Drug Reference and page Route of Main Clinical
(Generic or trade number Administration Use/Classification
name)
Acetaminophen/ Plumbs Online PO Oral Analgesic,
Tylenol/ APAP/ Antipyretic (Systemic Drug)
Paracetamol Analgesic in dogs and small
mammals.
Treats chronic pain
conditions in dogs with
renal dysfunction and in
situations where moderate
pain occurs.
Acetazolamide/ Plumbs PO Carbonic Anhydrase
Diamox/ Dazamide Online Inhibitor Diuretic,
Antiglaucoma
Agent (Systemic Drug)
Used for its effects on
aqueous humor production
in treating glaucoma,
metabolic alkalosis, and for
diuretic action.
Its used to treat
syringomyelia in dogs and
as an adjunctive therapy for
HYPP in horses.
Contraindications
(Complications with disease
or other drugs)
Contraindicated in cats,
ferrets, sugar gliders, and
hedgehogs.
Do not give in high doses to
dogs or immediately post-
operation.
Use cautiously in pregnancy
Possible drug interactions
with barbiturates,
phenothiazines, and other
drugs.
Do not use in patients with
significant hepatic, renal,
pulmonary, or adrenocortical
insufficiency, hyponatremia,
hypokalemia, hyperchloremic
acidosis, or electrolyte
imbalance.
Used with caution in patients
with severe respiratory
acidosis or patients that have
preexisting hematologic
abnormalities.
Use cautiously with
pregnancy
Possible interactions with
aspirin, insulin, and other
drugs.
Drug Reference and page Route of Main Clinical
(Generic or trade number Administration Use/Classification
name)
Acetylcysteine/ N- Plumbs Online Inhalant, topical Mucolytic (Systemic Drug)
acetylcysteine/ NAC/ ophthalmic, by Used as a treatment for
ACC/ Mucomyst gastric or duodenal acetaminophen, xylitol, or
tube, anecdote, phenol toxicity in small
adjunct. animals.
Used as an anti-
inflammatory for chronic
upper respiratory disease in
cats, as an adjunct in heavy
metal removal, and
topically in the eye to halt
the melting effect of
collagenases and
proteinases on the cornea.
Used to help break up
chondroids in horses with
strangles.
Contraindications
(Complications with disease
or other drugs)
Causes hypersensitivity and
bronchospasm when used in
the pulmonary tree.
Contraindicated in animals
that are hypersensitive to it.
Give oral doses on an empty
stomach.
Caution in nursing animals.
The use of activated charcoal
as a gut adsorbent of
acetaminophen is
controversial.
Drug Reference and page Route of Main Clinical Contraindications
(Generic or trade number Administration Use/Classification (Complications with disease
name) or other drugs)

Acetylsalicylic Acid/ Plumbs Online PO Analgesic, Antipyretic, Contraindicated in patients

Aspirin/ ASA Platelet Aggregation
Reducer, Antiinflammatory
(Systemic Drug)
Aspirin is used for its
analgesic, antipyretic,
and antiplatelet effects.
demonstrating previous
hypersensitivity reactions to
it or with bleeding ulcers.
Relatively contraindicated in
patients with hemorrhagic
disorders, asthma, or renal
insufficiency.
Used cautiously in patients
with severe hepatic failure or
diminished renal function.
Used cautiously in cats
because of their inability to
rapidly metabolize and
excrete salicylates.
Avoid use during pregnancy
Possible interactions with
aminoglycosides,
corticosteroids, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Activated Charcoal Plumbs Online PO Oral Adsorbent (Systemic
Drug)
Administered orally to adsorb
certain drugs or toxins to
prevent or reduce their
systemic absorption.
Adaptil Plumbs Online Diffuser/spray Pheromone Behavior
Modifier (Systemic Drug)
Useful in treating canine
behaviors associated with fear
or stress (separation anxiety,
destruction, excessive barking,
house soiling, licking,
phobias) or calming animals in
new environments or
situations.d
Contraindications(Complicati
ons with disease or
other drugs)
Should not be used for
mineral acids, salt toxicosis,
hydrocarbons, or caustic
alkalies. Other potential
contraindications to charcoal
therapy include: GI
obstruction or ileus,
hypernatremia, hyperosmolar
states, or imminent GI
surgery/endoscopy.
Possible drug interactions
with dairy products, mineral
oil, and other drugs.
None
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Adequan/ Plumbs Online IM, IA, SQ Proteolytic Enzyme Inhibitor,
Polysulfated Chondroprotectant (Systemic
Glycosaminoglycan/ Drug)
Chondroprotec Treatment of non-infectious
and/or traumatic joint
dysfunction and associated
lameness of the carpal joints
in horses.
Controls signs associated with
non-infectious degenerative
and/or traumatic arthritis in
dogs.
Afoxolaner/ NexGardPlumbs Online PO Oral insecticide/
acaricide (Systemic Drug)
For treatment and control of
fleas, American dog tick,
black-legged tick, Lone star
tick, and brown dog tick in
dogs 8 weeks or older.
Contraindications(Complicati
ons with disease or
other drugs)
The drug should not be used
in place of other therapies in
cases where infection is
present or suspected, or in
place of surgery or joint
immobilization where
indicated.
Some say it should not be
used within one week of
arthrotomy in dogs
Not recommended for
breeding animals
Some concern with use with
NSAIDs or anticoagulants
Use with caution in dogs with
a history of seizures or
epilepsy.
Not labeled for use in puppies
less than 8 weeks old or in
dogs that weigh less than 4
lbs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Albuterol/Salbutamol Plumbs PO, inhalant Beta-Adrenergic Use with caution in patients

/Proventil/Ventolin Online Agonist (Systemic Drug)
Used in dogs and cats for its
effects on bronchial smooth
muscle to alleviate
bronchospasm or cough and
in horses as a bronchodilator.
with diabetes,
hyperthyroidism,
hypertension, seizure
disorders, or cardiac disease.
It may inhibit uterine
contractions
Use cautiously in pregnancy
Possible interactions with
digoxin, beta-adrenergic
blockers, and other drugs.

Allopurinol/ Plumbs PO Xanthine Oxidase Inhibitor, Use with caution in patients

Zyloprim Online Purine Analog (Systemic
Drug)
Used as a uric acid reducer in
dogs, and cats
Used to treat gout in birds and
reptiles.
It is alternative treatment for
canine Leishmaniasis and
American Trypanosomiasis.
with renal or hepatic
dysfunction.
Contraindicated in red-tailed
hawks.
It can cause adverse effects to
the GI system, and can cause
hypersensitivity, and hepatic
and renal effects.
Use cautiously in pregnant
females and nursing dams.
Possible interactions with
amoxicillin, cyclosporine, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Aluminum hydroxide Plumbs Online PO Oral Antacid/Phosphate
gel/Amphogel Binder (Systemic Drug)
It is an oral
antacid/phosphate binder.
Used to treat
hyperphosphatemia in small
animal patients with renal
failure and sometimes as a
gastric antacid for ulcers.
Altrenogest/ Regu- Plumbs Online PO Oral Progestin (Systemic
Mate/ Matrix Drug)
Used in horses to suppress
estrus or maintain pregnancy
when progestin deficient
Used in swine to synchronize
estrus.
May be used in dogs for
luteal deficiency or as a
treatment to prevent
premature delivery.
Contraindications(Complicati
ons with disease or
other drugs)
Chronic use may lead to
electrolyte abnormalities and
possible aluminum toxicity.
It may inhibit gastric
emptying so use it cautiously
in patients with gastric outlet
obstruction.
Use with caution in patients
prone to developing
constipation.
It can decrease the effect of
drugs like corticosteroids,
digoxin, and others.
Give before meal or with
meal.
Often unsafe for pregnant
animals.
Rifampin may decrease
progestin activity if
administered concomitantly
Handle carefully with gloves
Store out of the light
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Amikacin/ Amikin/ Plumbs Online SQ, IM, IV Aminoglycoside
Amiglyde-V Antibiotic (Systemic Drug)
Used clinically to treat
serious gram-negative
infections in most species.
Approved for intrauterine
infusion in mares.
It is used with intra-articular
injection in foals to treat
gram-negative septic arthritis
Used with extreme caution in
patients with preexisting renal
disease
Other risk factors for the
development of toxicity
include age (both neonatal
and geriatric patients), fever,
sepsis and dehydration.
Used with caution in
working/service dogs
Caution in patients with
neuromuscular disorders
Sighthounds may require
reduced dosages
Used cautiously in neonatal or
geriatric animals.
Contraindicated in
rabbits/hares
Potential risk for pregnancy
Possible interactions with
cephalosporins, NSAIDs, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Aminopentamide/ Plumbs Online IM, SQ Anticholinergic/ Contraindicated with

Centrine Antispasmodic (Systemic
Drug)
Controls vomiting and
diarrhea in cats/dogs
glaucoma
Use cautiously in patients
with pyloric obstruction.
It should not be used if the
patient has a history of
hypersensitivity to
anticholinergic drugs,
tachycardias secondary to
thyrotoxicosis or cardiac
insufficiency, myocardial
ischemia, unstable cardiac
status during acute
hemorrhage, GI obstructive
disease, paralytic ileus, severe
ulcerative colitis, obstructive
uropathy or myasthenia gravis
Used with extreme caution in
patients with known or
suspected GI infections, or
with autonomic neuropathy.
Used with caution in patients
with hepatic disease, renal
disease, hyperthyroidism,
hypertension, CHF,
tachyarrhythmias, prostatic
hypertrophy, esophageal
reflux, and in geriatric or
pediatric patients.
Possible interactions with
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Aminophylline Plumbs Online IV, IM Phosphodiesterase Inhibitor Patients that are

Bronchodilator (Systemic
Drug)
Bronchodilator drug with
diuretic activity.
Used short-term for
bronchospasm & cardiogenic
pulmonary edema.
hypersensitive to
ethylenediamine should not
take it.
Used with caution in patients
with severe cardiac disease,
seizure disorders, gastric
ulcers, hyperthyroidism, renal
or hepatic disease, severe
hypoxia, or severe
hypertension.
Neonatal and geriatric
patients may have decreased
clearances of theophylline
and are more sensitive to it.
Patients with CHF may have
prolonged serum half-lives of
theophylline.
Possible effects on pregnancy
Many drug interactions
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Amitraz/ Mitaban Plumbs Online Topical solution/ (Dermatological Drug)
collar Treatment of generalized
demodicosis.
Treatment and prevention of
flea and tick infestation for
dogs.
General insecticidal/ miticidal
agent in several other species
Do not stress animals for at
least 24 hours after
application
Dont use in dogs <4 months
of age
use with caution in brittle
diabetic patients.
can be toxic to cats and
rabbits
Possible interactions with
MAO inhibitors or tricyclic
antidepressants.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Amitriptyline/Elavil Plumbs Online PO Tricyclic Behavior Modifier,
Antipruritic, Neuropathic
Pain Modifier (Systemic
Drug)
Used for behavioral
conditions such as separation
anxiety or generalized anxiety
in dogs, and excessive
grooming, spraying and
anxiety in cats
Useful for adjunctive
treatment of pruritus, or
chronic pain of neuropathic
origin in dogs and cats.
Could be useful for treatment
of lower urinary tract disease
in cats.
Contraindications(Complicati
ons with disease or
other drugs)
Concomitant use with
monoamine oxidase inhibitors
is generally contraindicated
Use with extreme caution in
patients with seizure disorders
Use with caution in patients
with thyroid disorders,
urinary retention, hepatic
disorders, KCS, glaucoma,
cardiac rhythm disorders,
diabetes, or adrenal tumors.
Restrict use to pregnant
animals only when the
benefits clearly outweigh the
risks.
Possible drug interactions
with CNS depressants,
anticholinergic agents, and
other drugs
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Amoxicillin Plumb Online PO Aminopenicillin (Systemic Use penicillin cautiously in

trihydrate/Amoxil/ Drug)
Amoxi-Tabs Used for a wide range of
infections in various species
Enhanced efficacy against
many lactamase-producing
bacteria, potentiated
amoxicillin is often chosen
for use in small animals, but
amoxicillin can be effectively
used particularly for treatment
of UTIs and Lyme disease
Used for empiric treatment of
abscesses in cats
patients who are documented
hypersensitive to other beta-
lactam antibiotics
Do not give to rabbits, guinea
pigs, chinchillas, or hamsters
Do not administer systemic
antibiotics orally in patients
with septicemia, shock, or
other grave illnesses
Possible drug interactions
with bacteriostatic
antimicrobials, methotrexate,
and probenecid.

Aldosterone Wiley Online IV infusion Mineralcorticoid Excessive amounts can lead

Library Stimulates reabsorption of to hypertension or cardiac
sodium into the blood. hypertrophy.
Stimulates excretion of Females can be more
Potassium sensitive to the effects.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Atipamezole/ Plumbs Online IM, IV, IO also IP or Alpha-2 Adrenergic
Antisedan SQ in rodents. Antagonist (Systemic Drug)
Reversal agent for
medetomidine and
dexmedetomidine.
Potential reversal for amitraz,
xylazine, clonidine,
tizanidine, and brimonidine
Not recommended in
pregnant, breeding, or
lactating animals due to the
lack of data establishing
safety.
Caution should be used in
administration of anesthetic
agents to elderly or debilitated
animals.
Do not give IV to reptiles
Possible drug interactions
with alpha-adrenergic
blockers and agonists.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Benazepril HCl/ Plumbs Online PO Angiotensin Converting Contraindicated in patients

Fortekor, Lotensin Enzyme (ACE)
Inhibitor (Systemic Drug)
Vasodilator to treat heart
failure, hypertension, chronic
renal failure, and protein-
losing nephropathies in dogs
and cats, especially in patients
with hypertension and
proteinuria.
Possible treatment for
idiopathic renal hemorrhage
in dogs
with hypersensitivity to ACE
inhibitors, and patients with
hyponatremia, coronary or
cerebrovascular insufficiency,
SLE, and hematologic
disorders.
It can cause GI disturbances,
hypotension, renal
dysfunction, and
hyperkalemia.
Avoided in critically ill acute
kidney injury patients.
Possible adverse effects on
the fetus
Distributed into milk in very
small amounts
Possible drug interactions
with aspirin, diuretics,
lithium, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Bismuth Plumbs Online PO Antidiarrheal, Use with caution in patients

subsalicylate/ BSS/ Gastroprotectant (Systemic
Pepto-Bismmol Drug)
Used to treat diarrhea, as a
gastroprotectant, and as a
component of triple therapy
for treating Helicobacter GI
infections.
with preexisting bleeding
disorders.
used cautiously, if at all, in
cats.
It is radiopaque; it may
interfere with GI tract
radiologic examinations.
Use with caution in pregnant
animals and in nursing dams.
Possible interactions with
tetracycline and aspirin.
Dont give other drugs within
two hours of this drug unless
veterinarian approves.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Buprenorphine/ Plumbs Online IV, IM, SQ, PO in Opiate Partial
Buprenex/Simbadol mice Agonist (Systemic Drug)
An analgesic for mild to
moderate pain or in
combination in pre-anesthetic
cocktails in small animals.
It generally causes fewer
adverse effects than morphine
and hydromorphone.
Controls post-operative
pain in cats
Longer onset of action than
other opiates.
Contraindications(Complicati
ons with disease or
other drugs)
Used with caution in patients
with hypothyroidism, severe
renal insufficiency,
adrenocortical insufficiency,
and in geriatric or severely
debilitated patients.
Used cautiously in patients
with compromised
cardiopulmonary function
Used with extreme caution in
patients with head trauma,
increased CSF pressure or
other CNS dysfunction
Used cautiously in patients
with biliary tract disease.
Used with caution in horses
that show signs of diminished
GI tract motility.
Use cautiously with pregnant
animals
Possible interactions with
local anesthetics,
anticonvulsants, CNS
depressants, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Buspirone/BuSpar Plumbs Online PO Anxiolytic (Systemic Drug)
Can be effective in treating
behavior disorders.
(fear/phobia related and for
social interaction.)
Used in dogs and cats.
Used to help motion sickness
in cats and for urine spraying.
Can take a week or more to
be effective
Can cause bradycardia and GI
disturbances.
It is not appropriate as sole
treatment of situational
anxieties.
Use with caution in patients
with severe hepatic or renal
disease.
It can cause behavior changes
in cats.
Use with caution in
aggressive animals and
working or service dogs.
Avoid use during nursing if
possible.
Possible effects to pregnancy
Possible interactions with
CNS depressants,
erythromycin, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Butorphanol/Stadol, Plumbs Online SC, PO, IV, IM Opiate Partial
Torbutrol, Torbugesic Agonist (Systemic Drug)
Used as an analgesic, premed,
antitussive for chronic, non-
productive coughs, or an
antiemetic.
It is a reasonably good
analgesic for horses,
especially for colic pain.
An analgesic in cattle,
camelids, small ruminants,
small mammals, and several
wildlife species
Used for relief of pain in cats
caused by major or minor
trauma, or pain associated
with surgical procedures
it can reverse CNS and
respiratory depression
without completely reversing
the analgesic effect of
the mu-agonist drugs.
Contraindications(Complicati
ons with disease or
other drugs)
Not good for pain in small
animals.
Cautioned in patients with
liver disease, hypothyroidism,
or renal insufficiency,
Addisons, head trauma,
increased CSF pressure or
CNS dysfunction, and in
geriatric or severely
debilitated patients.
The dose must be reduced in
dogs with MDR1 mutations.
Must be dosed frequently, and
it can cause sedation, ataxia,
anorexia, or diarrhea in dogs
and cats.
It is possible to cause
transient ataxia and sedation
in horses.
It may cause respiratory
depression in turtles or
tortoises
Possible drug interactions
with erythromycin, fentanyl,
pancuronium, theophylline,
and CNS depressnants.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Captopril/ Capoten Plumbs Online PO Angiotensin-Converting Contraindicated in patients

Enzyme (ACE)
Inhibitor (Systemic Drug)
vasodilator for the treatment
of CHF and hypertension
hypersensitive to ACE
inhibitors
Used with caution in patients
with renal insufficiency; may
need to reduce doses
Used with caution in patients
with hyponatremia or sodium
depletion, coronary or
cerebrovascular insufficiency,
preexisting hematologic
abnormalities or a collagen
vascular disease
Use with caution in pregnant
or nursing animals.
Possible interactions with
antacids, cimetidine,
diuretics, and other drugs.
Give on an empty stomach.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Carprofen/ Rimadyl Plumbs Online
PO, IV, SQ, IM in Non-Steroidal
birds Antiinflammatory
Agent (Systemic Drug)
Used for the relief of pain and
inflammation in dogs.
useful as an adjunctive
treatment of certain
neoplasias.
Contraindicated in dogs with
bleeding disorders or those
that have had prior serious
reactions to it or other
propionic-class
antiinflammatory agents.
Used with caution in geriatric
patients or those with
preexisting chronic diseases
Use of carprofen in dogs less
than 6 weeks of age, pregnant
dogs, dogs used for breeding
purposes, or lactating bitches
has not been established.
Drug may delay parturition
with an increased number of
dead pups at birth
Use caution with
corticosteroids and NSAIDs.
Other possible drug
interactions.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Cefazolin sodium/ Plumbs Online IV, IM, IO 1st Generation Use cautiously in patients that
Ancef/ Kefzol/ Cephalosporin (Systemic are documented
Zolicef Drug) hypersensitive to them or
Used for surgical prophylaxis, other beta-lactam antibiotics
and for a variety of systemic may cause antibiotic-induced
infections caused by enterocolitis
susceptible bacteria Patients in renal failure may
need dosage adjustments
Use with caution with
pregnancy and in nursing
dams.
Possible interactions with
nephrotoxic drugs and
probenecid.

