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HOMEOSTASIS
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9.1 Concept of Homeostasis
1. Explain the concept of homeostasis.
OUTSIDE
INTERNAL CONTROL
FACTORS MECHANISM
E g : Thermoregulation
E g : Temperature
Activates
Changes
Internal
environment
Concept of Homeostasis
continually monitored,
evaluated,
changed,
re-monitored,
body temperature,
blood pressure,
RECEPTOR
CONTROL
SYSTEM
EFFECTOR
Three basic components
make up a feedback system
RECEPTOR
EFFECTOR
Three basic components make
up a feedback system
RECEPTOR
CONTROL SYSTEM
Evaluates the input it receives
from receptors and generates
output commands when they
are needed.
CONTROL
EFFECTOR
SYSTEM A body structure that receives
output from the control centre
and produces a response or effect
that changes the controlled
condition.
Negative feedback
Positive feedback
A feedback mechanism in
Homeostatic mechanism which the response
that reduces the intensity of enhances the original
the original stimulus stimulus
Decrease Increase
Positive feedback Positive feedback
Corrective mechanism
Negative feedback
Steady-
state
condition
A generalized diagram of homeostasis
HOMEOSTASIS
Negative Feedback
Mechanism in
Controlling
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glucagon
Glycogen Glucose
INsulin is released when there is an
INcrease in the blood glucose level..
AND
Negative Feedback
in
Body Temperature
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Regulation
Learning Outcomes
If the temperature
rises, the blood
vessel dilates
(vasolidation).
Sweating
The
skin
vasoconstriction
Less heat is lost from the surface of the skin
If the temperature
falls, the blood
vessel constricts
(vasoconstriction).
If all else fails,
Thank you
LECTURE 2
9.3.1 Liver
Learning outcomes:
v
Describe the detailed structure of liver
v
Explain its homeostatic function
- Carbohydrate metabolism
- Detoxification
- Transamination & deamination of
amino acids
v
Illustrate Urea / Ornithine cycle
Liver
Each lobules
about 1 mm in
diameter
Structure of liver : Lobules
Structure of liver : Lobules
Acinus
Structure of liver : Hepatocytes
A lobule consists of
specialized liver cells
called hepatocytes.
Hepatocytes are
arranged in irregular,
branching,
interconnected plates
around a central vein.
Structure of liver : Hepatocytes
Hepatocytes have
prominent nuclei
and Golgi apparatus,
many mitochondria
and lysosomes.
Bile
Carbohydrate metabolism
Detoxification
v
-cells from islet of Langerhans of pancreas secrete
insulin and stimulate the liver
The conversion of glucose to glycogen is known as
glycogenesis and is stimulated by the presence of
insulin
When blood glucose level is low
Fall in glucose
Rise in glucose level
level
Fall in glucose
level
Rise in glucose
level
Islet of langerhans (detector)
Liver:
glycogen Negative feedback
Glucagon secreted
glucose
protein glucose
Figure : summary diagram of control blood glucose level
Transamination of amino acid
From deamination, amino acid is broken
into a non-nitrogenous part and a
nitrogenous part.
H R R
deamination
2 N C COOH + O2 2 C COOH + 2NH3
H
H O
ammonia
Keto acid
Detoxification
Urea, CO(NH2)2 is
the nitrogenous
waste product of
humans and other
land-living mammals
Ammonia from
deamination is
converted to urea in
the ornithine cycle
(urea cycle).
Formation of urea
Ammonia
NH2
carbon dioxide urea water
Formation of urea
ornithine, citrulline,
arginosuccinate and
arginine as intermediates,
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LECTURE 3
9.3.2 Kidney
Structure of kidney and nephron
Learning outcomes
Function:
Removal of metabolic
waste products
Regulation of the water
content of body fluids
Regulation of pH of body
fluids
Regulation of the
chemical composition of
body fluids
Structure of kidney
Pair of bean-shaped
organ
covered by fibrous
composed of tubular
connective tissue parts of the nephron and
blood vessels which
Hair-pin shaped.
Has descending
limb & ascending
limb.
Located in the
medulla of the
kidney.
Structure of nephron
Distal convoluted
tubule
Located in the
cortex of the kidney.
Structure of nephron
Collecting duct
End of kidney.
Ultrafiltration occurs
from the capillaries of
the glomerulus into
the lumen of the renal
capsule.
Urine formation :Ultrafiltration
H2O
HCO3-
H+
Urea
Glucose; amino
acids
Some drugs
Factors contributing to ultrafiltration
a) The hydrostatic blood
pressure in the glomerulus
is higher than in other
capillaries.
q
This high pressure is
mainly due to the high
resistance to outflow
presented by the efferent
arteriole, which is
smaller in diameter than
the afferent arteriole.
Factors contributing to ultrafiltration
b) Large amount of
glomerulus filtrate large
surface area for filtration
provided by the highly coiled
glomerulus capillaries.
