities:
/Investigators/reportedthatTetrasodiumEDTAcouldcontainanunspecifiedamountofthestartingmaterial,formaldehyde.
U.S.Production:
Glycine,N,N'1,2ethanediylbis[N(carboxymethyl),tetrasodiumsaltislistedasaHighProductionVolume(HPV)chemical
(65FR81686).ChemicalslistedasHPVwereproducedinorimportedintotheU.S.in>1millionpoundsin1990and/or1994.
TheHPVlistisbasedonthe1990InventoryUpdateRule.(IUR)(40CFRpart710subpartB51FR21438).
[EPA/OfficeofPollutionPreventionandToxics;HighProductionVolume(HPV)ChallengeProgram.Glycine,N,N'1,2ethanediylbis[N
(carboxymethyl),tetrasodiumsalt(64028).Availablefrom,asofOctober19,2011:http://www.epa.gov/hpv/pubs/general/opptsrch.htm**PEER
REVIEWED**
ProductionvolumesfornonconfidentialchemicalsreportedundertheInventoryUpdateRule.
Year ProductionRange(pounds)
1986 >50million100million
[USEPA;NonconfidentialProductionVolumeInformationSubmittedbyCompaniesforChemicalsUnderthe19862002InventoryUpdateRule(IUR).
Glycine,N,N'1,2ethanediylbis[N(carboxymethyl),tetrasodiumsalt(64028).Availablefrom,asofOctober19,2011:
http://www.epa.gov/oppt/iur/tools/data/2002vol.html**PEERREVIEWED**
Productionvolumefornonconfidentialchemicalsreportedunderthe2006InventoryUpdateRule.Chemical:Glycine,N,N'1,2
ethanediylbis[N(carboxymethyl),sodiumsalt.AggregatedNationalProductionVolume:100to<500millionpounds.
[USEPA;NonConfidential2006InventoryUpdateReporting.NationalChemicalInformation.Glycine,N,N'1,2ethanediylbis[N(carboxymethyl),
sodiumsalt(64028).Availablefrom,asofOctober19,2011:http://cfpub.epa.gov/iursearch/index.cfm?s=chem&err=t**PEERREVIEWED**
LaboratoryMethods:
SpecialReferences:
SynonymsandIdentifiers:
RelatedHSDBRecords:
809[Ethylenediaminetetraaceticacid](freeacid)
Synonyms:
ACETICACID,(ETHYLENEDINITRILO)TETRA,TETRASODIUMSALT
**PEERREVIEWED**
AQUAMOLLIN
**PEERREVIEWED**
CALSOL
**PEERREVIEWED**
CELONE
**PEERREVIEWED**
CHEELOXBF
**PEERREVIEWED**
CHEMCOLOX200
**PEERREVIEWED**
CHEMCOLOX240POWDER
**PEERREVIEWED**
COMPLEXONE
**PEERREVIEWED**
CONIGONBC
**PEERREVIEWED**
DISTOL
**PEERREVIEWED**
EdathamilTetrasodium
**PEERREVIEWED**
EDATHANILTETRASODIUM
**PEERREVIEWED**
EdeticAcidTetrasodiumSalt
**PEERREVIEWED**
EDTATETRASODIUMSALT
**PEERREVIEWED**
EndrateTetrasodium
**PEERREVIEWED**
N,N'1,2Ethanediylbis(N(Carboxymethyl)Glycine),TetrasodiumSalt
**PEERREVIEWED**
Ethylenebis(IminodiaceticAcid)TetrasodiumSalt
**PEERREVIEWED**
EthylenediaminetetraaceticAcidTetrasodiumSalt
**PEERREVIEWED**
(ETHYLENEDINITRILO)TETRAACETICACIDTETRASODIUMSALT
**PEERREVIEWED**
Glycine,N,N'1,2Ethanediylbis(N(Carboxymethyl),TetrasodiumSalt
**PEERREVIEWED**
HAMPENE100
**PEERREVIEWED**
IRGALON
**PEERREVIEWED**
METAQUESTC
**PEERREVIEWED**
NERVANAIDBLIQUID
**PEERREVIEWED**
NULLAPON
**PEERREVIEWED**
NULLAPONBFC
**PEERREVIEWED**
PERMAKLEER100
**PEERREVIEWED**
PERMAKLEERTETRACP
**PEERREVIEWED**
QUESTEX
**PEERREVIEWED**
SEQUESTRENE30A
**PEERREVIEWED**
SEQUESTRENEST
**PEERREVIEWED**
SodiumEdetate
**PEERREVIEWED**
SODIUMETHYLENEDIAMINETETRAACETATE
**PEERREVIEWED**
SYNTES12A
**PEERREVIEWED**
SYNTRONB
**PEERREVIEWED**
TetracemateTetrasodium
**PEERREVIEWED**
Tetracemin
**PEERREVIEWED**
TetrasodiumEdetate
**PEERREVIEWED**
TETRASODIUMETHYLENEDIAMINETETRAACETATE
**PEERREVIEWED**
TetrasodiumEthylenediamineN,N,N',N'Tetraacetate
**PEERREVIEWED**
TETRASODIUM(ETHYLENEDINITRILO)TETRAACETATE
**PEERREVIEWED**
TRILONB
**PEERREVIEWED**
TST
**PEERREVIEWED**
TYCLAROSOL
**PEERREVIEWED**
VERSENE67
**PEERREVIEWED**
VERSENE100
**PEERREVIEWED**
VERSENEBEADS
**PEERREVIEWED**
VERSENEFLAKE
**PEERREVIEWED**
WARKEELATES42
**PEERREVIEWED**
WARKEELATEPS47
**PEERREVIEWED**
Komplexon
**PEERREVIEWED**
Kalex
**PEERREVIEWED**
USEPA/OPPPesticideCode:039107
**PEERREVIEWED**
AssociatedChemicals:
DisodiumEDTA139333
Formulations/Preparations:
Thecosmeticgradematerialcontainsaminimumof99.0%TetrasodiumEDTAasNa4EDTA.2H2O
Anhydrousordihydrate.
[Lewis,R.J.,Sr(Ed.).Hawley'sCondensedChemicalDictionary.13thed.NewYork,NY:JohnWiley&Sons,Inc.1997.,p.1092]**PEER
REVIEWED**
AdministrativeInformation:
HazardousSubstancesDatabankNumber:5003
LastRevisionDate:20120426
LastReviewDate:ReviewedbySRPon1/19/2012
UpdateHistory:
CompleteUpdateon20120426,0fieldsadded/edited/deleted
FieldUpdateon20030610,0fieldsadded/edited/deleted
CompleteUpdateon02/14/2003,1fieldadded/edited/deleted.
CompleteUpdateon06/08/1999,31fieldsadded/edited/deleted.
FieldUpdateon11/16/1998,1fieldadded/edited/deleted.
Fieldupdateon01/02/1993,1fieldadded/edited/deleted.
Fieldupdateon03/06/1990,1fieldadded/edited/deleted.
CompleteUpdateon10/31/1989,4fieldsadded/edited/deleted.
CompleteUpdateon10/14/1986
Created19830401bySYS

TETRASODIUM EDTA - National Library of Medicine HSDB Database

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