Cefovicin/ Convenia Plumbs Online SQ Injectable Long-Acting Contraindicated in animals

Cephalosporin (Systemic
Drug)
Use in dogs and cats to treat
various skin infections
with a known allergy to
cefovecin or to other beta-
lactam antibiotics
Possible anaphylaxis
use with caution in animals
with severe renal dysfunction.
Possible interactions with
NSAIDs and drugs such as
carprofen and furosemide.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Cefpodoxime Plumbs Online PO 3rd Generation Contraindicated in patients

proxetil/ Simplicef/ Cephalosporin (Systemic
Vantin Drug)
Indicated for the treatment of
skin infections in dogs caused
by susceptible strains
of Staphylococcus
pseudintermedius,
Staphylococcus aureus,
Streptococcus canis, E. coli,
Proteus
mirabilis, and Pasteurella
multocida
Possible use in cats
hypersensitive to it or other
cephalosporins
Dosages and/or dosage
frequency may need to be
adjusted in patients with
significantly diminished renal
function.
Use with caution in patients
with seizure disorders.
The drug enters maternal milk
in low concentrations.
Possible interactions with
antacids, prebenecid, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Ceftiofur/Excenel, Plumbs Online IM, SQ 3rd Generation Used cautiously in patients

RTU, Spectramast Cephalosporin (Systemic
Drug)
treatment and control of
swine bacterial respiratory
disease
Treatment of Bovine
respiratory diseases
Treatment of subclinical and
clinical mastitis in dairy cattle
that are documented
hypersensitive to them and
other beta-lactam antibiotics
Potentially could cause
granulocytopenia,
thrombocytopenia, or
diarrhea.
Causes pain on IM injection
to small animals.
May need to reduce dose in
renal failure.
Milk and slaughter
withdrawal times for cattle
and swine treated with
various forms.
Trim-out of edible tissues at
slaughter may occur because
of IM or SQ injection.
Possible interactions with
aminoglycosides, nephrotoxic
drugs, or probenecid.
Do not give more than 15 mL
at one site.
Do not give in a vein or
artery.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Cephalexin/Keflex, Plumbs
Cefalexin, Rilexine online
PO, sometimes IV, 1st Generation
IM in guinea pigs, Cephalosporin (Systemic
Drug)
Treatment of secondary
superficial bacterial
pyoderma in dogs
Used clinically in cats,
horses, rabbits, ferrets, and
birds, particularly for
susceptible Staphylococcal
infections.
Use cautiously in patients
that are hypersensitive to
other beta-lactam
antibiotics such as
penicillins, cefamycins,
and carbapenems.
Give IV in patients with
septicemia, shock or other
grave illnesses.
When given orally,
cephalosporins may cause
GI effects. Administering
the drug with a small meal
may help alleviate these
effects.
Probenecid competitively
blocks the tubular secretion
of most cephalosporins.
Small amounts of
cephalexin may be
distributed into maternal
milk; it could potentially
affect gut flora in neonates.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Charcoal, activated Plumbs Online PO Oral Adsorbent (Systemic Too rapid of administration
Drug) may induce emesis/aspiration.
Used for GI tract toxins/drug Charcoal should not be used
overdoses. for mineral acids.
Potential contraindications
include GI obstruction or ileus,
hypernatremia, hyperosmolar
states, or imminent GI
surgery/endoscopy.
Possible interactions with
dairy products, mineral oil,
and other drugs.

Chlorambucil/ Plumbs Online PO, SQ, IM, IV Immunosuppressant/Antineop Contraindicated in patients

Leukeran lastic (Systemic Drug)
Useful as part of multi-drug
protocols or as a solo
metronomic agent in a variety
of neoplastic diseases
Useful as adjunctive therapy
for some immune-mediated
conditions
that are hypersensitive to it or
have demonstrated resistance
to its effects.
Used with caution in patients
with preexisting bone marrow
depression or infection, or
susceptible to bone marrow
depression or infection.
It may potentially cause a
variety of fetal abnormalities;
it should be avoided in
pregnancy.
Possible interactions with
myelosuppressives and
immunosuppressives.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Chloramphenicol/ Plumbs Online PO, IV, SQ, IM Broad-Spectrum
Chloromycetin Antibacterial (Systemic
Drug)
Used for a variety of
infections in small animals
and horses, particularly those
caused by anaerobic bacteria
In dogs, it is a potentially
useful drug in treating
methicillin-resistant
staphylococcal infections or
treating bacterial prostatic
infections.
Poses a low risk for serious
enteropathies to hindgut-
fermenting and it may be
useful in them.
Do not use in food animals.
Used with extreme caution in
patients with preexisting
hematologic abnormalities,
especially a preexisting non-
regenerative anemia
Only use in patients in hepatic
failure when no other effective
antibiotics are available and
then only with prolonged
dosing intervals
Used with caution in patients
with impaired hepatic or renal
function
Use with caution in cats.
Used with caution in neonatal
animals, particularly in young
kittens.
Use cautiously with pregnant
and nursing animals.
Possible interactions with anti-
anemia drugs, aspirin,
lidocaine, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Chlorothiazide/ Plumbs Online PO Thiazide Diuretic (Systemic Contraindicated in patients

Diuril Drug)
used for the treatment of
nephrogenic diabetes
insipidus and to help prevent
the recurrence of calcium
oxalate uroliths in dogs.
Used to be FDA-approved for
use in dairy cattle for the
treatment of post parturient
udder edema
with anuria or that are
hypersensitive to any one of
these agents
Contraindicated in pregnant
females who are otherwise
healthy and have only mild
edema
Used with extreme caution in
patients with severe renal
disease or with preexisting
electrolyte or water balance
abnormalities, impaired
hepatic function,
hyperuricemia, lupus, or
diabetes mellitus.
Chlorothiazide enters maternal
milk and can reduce milk
volume and suppress lactation.
Possible interactions with
corticosteroids, insulin,
lithium, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Chlorpheneramine Plumbs Online PO Antihistamine (Systemic Contraindicated in patients

maleate/ Chlor- Drug)
Trimetron Used to reduce or help
prevent histamine mediated
adverse effects
Given as preventative
therapy in small animals
May also be of benefit as a
mild sedative in small
animals.
that are hypersensitive to it or
other antihistamines in its
class.
Used with caution in patients
with angle closure glaucoma,
prostatic hypertrophy,
pyloroduodenal or bladder
neck obstructions, and COPD
if mucosal secretions are a
problem.
Cautiously used in patients
with hyperthyroidism,
cardiovascular disease
or hypertension.
Use with caution in nursing
dams.
Possible interactions with
anticoagulants, mao
inhibitors, and CNS
depressants.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Chlorpromazine/ Plumbs Online IM, IV, SQ Phenothiazine, Sedative/
Thorazine Antiemetic (Systemic Drug)
Used for its antiemetic effects
in small animals and
occasionally as a preoperative
medication and
sedative/tranquilizer.
May be particularly useful to
treat motion sickness in cats.
It will inhibit apomorphine-
induced emesis in the dog.
It will also inhibit the emetic
effects of morphine in the
dog.
Only use IV in rabbits.
Use cautiously and in smaller
doses in animals with hepatic
dysfunction, cardiac disease,
or general debilitation.
Relatively contraindicated in
patients with hypovolemia or
shock, and those with tetanus
or strychnine intoxication.
IV injections must be diluted
with saline
Dogs with MDR1 mutations
may develop a more
pronounced sedation that lasts
longer than normal
Used very cautiously as
restraining agents in
aggressive dogs: it may make
them more prone to startle
and react to noises or other
sensory inputs.
Safety to nursing offspring
cannot be assured.
Use cautiously in pregnant
animals.
Possible drug interactions
with antacids, acetaminophen,
and other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Ciprofloxacin/ Cipro Plumbs Online PO, IV Fluoroquinolone
Antibiotic (Systemic Drug)
Used as an alternative to
enrofloxacin when a larger
oral dosage form or IV
product is desired.
Used as a fluoroquinolone
when specifically indicated.
Contraindications(Complicati
ons with disease or
other drugs)
Banned from use in food
animals
Relatively contraindicated in
small and medium breed dogs
from 2-8 months of age,
possibly longer in large dogs.
Do not let animals become
dehydrated when using the
drug.
Used with caution in patients
with seizure disorders.
Patients with severe renal or
hepatic impairment may
require dosage adjustments
Use high doses cautiously in
cats.
Use with caution with
pregnant animals.
Possible drug interactions
with cyclosporine and other
drugs.
Do not give at the same time
with other drugs or vitamins
that contain calcium, iron, or
aluminum
May stunt bone growth or
cause joint abnormalities if
used in young animals, during
pregnancy or while nursing.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Cisplatin/ CDDP/ Plumbs Online IV Antineoplastic (Systemic Contraindicated in cats as

Platinol-AQ Drug)
Used in dogs to treat
neoplastic diseases.
May be useful for the
palliative control of
neoplastic pulmonary
effusions after intracavitary
administration.
Some forms may treat skin
cancer in horses.
death can occur within 2-4
days.
Contraindicated in patients
with preexisting significant
renal impairment,
myelosuppression, or a
history of hypersensitivity to
platinum-containing
compounds.
Used with caution in patients
with CHF.
Potential risks for pregnancy.
Possible interactions with
aminoglycosides,
amphotericin B, furosemide,
and phenytoin.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Clavamox/ Plumbs Online PO Potentiated Use cautiously in patients

Amoxicillin- Aminopenicillin (Systemic
clavulanic acid/ Drug)
Augmentin Use in dogs and cats for the
treatment of urinary tract,
skin and soft tissue infections
caused by susceptible
organisms
Indicated for canine
periodontal disease due to
susceptible strains of bacteria
Used for empiric treatment of
bacterial cystitis in female
dogs, and hepatobiliary
infections in dogs or cats.
who are documented
hypersensitive to them and
other beta-lactam antibiotics
Do not administer systemic
antibiotics orally in patients
with septicemia, shock, or
other grave illnesses
Do not give to rabbits, guinea
pigs, chinchillas, or hamsters.
Possible interactions with
bacteriostatic antimicrobials,
methotrexate, and probenecid.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Clemastine/ Tavist Plumbs Online PO Antihistamine (Systemic Contraindicated in patients

Drug)
Used for symptomatic relief
of histamine1related allergic
conditions.
hypersensitive to it.
It should be used with caution
in patients with prostatic
hypertrophy, bladder neck
obstruction, severe cardiac
failure, angle-closure
glaucoma, or pyeloduodenal
obstruction.
Use cautiously in pregnant
and nursing dams, and
especially with newborns.
Possible drug interactions
with CNS depressants and
Monoamine oxidase
inhibitors.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Clindamycin/ Plumbs Online PO, IV, sometimes Lincosamide
Antirobe/ Cleocin IM Antibiotic (Systemic Drug)
Used in dogs for wounds,
abscesses and osteomyelitis
caused by Staphylococcus
aureus
Treats pathogenic anaerobic
organisms
Used for a variety of
protozoal infections,
including toxoplasmosis
Contraindicated for use in
rabbits, hamsters, chinchillas,
guinea pigs, horses, and
ruminants because of serious
gastrointestinal effects that
may occur, including death.
Contraindicated in patients
with known hypersensitivity
to it or lincomycin.
May cause esophagitis and
potentially, esophageal
strictures in small animals
Use is generally avoided in
neonatal small animals.
Use with caution in animals
with very severe renal and/or
hepatic disease
Because clindamycin is
distributed into milk, nursing
puppies or kittens of mothers
receiving clindamycin may
develop diarrhea.
Possible interactions with
cyclosporine, erythromycin,
and neuromuscular blocking
agents.
Do not dry pill
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Clomipramine/ Plumbs Online PO Tricyclic Contraindicated if prior

Clomicalm/ Anafranil Antidepressant (Systemic
Drug)
Used primarily in dogs as a
treatment for obsessive-
compulsive disorders and
may be useful for dominance
aggression and anxiety.
May also be useful in cats,
particularly for urine spraying
It may treat neuropathic pain
in small animals.
It has been used to treat
feather picking in birds.
sensitivity has been noted
with any other tricyclic.
Contraindicated with
monoamine oxidase
inhibitors.
Use with caution in animals
with preexisting seizure
disorders.
Use with caution in patients
with decreased GI motility,
urinary retention, cardiac
rhythm disturbances, or
increased intraocular
pressure.
Used cautiously in patients
with hyperthyroidism or those
that are receiving thyroid
supplementation
Use cautiously in pregnancy
Possible interactions with
anticholinergics, CNS
depressants, and other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Corticotropin Plumbs Online IM Hormonal Diagnostic
(ACTH)/ Acthar Agent (Systemic Drug)
It was approved for use in
dogs, cats, and cattle for
stimulation of the adrenal
cortex when there is a
deficiency of ACTH and as a
therapeutic agent in primary
bovine ketosis.
Used most often in the
diagnosis of
hypoadrenocorticism,
iatrogenic Cushings
syndrome, and to monitor the
response to mitotane or
trilostane therapy in
Cushings syndrome.
Used to monitor therapy
when treating with anti-
adrenal drugs.
Contraindications(Complicati
ons with disease or
other drugs)
ACTH gel should not be used
in patients hypersensitive to
porcine proteins
Do not administer gel form
IV.
Used during pregnancy only
when the potential benefits
outweigh the risks; possible
effects.
Possible interactions with
anticholinesterases and
diuretics.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Cosequin/ Plumbs Online PO Nutritional High dose chondroitin sulfate

Glucosamine + Supplement (Systemic Drug)
Chondroitin Sulfate Useful in treating
osteoarthritis or other painful
conditions in domestic
animals
Could be of benefit in cats
with FLUTD
and/or glucosamine
potentially could enhance the
effects of warfarin, heparin,
or other drugs that affect
coagulation.
By reducing doxorubicin
or etoposide inhibition of
topoisomerase II,
glucosamine may induce
resistance to these agents.

Cosyntropin/ Plumbs Online IV Hormonal Diagnostic Contraindicated in patients

Tetracosactide/ Agent (Systemic Drug)
Cortrosyn Used primarily as an
alternative to ACTH to test
for adrenocortical
insufficiency or
hyperadrenocorticism.
Used to help diagnose
iatrogenic Cushings
syndrome, and monitor the
response to mitotane or
trilostane therapy in
Cushings syndrome.
with known hypersensitivity
to cosyntropin.
Use caution in patients that
have shown hypersensitive
reactions to ACTH in the past
Possible effects to the fetus
Possible interactions with
anticholinesterases and
diuretics.

Cyanocobalamin Plumbs Online SQ, IM Vitamin/ None

(Vitamin B12) Nutritional (Systemic Drug)
Used for treating deficiencies
of vitamin B12
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Cyclophosphamide/ Plumbs Online PO, IV Immunosuppressive/
Cytoxan/ Neosar Antineoplastic (Systemic
Drug)
Used primarily in small
animals in combination with
other agents both as an
antineoplastic agent and as an
immunosuppressant.
Sometimes used as a
chemical shearing agent in
sheep, but this use is
discouraged
Contraindications(Complicati
ons with disease or
other drugs)
Should not be used in patients
with prior anaphylactic
reactions to the drug,
Used with caution, however
in patients with leukopenia,
thrombocytopenia, previous
radiotherapy, impaired
hepatic or renal function, or in
those for which
immunosuppression
Used only n patients that can
be adequately and regularly
monitored.
Use cautiously in pregnant
animals
Do not use in nursing dams
Possible drug interactions
with cyclosporine,
phenobarbital, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Cyclosporine/ Plumbs Online PO Immunosuppressive Contraindicated in dogs with

Neoral/ Sandimmune (Systemic Drug)
Used for the control of atopic
dermatitis
For the control of feline
allergic dermatitis
Treats perianal fistulas in
dogs.
a history of malignant
neoplasia.
Used with caution in patients
with hepatic or renal disease.
Contraindicated in cats with a
history of cyclosporine
hypersensitivity, malignant
disorders or suspected
malignancy, infected with
feline leukemia virus, feline
immunodeficiency virus,
clinical toxoplasmosis or
other serious systemic
illness.
It is not for use in breeding
cats, pregnant or lactating
queens
Cats should be tested and
found to be negative for FeLV
and FIV infections before
treatment.
caution in cases with diabetes
mellitus or renal
insufficiency.
Possible interactions with
corticosteroids, estrogens, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Cystorelin/ Plumbs Online IM, IV Hormonal Agent (Systemic
Gonadorelin/ GnRh Drug)
Used to treat ovarian cysts &
other reproductive disorders
in a variety of species.
Used to synchronize estrous
cycles to allow for fixed time
artificial insemination in
cattle
Cyproheptadine/ Plumbs Online PO, rectally Antihistamine (Systemic
Periactin Drug)
Used as an appetite stimulant,
primarily in cats: can be
useful in management of
serotonin-syndrome in small
animals. Has also been tried
as an antipruritic/
antihistamine in dogs & cats
and for photic head shaking
or treatment of equine
Cushings in horses.
Contraindications(Complicati
ons with disease or
other drugs)
None
Used with caution in patients
with prostatic hypertrophy,
bladder neck obstruction,
severe cardiac failure,
epilepsy, angle-closure
glaucoma, or pyeloduodenal
obstruction.
Use cautiously during
pregnancy.
Possible interactions with
CNS depressants,
Mirtazapine, SSRIs, tricyclic
antidepressants, and
Tramadol.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Deracoxib/ Plumbs Online PO Nonsteroidal Used with caution in patients

Deramaxx Antiinflammatory
Agent (Systemic Drug)
For treatment of post-
operative pain associated with
orthopedic and dental surgery
and for the treatment of pain
and inflammation associated
with osteoarthritis in dogs.
with concurrent GI ulcerative
diseases, renal or hepatic
dysfunction, those in
hypoproteinemic states, or
with conditions that may
predispose them to
hypercoagulability.
It is not approved for use in
cats.
Use with caution with
nursing/pregnancy.
Use in conjunction with
other NSAIDs or
corticosteroids be avoided
Possible interactions with
ACE inhibitors, aspirins, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Dormosedan/ Plumbs Online IV, IM Alpha-2 Adrenergic Contraindicated in horses

