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Virology Replication occurs when the virus takes

control of the host cell


History Unable to multiply on their own
Lack genes and enzymes necessary for
3700 BC Memphis Egypt
energy production
1st written record of virus infection
Do not divide by binary fission
1000 BC China
Genetic Material is either DNA or RNA but
Smallpox outbreak
never both
Variolation
Do not have call wall and no cellular
1796 Edward Jenner used cowpox
organization
(variola) infected materials
1840 Jacob Henle hypothesized there were Oncogenetic Vius - Virus that causes cancer
small infectious agents
1880 Germ Theory Pasteur associates Ex.
rabies as a viral infection
Adolf Mayer experiment EBV nasopharyngeal cancer, Burkitts
1881 Development of the 1st artificially lymphoma, B- cell lymphoma
produced virus vaccines HHV-8 Kaposis Carcinoma
1892 Ivanofsky extended Mayers HPV Cervical Cancer: Serotype 16
observation Beginning of Virology and 18
1898 Baijenrick confirmed Ivanofskys HTLV (Human T-Lymphotropic Virus
experiment about tobacco mosaic Type 1) adult T cell lymphoma
virus Contagium vivum fluidum Hepa B and C virus Hepatocellular
1990 Reed recognized Yellow Fever Carcinoma
(filterable agent)
1915 Twort and dHerelle recognized virus Viroids Small, cellular infectious RNA molecules
infecting bacteria; Plaque essay w/rod like secondary structures which do not
1935 Stanley crystallized tobacco mosaic posses capsid and envelope
virus Can shunt the growth of plants and
1937 Theiler propagated virus in chick interfere w/ the metabolisms of plant cell
embryo: 17D strain attenuated
Prions - Infectious agent believed to consist of a
vaccine was develop single type of protein molecule w/ no nucleic acid
1939 Use of Electron Microscope in component
visualizing the Mosaic Virus Studied my Stanley B. Prusiner (1997
1940 1st Photo of the virus was taken Nobel Prize for Physiology or Medicine)
1945-1955 Cell Culture System
1959 Negative Staining of Virus Prion Diseases

Bovine Sporangium Encelopathy


Virus-Minute infectious organism that cause Gerstmann Straussler - Scheinker
disease in all life forms
-Smallest and most primitive of the Karu
conventional infectious agents Fetal Familial Insomnia
- Obligate intracellular pathogens Creutzfeldt-Jakob Disease
Unique Characteristics Scrapie
Energy-less Mad Cow Disease
Basic life forms composed of a protein
Bovine Sporangium Encelopathy
coat, called a capsid that surrounds the
genetic materials. They do not have -Transmissible neurodegenerative, fatal brain
organelles or ribosomes disease
-Fatal degenerative disease that affects the
nervous system of sheeps and goats. It is one of
several TSE, related to BSE or Mad Cow disease

Gerstmann Straussler Scheinker Mad Cow Disease

-Very rare, usually familial, fatal neurodegenerative -Incurable, fatal brain disease that affects cattle and
disease that affects patients from 20-60 years of possibly some other animals, such as goats and
age. This extremely rare disease is classified as sheep
Transmissible Sporangium Encephalopathy - Medical name is Bovine Sporangium Encelopathy
-Affects cows nervous system, causing cow to act
Karu strangely and lose control of its ability to do normal
things such as walking,
-An incurable degenerative neurological disorder
that is a type of TSE found in humans

Fetal Familial Insomnia

-Very rare autosomal dominant inherited prion


disease of the brain
-Has no known cure, involves progressively
VIRUS VS BACTERIA
worsening insomnia, which lead to hallucination,
delirium, and confusional states that is like of
VIRUS BACTERIA
dementia
Without Ribosomes With Ribosomes
-Average survival span after onset of symtoms is
No cell Unicellular
18 months
No cell-membrane With cell-membrane
Creutzfeldt-Jakob Disease No nucleus No nucleus
Replicate by invading a Multiply by Binary
-Very rare degenerative disorder, symptoms starts host cell and take over the Fussion
around age 60 cell causing it to make
-Memory problems, behavior changes, vision copies of the final DNA and
problems and poor muscle coordination progress RNA
quickly to dementia, coma and death/.Most patient Either DNA or RNA as Posses both DNA
die within 1 year
genetic material and RNA
Vaccines and Antiviral Antibiotics
Scrapie drugs

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