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5861059 Mnasnan Se-amorntham (Nancy) 1107 No.

7 General Chemistry

VitaminE-tocopherol

Purposes
VitaminEisthemajorfat-solubleantioxidantforcellantioxidantdefensesystem
andiscompletelygetfromthediet.Ithascopiousessentialrolesforthehumanbody
includingkeeps/guardsbodytissuefromdamagewhichmaycausebysubstances
calledfreeradicals.Moreover,VitaminEcansupportandkeeptheimmunesystem
strongagainstvirusesandbacteria.VitaminEhasbeenshowntobeeffectiveagainst
manypossibleconditionsandnumerousdiseasessuchascancer,ageing,arthritisand
cataracts.Withthisbenefit,VitaminEcanpreventplatelethyperaggregation,whichcan
leadtoatherosclerosisaswell.DespitevitaminEcanpreventcancer,heartdisease,
dementia,liverdisease,andstroke,itstillrequiresfurtherresearch.Furthermore,italso
helpstodecreasetheprostaglandinsproductionsuchasthromboxane,whichcause
plateletclumping.ThecurrentworksreviewdiscussesaboutvitaminErolesand
functionsinhumanhealthincludingsomediseasesaswellastheconsequencesof
vitaminEdeficiency.Themainfocusofthereviewisonthetocopherolclassofthe
vitamers.[1]

Applications
VitaminEord--tocopherolwasselectedasactiveelementbecauseofitswell-
valuedremarkableantioxidantproperties(suchasradicalscavenger)forfoodand
pharmaceuticalindustries.TheincreaseofthepHvalueswiththeincreasedloadingof
d--tocopherolhasbeencertifiedtothevitaminEantioxidantproperties,whichlimits
theformationoffreefattyacidscommonlyobservedinphospholipids-composed
formulations.[4]
However,thesafetyofvitaminEsupplementationhavebeenraisedonthis
regard,especiallyinhighdoses.Anincreasedriskofbleedinghasbeenproposed,
particularlyinpatientstakingblood-thinningagentssuchaswarfarin,heparin,oraspirin,
5861059 Mnasnan Se-amorntham (Nancy) 1107 No. 7 General Chemistry

andinpatientswithvitaminKdeficiency.Onthecontrary,testimonysuggeststhat
regularuseofhigh-dosevitaminEsupplementsmayincreasetheriskofdeathfromall
causesbyasmallamount,whereashumanresearchisconflicting.Cautionisjustified.[3]

Properties

Chemicalproperties[5]
PropertyName PropertyValue

MolecularWeight 430.717g/mol

HydrogenBondDonorCount 1

HydrogenBondAcceptorCount 2

RotatableBondCount 12

MonoisotopicMass 430.381g/mol

ExactMass 430.381g/mol

CompoundIsCanonicalized true

FormalCharge 0

HeavyAtomCount 31

DefinedAtomStereocenterCount 3

IsotopeAtomCount 0

Covalently-BondedUnitCount 1

Physicalproperties
VitaminE-tocopherolmayplayanimportantroleinchronicdiseaseand
carcinogenesisprevention.However,the-tocopherolutilizationasafunctional
5861059 Mnasnan Se-amorntham (Nancy) 1107 No. 7 General Chemistry

ingredientinfoodandbeveragesiscurrentlylimited.Thisisbecauseofitsheatand
oxygensensitivity,poorwater-solubility,andlowandvariablebioavailability.[2]
PhysicalDescription[5]
- Liquid

Color
- Paleyellowoil
- Transparentneedles

Odor
- Littleornoodor

Taste
- Littleornotaste

MeltingPoint
- 3C

WaterSolubility
- Insolubleinwater,butwater-dispersible.
- Inwater,1.9X10-6mg/Lat25degC(est)
- Inwater-ethanolsolution,20.82mg/Lat33degC
- Solubleinalcohol,ether,acetone,chloroform

Density
- 0.950g/cucmat25deC

VaporPressure
- 1.4X10-8mmHgat25degC(est)

5861059 Mnasnan Se-amorntham (Nancy) 1107 No. 7 General Chemistry

References
1. Rizvi,S.,Raza,S.,Ahmed,F.,Ahmad,A.,Abbas,S.,&Mahdi,F.(2013).TheRoleof
VitaminEinHumanHealthandSomeDiseases.SultanQaboosUniversity
MedicalJournal,157-165.
2. Saberia,A.H.,Fangb,Y.,&McClements,D.J.(2013).Effectofglycerolon
formation,stability,andpropertiesofvitamin-Eenrichednanoemulsions
producedusingspontaneousemulsification.JournalofColloidandInterface
Science,105113.
3. Standard,N.(2011,December).TheResearchBehindVitaminE.RetrievedMay
18,2017fromNaturalMedicine:
http://www.naturalmedicinejournal.com/journal/2011-12/research-behind-vitami
n-e
4. Teixeiraa,M.,Severinob,P.,Andreanic,T.,Boonmee,P.,Santinig,A.,Silvac,A.,&
Soutoa,E.(2017).d--tocopherolnanoemulsions:Sizeproperties,rheological
behavior,surfacetension,osmolarityandcytotoxicity.SaudiPharmaceutical
Journal,231235.
5. VitaminE.(n.d.).RetrievedMay18,2017fromPubchem:
https://pubchem.ncbi.nlm.nih.gov/compound/14985#section=Top