Febrile neutropenia

Disease Pathogen/Etiology Manifestations Diagnosis Treatment

Febrile <PMN production: Fever/diminished signs and >38.3C or 38C two High risk:
neutropenia Marrow/Iatrogenic/ symptoms of infection readings >2h Pipe/Tazo (or Cef 3/
Deficiency Carbapenems) IV
Search for: ACN <500 or 1000 +
>PMN peripheral mucositis/line infections/other trending down 0.5 Metronidazole IV/PO
destruction: sites/examine perianal region/ +
Autoimmune/Splenic Avoid DRE C&S: Blood/Urine/ Vancomycin IV
sequestration Sputum/Stools/ +
History: Chemotherapy 5-10d Catheters Amphotericin B (after
<WBC 3-5 w fever)
Imaging
Low risk:
Ciprofloxacine PO +
Amox/Clav PO

Prophylaxis:
G-CSF
GM-CSF