Detomedine Agonist (Systemic Drug)
Similar to xylazine but has
better analgesia of the rear
limbs
Only FDA-approved for use
as a sedative analgesic in
horses, but it has been used
clinically in other species.
with preexisting AV or SA
heart block, severe coronary
insufficiency, cerebrovascular
disease, respiratory disease or
chronic renal failure.
Use cautiously in animals
with endotoxic or traumatic
shock or approaching shock,
and advanced hepatic or renal
disease.
Use cautiously in animals
with stress due to temperature
extremes, fatigue, or high
altitude.
Use with caution in patients
treated for intestinal
impactions, or with suspected
colic.
Horses can still respond to
external stimuli even when
fully sedated
Not recommended for
breeding animals.
Possible drug interactions
with yohimbine, epinephrine,
and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Desoxycortico- Plumbs Online IM, SQ Mineralocorticoid (Systemic Contraindicated in dogs

sterone pivalate/ Drug)
Percorten/ Zycortal Indicated for the parenteral
treatment of adrenocortical
insufficiency in dogs.
It is also used extra-label in
cats.
suffering from CHF, severe
renal disease, or edema.
Do not administer DOCP IV
Addisons patients must
receive glucocorticoid
supplementation in periods of
high stress/illness.
It may cause irritation at
injection site.
Should not be given to
pregnant dams.
Possible drug interactions
with aspirin, insulin, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Dexamethasone Plumbs Online IV, IM, PO Glucocorticoid (Systemic
(Dexamethasone Drug)
sodium phosphate)/ Used as a replacement of
Azium/ Dexasone glucocorticoid activity in
patients with adrenal
insufficiency, as an anti-
inflammatory agent, and as an
immunosuppressive.
Do not use alone in the
treatment of adrenal
insufficiency.
Do not inject rapidly
Can cause GI complications
and bleeding
Animals with significantly
diminished renal function
may be more susceptible to
GI adverse effects.
Rabbits can develop serious
adverse effects to it
Systemic use is
contraindicated in systemic
fungal infections when
administered IM in patients
with idiopathic
thrombocytopenia and those
hypersensitive to a particular
drug.
Use of sustained-release
injectable glucocorticoids is
contraindicated for chronic
corticosteroid therapy of
systemic diseases.
Use with caution in animals
(especially cats) that are at
risk of diabetes.
Potential risk for pregnancy
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Dexmedetomidine/ Plumbs Online Oromucosal gel, IM, Alpha-2-Adrenergic
Domitor/ Sileo IV Agonist (Systemic Drug)
Used in dogs and cats as a
sedative and analgesic to
facilitate clinical
examinations, clinical
procedures, minor surgical
procedures, and minor dental
procedures, and as a
preanesthetic to general
anesthesia
Can be used as an emetic in
cats and to treat noise
aversion in dogs.
Contraindications(Complicati
ons with disease or
other drugs)
Do not give to dogs and cats
with cardiovascular disease,
respiratory disorders, liver or
kidney diseases, or in
conditions of shock, severe
debilitation, or stress caused
by extreme heat, cold, or
fatigue.
Not recommended in cats
with respiratory disease.
Use with caution in animals
with seizures.
Lowers the seizure threshold
in cats undergoing anesthesia
with enflurane.
It reduces tear production in
dogs
It should not be swallowed
Not recommended for use in
pregnant dogs or those used
for breeding purposes
Possible interactions with
anesthetics, epinephrine, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Diazepam/ Valium/ Plumbs Online Rectally, intranasally, Benzodiazepine (Systemic
Diastat IV CRI, IV bolus, Drug)
PO, IM Used for sedation, relief of
anxiety and behavioral
disorders, treatment of
seizures, appetite stimulant,
and injectable anesthetic (in
combination with Ketamine)
Used clinically as a muscle
relaxant and appetite
stimulant.
Preanesthetic for
neuroleptanalgesia.
Not a management drug, only
a quick, temporary fix.
Can be used in cats only one
time to make them eat.
If overdose occurs, it can
cause dogs to become
excitable and may cause
excessive CNS depression.
Inject IV very slowly
Use in cats is controversial
Use cautiously in patients
with hepatic or renal disease
and debilitated or geriatric
patients
Administered very cautiously
to patients in coma, shock, or
with significant respiratory
depression.
Used very cautiously in
aggressive patients
If administering the drug IV,
be prepared to administer
cardiovascular or respiratory
support.
Rapid IV bolus administration
can potentially cause
hypotension
Potential risks for pregnancy
May cause CNS effects in
nursing neonates.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Dichlorophen/ PubChem PO Antihelminthic, Fungicide, Effects were observed both in

Panacide Anti-protozoan vitro and in vivo
Treats large tapeworms in when combined with
domestic animals phenylmercuric acetate

Diethystilbestrol/ Plumbs Online PO Hormonal Agent (Systemic
DES Drug)
Used in estrogen responsive
incontinence in spayed female
dogs and the medical
treatment of benign prostatic
hypertrophy in male dogs.
Previously used for the
prevention of pregnancy after
mismating in female dogs and
cats
Do not use in food animals
Used with extreme caution in
patients with preexisting
anemias or leukopenias.
DES is contraindicated in
females with estrogen-
sensitive neoplasms.
Contraindicated during
pregnancy.
Possible interactions with
corticosteroids, phenobarbital,
warfarin, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Digoxin/ Lanoxin Plumbs Online PO, IV Cardiac Glycoside (Systemic
Drug)
treatment of CHF, atrial
fibrillation or flutter, and
supraventricular tachycardias.
Management of rapid atrial
fibrillation with concurrent
CHF
Contraindicated in patients
with V-fib, digitalis
intoxication
Contraindicated in cats with
hypertrophic cardiomyopathy.
Extreme Caution in patients
with glomerulonephritis &
heart failure or with
idiopathic hypertrophic
subaortic stenosis
Use with caution in patients
with renal disease
Drugs like antacids,
sucrasulfate, and others may
reduce serum levels and drugs
like anticholinergics,
quinidine, and others may
increase serum levels.
Possible interactions with
beta-blockers and other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Diltiazem/ Cardizem/ Plumbs Online IV, PO Calcium-Channel
Dilacor XR Blocker (Systemic Drug)
Useful in dogs for
supraventricular tachycardia
or decreasing the ventricular
rate associated with atrial
fibrillation.
Used for the treatment of
feline hypertrophic
cardiomyopathy
Could be used for
hypertension, pulmonary
artery hypertension,
adjunctive treatment of acute
kidney injury and the
treatment of supraventricular
tachycardia.
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in patients
with severe hypotension, sick
sinus syndrome or 2nd or 3rd
degree AV block, acute MI,
radiographically documented
pulmonary congestion, or
when the patient is
hypersensitive to it.
Used with caution in geriatric
patients or those with heart
failure
Used with caution in patients
with hepatic or renal
impairment.
If giving direct IV, give over
at least two minutes.
Potential risk for pregnancy
Use with caution in nursing
dams
Possible interactions with
beta-blockers, general
anesthetics, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Dioctyl calcium Plumbs Online PO Surfactant, Stool
Sulfosuccinate/ Softener (Systemic Drug)
Docusate/ Colace Used in small animals when
feces are hard or dry, or with
anorectal conditions when
passing firm feces would be
painful or detrimental.
Treats fecal impactions in
horses
Use with caution in patients
with pre-existing fluid or
electrolyte abnormalities
Potential risk for pregnancy
Possible interactions with
mineral oil
Give on an empty stomach

Dobutamine/ Plumbs Online CRI IV Parenteral Beta-Adrenergic Contraindicated in patients

Dobutrex Inotropic (Systemic Drug)
Short-term treatment of heart
failure
Useful in shock patients when
fluid therapy alone has not
restored acceptable arterial
blood pressure, cardiac
output, or tissue perfusion.
with known hypersensitivity
to the drug or with idiopathic
hypertropic subaortic
stenosis
Used very cautiously after
myocardial infarction.
Adequate vascular volume is
required for dobutamine use
Use with extreme caution in
patients with ventricular
tachyarrhythmias or atrial
fibrillation
Possible interactions with
atropine, beta-blockers, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Dopamine/ Intropin Plumbs Online CRI IV Adrenergic/Dopaminergic Contraindicated in patients

Inotropic Agent (Systemic
Drug)
Dose-dependent, used to treat
shock and CHF and to
increase renal perfusion
with pheochromocytoma,
ventricular fibrillation, and
uncorrected tachyarrhythmias.
Used with caution in patients
with ischemic heart disease or
an occlusive vascular disease
Dosage reduced if
arrhythmias occur.
Safe for pregnancy if used
cautiously.
Possible interactions with
general anesthetics, beta-
blockers, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Doxorubicin/ Plumbs Online IV Antineoplastic (Systemic Contraindicated in patients

Adriamycin/ Doxil Drug)
Useful in the treatment of a
variety of lymphomas,
carcinomas, leukemias, and
sarcomas in both the dog and
cat
Used by itself and with other
drugs.
with myelosuppression,
impaired cardiac function, or
that have reached the total
cumulative dose level of
doxorubicin and/or
daunorubicin
Contraindicated in cats with
preexisting renal
insufficiency.
Used with caution in patients
with
hyperuricemia/hyperuricuria,
or impaired hepatic function.
Give slowly IV, over 10
minutes.
Doberman pinchers, Great
Danes, Rottweilers, and
Boxers are predisposed to
developing cardiomyopathy
breeds susceptible to the
MDR1-allele mutation may
be at higher risk for toxicity
Wear gloves!
Potential risk for pregnancy;
It is teratogenic and
embryotoxic
Avoid use in nursing dams
Possible interactions with
antineoplastic agents,
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Doxycycline/ Plumbs Online PO, IV, IM in birds Tetracycline
Vibramycin Antibiotic (Systemic Drug)
use in small animals in
azotemic patients
used in small animals to treat
infections caused
by Borrelia spp, Leptospira sp
p, Rickettsia spp, Chlamydia s
pp, Mycoplasmaspp, Bartonell
a spp, and Bordetella spp.
Part of canine heartworm
treatment
Treatment of chlamydiosis in
birds
They can retard fetal skeletal
development and discolor
deciduous teeth; they should
only be used in the last half of
pregnancy when the benefits
outweigh the fetal risks
Avoid use in nursing dams
Can be used in patients with
renal insufficiency
Used with caution in dogs
with significant liver
dysfunction.
Pilling should be followed by
at least 6 mL of water or
food.
May cause GI upset
May result in overgrowth of
nonsusceptible bacteria or
fungi.
Parenteral administration in
horses is contraindicated.
Possible interactions with oral
antacids, iron, penicillin, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Enalapril/ Enacard/ Plumbs Online PO Angiotensin-Converting Contraindicated in patients

Vasotec Enzyme (ACE)
Inhibitor (Systemic Drug)
Used in the treatment of
heart failure, proteinuria or
hypertension; may also be
of benefit in the treatment
of chronic renal failure.
that have demonstrated
hypersensitivity to the
ACE inhibitors
Used with caution and
close supervision in
patients with renal
insufficiency
Use critically ill patients
with acute kidney injury is
not recommended
Used with caution in
patients with hyponatremia
or sodium depletion,
coronary or
cerebrovascular
insufficiency, preexisting
hematologic abnormalities,
or a collagen vascular
disease
Potential risks for
pregnancy; use with
caution
Cannot assume safe for
nursing
Possible interactions with
antidiabetic agents,
NSAIDs and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Enrofloxacin/ Baytril Plumbs Online
PO, IM, SQ, IV Fluoroquinolone
Antibiotic (Systemic Drug)
For the management of
diseases associated with
bacteria susceptible to
enrofloxacin.
Only used in cats for the most
susceptible bacterial infections
Do not use in food animals.
Contraindicated in small and
medium breed dogs from 2-8
months of age
Animals should not be allowed
to become dehydrated during
therapy
Used with caution in patients
with seizure disorders
Not recommended in cats with
impaired renal function
Do not use in foals
Do not give rapidly IV to
horses
Higher doses not
recommended in cats; may
cause blindness.
Not generally recommended
for use during pregnancy
Possible interactions with
antacids, antibiotics, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Ephedrine/ Vatronol, Plumbs Online PO, IV bolus, Sympathomimetic Contraindicated in patients

Terbutaline, Brethine, Bronchodilator/ Vasopressor
Albuterol, Proventil (Systemic Drug)
Used primarily for treatment
of urinary incontinence
Used to try and treat nasal
congestion and/or
bronchoconstriction in small
animals
with severe cardiovascular
disease, particularly with
arrhythmias.
Used with caution in patients
with glaucoma, prostatic
hypertrophy,
hyperthyroidism, diabetes
mellitus, cardiovascular
disorders or hypertension.
Used with caution in patients
with glaucoma, prostatic
hypertrophy,
hyperthyroidism, diabetes
mellitus, cardiovascular
disorders or hypertension.
If ephedrine is absolutely
necessary for the dam,
consider using milk replacer.
Possible interactions with
acepromazine alpha-blockers,
beta-blockers, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Epinephrine/ Plumbs Online IV, IO, IM, IT Alpha- & Beta-Adrenergic
Adrenalin Agonist (Systemic Drug)
Increases heart rate and
cardiac output, causes
constriction of the blood
vessels in skin, dilation of the
blood vessels in muscle,
dilation of the bronchioles, and
increase in metabolic rate
Used as a treatment for
anaphylaxis or for cardiac
resuscitation.
Contraindicated in patients
with narrow-angle glaucoma,
hypersensitivity to
epinephrine, anaphylactic
shock, during general
anesthesia with halogenated
hydrocarbons, during labor,
and during cardiac dilatation
or coronary insufficiency.
Should not be injected with
local anesthetics into small
appendages; can cause
sloughing and necrosis
Use with caution in cases of
hypovolemia
Used with extreme caution in
patients with a prefibrillatory
cardiac rhythm,
Possible effects on pregnancy
Possible interactions with
general anesthetics,
antihistamines, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Eprinomectin/ Plumbs Online SQ, pour on Topical Avermectin
Ivomec/ Eprinex/ Antiparasitic Agent (Systemic
LongRange Drug)
Indicated for a variety
gastrointestinal
roundworms, cattle grubs,
lice, mange mites, horn flies,
and lungworms in cattle.
Treatment of psoroptic mange
in horses or ear mites in
rabbits
Do not give the pour-on
PO or IV.
Underdosing and/or
subtherapeutic concentrations
may encourage the
development of parasite
resistance.
Not for IM or IV use
Not for use in bulls, breeding
males, and calves less than 3
months old.

Do not use in lactating dairy

cattle.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Erythropoietin/ Plumbs Online SQ Erythropoietic Contraindicated in patients

Epoetin Alfa/ EPO, Agent (Systemic Drug)
rHuEPO/ Epogen/ Used to treat dogs and cats
Procrit for anemia associated with
chronic renal failure.
with uncontrolled
hypertension or those that are
hypersensitive to it
Do not use in horses
Caution in animals with
moderate to severe
hypertension or iron
deficiency
Use with caution in
pregnancy
Possible interactions with
androgens, probenecid, and
desmopressin.

Epsiprantel/ Cestex Plumbs Online PO Cestocidal Antiparasitic Dont use in puppies or

Agent (Systemic Drug) kittens less than 7 weeks of
Treatment (removal) age.
of Dipylidium
caninum and Taenia
pisiformis in dogs,
and Dipylidium
caninum and Taenia
taeniaeformis in cats.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Erythromycin/ Plumbs Online PO Macrolide Avoid use in patients with

Gallimycin Antibiotic (Systemic Drug)
Approved to treat infections
caused by susceptible
organisms in cats, dogs, and
cattle
Treatment of C. equi
infections in foals
Increase gastric emptying in
dogs and cats.
Treating reflux esophagitis,
especially in cats and for
treating colonic motility
disorders in dogs.
preexisting liver dysfunction.
contraindicated in rabbits,
gerbils, guinea pigs, and
hamsters.
contraindicated in adult
horses
oral erythromycin should not
be used in ruminants
Use with caution with
pregnancy
Possible interactions with
digoxin, warfarin, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Estradiol cypionate/ Plumbs Online IM Hormonal Agent
ECP (Estrogen) (Systemic Drug)
Enhancing estrus behavior
and receptivity in
ovariectomized mares and to
treat estrogen-responsive
incontinence.
Has been used as an
abortifacient (but rarely
recommended today).
Etodolac/ EtoGesic/ Plumbs Online PO, SQ Non-Steroidal
Lodine Antiinflammatory
Agent (Systemic Drug)
Management of pain and
inflammation associated with
osteoarthritis in dogs.
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated during
pregnancy
Should not be used to treat
estrogenresponsive
incontinence in small
animals;
In ferrets, estradiol is
reportedly very toxic to bone
marrow.
Decrease the quantity and
quality of maternal milk.
Possible interactions with
corticosteroids, phenobarbital,
and other drugs.
Used with caution in dogs
with preexisting or occult GI,
hepatic, cardiovascular, or
hematologic abnormalities
Use with caution with
pregnant and nursing animals.
Avoid using with any other
ulcerogenic
drugs like corticosteroids or
other NSAIDs
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Famotidine/ Pepcid Plumbs Online PO, IV, IM SQ H2-Receptor
Antagonist (Systemic Drug)
Useful for the treatment
and/or prophylaxis of gastric,
abomasal and duodenal
ulcers, uremic gastritis, stress-
related or drug-induced
erosive gastritis, esophagitis,
duodenal gastric reflux, and
esophageal reflux.
Feliway/ D.A.P./ Plumbs Online Diffusere/ Spray Pheromone Behavior
Modipher EQ Spary Modifier (Systemic Drug)
(Pheromones) Useful in cats for urine
marking or spraying,
vertical scratching,
avoidance of social
contact, loss of appetite,
stressful situations, or
inter-cat aggression
Contraindications(Complicati
ons with disease or
other drugs)
Used cautiously in geriatric
patients and patients with
significantly impaired hepatic
or renal function.
Use with caution in patients
with severe cardiac disease.
Use in pregnancy when
potential benefits outweigh
the risks.
Possible interactions with
azole antifungals, iron salts,
Cefpodoxime, and
Cefuroxime.
None
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Fenbendazole/ Plumbs Online PO Antiparasitic Agent (Systemic
Panacur/ Safe-Guard Drug)
removal of ascarids,
Hookworms, whipworms, and
tapeworms in dogs.
Also approved for use in
removing parasites in cats,
cattle, horses, and swine
Fentanyl/ Duragesic Plumbs Online Transdermal patch Opioid (Systemic Drug)
Useful for the adjunctive
control of postoperative pain,
severe pain associated with
chronic pain, dull pain, and
non-specific, widespread pain
Contraindications(Complicati
ons with disease or
other drugs)
It is not effective
against Dipylidium caninum.
Not FDA-approved for use in
horses intended for food
purposes.
Should not be given
concurrently with the
bromsalan flukicides; it may
cause abortion in cattle and
sheep.
Use cautiously with other
CNS depressants
Used cautiously in geriatric,
very ill or debilitated patients
and those with a preexisting
respiratory problem.
Approach cats slowly as not
to startle, and keep animal out
of very bright light or sunlight
while pupils are dilated.
Dont expose patch to heat
sources
Use cautiously with
pregnancy
Possible interactions with
CNS depressants, diuretics,
muscle relaxants, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Firocoxib/ Previcox/ Plumbs Online PO, IV Oral COX-2 Inhibitor
Equioxx (NSAID) (Systemic Drug)
In dogs and horses for the
control of pain and
inflammation associated with
osteoarthritis and in dogs for
the control of post-operative
pain and inflammation
associated with orthopedic
surgery.
Useful for treating fever, pain,
and/or inflammation
associated with other
conditions, like post-surgery
or trauma.
Contraindications(Complicati
ons with disease or
other drugs)
Used with caution in patients
with preexisting renal, hepatic
or cardiovascular dysfunction,
and those that are dehydrated,
hypovolemic, hypotensive, or
on concomitant diuretic
therapy
cannot be accurately dosed in
dogs less than 12.5 pounds
contraindicated in dogs with
active GI ulcerative
conditions.
contraindicated in patients
with bleeding disorders or
thrombocytopenia,
treatment should be
terminated in horses if signs
such as inappetence, colic,
abnormal feces, or lethargy
are observed.
Caution in pregnancy
Avoid use with NSAIDs or
corticosteroids, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Fluazuron/ Animal Health Topical spray, Insect Growth Regulatro Slaughter withdrawal time is
Ivermectin/ Acatak/ Direct absorbed orally Kills ticks, roundworms, 28 days.
Duostar lungworms, lice, mites, and Slaughter for calves must be 4
buffalo fly. months after the mother was
treated.
Do not use on cattle that are
producing or will produce
milk.