Factors contributing to ultrafiltration
c) High permeability of the
glomerulus
q
The wall of Bowmans
capsule in contact with
capillaries consists of
specialized epithelial cell
called podocytes.
q
These cells have numerous
cytoplasmic extension
called foot processes that
cover most of the
capillaries.
Factors contributing to ultrafiltration
q
Foot processes of
adjacent podocytes
are separated by
narrow gaps called
filtration slits.
q
The perforated walls of the
capillaries and the
podocytes form a filtration
membrane that permits fluid
and small solutes dissolved in
q
This filtrate membrane holds
back blood cells, platelets,
and most of the plasma
protein.
2) Reabsorption (proximal convoluted
tubule, loop of Henle, distal convoluted
tubule and collecting duct)
)
Reabsorbing of NaCl (salt) and
water
Salt moves from the filtrate to
the interstitial fluid by active
transport
Water follows passively by
osmosis
Reabsorption and secretion at
proximal convoluted tubule
Reabsorption from
proximal tubule
into blood
Secretion from
blood into proximal
tubule
Reabsorption in the proximal convoluted
tubule
)
Glucose , amino acids ,
vitamins and other
useful materials are
also reabsorbed into
the blood.
)
This is accomplished
by a combination of
active transport,
diffusion and osmosis.
ii. Decending limb of the loop
of Henle
Reabsorption from
distal tubule into
blood
Secretion from
blood into distal
convoluted tubule
v. Collecting duct
1) Countercurrent
Fluids past each other in opposite directions.
Fluid flow down one side of the loop the
descending limb, and up the other side the
ascending limb
2) Multiplier
Fluid flow down the descending limb, high
concentration of NaCl ; hypertonic
Fluid flow up the ascending limb, less
concentration of NaCl ; hypotonic
counter current multiplier mechanism
The loop of Henle as a
countercurrent multiplier
The loop of Henle maintains the interstitial fluid
gradient of NaCl in medulla.
The filtrate concentration of this salt increases
because of the loss of water from the
descending limb.
Then the ascending limb leaks the salt into the
interstitial fluid.
Additional salt is actively transported out of the
thick segment of the ascending limb.
The loop of Henle as a countercurrent
multiplier
The high concentration of
salt in the medulla makes
water leave the
descending limb by
osmosis
-
water regulation by ADH
-
The action of aldosterone on Na+
reabsorption
-
pH regulation of the tissue fluid
Water regulation by ADH
Concepts
The kidneys play central role in the
regulation of the water content of the
body or osmoregulation.
The water content of the blood is
monitored by osmoreceptor cells in the
hypothalamus and they stimulate the
pituitary gland to secrete antidiuretic
hormone, ADH.
What happens if you havent
had a drink for a while?
Its concentration is
carefully regulated by
the hormone,
aldosterone.
Sodium reabsorption is regulated
by the hormone Aldosterone
Aldosterone secretion can be
stimulated by a decrease in
blood pressure.
Aldosterone is secreted by
the cortex of the adrenal
glands.
Sodium reabsorption is regulated
by the hormone Aldosterone
This hormone
stimulates the distal
tubules and collecting
duct to increase
sodium reabsorption.
H2CO3 H+ + HCO3-
Process
In the distal
convoluted tubule
longer-term
adjustments in the
ion balance of the
blood are made.
If the blood pH is
tending to fall below
7.4, H+ ions from the
plasma are secreted
If the blood pH rises
above 7.4, OH- ions
from plasma are
secreted in the distal
convoluted tubule.
9.4 Water regulation in plants
Objectives :
a) Describe the role of stomata in regulation
of water loss
b) Explain the importance of transpiration
c) Describe the various types of plant
adaptation to the environment in relation
to morphology, anatomy and physiology
The role of stomata in
regulation of water loss
On a short term basis,
closing of the stomata can
control water loss
Transpiration is an important
process to plants, because it
provides the force to pull
water and mineral ions up
the xylem vessels
The importance of transpiration
Xerophytes
Hydrophytes
Mesophytes
Halophytes
Xerophytes
Live in short water supply
Problem: loss of water death
Features to reduce water loss
Waxy cuticle
Smaller leaves
Presence of trichomes
Leaf rolled up
Succulent
Stomata
Close in the day
Open in the night
Photosynthesis - CAM
Hydrophytes
Live in water
Adaptation:
Xylem vessel is poorly
developed
Large leaves
Lack sclerenchyma tissue
Stem and leaves have
paerenchyma tissue
Large air spaces
Mesophytes
Live with an adequate
water supply
Most angiosperm plants
No special adaptation
Hot & dry:
close stomata
Seeds dormant
Halophytes
Live in areas of high salinity
Problem:
absorption of water from salty
water
High rate of transpiration
Adaptive:
Root accumulate minerals by
active absorption
Thick layer of cuticle
Succulent leaves
Reduced stomata and hairs
Root submerged in salt
water/knee root
The End
Thank you and till we meet again