Fluconazole/ Plumbs Online PO, IV Antifungal (Systemic Drug)
Diflucan useful in the treatment of
systemic mycoses
useful for superficial
candidiasis or
dermatophytosis
useful in treating CNS
infections or fungal urinary
tract infections
Should not be used in patients
hypersensitive to it or other
azole antifungal agents
In patients with hepatic
impairment it should be used
only when the potential
benefits outweigh the risks.
Doses or dosing intervals may
need to be adjusted in patients
with renal impairment.
Fluconazole is reportedly toxic
to budgerigars
Not recommended for
pregnant animals
Use with caution in nursing
dams
Possible drug interactions with
cimetidine, corticosteroids,
NSAID's, and other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Flunixin meglumine/ Plumbs Online IV, IM, SQ, PO Non-Steroidal
Banamine Antiinflammatory
Agent (Systemic Drug)
Use in horses for alleviation
of inflammation and pain
associated with
musculoskeletal disorders and
for visceral pain associated
with colic
Used in cattle for the control
of pyrexia associated with
bovine respiratory disease and
endotoxemia, and control of
inflammation in endotoxemia.
Use in swine to control
pyrexia associated with swine
respiratory disease.
Analgesic for visceral pain in
ruminants.
Contraindications(Complicati
ons with disease or
other drugs)
Used cautiously in animals
with renal, hepatic, or
hematologic diseases
Do not inject intra-arterially.
Avoid use in horses with
known or suspected EGUS
The IM route is extra-label in
cattle and should only be used
when the IV route is not
feasible for use
Longer withdrawal times
would be required after IM
use.
Usually contraindicated in cats
Avoid use in birds
Use cautiously in pregnant
animals
Do not use in breeding bulls
Possible interactions with
aspirin, cyclosporine, and
other drugs.
If injecting IM in horses, do
not inject into neck muscles.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
5-Fluorouracil Plumbs Online Eye drops Antineoplastic
Agent (Ophthalmic Drug)
Used as an adjunct in ocular
and periorbital surgeries.
Used to treat ocular surface
neoplasia such as squamous
cell carcinoma and periorbital
tumors such as neoplasia and
sarcoids
Fluoxetine/ Prozac/ Plumbs Online PO Selective Serotonin-Reuptake
Reconcile Inhibitor (SSRI) (Systemic
Drug)
Beneficial for the treatment of
canine aggression, stereotypic
behaviors, and anxiety.
Useful in cats for the same
behaviors and for
inappropriate elimination.
Used for treatment of canine
separation anxiety in
conjunction with a behavior
modification plan.
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in cats
Do not use in patients with
myelosuppression, with
concurrent serious infections,
or that are hypersensitive to it.
Should not be used in dogs
with epilepsy or a history of
seizures and it should not be
given with drugs like
acepromazine and
chlorpromazine that lower the
seizure threshold.
Contraindicated in patients
with known hypersensitivity to
it, as well as those receiving
monoamine oxidase inhibitors
Used with caution in patients
with diabetes mellitus
Use with caution in pregnant
and nursing animals
Possible drug interactions with
diuretics, insulin, tramadol,
and other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Furosemide/ Lasix/ Plumbs Online IV, IM, PO, SQ Loop Diuretic (Systemic
Frusomide Drug)
Used in small animals for the
treatment of congestive
cardiomyopathy, pulmonary
edema, hypercalcuric
nephropathy, uremia, as
adjunctive therapy in
hyperkalemia and,
occasionally, as an
antihypertensive agent
Used for its diuretic activity
in all species
Used for treatment of post-
parturient udder edema.
Used to help prevent or
reduce epistaxis in
racehorses.
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in patients
with anuria or that are
hypersensitive to the drug
Used with caution in patients
with preexisting electrolyte or
water balance abnormalities,
impaired hepatic function, and
diabetes mellitus.
Use very cautiously with other
drugs that can cause renal- or
ototoxicity as furosemide may
potentiate toxic effects.
Use cautiously in pregnancy
Possible drug interactions with
ACE inhibitors,
aminoglycosides,
corticosteroids, and other
drugs
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Gabapentin/ Plumbs Online PO Anticonvulsant, Neuropathic
Neurontin Pain Analgesic (Systemic
Drug)
As an analgesic, it is useful in
treating chronic pain
May be useful in dogs & cats
as adjunctive therapy for
refractory or complex partial
seizures and in many species
for the treatment of pain
(especially neuropathic pain).
Gamithramycin/ Plumbs Online SQ Macrolide (Azalide)
Zactran Antibiotic (Systemic Drug)
treatment of bovine
respiratory disease (
control of respiratory
disease in beef and non-
lactating dairy cattle
Contraindications(Complicati
ons with disease or
other drugs)
Used with caution in patients
with renal insufficiency
Avoid use of xylitol-containing
oral liquid in dogs.
Use with caution in pregnant
animals.
Possible drug interactions with
antacids, morphine, and
hydrocodone.
Potentially animals
hypersensitive to other
azalide or macrolide
antibiotics could also react to
gamithromycin
SQ injection may cause a
temporary local tissue
reaction in some animals that
may result in trim loss of
edible tissues at slaughter.
Cross-resistance may occur
with other macrolide/azalide
antibiotics.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Gentamicin/ Plumbs Online IV, IM, SQ, PO Aminoglycoside
Gentocin/ Garamycin Antibiotic (Systemic Drug)
Treats a variety of bacteria,
predominantly gram-negative
aerobic bacilli, but also many
staphylococci strains.
Usually reserved for serious
infections.
Used with extreme caution in
patients with preexisting renal
disease
Use with caution in neonatal
and geriatric patients, patients
with fever, hypokalemia,
treatment duration, sepsis and
dehydration.
Used with caution in
working/service dogs
Used with caution in patients
with neuromuscular disorders
Should not be used in animals
with botulism.
Sighthound dogs may require
reduced dosages
Contraindicated in rabbits
Potential risk for pregnancy
Possible interactions with
cephalosporins, diuretics, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Gentamicin/ VetStreet ointment Anti-inflammatory/ Do not use in animals with a

Mometasone/ Antifungal
Clotrimazole/ Useful for treating acute or
Mometamax Otic chronic canine otitis externa
Suspension (outer ear infections) when
caused by yeast or bacteria
susceptible to gentamicin.
Used to reduce the
discomfort, redness, swelling,
crusty material and odor
associated with ear
inflammations and infections
ruptured ear drum
Use with caution in pregnant
animals
Do not use in service/working
animals
Do not use if the animal has
had an allergic reaction to any
of the 3 ingredients or to
similar products
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Glipizide/ Glucotrol Plumbs Online PO Sulfonylurea Antidiabetic Contraindicated with severe

Agent (Systemic Drug)
May be of benefit in treating
cats with type II diabetes if
they have a population of
functioning beta cells
burns, trauma or infection,
diabetic coma or other
hypoglycemic conditions,
major surgery, ketosis,
ketoacidosis or other
significant acidotic conditions.
Should only be used when its
potential benefits outweigh its
risks if the patient has
untreated adrenal or pituitary
insufficiency; thyroid, renal or
hepatic function impairment;
prolonged vomiting; high
fever; malnourishment or
debilitated condition.
It may become ineffective in
weeks to months after starting
therapy
Possible drug interactions with
alcohol, beta-blockers,
diuretics, and other drugs.
Give with meals
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Glucosamine Plumbs Online PO Nutritional May exacerbate symptoms

chondroitin sulfate Supplement (Systemic Drug) associated with asthma
Useful in treating
osteoarthritis or other painful Caution is advised in patients
conditions in domestic with bronchoconstrictive
animals conditions.
Potentially could be of benefit
in cats with FLUTD
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Glycopyrrolate/ Plumbs Online IV, IM SQ Anticholinergic
Robinul-V (Antimuscarinic) (Systemic
Drug)
Preanesthetic anticholinergic
agent for dogs and cats
Treat sinus bradycardia,
sinoatrial arrest, and
incomplete AV block
Prevents the peripheral
muscarinic effects of
cholinergic agents
Beneficial in young animals
when cardiac output is
dependent on heart rate or
when potent opioids are used.
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in dogs and
cats hypersensitive to
glycopyrrolate
It should not be used in
pregnant animals.
Used with extreme caution in
patients with known or
suspected GI infections
Contraindicated with narrow
angle glaucoma, tachycardias,
ileus, and urinary obstruction.
Used with caution in patients
with hepatic or renal disease,
geriatric or pediatric patients,
hyperthyroidism, hypertension,
hypertrophic
cardiomyopathy/CHF,
tachyarrhythmias, prostatic
hypertrophy, or esophageal
reflux.
These drugs can produce sinus
tachycardia and predispose
hypotensive patients to cardiac
arrhythmias
Possible drug interactions with
amitraz, antacids, beta-
blockers, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Griseofulvin/ Plumbs Online PO Antifungal Agent (Systemic Contraindicated in patients

Fulvicin Drug)
Use in dogs and cats to treat
dermatophytic fungal
infections of the skin, hair
and claws, and to treat
ringworm in horses
Can be used also in laboratory
animals.
hypersensitive to it or with
hepatocellular failure
It should not be used in
pregnant animals
Kittens may be overly
sensitive to the adverse
effects
Cats should be tested for FIV
before using
Dosages given to cats during
the first trimester can cause
cleft palate and other skeletal
and brain malformations in
kittens.
Contraindicated during
pregnancy
Possible drug interactions
with alcohol, aspirin,
phenobarbital, and other
drugs.
Give with fatty foods
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Hemoglobin Plumbs Online IV Semi-Synthetic Hemoglobin Contraindicated in dogs with

glutamer/ Oxyglobin Replacer, Colloid (Systemic
Drug)
Bovine-source polymerized
hemoglobin product for the
treatment of anemia.
Indicated for the treatment of
dogs with anemia
Extra-label use in cats or foals
for neonatal isoerythrolysis
Extra-label use treating
anemia and as a colloid for
treating hypotension in dogs
and cats
advanced cardiac disease or
otherwise severely impaired
cardiac function or renal
impairment with oliguria or
anuria.
It can cause vasoconstriction
The amount required for fluid
resuscitation in trauma
patients is approximately 1/3
that of hetastarch
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Hetastarch Plumbs Online IV bolus or CRI Colloid Volume Contraindicated in patients

Expander (Systemic Drug)
Used to treat hypovolemia
when colloidal therapy is
required.
In horses, hetastarch may be
useful in increasing plasma
oncotic pressure and volume
expansion in hypoproteinemic
conditions and may reduce
endotoxin-induced vascular
permeability
with heart failure, severe
bleeding disorders, & patients
in oliguric or anuric renal
failure.
Use with caution in patients
with thrombocytopenia,
patients undergoing CNS
surgery and with liver
disease.
Potential risk for pregnancy
Possible interactions with
warfarin, ARBs, and
ceftriaxone.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Hydralazine/ Plumbs Online PO, IV in horses Vasodilator (Systemic Drug)
Apresoline Used primarily for
hypertension or adjunctive
treatment of heart failure.
Used as an afterload reducer
for the adjunctive treatment in
CHF and as an
antihypertensive agent in
dogs and cats
It may be useful in dogs and
cats with large septal defects
or severe aortic regurgitation
Contraindicated in patients
hypersensitive to it and those
with coronary artery disease.
It is not recommended to use
the drug in patients with
hypovolemia or preexisting
hypotension.
Doses need to be titrated
upwards carefully
Used with caution in patients
with renal disease and in
patients with intracerebral
bleeding.
Use cautiously during
pregnancy
Possible drug interactions
with ACE inhibitors, beta-
blockers, diuretics, and other
drugs.
Give with food
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Hydrocortisone Plumbs Online Eye drops Corticosteroid Contraindicated in patients

Antiinflammatory
Agent (Ophthalmic Drug)
Used alone or in combination
with triple antibiotics for
inflammatory conjunctivitis.
with a history of
hypersensitivity to it or any
component of the
formulation.
It should not be used if
corneal abrasion or ulceration
are suspected and should not
be used to treat fungal or viral
keratitis
Used with extreme caution in
birds.

(Dermatological Drug) Tuberculosis of the skin and

For adjunctive treatment of pregnancy are
topical localized pruritic and/or contraindications.
inflammatory conditions. Local skin reactions are
possible
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Hydroxyzine/ Atarax/ Plumbs Online
Vistaril
PO Antihistamine (Systemic
Drug)
Used principally for its
antihistaminic, antipruritic,
and sedative/tranquilization
qualities, often in atopic
patients.
used with caution in patients
with prostatic hypertrophy,
bladder neck obstruction,
severe cardiac failure, angle-
closure glaucoma, or
pyeloduodenal obstruction.
Animal studies have shown
an adverse effect on the fetus
so use cautiously.
Possible drug interactions
with anticholinergics,
epinephrine, and CNS
depressants.

Ibuprofen/ propionic MERCK vet manual PO NSAID drug
acid Used for its anti-
inflammatory, antipyretic, and
analgesic properties
Prolonged use may cause
gastric ulcers and
perforations, GI irritation or
ulceration, GI hemorrhage,
and renal damage in dogs.
Cats are more susceptible
than dogs (half the dosage)
TOXICITY if given too much
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Imidacloprid/ Plumbs Online topical (Dermatological Drug)
Flumethrin Treatment of adult and larval
stage fleas in dogs and cats.
Some combinations kill
mosquitoes, heartworm
hookworms, roundworms,
and whipworms in dogs.
Some combos kill ear mites in
cats.
Imipramine/ Tofranil Plumbs Online PO, IV in horses Tricyclic
Antidepressant (Systemic
Drug)
Used for urinary
incontinence, cataplexy and
tricyclic-responsive behavior
disorders in dogs and cats
Useful for the adjunctive
treatment of chronic pain
In horses, it has been used to
treat narcolepsy and
ejaculatory dysfunction
Contraindications(Complicati
ons with disease or
other drugs)
Do not use in puppies <7
weeks old, dogs weighing <3
lbs. or kittens <8 weeks old
Consult a veterinarian before
using on debilitated, aged,
pregnant, or nursing animals
or those on medication.
Concomitant use with
monoamine oxidase inhibitors
is generally contraindicated.
Use with caution in patients
with seizure disorders;
imipramine may lower
seizure threshold.
Restrict use to pregnant
animals only when the
benefits clearly outweigh the
risks
Imipramine is excreted into
milk in low concentrations
Use cautiously with
anticholinergic agents, CNS
depressants, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Indoxacarb/ Activyl Plumbs Online Topical solution (Dermatological Drug) Use with caution in
Treatment of fleas in dogs households with both dogs
and cats. and cats

Insulin,regular Plumbs Online IV, IM, SQ Hormone (Systemic Drug)
Pancreatic hormone used to
treat diabetic ketoacidosis,
uncomplicated diabetes
mellitus, & as adjunctive
therapy in treating
hyperkalemia.
Contraindicated during
episodes of hyperglycemia
Do not inject insulin at the
same site day after day
Possible risks for pregnancy
Possible drug reactions with
beta-adrenergic blockers,
clonidine, reserpine, and
digoxin among others

Insulin, NPH, Wannamaker SQ Intermediate acting insulin Overdose may cause

Ultralente, or PZI Used for the control of weakness, ataxia, shaking,
uncomplicated diabetes and seizures.
mellitus in dogs and cats.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Interferon/ Intron-A Plumbs Online
SQ, PO Immunomodulator (Systemic
Drug)
Used in cats to treat a variety
of virus-induced diseases
Consider the risks versus
benefits in patients with
preexisting autoimmune
disease, severe cardiac
disease, pulmonary disease,
brittle diabetes, herpes
infections, hypersensitivity to
the drug, or CNS disorders.
May be contraindicated in
cats with FIP
Potential risk for pregnancy
Effects may occur when
interferon alfa is used in
conjunction with zidovudine
or acyclovir
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Ipecac syrup Drugs.com PO Emetic Use in strychnine poisoning

Causes vomiting in
emergency situations like
poisoning or drug overdose.
may precipitate seizures, and
use in corrosive poisoning
may cause additional injury to
the esophagus
Should not be used in
semiconscious or unconscious
patients since there is an
increased risk for aspiration
pneumonia.
Do not use in patients who
have ingested petroleum
distillates such as kerosene,
gasoline, coal oil, fuel oil,
paint thinner, or cleaning
fluid because of the high risk
of aspiration
Possible interactions with
antimetics, activated charcoal,
and milk.
Do not used in patients with
seizures, depressed gag
reflexes, shock, or
unconsciousness.
Use with caution in patients
with heart disease.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Iron/ Ferrous Sulfate/ Plumbs Online PO Nutritional/
Fer-In-Sol/ Feosol Hematinic (Systemic Drug)
Treatment of iron-deficiency
anemia in dogs and as
adjunctive therapy in dogs or
cats when receiving epoetin or
darbepoetin therapy.
Used in the treatment of iron
deficiency anemia associated
with newborn animals
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in patients
with hemosiderosis,
hemochromatosis, hemolytic
anemias, or known
hypersensitivity to any
component of the product.
Contraindicated in patients
with GI ulcerative diseases.
Possible interactions with
antacids, calcium,
tetracyclines, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Isoflurane/ Isoflo/ Plumbs Online inhalant General Anesthetic,
Iso-thesia Inhalant (Systemic Drug)
Primary inhalant anesthetic
Isoflurane with oxygen can be
used for refractory status
epilepticus in dogs that are
refractory to benzodiazepine
boluses
Used with caution in patients
with increased CSF or head
injury, or myasthenia gravis.
Contraindicated in patients
with a history or predilection
towards malignant
hyperthermia
Can be irritating to the
respiratory system and are not
recommended for mask
induction
Because of its respiratory
depressant effects,
intermittent positive pressure
ventilation may be required to
achieve anesthesia
It may be fetotoxic so use
with caution during
pregnancy
Possible drug interactions
with aminoglycocides, ACE
inhibitors, opioids, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Isoproterenol/ Plumbs Online IV Beta-Adrenergic Contraindicated in patients

Isuprel/ Isoprenoline Agonist (Systemic Drug)
Used in the treatment of acute
bronchial constriction, cardiac
arrhythmias (complete AV
block) and, occasionally, as
adjunctive therapy in shock or
heart failure
that have tachycardias or AV
block caused by cardiac
glycoside intoxication.
Contraindicated in ventricular
arrhythmias that do not
require increased inotropic
activity.
Use with caution in patients
with coronary insufficiency,
hyperthyroidism, renal
disease, hypertension or
diabetes
Potential risk for pregnancy
Possible drug interactions
with general anesthetics, beta-
blockers, Digoxin, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Itraconazole/ Plumbs Online PO Antifungal (Systemic Drug) Use in patients with hepatic
Sporanox/ Intrafungol Used in the treatment of impairment or achlorhydria
systemic and cutaneous only when the potential
mycoses. benefits outweigh the risks.
Use with caution in animals
with reduced cardiac function.
African grey parrots appear to
be extremely sensitive to it.
Animal studies have shown an
adverse effect on the fetus so
use with caution with
pregnancy.
It does enter maternal milk.
Possible drug interactions with
antacids, Ivermectin,
corticosteroids, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Ivermectin/ Plumbs Online PO, SQ, IM is ok for Antiparasitic (Systemic Drug)
Heartgard/ Ivomec reptiles FDA-approved in horses for
the control of large adult
strongyles, small strongyles,
pinworms, ascarids,
hairworms, large-mouth
stomach worms, neck
threadworms, bots,
lungworms, intestinal
threadworms, and summer
sores.
FDA-approved in cattle to
control GI roundworms,
lungworms, cattle grubs,
sucking lice, and mites.
FDA-approved in swine to
treat GI roundworms,
lungworms, lice, and mange
mites
FDA-approved only for use
as a preventative for
heartworm in dogs
FDA-approved for heartworm
prevention and control of
hookworms in cats.
Contraindications(Complicati
ons with disease or
other drugs)
Do not use in foals less than 4
months old or puppies less
than 6 weeks old.
observe Collie-type breeds for
at least 8 hours after
administration.
not FDA-approved for use in
lactating dairy animals or
females of breeding age
The injectable products for
use in cattle and swine should
be given subcutaneously only;
do not give IM or IV.
Possible drug reactions with
Ketamine, Benzodiazepines,
and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Kaopectate/ BSS/ Plumbs Online PO Antidiarrheal, Use with caution in patients

Pepto-Bismol Gastroprotectant (Systemic
Drug)
Used to treat diarrhea, as a
gastroprotectant, and as a
component of triple therapy
for treating Helicobacter GI
infections.
with preexisting bleeding
disorders.
Used cautiously, if at all, in
cats.
It is radiopaque
Use with caution in pregnant
and nursing dams
Potential interactions with
tetracycline and aspirin.
Dont give other drugs within
two hours of this drug unless
veterinarian approves.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Ketamine HCl/ Plumbs Online IV, IM, sometimes Dissociative General
Ketaset/ Ketaflo/ sprayed in the mouth, Anesthetic, NMDA-Receptor
Vetalar sometimes IP or SQ Antagonist (Systemic Drug)
Used for restraint, or as an
anesthetic agent for surgical
procedures that do not require
skeletal muscle relaxation
May be used to treat status
epilepticus in dogs
Commonly combined with
acepromazine, xyalazine, and
diazepam to increase muscle
relaxation
Possible drug interactions
with Ivermectin,
Medetomidine, CNS
depressants, thyroid
hormones, and other drugs.
Contraindications(Complicati
ons with disease or
other drugs)
Do not use in food animals
Caution in patients with
significant hypertension, heart
failure, and arterial aneurysms
Dont use in patients with
hepatic or renal insufficiency
Contraindicated when used
alone for major surgery.
Cats eyes can remain open
after receiving ketamine, and
should be protected from
injury plus an ophthalmic
lubricant
Relative contraindications:
Significant blood loss,
malignant hyperthermia,
increased intra-ocular
pressure or open globe
injuries, procedures involving
the pharynx, larynx, or
trachea.
Caution: Significant
hypertension, heart failure, &
arterial aneurysms, hepatic or
renal insufficiency, seizure
disorders.
Oral, ocular, and laryngeal
reflexes are maintained
Minimize noise during
recovery
Withhold food for 6 hours
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Ketoprofen/ Ketofen/ Plumbs Online
Anafen
IM, IV, SQ, PO Nonsteroidal
Antiinflammatory
Agent (Systemic Drug)
Approved for IV use in horses
for the alleviation of
inflammation and pain
associated with
musculoskeletal disorders.
Used short-term for analgesia
in cats
Used only when the potential
benefits outweigh the risks in
cases where GI ulceration or
bleeding is evident or in
patients with significant renal
or hepatic impairment.
It is not labeled for use in
breeding
animals.
It may mask the clinical signs
of infection
Increased toxicity risks in
patients with hypoproteinemia
Caution in use on breeding
horses
Ketoprofen enters canine
milk; use with caution.
Possible drug interactions
with Aspirin, Cyclosorine,
Corticosteroids, and other
drugs.
Give with food to small
animals.
Do not inject this drug into an
artery or SQ in horses.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Lactated Ringers Drugs.com Usually SQ Balanced electrolyte solution
solution Source of water and
electrolytes or as an
alkalinizing agent.
Lactulose/ Cephulac Plumbs Online PO Disaccharide Laxative,
Ammonia Reducer (Systemic
Drug)
Reduces ammonia blood
levels in the prevention and
treatment of hepatic
encephalopathy in small
animals, pet birds and
potentially, horses
Laxative for small animals.
Contraindications(Complicati
ons with disease or
other drugs)
Caution in patients with CHF,
severe renal insufficiency, and
in clinical states in which
there exists edema with
sodium retention.
Used with great care in
patients with hyperkalemia,
severe renal failure, and in
conditions in which
potassium retention is present.
Used with great care in
patients with metabolic or
respiratory alkalosis.
Do not administer with blood
products.
It may alter the insulin
requirements in diabetic
patients
In patients with preexisting
fluid and electrolyte
imbalances, lactulose may
exacerbate these conditions if
it causes diarrhea; use
cautiously.
Possible drug interactions
with oral antacids, laxatives,
neomycin, and gentamicin.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Levamisole/ Plumbs Online PO, SQ Antiparasitic, Immune
Levasole/ Tramisol Stimulant (Systemic Drug)
Indicated for the treatment of
many nematodes in cattle,
sheep and goats, swine,
poultry
May be useful as an immune
stimulant; infrequently used
today.
May be useful in horses for
the control of clinical signs
secondary to inflammation
after treatment with
antiprotozoal therapy.
Has been used in dogs as a
microfilaricide to
treat heartworm
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in lactating
animals
Used cautiously in animals
that are severely debilitated,
or have significant renal or
hepatic impairment.
Delay use in cattle that are
stressed due to vaccination,
dehorning, or castration.
Avoid if possible,
administering IM to birds.
May be contraindicated in
cats with FIV or FIP and
likely ineffective in cats with
FeLV
Potential risk for pregnancy
Use cautiously in nursing
dams.
May cause abortion in goats.
Possible drug interactions
with Aspirin, Warfarin, and
other drugs.
Not FDA-approved for use in
dairy animals of breeding age.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Levothyroxine Plumbs Online IV,PO Thyroid Hormone (Systemic Contraindicated in patients

sodium/ Thyro-Tabs/ Drug)
Canine, Synthroid Indicated for the treatment of
hypothyroidism in all species.
In horses, it has been used to
treat equine metabolic
syndrome.
with acute myocardial
infarction, thyrotoxicosis, or
untreated adrenal
insufficiency.
Used with caution in patients
with concurrent
hypoadrenocorticism, cardiac
disease, diabetes mellitus, or
in very elderly patients.
Dogs with
hypoadrenocorticism should
receive replacement of
mineralocorticoid and
glucocorticoid therapy before
receiving levothyroxine
Possible drug interactions
with oral antacids,
antidepressants,
corticosteroids, Ketamine,
and other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Lidocaine/ Plumbs Online IV, IO Antiarrhythmic, Local
Xylocaine/ Anesthetic (Systemic Drug)
Lignocaine Use as a local and topical
anesthetic agent
Sometimes used to treat
ventricular arrhythmias
It may terminate
supraventricular tachycardia
in dogs.
Could be useful in dogs with
GDV to reduce cardiac
arrhythmias, acute kidney
injury and hospitalization
times
In horses, lidocaine has been
used as part of partial IV
anesthesia protocols
Low dose IV lidocaine
infusions can be used to treat
hyperalgesia and neuropathic
pain states induced by trauma
or surgical procedures
Contraindications(Complicati
ons with disease or
other drugs)
Cats may be more sensitive to
it than dogs.
Contraindicated in patients
with known hypersensitivity
to the amide-class local
anesthetics, a severe degree of
SA, AV or intraventricular
heart block, or Adams-Stokes
syndrome.
Used with caution in patients
with liver disease, congestive
heart failure, shock,
hypovolemia, severe
respiratory depression, or
marked hypoxia
Used with caution in patients
with bradycardia or
incomplete heart block having
VPCs
do NOT use with products
containing epinephrine.
These drugs are safe if they
are not administered when the
animal is near term
Possible drug interactions
with gas anesthetics,
Xylazine, Ketamine, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Diphenoxylate/ Plumbs Online PO Opiate Agonist/ Do not use in cats.

Lomotil Anticholinergic (Systemic
Drug)
Used primarily in dogs for its
antidiarrheal and antitussive
properties.
Contraindicated in patients
with known hypersensitivity
to narcotic analgesics, those
receiving monoamine oxidase
inhibitors, those with diarrhea
caused by a toxic ingestion,
and intestinal obstruction.
Use with caution in patients
with respiratory disease,
hepatic encephalopathy,
hypothyroidism, severe renal
insufficiency, adrenocortical
insufficiency, head injuries, or
increased intracranial
pressure, acute abdominal
conditions, & in geriatric or
severely debilitated patients.
Potential risk for pregnant or
nursing animals
Possible interactions with
monoamine oxidase inhibiters
and CNS depressants.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Loperamide/ Plumbs Online PO Opiate Use in cats is controversial

Imodium Antidiarrheal (Systemic
Drug)
Used as a GI motility
modifier in small animals
Useful for treating or helping
to reduce chemotherapy-
induced diarrhea in dogs
Contraindicated in dogs tested
positive for the ABCB 1-1
(MDR1) mutation
Avoid use if diarrhea etiology
is due to invasive
microorganisms or by an
ingested toxin
Used with caution in patients
with hypothyroidism, severe
renal insufficiency,
adrenocortical insufficiency,
and in geriatric or severely
debilitated patients.
Used with caution in patients
with head injuries or
increased intracranial pressure
and acute abdominal
conditions
Used with extreme caution in
patients suffering from
respiratory disease or from
acute respiratory dysfunction
Used with extreme caution in
patients with hepatic disease
and with CNS clinical signs
of hepatic encephalopathy.
Use with caution in dogs
weighing less than 10 kg.
Possible drug interactions
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Lufenuron/ Program/ Plumbs Online
Sentinel
PO Chitin Synthesis Cat product should not be
Inhibitor (Systemic Drug) used in dogs.
Use in dogs and cats 6 weeks
of age and older for the
control of flea populations.
The 6-month injectable for
cats is indicated for flea
control in cats 6 weeks old or
older.
Potential antifungal agent.

Lufenuron + Plumbs Online PO Chitin Synthesis None

milbemycin oxime/ Inhibitor (Systemic Drug)
Sentinel Use in puppies and dogs 4
weeks and older for
prevention and control of flea
populations, prevention of
heartworm disease, control of
adult hookworms, and the
removal and control of adult
roundworms and whipworms.

L-lysine Plumbs Online PO Nutritional Amino Acid, Anti- Possible drug interactions
Feline Herpesvirus (Systemic with Arginine and oral
Drug) Calcium.
may be effective in
suppressing FHV-1 infections
in cats
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Lutalyse/ Dinoprost Plumbs Online SQ, IM Prostaglandin (Systemic
Tromethamine Drug)
Prostaglandin F-2- Used in cattle as a luteolytic
alpha Tromethamine agent for estrous
synchronization, unobserved
estrous, pyometra, and as an
abortifacient
Used in swine as a parturient
inducing agent.
Use in cycling mares as a
luteolytic agent to control the
time of estrus and to assist in
inducing estrus in difficult to
breed mares.
Use in small animals as an
abortifacient agent and
adjunctive medical therapy in
pyometra,
Used also in sheep and goat
reproductive medicine.
Contraindications(Complicati
ons with disease or
other drugs)
Do not use in any species
during pregnancy except as an
abortifacient or parturition
inducer
Contraindicated in animals
with bronchoconstrictive
respiratory disease
Do NOT give IV
Contraindicated in mares with
acute or subacute disorders of
the vascular system, GI tract,
respiratory system, or
reproductive tract.
Used with extreme caution in
dogs or cats greater than 8
years old, or with preexisting
cardiopulmonary or other
serious disease.
It has been associated with
acute toxicity and death in
camelids.
Possible drug interactions
with other oxytocic agents.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Magnesium Plumbs Online PO Oral
hydroxide Antacid/Laxative (Systemic
Drug)
Used for treatment of
esophagitis, gastric
hyperacidity, peptic ulcer and
gastritis
Used as an oral laxative in
small animals.
Used to increase rumen pH
and as a laxative in the
treatment of rumen overload
syndrome in ruminants.
Magnesium sulfate Plumbs Online IV, sometimes SQ or Parenteral
PO Electrolyte (Systemic Drug)
Used as a source of
magnesium and is given via
the IV route in magnesium
deficient states
Used for adjunctive therapy
of malignant hyperthermia in
swine
Used as an anticonvulsant.
Used for refractory
ventricular arrhythmias.
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in patients
with renal disease.
Oral magnesium hydroxide
should only be used clinically
in ruminants with
documented rumen acidosis
and should not be used for
treatment of other suspected
rumen disorders or
hypomagnesemia.
Possible drug interactions
with Quinide,
Smypathomimetic agents, and
other drugs.
contraindicated in patients
with myocardial damage or
heart block
given with caution to patients
with impaired renal function
Use only if needed in
pregnancy
Possible drug reactions with
calcium, CNS depressant
drugs, Digoxin, and
neuromuscular blocking
agents.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Mannitol Plumbs Online IV, IO Osmotic Diuretic (Systemic
Drug)
Used to promote diuresis in
acute oliguric renal failure,
reduce intraocular and
intracerebral pressures,
enhance urinary excretion of
some toxins, and to rapidly
reduce edema or ascites.
used for intravenous fluid
diuresis expulsion therapy
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in patients
with anuria secondary to renal
disease, severe dehydration,
severe pulmonary congestion
or pulmonary edema
Use with extreme caution in
hypovolemic patients or when
treating ethylene glycol
toxicity or other
hyperosmolar states
Can cause false positive test
results for ethylene glycol so
test before giving drug
Stop use if progressive heart
failure, pulmonary
congestion, progressive renal
failure or damage develops.
Use with caution when
treating secondary glaucomas
Do not give with whole blood
products, unless at least 20
mEq/L of sodium chloride is
added to the solution
Be certain crystals in the
solution are re-dissolved
before administering
May cause adverse effects to
the fetus when used in
pregnant animals.
Possible drug interactions
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Marbofloxacin/ Plumbs Online PO Fluoroquinolone Contraindicated in small and

Zeniquin Antibiotic (Systemic Drug)
Used for the treatment of
susceptible bacterial
infections in dogs and cats
Used for resistant UTIs, and
pyelonephritis
Treats clinical signs
associated with canine
leishmaniasis
medium breed dogs up to 8
months of age, large breeds to
12 months old, and giant
breeds to 18 months old
Contraindicated in cats less
than 12 months of age
Used with caution in patients
with seizure disorders.
Dont use in food animals
Possible drug interactions
with antacids, Cyclosporine,
Iron, and other drugs.
Best to give on an empty
stomach
Do not give at the same time
with other drugs or vitamins
that contain calcium, iron, or
aluminum
May stunt bone growth or
cause joint abnormalities if
used in young animals, during
pregnancy or while nursing.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Maropitant/ Cerenia Plumbs Online SQ, IV, PO Neurokinin (NK1) Receptor
Antagonist
Antiemetic (Systemic Drug)
Indicated for the prevention
and treatment of acute
vomiting and vomiting
because of motion sickness in
dogs that are at least 8 weeks
old.
Prevents vomiting in cats at
least 16 weeks old.
Decreases vomiting resulting
from use of other drugs.
effective in preventing
vomiting associated with
chemotherapy if administered
prior to the chemotherapeutic
agent
Give 3 hrs. before travelling
to prevent motion sickness.
Contraindications(Complicati
ons with disease or
other drugs)
Safe use has not been
evaluated in dogs or cats with
GI obstruction or that have
ingested toxins.
Safety has not been reported
in patients with underlying
cardiac disease, when
administered with cardiac
antiarrhythmic drugs, or when
administered with
doxorubicin
Use with caution in patients
with hepatic dysfunction
Use with caution with other
medications that are highly
protein bound
Use with caution in puppies
less than 11 weeks old
It may be susceptible to
interactions with drugs
such chloramphenicol,
phenobarbital, erythromycin,
ketoconazole, itraconazole,
NSAIDs, etc.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Meclizine/ Antivert Plumbs Online PO Antihistamine, Used with caution in patients

Antiemetic (Systemic Drug)
Used in small animals as an
antiemetic and for the
treatment and prevention of
motion sickness
with prostatic hypertrophy,
bladder neck obstruction,
severe cardiac failure, angle-
closure glaucoma, or
pyeloduodenal obstruction.
It is unknown if meclizine
enters milk; its
anticholinergic activity may,
potentially, inhibit lactation.
Possible drug interactions
with CNS depressants or
Anticholinergics.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Meclofenamic acid/ Wedgwood PO Analgesic, NSAID Horses with heavy

Arquel pharmacy Used to treat acute and infestations of Gastrophelus
chronic inflammation of the may be more likely to
musculoskeletal system in develop colic.
horses Slow onset of full clinical
Useful in chronic problems of action
the hoof Hypoproteinemic animals
may require a lower dose to
prevent signs of toxicity.
Meclofenamate crosses the
placenta and has been shown
to delay parturition in other
species.
Used with caution in horses
with liver disease, decreased
renal function or pre-existing
GI problems
Used with additional caution
with other drugs that may
cause GI ulceration, including
corticosteroids or other
NSAIDs.
Combination with aspirin
may increase blood loss due
to GI side effects.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Melarsomine/ Plumbs Online Deep IM, PO, Arsenical
Immiticide Antiparasitic (Systemic Drug)
Treatment of heartworm
disease caused by immature
to mature adult infections
of D. immitis in dogs
May also be useful for
treating ferrets
Contraindicated in dogs with
class IV (very severe)
heartworm disease
Do NOT use for cats
Older dogs (>8 years) may be
more susceptible to adverse
effects than younger dogs.
Do NOT give IV or SC
Some large breeds might be
susceptible to tissue damage.
Possible drug interactions
with Aspirin and CNS
depressant drugs.
Strict exercise restriction after
dosing is essential.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Meloxicam/ Metaca Plumbs Online PO, IV, SQ, Nonsteroidal
transmucosal oral, Antiinflammatory Agent
IM in pigs and birds (NSAID) (Systemic Drug)
Used for treating pain,
inflammation and
osteoarthritis in dogs.
Short-term use is also FDA-
approved for cats for the
control of postoperative pain
and inflammation associated
with orthopedic surgery,
ovariohysterectomy and
castration
Contraindications(Complicati
ons with disease or
other drugs)
Used with extreme caution in
dogs with active GI
ulceration, bleeding, or
receiving glucocorticoids
Used with caution in patients
with impaired hepatic, cardiac
or renal function and
hemorrhagic disorders
A 5-7 day washout period
after stopping meloxicam has
been recommended before
starting a new NSAID
Contraindicated in cats with
known hypersensitivity to
meloxicam or other NSAIDs
Safe use has not been
established for dogs under 6
mon. and cats under 4 mon. of
age.
Most NSAIDs are excreted in
milk; use cautiously.
Possible drug interactions
with inhalant anesthetics,
ACE inhibitors, Aspirin, and
others.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Meperidine/ Plumbs Online IM, SQ, IV Opiate Agonist (Systemic
Demerol/ Pethidine Drug)
Used as an analgesic
Sometimes used as
sedative/analgesic in small
animals for both post-
operative pain and medical
conditions such as acute
pancreatitis and thermal burns
occasionally used in equine
medicine in the treatment of
colic and in other large
animal species for pain
control.
It has a short analgesic
duration of activity and can
cause significant histamine
release.
Contraindicated in cases
where the patient is
hypersensitive to narcotic
analgesics, or in patients
receiving monoamine oxidase
inhibitors
Contraindicated in patients
with diarrhea caused by a
toxic ingestion
Used with caution in patients
with hypothyroidism, severe
renal insufficiency,
adrenocortical insufficiency,
and in geriatric or severely
debilitated patients.
Use with caution in cats
If given IV, it must be given
very slowly
Use with caution in patients
with head injuries or
increased intracranial pressure
and acute abdominal
conditions
Use with extreme caution in
patients with respiratory
disease or acute respiratory
dysfunction
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Methimazole/ Plumbs Online PO, transdermal Antithyroid (Systemic Drug)
Tapazole Used to treat feline
hyperthyroidism
May be useful for the
prophylactic prevention of
cisplatin-induced
nephrotoxicity in dogs
Transdermal application has
been used with some
therapeutic success in cats
that do not tolerate oral
dosing.
Contraindicated in patients
who are hypersensitive to it,
carbimazole, or the excipient,
polyethylene glycol.
Contraindicated in cats with
autoimmune disease, primary
liver disease, renal failure,
hematologic disorders or
coagulopathies
Do not use in pregnant or
lactating queens
Kittens should be placed on a
milk replacer after receiving
colostrum from mothers on
methimazole
Possible drug interactions
with Phenobarbital, Beta-
blockers, and other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Methocarbamol/ Plumbs Online IV, PO Muscle Relaxant (Systemic
Robaxin Drug)
In dogs and cats,
methocarbamol is approved
as adjunctive therapy of acute
inflammatory and traumatic
conditions of the skeletal
muscle and to reduce
muscular spasms
In horses it can also effect
striated muscle relaxation
Used for the adjunctive
treatment of intervertebral
disk disease in dogs
Useful in treating tremors and
muscle fasciculations
associated with various
toxicities in dogs and cats
Contraindications(Complicati
ons with disease or
other drugs)
Known or suspected renal
pathology is a
contraindication to injectable
methocarbamol therapy
Do not use in food animals.
Do not administer SQ and
avoid extravasation.
Do not exceed 2 mL per
minute when injecting IV in
dogs and cats.
Used with caution during
pregnancy as studies
demonstrating its safety
during pregnancy are lacking
Potential risks for pregnancy
and nursing
Possible drug interactions
with CNS depressants and
Pyridostigmine.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Methohexital/ Plumbs Online IV Ultra-Short Acting Contraindicated in patients

Brevital Barbiturate (Systemic Drug)
Ultrashort acting anesthetic
agent in small animals.
May be useful in sighthounds
due to rapid redistribution and
metabolism by the liver.
Useful when general
anesthesia must be
administered to a patient with
a full stomach
hypersensitive to barbiturates
or that do not have adequate
veins for safe IV
administration.
Contraindicated with seizure-
prone animals, severe
cardiovascular disease or
preexisting ventricular
arrhythmias, shock, increased
intracranial pressure,
myasthenia gravis, asthma,
and conditions where
hypnotic effects may be
prolonged
Not recommended for use in
cattle.
Possible risks when used with
CNS depressants.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Methypredniso- Plumbs Online PO, IV, IM Glucocorticoid (Systemic
lone acetate/ Medrol/ Drug)
Depo-Medrol Used as a replacement of
glucocorticoid activity in
patients with adrenal
insufficiency, as an
antiinflammatory agent, and
as an immunosuppressive
Relatively contraindicated for
systemic fungal infections
and in viral infections in
animals with arrested
tuberculosis, peptic ulcers,
acute psychoses, corneal
ulcer, & Cushingoid
syndrome.
Use cautiously in patients
with diabetes, osteoporosis,
chronic psychotic reactions,
predisposition to
thrombophlebitis,
hypertension, CHF, renal
insufficiency, & active
tuberculosis necessitates
Use with caution in pregnant
and nursing dams.
Possible interactions with
analgesics, aspirin,
barbiturates, and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Metoclopramide/ Plumbs Online IV, SQ, IM, PO GI Prokinetic Contraindicated with GI

Reglan Agent (Systemic Drug)
Used clinically for gastric
stasis disorders,
gastroesophageal reflux, to
allow intubation of the small
intestine, as a general
antiemetic, and as an
antiemetic to prevent or treat
chemotherapy-induced
vomiting
obstruction or perforation
Antiemetic effects appear
more pronounced in dogs than
cats
Distal esophageal motility
effects are greater in cats than
dogs.
Contraindicated in patients
with seizure disorders or head
trauma.
It may be contraindicated
when used with tricyclic
antidepressants (amitriptyline,
clomipramine, etc.), SSRI-
type antidepressants
(paroxetine, fluoxetine,
sertraline, etc.), or
mirtazapine.
Major drug interactions with
tramadol and selegiline are
possible.
It should be avoided in dogs
with pseudopregnancy
Used with caution in patients
with CHF
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Metronidazole/ Plumbs Online PO, IV Antibiotic, Prohibited for use in food

Flagyl Antiparasitic (Systemic Drug)
Used extensively in the
treatment of Giardia in both
dogs and cats
Used clinically in small
animals for the treatment of
other parasites as well as
treating both enteric and
systemic anaerobic infections
(also in horses).
Used as a perioperative
surgical prophylaxis antibiotic
animals
Contraindicated in animals
hypersensitive to the drug or
nitroimidazole derivatives
Recommended not to use the
drug in severely debilitated,
pregnant or nursing animals
Used with caution in animals
with hepatic dysfunction
Because of the risk for
neurotoxicity in dogs, total
daily doses of metronidazole
should not exceed 65 mg/kg
per day
Possible drug interactions
with alcohol, Phenobarbital,
and other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Midazolam/ Versed Plumbs Online SQ, IV, IM, Parenteral
intranasal in birds Benzodiazepine (Systemic
Drug)
Used principally for its
sedative, anxiolytic and
muscle relaxant properties as
a premedicant in combination
with other drugs prior to
induction of general
anesthesia.
sedation may be adequate in
rabbits, ferrets and some birds
May be beneficial in treating
status epilepticus when given
either IV, IM, or intranasally
Contraindications(Complicati
ons with disease or
other drugs)
Use cautiously in patients
with hepatic or renal disease,
and debilitated or geriatric
patients
Use cautiously in patients in
coma, shock, or with
significant respiratory
depression
Midazolam with etomidate
should be used with caution
in dogs undergoing ocular
surgery
use during the 1st trimester of
pregnancy should only occur
when the benefits clearly
outweigh the risks
Midazolam is excreted in
milk and may cause CNS
effects in nursing neonates.
Many possible drug
interactions
Use cautiously with Ketamine
and Etomidate.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Milbemycin oxime Plumbs Online PO Milbemycin oxime is a Test for preexisting

Macrolide
Antiparasitic (Systemic Drug)
Milbemycin tablets are a
once-a-month heartworm
preventative also used to
control hookworms and used
against roundworms and
whipworms.
heartworm infections.
Only use Interceptor in
dogs 4 weeks of age or older,
and at least 2 lbs. body weight
Possible risk with some drugs

Praziquantel/ Aticestodal
Droncit Antiparasitic (Systemic Drug) Do not use praziquantel in
Used for the treatment puppies <4 weeks old or
of Dipylidium kittens <6 weeks old
IM, SQ, PO caninum, Taenia pisiformis, Possible risk with some
and Echinococcus drugs.
granulosis in dogs,
and Dipylidium
caninum and Taenia
taeniaeformis in cats
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Minocycline/ Plumbs Online PO Tetracycline Contraindicated in patients

Minocin Antibiotic (Systemic Drug)
May be useful for treating
Brucellosis, Lyme disease,
and certain nosocomial
infections
May be effective for treating
some methicillin-resistant
strains of Staphylococcus
pseudintermedius
that are pregnant or nursing,
or in animals <6 months old
Because they can retard fetal
skeletal development and
discolor deciduous teeth, they
should only be used in the last
half of pregnancy when the
benefits outweigh the fetal
risks
Potential risk with antacids,
oral iron, Penicillins,
Sucrasulfate, and a few
others.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Morphine Plumbs Online IM, SQ, IV slowly, Opiate Agonist (Systemic
PO Drug)
Treatment of acute pain in
dogs, cats, horses, swine,
sheep, and goats
Preanesthetic agent in several
species.
For sedation and analgesia in
critically ill small animals
Morphine has been used as an
antitussive, antidiarrheal, and
adjunctive therapy for some
cardiac abnormalities in dogs.
Used with caution in patients
with hypothyroidism or renal
insufficiency, adrenocortical
insufficiency, and in geriatric
or severely debilitated
patients
Contraindicated in cases
where the patient is
hypersensitive to narcotic
analgesics, receiving
monamine oxidase inhibitors,
or with diarrhea caused by a
toxic ingestion
Used with extreme caution in
patients with head injuries,
increased intracranial
pressure, and acute abdominal
conditions
Used cautiously in patients
suffering from acute uremia
Neonatal, debilitated, or
geriatric patients may be more
susceptible to the effects and
require low doses.
It appears in maternal milk,
but effects on offspring may
not be significant when used
for short periods
Use cautiously with diuretics,
muscle relaxants, warfarin,
and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Moxidectin/ Plumbs Online Topical, PO, SQ Avermectin
Cydectin/ ProHeart/ Antiparasitic (Systemic Drug)
Advantage Multi It is an antiparasitic with
products FDA-approved for
cattle, dogs, cats, ferrets,
sheep, & horses.
The injectable product is for
use in dogs 6 months or older
to treat heartworm and
hookworm.
Topical combination is for
heartworm, fleas,
hookworms, and
roundworms.
Treats ear mites in cats &
whipworm and sarcoptic
mange in dogs.
Only use the oral product in
dogs negative for heartworm
The 6-month injectable
product is contraindicated in
patients previously found
hypersensitive to the drug, or
are sick, debilitated,
underweight or who have a
history of weight loss.
Use with caution in dogs with
pre-existing allergic disease.
Caution should be used when
administering concurrently
with vaccinations
Do not use on sick, debilitated
or underweight cats or ferrets.
Not for use in female dairy
cattle of breeding age.
Is not labeled for use in foals
younger than 4 months of age.
Animals with very low body
fat could be more prone to
develop adverse reactions.
Use caution with some drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Naloxone/ Narcan Plumbs Online IV, IM, SQ, IO, IP Antidote, Opiate
Antagonist (Systemic Drug)
Used almost exclusively for
its opiate reversal effects
May be useful in treating
post-anesthetic dysphoria
May be used as a test drug to
diminished tail chasing or
other self-mutilating
behaviors.
Nitenpyram/ CapstarPlumbs Online PO Oral Insecticide (Systemic
Drug)
A flea adulticide in dogs and
cats that are, at least, 2
pounds in weight and 4 weeks
old
may be effective for treating
fly larvae (maggots) of
various species.
Contraindications(Complicati
ons with disease or
other drugs)
Used cautiously in animals
that have preexisting cardiac
abnormalities or that may be
opioid dependent
It should be avoided when
Excitotoxicity is suspected
When used to reduce post-
operative dysphoria
associated with perioperative
opioids, naloxone dosage and
administration rate must be
carefully titrated or
hyperalgesia can occur
Caution when use with
Yohimbine and a few other
drugs.
Nitenpyram is not to be used
in animals under 2 pounds of
body weight or under 4 weeks
of age. Use with caution in
animals under 8 weeks old.
In some instances, birth
defects and fetal/neonatal loss
were reported after treatment
of pregnant and/or lactating
animals.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Nitroglycerin Plumbs Online Transdermal Venodilator; Afterload Contraindicated in patients

Ointment/ Nitro-bid/ ointment Reducer (Systemic Drug)
Minitran used primarily as an
adjunctive vasodilator in heart
failure and cardiogenic edema
with severe anemia or those
hypersensitive to them.
They should be used with
caution in patients with
cerebral hemorrhage or head
trauma, diuretic-induced
hypovolemia or other
hypotensive conditions.
Potential risks for pregnant
animals.
Do not use with Epinephrine
Possible risks when used with
Phenothiazines and others.
Rotate application sites.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Oclacitinib/ Apoquel Plumbs Online PO Janus Kinase (JAK) Inhibitor,
Antipruritic (Systemic Drug)
FDA-approved in dogs (at
least 1-year old) for the
control of pruritus associated
with allergic dermatitis and
control of atopic dermatitis
Omeprazole/ Plumbs Online PO Proton Pump
Gastrogard/ Prilosec Inhibitor (Systemic Drug)
Useful in treating both
gastroduodenal ulcer disease
and preventing or treating
gastric erosions caused by
ulcerogenic drugs
Omeprazole may reduce
cerebrospinal fluid (CSF)
production in dogs and be
useful in conditions causing
intracranial hypertension
Treatment and prevention of
recurrence of gastric ulcers in
horses
Contraindications(Complicati
ons with disease or
other drugs)
Not for use in dogs <12
months of age, those with
serious infections, breeding
dogs, or pregnant or lactating
bitches
It may increase susceptibility
to infection, including
demodicosis, and exacerbate
neoplastic conditions
The drugs label states that it
should not be used in
breeding dogs, or pregnant or
lactating bitches.
In patients with hepatic or
renal disease, the drugs half-
life may be prolonged and
dosage adjustment may be
necessary if the disease is
severe.
Possible risks with drugs like
Cyclosporine, Digoxin,
Warfarin, and others.
Use before the first meal of
the day if possible.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Ondansetron/ Plumbs Online PO, IV, IM, SQ 5-HT3 Receptor
Zofran Antagonist (Systemic Drug)
an antiemetic used for severe
vomiting in dogs and cats
effective for treating
chemotherapy associated-
vomiting
Orbifloxacin/ Orbax Plumbs Online PO Fluoroquinolone
Antibiotic (Systemic Drug)
Orbifloxacin is indicated for
treatment in dogs and cats for
susceptible bacterial
infections. Orbifloxacin may
also be of benefit in treating
susceptible gram-negative
infections in horses
Contraindications(Complicati
ons with disease or
other drugs)
Ondansetron may mask ileus
or gastric distention; it should
not be used in place of
nasogastric suction
Use wit
h caution in patients with
hepatic dysfunction
Excreted in the maternal milk
of rats; exercise caution when
5-HT3 antagonists are
administered to nursing
patients.
Possible drug interactions
with Tramadol, Apomorphine
and others.
Orbifloxacin, like other
fluoroquinolones, can cause
arthropathies in immature,
growing animals
It is contraindicated in
immature dogs during the
rapid growth phase
Orbifloxacin should be used
with caution in animals with
known or suspected CNS
disorders
Possible drug interactions
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Orbifloxacin/ Plumbs Online PO Azole Antifungal (Systemic Posaconazole is excreted into

Mometasone/ Drug)
Posaconazole/ useful for treating systemic or
Noxafil severe fungal infections in
dogs and cats
Mometasone is a
Dermatological Drug
(topical)
useful for adjunctive
treatment of pruritic and/or
inflammatory conditions that
may be associated with
bacterial and/or yeast skin
infections
rat milk, and safe use during
nursing is not known
No known contraindications
Safe use in pregnancy has not
been established
Use cautiously with drugs like
Cimetidine, Digoxin,
Metaclopramide, and others.
Give after food.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Oxazepam/ Serax Plumbs Online PO Benzodiazepine (Systemic
Drug)
Used in small animal
medicine as an appetite
stimulant in cats and dogs
It may be useful for
adjunctive therapy of
behavior-related disorders for
both dogs and cats.
It may be a good choice for
treating geriatric patients and
those with liver dysfunction
Contraindications(Complicati
ons with disease or
other drugs)
Use in feline patients with
liver dysfunction is somewhat
controversial as it has has
been associated with
fulminant hepatic failure
Contraindicated in patients
who are hypersensitive to it or
other benzodiazepines or have
acute narrow angle
glaucoma.
It is excreted in maternal milk
Use with caution with CNS
depressants, Theophyllines,
and other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Oxymorphone/ Plumbs Online IV, IM, SQ Opiate Agonist (Systemic
Numorphan Drug)
Used in dogs and cats as a
sedative/restraining agent,
analgesic, and preanesthetic;
Used occasionally in horses
as an analgesic and anesthesia
induction agent
It may also be used in swine
as an adjunctive analgesic
with ketamine/xylazine
anesthesia and small rodents
as an analgesic/anesthetic for
minor surgical procedures
used with caution in patients
with hypothyroidism, severe
renal insufficiency,
adrenocortical insufficiency,
and in geriatric or severely
debilitated patients.
contraindicated in patients
hypersensitive to narcotic
analgesics, and generally in
patients with diarrhea caused
by toxic ingestion
used with extreme caution in
patients with head injuries
used with extreme caution in
patients suffering from
respiratory disease or acute
respiratory dysfunction
Neonatal, debilitated, or
geriatric patients may be more
susceptible to the effects
It can cause bradycardia
In horses, opiates can mask
the behavioral and
cardiovascular clinical signs
associated with mild colic.
Use cautiously with diuretics,
CNS depressants, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Oxytocin/ Pitocin Plumbs Online SQ, IM, IV in Hormonal Agent (Systemic
rodents, Drug)
Used for induction or
enhancement of uterine
contractions at parturition,
treatment of postpartum
retained placenta and metritis,
uterine involution after
manual correction of
prolapsed uterus in dogs, and
in treating agalactia.
Contraindicated in animals
with dystocia due to abnormal
presentation of fetus, unless
correction is made
Before using oxytocin, treat
hypoglycemia or
hypocalcemia if present.
When used prepartum,
oxytocin should be used only
when the cervix is relaxed
naturally or by the prior
administration of estrogens
Use with caution with
Thiopental and
Vasoconstrictors.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Oxytetracycline/ Plumbs Online IV, PO, or SQ/IM in Tetracycline
Terramycin cattle Antibiotic (Systemic Drug)
May be very useful to treat
mycoplasma, rickettsia,
spirochetes, & Chlamydia.
In cattle, they may be
indicated for infectious
diseases such as Bovine
Respiratory Disease,
diphtheria, foot rot, and
pinkeye, bacterial enteritis,
wooden tongue, leptospirosis,
wound infections, and acute
metritis.
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in patients
hypersensitive to it or other
tetracyclines.
Contraindicated in pregnancy;
may cause congenital
malformations or
embryotoxicity.
It is excreted in milk.
Use cautiously with renal
insufficiency or hepatic
impairment
Avoid concurrent
administration of other
nephrotoxic or hepatotoxic
drugs with tetracyclines.
These drugs administered
orally to hamsters, gerbils,
guinea pigs, and rabbits may
either be toxic or not
absorbed
May permanently stain teeth
and developing bones in
young animals.
Increases sunburn risk
Injectable forms may be
painful
Give on an empty stomach
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Panalog/ Nystatin Plumbs Online topical Useful for topical lesions Usually safe, but
caused by yeasts or yeast-like hypersensitivity reactions are
organisms possible
Used for mixed otitis
infections

Pancrealipase/ Plumbs Online PO Pancreatic Enzymes (Systemic Contraindicated in animals that

Viokase Drug)
Used to treat patients with
exocrine pancreatic enzyme
insufficiency
Used to test for pancreatic
insufficiency secondary to
chronic pancreatitis.
are hypersensitive to pork
proteins
Do not inhale the powder
Avoid contact with mucous
membranes or skin.
Potential risks for pregnancy.
Possible interactions with
cimetidine and antacids.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Paroxetine/ Paxil Plumbs Online PO Selective Serotonin Reuptake Contraindicated in patients

Inhibitor (SSRI)
Antidepressant (Systemic
Drug)
Treatment of canine
aggression, and stereotypic or
other obsessive-compulsive
behaviors.
Occasionally used in cats.
with known hypersensitivity to
it or those receiving
monoamine oxidase inhibitors
Use with caution in patients
with seizure disorders, severe
cardiac, hepatic, or renal
disease; doses may need to be
reduced.
Withdraw use gradually
Animal studies have shown an
adverse effect on the fetus
The drug is excreted into milk
but at low levels; caution is
advised in nursing patients.
Many possible drug
interactions
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Penicillin-G Plumbs Online IM, IV, SQ, PO in Penicillin
ferrets Antibiotic (Systemic Drug)
Used for susceptible gram-
positive aerobes & anaerobes
as well as group A beta-
hemolytic streptococci,
spirochetes, gram-negative
aerobic cocci, and some gram
negative aerobic bacilli.
Hypersensitivity possible. use
cautiously in patients who are
hypersensitive to other beta-
lactam antibiotics
Dont give PO in patients with
septicemia, shock, or other
grave illnesses; they may
cause GI effects.
High doses may cause
electrolyte imbalances.
Snakes, birds, turtles, guinea
pigs, and chinchillas are
reportedly sensitive to
procaine penicillin G.
They have been shown to cross
the placenta
They are excreted in maternal
milk in low concentrations
Use with cautiously with
aminoglycosides,
Methotrexate, and Probenecid.
May cause falsely
elevated serum uric
acid values or false-positive
urine glucose determinations.
Do not give Procaine
Penicillin G IV.
Injectable solutions may cause
stinging when injected under
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Pentobarbital Plumbs Online IV, in some rodents Barbiturate (Systemic Drug)
Sodium/ Nembutal IP is used Used therapeutically as a
sedative/anesthetic, & for
treating intractable seizures; It
is also used as a euthanasia
agent.
Used to be used mainly for
anesthesia in small animals.
Not used with seizures caused
by lidocaine intoxication
Short acting45 min. to 1.5
hours
Contraindicated in patients
with severe liver disease or
with previous hypersensitivity
Large doses are
contraindicated in patients
with nephritis or severe
respiratory dysfunction.
Use for C-section is not
recommended.
Not an ideal agent for adult
horses
Contraindicated with
pregnancy; It may cause
congenital malformations or
embryotoxicity.
Use cautiously in patients that
are hypovolemic, anemic, have
borderline hypoadrenal
function, or cardiac or
respiratory disease
Use with caution in nursing
mothers and neonates
Cats, especially females, can
be particularly sensitive to it.
Give SLOWLY intravenously
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Phenobarbital/ Plumbs Online PO, IV Barbiturate (Systemic Drug)
Phenobarbitone Anticonvulsant used for status
epilepticus in dogs, cats, and
horses, to prevent the
recurrence of seizures
Can be used to control
excessive drooling in dogs
and to reduce feline
vocalization while riding in
automobiles.
Occasionally used as an oral
sedative agent
Caution for patients that are
hypovolemic, anemic, have
borderline hypoadrenal
function, or cardiac or
respiratory disease.
Large doses are
contraindicated in patients
with nephritis or severe
respiratory dysfunction.
Contraindicated in
hypersensitive patients or
patients with severe liver
disease.
When giving IV, give slowly
Commercially available
injectable preparations must
not be given SQ or
perivascularly as tissue
irritation and possible
necrosis may result.
Associated with rare
congenital defects and
bleeding problems in
newborns.
Small amounts are excreted in
maternal milk so be cautious.
Use with caution with
Acetaminophen,
antihistamines, opiates, and
many other drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Phenylbutazone/ Plumbs Online PO, IV Non-Steroidal Contraindicated in patients

Butazolidin Bute Antiinflammatory
Agent (Systemic Drug)
Used primarily for treating
pain and inflammation in
horses. (possible to use in
other species as well)
with preexisting hematologic
or bone marrow
abnormalities, preexisting GI
ulcers, & in food or dairy
cattle.
Caution in foals and ponies.
Undernourished or parasite
infested foals are more
susceptible to adverse effects
Avoid use in horses with
EGUS
Contraindicated in patients
with previous hypersensitivity
reactions,
Use cautiously in patients
with a history of allergies to
other drugs.
Dont administer injectable
preparation IM or SC
Used in pregnancy only when
the potential benefits
outweigh the risks
Use with caution with
Penicillin, NSAIDs,
Warfarin, Sulfonamides, and
others.
55-60 day withdrawal interval
following chronic oral
administration (>10 days),
and a minimum withdrawal
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Phenylpropanol- Plumbs Online PO Sympathomimetic (Systemic Use with caution in patients

Amine/ PPA, Proin/ Drug)
Ornade, Prolamine, Treats urinary incontinence in
Dexatrim dogs and sometimes cats.
Used to treat nasal congestion
in small animals.
with glaucoma, prostatic
hypertrophy,
hyperthyroidism, diabetes
mellitus, cardiovascular
disorders, kidney
insufficiency or hypertension.
It may cause decreased ovum
implantation
PPA may potentiate decreased
platelet aggregation when
used with Aspirin
Use with caution with
NSAIDs and other drugs
such as Isoflurane,
Desflurane, and Sevoflurane.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Pimobendan/ Plumbs Online PO Inodilator (Systemic Drug) Give on an empty stomach.

Vetmedin Treats dogs with (CHF)
secondary to dilated
cardiomyopathy or chronic
mitral valve insufficiency,
myxomatous/degenerative
mitral valve disease.
It may increase risks for
arrhythmias.
Contraindicated in animals
hypersensitive to it, with
hypertrophic cardiomyopathy,
aortic stenosis, or any
condition where an
augmentation of cardiac
output is inappropriate for
functional or anatomic
reasons
It should be used with caution
in patients with uncontrolled
cardiac arrhythmias.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Piroxicam/ Feldene Plumbs Online PO Non-Steroidal
Antiinflammatory (NSAID),
Anti-Tumor (Systemic Drug)
In dogs and cats, its primary
use is as adjunctive treatment
of bladder transitional cell
carcinoma.
It may also be of benefit in
squamous cell carcinomas,
mammary adenocarcinoma,
and transmissible venereal
tumor
May be beneficial in reducing
the pain and inflammation
associated with degenerative
joint disease
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in patients
hypersensitive to it or that are
severely allergic to aspirin or
other NSAIDs
Used with caution in patients
with severely compromised
cardiac function.
Used with extreme caution in
cats.
Animal studies have shown
an adverse effect on the fetus.
Most NSAIDs are excreted in
maternal milk; use with
caution in nursing patients.
Use with caution with
Aspirin, anticoagulants,
Corticosteroids, and others.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Pitressin(ADH)/ Plumbs Online CRI IV, IO Antidiuretic Hormone;
Vasopressin/ Pressor Agent (Systemic
Drug)
Diagnostic agent and as a
treatment for, central
diabetes insipidus in small
animals.
It has some potential
advantages over
epinephrine
Used to treat acute GI
hemorrhage and stimulate
GI peristalsis.
Treatment of hypotensive
septic patients
unresponsive to
conventional vasopressors
Tshock syndromes and for
cardiopulmonary-cerebral
resuscitation (CPCR)
Used with caution in
patients with vascular
disease, seizure disorders,
heart failure, or asthma.
Potential risk for
pregnancy
Alcohol, epinephrine, and
a few other drugs can
inhibit the antidiuretic
activity of vasopressin
while antidepressants and a
few other drugs potentiate
them.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Ponazuril/ Toltrazuril Plumbs Online PO Antiprotozoal (Systemic Before treating, other

sulfone/ Marquis Drug) conditions that can cause
Treatment of equine protozoal ataxia should be ruled out.
myeloencephalitis
Potentially useful in
treating Neospora caninum,
Toxoplasma, or other
protozoal infections in other
species
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Polysulfated Plumbs Online (IM, IV, or IA in Proteolytic Enzyme Inhibitor,
Glycosaminoglycan/ horses) Chondroprotectant (Systemic
Adequan/ Drug)
Chondroprotec IM, SQ Treatment of non-infectious
and/or traumatic joint
dysfunction and associated
lameness of the carpal joints
FDA-approved for the control
of signs associated with non-
infectious degenerative and/or
traumatic arthritis in dogs.
Should not be used in place of
other therapies in cases of
infection, or in place of
surgery or joint
immobilization where
indicated.
Some clinicians feel that it
should not be used within one
week of arthrotomy in dogs
because it may cause
increased bleeding
use with caution during
pregnancy or in breeding
animals
There is some concern that it
should not be used in
conjunction with other
NSAIDs or other
anticoagulants.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Potassium bromide Plumbs Online PO Anticonvulsant (Systemic
Drug)
Primary therapy and
adjunctive therapy to control
seizures in dogs.
Treatment in dogs not
adequately controlled with
phenobarbital alone
May be suitable for use in
some cats with chronic
seizure disorders
Contraindications(Complicati
ons with disease or
other drugs)
Older animals and those with
additional disease may be
prone to intolerance at blood
levels that are tolerable by
younger, healthier dogs.
Patients with renal dysfunction
may require dosage
adjustments.
Use with caution as it can
cause severe pulmonary effects
in cats.
Use with caution in pregnancy
or lactation.
Use with caution with
diuretics, with IV fluids
containing sodium, CNS
sedating drugs, and drugs that
lower the seizure threshold.
Potassium bromide
must NOT be administered IV.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Potassium Plumbs Online PO, SQ, IV fluid Electrolyte (Systemic Drug) Contraindicated in patients
gluconate/ Used to prevent or treat with hyperkalemia, renal
Potassium Acetate, potassium deficits failure or impairment, severe
Potassium Chloride hemolytic reactions, untreated
Addisons disease, and acute
dehydration
Solid oral dosage forms should
not be used in patients where
GI motility is impaired
Use cautiously in patients
receiving Digoxin
Fatal hyperkalemia may
develop if potassium salts are
administered too rapidly IV or
if potassium renal excretory
mechanisms are impaired.
With ACE inhibitors,
Potassium retention may occur

Use with caution with Digoxin

NSAIDs, and Potassium-
Sparing diuretics
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Pralidoxime chlor- Plumbs Online IV, IM, SQ Antidote, Cholinesterase
ide (2-PAM)/ Reactivator (Systemic Drug)
Protopam Chloride Used in the treatment of
organophosphate poisoning,
often in conjunction with
atropine and supportive
therapy.
Not generally recommended
for use in carbamate
poisoning
Used with caution in patients
receiving anticholinesterase
agents for the treatment of
myasthenia gravis
Used cautiously and at a
reduced dosage rate in patients
with renal impairment.
It is not known whether this
drug is excreted in maternal
milk; exercise caution.
Animal studies have shown an
adverse effect on the fetus
Use with caution with
Barbiturates
Use of Cimetidine,
Succinylcholine, Theophylline,
and Respiratory Depressant
Drugs should be avoided in
patients with organophosphate
toxicity.
28-day meat and a 6-day milk
withdrawal time
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Praziquantel/ Plumbs Online IM, SQ, PO Anticestodal
Droncit Antiparasitic (Systemic Drug)
Treatment of Dipylidium
caninum, Taenia pisiformis,
and Echinococcus
granulosis in dogs,
and Dipylidium
caninum and Taenia
taeniaeformis in cats
Can also be used for
treating Alaria spp. in dogs
and cats and Spirometra
mansonoidesinfections in
cats.
Do not use in puppies <4
weeks old or kittens <6 weeks
old.
Praziquantel appears in
maternal milk at a
concentration of 25% of
that in maternal serum, but is
unlikely to pose harm to
nursing offspring.
Cimetidine may increase the
serum concentration of
praziquantel.
Ketoconazole and
Itraconazole may increase
praziquantel levels.
Grapefruit juice can
significantly increase
praziquantel serum levels in
Beagles
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Prednisolone/ Pred Plumbs Online Ophthalmic drops Corticosteroid
Forte/ Omnipred Antiinflammatory
Agent (Ophthalmic Drug)
Used for symptomatic relief
of corticosteroid-responsive
inflammatory conditions of
the palpebral and bulbar
conjunctiva, cornea, and
anterior segment of the globe
In horses it is used for
treatment of uveitis
Used to treat inflammation
associated with corneal injury
from chemical, radiation, or
thermal burns or penetration
of foreign bodies.
Contraindications(Complicati
ons with disease or
other drugs)
Topical corticosteroids are
contraindicated with known
or suspected corneal
ulceration or corneal infection
Caution in patients with
diabetes mellitus or other
endocrine diseases, infectious
diseases, chronic renal failure,
CHF, systemic hypertension,
or gastric ulceration.
Do not use with fungal
keratitis or feline herpes
keratitis
Wait 5 minutes after applying
this medication before
applying any other
medications to the eye.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Procainamide/ Plumbs Online PO, IM, IV Antiarrhythmic (Systemic Contraindicated in patients

Pronestyl Drug)
Useful for the treatment of
ventricular premature
complexes, ventricular
tachycardia, or
supraventricular tachycardias
associated with wide QRS
complexes.
with myasthenia gravis
Contraindicated in patients
hypersensitive to it, procaine,
or other chemically related
drugs
Used with extreme caution in
patients with cardiac
glycoside intoxication.
Use with caution in patients
with significant hepatic or
renal disease or with CHF.
Dosages should be reduced in
patients with renal failure,
CHF, or those that are
critically ill.
Do not use in Dobermans and
Boxers with dilated
cardiomyopathy or dogs with
subaortic stenosis.
It is excreted in maternal milk
and absorbed in nursing
offspring so use with caution
in nursing patients
Use with caution with other
antidysrhythmic agents
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Propantheline Plumbs Online PO in cats, IV in Quaternary Antimuscarinic Contraindicated in Australia in

Bromide/ Pro- horses. (Systemic Drug)
Banthine In small animals, it is used for
its antispasmodic/
antisecretory effects in the
treatment of diarrhea.
Used in the treatment of
hyperreflexic detrusor or urge
incontinence and as an oral
treatment in anticholinergic
responsive bradycardias.
In horses, it can be used
intravenously to reduce
colonic peristalsis and for
relaxing the rectum to allow
easier rectal examination and
surgery.
cases of tympanic equine colic
Dont use in cases of dry
choke
Contraindicated if the patient
has a history of
hypersensitivity, tachycardias
secondary to thyrotoxicosis or
cardiac insufficiency,
myocardial ischemia, unstable
cardiac status during acute
hemorrhage, GI obstructive
disease, paralytic ileus, severe
ulcerative colitis, obstructive
uropathy, or myasthenia
gravis.
Extreme caution with patients
with GI infections or
autonomic neuropathy.
Caution in patients with
hepatic or renal disease,
hyperthyroidism, hypertension,
CHF, tachyarrhythmias,
prostatic hypertrophy,
esophageal reflux, and in
geriatric or pediatric patients.
Use with caution in nursing
patients.
Drug interactions with
antihistamines, corticosteroids,
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Propofol/ Rapinovel/ Plumbs Online IM, SQ, IV Injectable Anesthetic
PropoFlo/ Diprivan (Systemic Drug)
May be useful as an induction
agent and as an anesthetic for
outpatient diagnostic or
minor/short procedures.
For relatively short
procedures it can be used as a
CRI for total IV anesthesia,
but does not provide
analgesia.
treatment for refractory status
epilepticus
useful in patients with
preexisting cardiac
dysrhythmias.
Contraindications(Complicati
ons with disease or
other drugs)
Do not use in patients where
general anesthesia or sedation
is contraindicated.
Cats dont tolerate it as well
as dogs.
Use with caution in patients
that are in shock, under severe
stress, or have undergone
trauma.
Use with caution in animals
with hypoproteinemia,
hyperlipidemia, seizures, or
anaphylaxis history.
Greyhounds clear propofol
more slowly than mixed-
breed or Beagle dogs.
Potential risks when used
with opiates, other
anesthetics, anticholinergics,
and others.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Propanolol/ Inderal Plumbs Online PO, IV, SQ Beta-Adrenergic
Blocker (Systemic Drug)
Acute treatment of atrial and
ventricular premature
complexes, supraventricular
premature complexes and
tachyarrhythmias, ventricular
or atrial tachyarrhythmias
secondary to digitalis, atrial
tachycardia secondary to
Wolff-Parkinson-White with
normal QRS complexes, and
atrial fibrillation
Short-term treatment of
hypertension and clinical signs
associated with thyrotoxicosis
in cats and pheochromocytoma
in dogs.
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in heart
failure, hypersensitivity to this
class of agents, greater than 1st
degree heart block, or sinus
bradycardia
Generally contraindicated in
patients with CHF unless
secondary to a
tachyarrhythmia responsive to
beta-blockers or with
bronchospastic lung disease.
Use with caution in patients
with significant renal or
hepatic insufficiency, sinus
node dysfunction, labile
diabetic patients, digitalized or
digitalis intoxicated patients.
Potential risks for pregnancy
Use with caution in nursing
patients.
Possible interactions with
antacids, anticholinergics,
epinephrine, and other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Prostglandin F2 Plumbs Online SQ, IM in cattle to Prostaglandin (Systemic
Alpha/ Lutalyse induce parturition or Drug)
in many species to Labeled for use in cattle as a
abort, PO luteolytic agent for estrous
synchronization, unobserved
estrous in lactating dairy cattle,
pyometra, and as an
abortifacient in feedlot and
nonlactating dairy cattle.
It is labeled in swine to act as a
parturient inducing agent.
The product is labeled for use
in cycling mares as a luteolytic
agent to control the time of
estrus and to assist in inducing
estrus in difficult to breed
mares.
Used in small animals as an
abortifacient agent and
adjunctive medical therapy in
pyometra.
Used in sheep and goat
reproductive medicine.
Contraindications(Complicati
ons with disease or
other drugs)
It should not be used in any
species during pregnancy.
Contraindicated in animals
with bronchoconstrictive
respiratory disease.
It should not be administered
intravenously.
Contraindicated in mares with
acute or subacute disorders of
the vascular system, GI tract,
respiratory system, or
reproductive tract.
Used with extreme caution in
dogs or cats greater than 8
years old, or with preexisting
cardiopulmonary or other
serious diseases.
Associated with acute toxicity
and death in camelids.
In swine, it should not be
administered prior to 3 days of
predicted farrowing as
increased neonatal mortality
may result.
Dogs are more sensitive to it
than other species
The activity of other oxytocic
agents may be enhanced by it.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Psyllium/ Metamucil Plumbs Online
PO (with food), NG Bulk Forming GI
tube in horses, Laxative/Antidiarrheal
(Systemic Drug)
Used for treatment &
prevention of sand colic in
horses
Used as a laxative, & to
increase stool consistency in
patients with chronic, watery
diarrhea.
Contraindicated in rabbits.
where prompt intestinal
evacuation is required, or
when fecal impaction or
intestinal obstruction is
present as it may damage
intestinal mucosa and cause
blockage.
Bulk-forming laxatives
should not be used in cases
where prompt intestinal
evacuation is required, or
when fecal impaction or
intestinal obstruction is
present.
Use with caution with
Aspirin, Digoxin, and
Nitrofurantoin. Separate these
drugs by 3 hours between
administration.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Pyrantel pamoate/ Plumbs Online PO Antiparasitic (Systemic Drug)
Strongid/ Nemex Used for the removal of
ascarids, hookworms, and
stomach worm in dogs. It is
not FDA approved for cats
but can be used with the same
results.
It is used for the removal of
Strongylus vulgaris and
equinus, Parasacaris
equorum, and Probstymayria
vivipara in horses. It has
variable activity against
Oxyuris equi, S. edentatus,
and small strongyles.
Pyrantel is active against
ileocecal tapeworm when
used at twice the
recommended dose, although
resistance has been reported.
It is not FDA approved in
cattle, sheep, and goats, but
can be used to kill various
parasites. It has been used in
birds and llamas as well.
It kills roundworm in swine
and also stomach worm.
Contraindications(Complicati
ons with disease or
other drugs)
Resistance to antiparasitic
agents is an ongoing problem
Use with caution in severely
debilitated animals (not
recommended for use)
When administered at
recommended doses, adverse
effects are unlikely, but
emesis may possibly occur in
small animals.
Interactions with Levamisole,
Morantel, Organophosphates,
and Piperazine.
Rarely, some small animals
may vomit after getting it;
give with food if this happens.
Shake container well before
each use
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Quinidine Plumbs Online PO, IM, IV, NG tube Antiarrhythmic (Systemic
in horses Drug)
Agent used in small animals
& horses to treat ventricular
arrhythmias, refractory
supraventricular tachycardias,
and supraventricular
arrhythmias associated with
anomalous conduction in
Wolff-Parkinson-White
(WPW) syndrome.
It should be used with
extreme caution, if at all, in
any form of AV block or if
any clinical signs of digitalis
toxicity are exhibited.
Quinidine should be used
with caution in patients with
uncorrected hypokalemia,
hypoxia, and disorders of
acid-base balance.
Use cautiously in patients
with hepatic or renal
insufficiency as accumulation
of the drug may result.
GI upset may be decreased if
administered with food.
Do not allow animal to chew
or crush sustained-release oral
dosage forms.
Many drug interactions: for
example, Antacids may delay
oral absorption so you must
separate dosages. Also,
Dexamethasone in dogs, can
increase quinidine volume of
distribution (49-78%) and
eliminate half-life. (And
others)
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Ranitidine/ Zantac Plumbs Online SQ, IM, IV, PO H2 Receptor Antagonist, It should be used cautiously
Prokinetic (Systemic Drug) and possibly at reduced dosage
Used to reduce acid output in in patients with diminished
stomach; it also has renal function.
prokinetic activity Ranitidine (dose-dependent)
Treats hypersecretory may inhibit acetaminophen
conditions associated with metabolism.
gastrinomas and systemic
mastocytosis.
Treatment and/or prophylaxis
of gastric, abomasal and
duodenal ulcers, various
forms of gastritis, duodenal
gastric reflux and esophageal
reflux.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Robenacoxib/ Onsior Plumbs Online
PO, SQ NSAID (Systemic Drug)
control of postoperative pain
and inflammation associated
with orthopedic surgery,
ovariohysterectomy, and
castration in cats and soft
tissue surgery in dogs.
Contraindicated in patients
with hypersensitivity to it or
known intolerance to NSAIDs
or with GI ulcers. It is also
contraindicated in dogs with
hepatic disease.
It should not be used
concurrently with
corticosteroids or other
NSAIDs.
Stop administration if appetite
decreases or if the cat
becomes lethargic.
Not recommended for use in
pregnant or lactating dogs or
cats.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Selamectin/ Plumbs Online topically Avermectin (Topical)
Revolution Antiparasitic (Systemic Drug)
Treats flea infestations,
heartworm, and ear mites in
dogs and cats.
Can treat sarcoptic mange and
tick infestations in dogs and
hookworms and roundworms
in cats.
Can treat notoedric mange,
nasal mites, and cutaneous
myiasis in dogs, and
cheyletiellosis in dogs. cats
and rabbits.
Use with caution when using
in sick, underweight, or
debilitated dogs or cats.
It is not recommended for
use in dogs under 6 weeks of
age and in cats under 8 weeks
of age.
Use cautiously in breeds such
as collies, whippets, shelties,
and Australian shepherds.
Caution is advised if using
other drugs that can inhibit p-
glycoprotein
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Selegiline/ I- Plumbs Online PO Monoamine Oxidase Contraindicated in patients

deprenyl/ Anipryl/ Inhibitor (Systemic Drug)
Eldepryl Use in dogs for the control of
clinical signs associated with
canine cognitive dysfunction
syndrome and control of
clinical signs associated with
uncomplicated canine
pituitary dependent
hyperadrenocorticism
Useful in treating social or
noise phobias.
May be of use in feline
cognitive dysfunction
syndrome.
receiving meperidine or
tramadol and possibly with
other opioids
Perform appropriate
diagnostic tests to confirm the
diagnosis before starting
therapy
Do not treat
hyperadrenocorticism not of
pituitary origin.
Use with caution in pregnant
dams
Possible interactions with
amitraz, opioids, and other
drugs.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Sevoflurane/ Plumbs Online inhalant Inhalational Contraindicated in patients

SevoFlo/ Ultane Anesthetic (Systemic Drug)
Used in dogs, cats, horses,
small mammals and
ruminants, birds, reptiles, etc.
with a history of malignant
hyperthermia
It should be used with caution
in patients with increased
CSF/ head injury, or renal
insufficiency.
In rabbits, sevoflurane can
cause breath holding and
struggling.
Sevoflurane may have a low
margin of safety in guinea
pigs.

Silymarin, Milk Plumbs Online PO Hepatoprotectant (Systemic Decreased efficacy

Thistle, Silybin/ Drug)
Marin used to treat a variety of liver
diseases in domestic animals
It may be beneficial in
preventing certain cancers
and reducing the negative
effects of chemotherapy
of antiviral drugs is possible.
Silymarin may inhibit
cytochrome P450 isoenzyme
2C9 (CYP2C9). Drugs such
as warfarin, amitriptyline, and
verapamil that have narrow
therapeutic indexes should be
used with caution.
Silymarin may increase the
clearance of drugs that
undergo hepatic
glucuronidation
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Sucralfate/ Carafate Plumbs Online PO GI-mucosal It may cause constipation

Protectant (Systemic Drug)
treatment of oral, esophageal,
gastric, and duodenal ulcers
and to prevent drug-induced
gastric erosions.
Sucralfate may impair the oral
absorption of some
medications such as
Doxycycline, Erythromycin,
Penicillamine, Tetracycline,
and Warfarin, among others.
Shake well before using.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Sufadiazine- Drugs.com PO, SQ in rabbits, Potentiated Sulfonamide Should not be used in dogs or
Trimethoprim/ TMS/ IM in rodents, birds, Antimicrobial (Systemic horses showing marked liver
Co-trimoxazole/ and reptiles, IV in Drug) parenchymal damage, blood
Tribrissen horses Used in many species to treat dyscrasias, or those with a
infections caused by history of sulfonamide
susceptible organisms sensitivity
Not for use in food animals
Contraindicated for
Dobermans
Used with caution in patients
with pre-existing hepatic or
renal disease.
Avoid the use of sulfadiazine
in dogs known to have
uroliths, at increased risk for
developing uroliths or known
to have highly concentrated or
acidic urine.
Use with caution in nursing
dams
Possible interactions with
antacids, cyclosporine, and
other drugs.
Do not let animals become
dehydrated during therapy.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Sulfadimethoxine/ Plumbs Online PO, IV (also IM or Sulfonamide
Albon SC in hedgehogs) Antimicrobial (Systemic
Drug)
Used in dogs and cats for
respiratory, genitourinary,
enteric and soft tissue
infections caused by
susceptible organisms.
It can be used in the treatment
of coccidiosis in dogs
In horses, it is approved for
the treatment of respiratory
infections caused
by Streptococcus equi.
In cattle, it is approved for
treating shipping fever
complex, calf diphtheria,
bacterial pneumonia and foot
rot.
In poultry, it is added to
drinking water to treat
coccidiosis, fowl cholera, and
infectious coryza.
Contraindications(Complicati
ons with disease or
other drugs)
Contraindicated in patients
with severe renal or hepatic
impairment
Use with caution in patients
with diminished renal or
hepatic function or urinary
obstruction.
Contraindicated in
Dobermans
They should be used in
pregnant animals only when
the benefits clearly outweigh
the risks of therapy because
they can cross the placenta.
They can be distributed in the
milk
Antacids: May decrease the
oral bioavailability of
sulfonamides if administered
concurrently.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Tiletamine + Plumbs Online IM, (IV in some Injectable Anesthetic/
Zolazepam/ Telazol species) Tranquilizer (Systemic Drug)
Used for restraint or
anesthesia combined with
muscle relaxation in cats, and
for restraint and minor
procedures of short duration
which require mild to
moderate analgesia in dogs.
Contraindicated in animals
with severe cardiac,
pulmonary or pancreatic
disease.
Avoid Ketamine with head
trauma and KCS patients
It may cause hypothermia
It is contraindicated in rabbits
due to renal toxicity.
Avoid use in large, exotic cats
(contraindicated in tigers) as
it may cause seizures,
permanent neurologic
abnormalities, or death.
Use eye lube as it can cause
dry eyes
Cats do not tolerate ET with
this agent.
Dosages may need to be
reduced in geriatric,
debilitated, or animals with
renal dysfunction.
It crosses the placenta and
may cause respiratory
depression in newborns
Possible interactions with
barbiturates, ketamine, and
other drugs.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Tetracycline Plumbs Online PO (or IM in gerbils) Tetracycline
Antibiotic (Systemic Drug)
Antimicrobial drug
Useful in controlling a variety
of sterile inflammatory skin
conditions in dogs
Theophylline Plumbs Online PO Phosphodiesterase Inhibitor
Bronchodilator (Systemic
Drug)
used primarily for their
bronchodilatory effects
Theophylline could
potentially be of benefit in
dogs with pulmonary artery
hypertension if the underlying
cause COPD.
Contraindications(Complicati
ons with disease or
other drugs)
Because tetracyclines can
retard fetal skeletal
development and discolor
deciduous teeth, they should
only be used in the last half of
pregnancy when the benefits
outweigh the fetal risks.
Tetracycline must be used
cautiously in patients with
renal insufficiency or hepatic
impairment.
contraindicated in patients
who are hypersensitive to any
of the xanthines
Use with caution in patients
with severe cardiac disease,
seizure disorders, gastric
ulcers, hyperthyroidism, renal
or hepatic disease, severe
hypoxia, or severe
hypertension.
Certain drugs can increase or
decrease levels and effects of
the drug
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Tobramycin/ Plumbs Online IV, IM SC Aminoglycoside Used with extreme caution in

Nebcin, TOPI Antibiotic (Systemic Drug)
treat serious gram-negative
infections in most species.
patients with preexisting renal
disease
Other risk factors for the
development of toxicity
include age (both neonatal
and geriatric), fever, sepsis,
and dehydration.
Aminoglycosides should be
used with caution in patients
with neuromuscular disorders
Tobramycin can cross the
placenta and concentrate in
fetal kidneys
There are risks with
cephalosporins and diuretics
among others.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Toceranib Plumbs Online PO Tyrosine Kinase Inhibitor contraindications as breeding,

phosphate/ Palladia Antineoplastic (Systemic
Drug)
Toceranib may prove useful
for treating a variety of tumors
in dogs
Preliminary data suggest that
toceranib may have biological
activity against feline tumors
as well.
pregnant or lactating bitches.
Safe use has not been
evaluated in dogs less than 24
months of age or weighing <5
kg.
Toceranib can cause vascular
dysfunction leading to edema
and thromboembolism, so wait
at least 3 days after stopping
the drug before performing
surgery.
Use with caution with
NSAIDs, Calcitriol, and
CYP3A4 inhibitors

Tramadol hydro- Plumbs Online PO, sometimes IV in Opiate-Like (mu-Receptor)
Chloride/ Ultram horses Agonist (Systemic Drug)
treatment of post-operative or
chronic pain or cough in dogs,
cats and potentially, other
species.
combination product
containing acetaminophen is
contraindicated in cats.
used with caution in animals
with preexisting seizure
disorders
Use with caution in
conjunction with other drugs
that can cause CNS or
respiratory depression
used with caution in geriatric
or severely debilitated animals.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Triamcinolone/ Plumbs Online PO, IM, SQ Glucocorticoid (Systemic Relatively Contraindicated in

Vetalog Drug)
Indicated for the treatment of
inflammation and related
disorders in dogs, cats, and
horses.
Indicated for use in dogs and
cats for the management and
treatment of acute arthritis,
allergic and dermatologic
disorders.
systemic fungal infections
and in viral infections in
animals with arrested
tuberculosis, peptic ulcer,
acute psychoses, corneal
ulcer, & Cushingoid
syndrome.
Relatively contraindicated in
the presence of diabetes,
osteoporosis, chronic
psychotic reactions,
predisposition to
thrombophlebitis,
hypertension, CHF, renal
insufficiency, & active
tuberculosis.
May potentially inhibit the
growth of nursing newborns.
Potential risk for pregnancy
Potential drug interactions
with aspirin, barbiturates,
cyclosporine, and other drugs.
Give orally with food.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Tiamulin/ Denagard Merck Vet Manual PO Diterpine Pleuromutilin
and Plumbs Online Antibiotic (Systemic Drug)
Active against gram-positive
bacteria, mycoplasmas, and
anaerobes,
Treatment of swine dysentery,
pneumonia, and mycoplasmal
arthritis
Can cause weight gain in
swine.
Possible interactions with
monensin and salinomycin;
they can become toxic.
Should not be administered to
animals having access to
feeds containing polyether
ionophores
Shouldnt be used in pigs
over 250 lbs.

Trilostane/ Vetoryl Plumbs Online
PO Adrenal Steroid Synthesis Use with caution in patients
Inhibitor (Systemic Drug) with renal or hepatic
may be useful for treating impairment.
pituitary-dependent Do not use in pregnant dogs.
hyperadrenocorticism (HAC)
or adrenal-dependent HAC in
dogs, feline pituitary-
dependent HAC, and equine
HAC. It is labeled as indicated
for use in dogs for the
treatment of pituitary-
dependent HAC or HAC due
to adrenocortical tumors.
may also be useful in treating
Pomeranians with Alopecia X
and Alaskan malamutes with
adult-onset alopecia
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Tulathromycin/ Plumbs Online IM, SC in goats Injectable Macrolide
Draxxin Antibiotic (Systemic Drug)
treatment of bovine and swine
respiratory disease and of
bovine foot rot and infectious
bovine keratoconjunctivitis
may prove useful as a
treatment of Rhodococcus equi
infections in foals and in
treating various infections in
small ruminants and rabbits.
Ursodiol/ Actigall/ Plumbs Online PO Bile Acid (Systemic Drug)
Ursodeoxycholic acid useful as adjunctive therapy
for the management of
gallbladder mucocele and in
patients with chronic liver
disease
Contraindications(Complicati
ons with disease or
other drugs)
Cattle intended for human
consumption must not be
slaughtered within 18 days
from the last treatment.
Do not use in female dairy
cattle 20 months of age or
older.
Do not use in calves to be
processed for veal.
Swine intended for human
consumption must not be
slaughtered within 5 days from
the last treatment.
contraindicated in rabbits and
other hindgut fermenters
Use with caution with
Aluminum-containing
antacids, Cholestyraine Resin,
and Taurine.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Vasopressin(ADH)/ Plumbs online
Pitressin/ Arginine
Vasopressin/
Antidiuretic hormone
IV, IO, IM, Hormone; Pressor
Agent (Systemic Drug)
used primarily as a diagnostic
agent and for the adjunctive
treatment of shock syndromes
and CPCR
treatmen of diabetes insipidus
in small animals.
used with caution in patients
with vascular disease, seizure
disorders, heart failure, or
asthma.
Alcohol, Epinephrine,
Heparin, and Norepinephrine
may inhibit the antidiuretic
activity.
Antidepressants, Tricyclic,
Carbamazepine,
Chlorpropamide, and
Fludrocortisone may
potentiate the antidiuretic
effects of vasopressin.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Vincristine (Sulfate)/ Plumbs online
Oncovin
IV, PO in horses and Antineoplastic (Systemic
sometimes with dogs. Drug)
A Vinca alkaloid
antineoplastic used for a
variety of tumors in dogs &
cats
Used for the treatment of
immune-mediated
thrombocytopenia.
Used with caution in patients
with hepatic disease,
leukopenia, infection, or
preexisting neuromuscular
disease
Use with caution in herding
breeds
Wear gloves and protective
clothing when working with
this drug.
Be careful if using with
Asparaginase
Caution is advised if using
with other drugs that can
inhibit p-glycoprotein

Vitamin B12/ Plumbs online SQ (IM or SQ for treating deficiencies of No contraindications or drug
Cyanocobalamin horses, cattle, swine vitamin B12 due to GI diseaseinteractions
and sheep) or pancreatic insufficiencies.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Vitamin K1/ Plumbs online PO, SQ and IM in Vitamin/Nutritional Risk of anaphylaxis

Mephyton/ cattle, sheep, goats, (Systemic Drug)
Phytonadione pigs, and horses. IM Fat Soluble Vitamin (Systemic
in birds. Drug),
Treatment of anticoagulant
rodenticide toxicit,
Treatment of dicumarol
toxicity, sulfaquinoxaline
toxicity, and bleeding
disorders associated with
faulty formation of vitamin K-
dependent coagulation factors.
development
Do not give IV
Do not give PO if the animal
has been vomiting or if it has
just been given activated
charcoal.
Use carefully with antibiotics
and mineral oil.
It antagonizes Warfarin.
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Warfarin/ Plumbs online PO Anticoagulant (Systemic Drug) Use with extreme caution
Coumadin in cats.
Used primarily for long-term Warfarin is contraindicated
thromboprophylaxis, in dogs. in patients with preexistent
hemorrhagic tendencies or
diseases, those undergoing
or contemplating eye or
CNS surgery, major
regional lumbar block
anesthesia, or surgery of
large, open surfaces.
It should not be used in
patients with active
bleeding from the GI,
respiratory, or GU tract.
It is contraindicated during
pregnancy.
Many drugs increase or
decrease the anticoagulant
response of Warfarin.
 Drug Reference and Route of Classification/Main Clinical
(Generic or trade page number Administration Use
name)
Xylazine/ Rompun, Plumbs online IV, IM, SQ Alpha2-Adrenergic
AnaSed Agonist (Systemic Drug)
Tranquilizer, Sedative, used for
analgesia, short-term anesthesia
(combined w/ other agents), pre-
anesthetic, induction of vomiting.
Used in horses for effective
analgesia, sedation for procedures
such as hoof trims, dental work,
and palpations. Also, treating colic
pains, castration, or suturing
wounds.
Contraindications(Complicati
ons with disease or
other drugs)
It has large and small
animal versions.
Horses can still kick and
dogs can still bite.
Do not use for animals
receiving epinephrine or
that have active ventricular
arrhythmias.
Extreme caution:
preexisting cardiac
dysfunction, hypotension/
shock, respiratory
dysfunction, severe hepatic
or renal insufficiency,
preexisting seizure
disorders, or if severely
debilitated.
Do not use in cattle in the
last trimester of pregnancy.
Do not give to ruminants
that are debilitated,
dehydrated, or that have a
urinary tract obstruction.
Avoid IA injection.
Caution in patients treated
for intestinal impactions.
Use cautiously in horses in
certain stages of laminitis.
Manufacturers warn
 Drug Reference and Route of Classification/Main Clinical Contraindications(Complicati
(Generic or trade page number Administration Use ons with disease or
name) other drugs)

Yohimbine Plumbs online IV, IM, IP in Alpha2-Adrenergic Antidote for xylazine

Yobine, Antagonil rabbits/rodent Antagonist (Systemic Drug) toxicity
Yohimbine should be used
Antidote for xylazine toxicity cautiously in patients with
(antagonist for xylazine) seizure disorders.
Use with caution
with other alpha2-
adrenergic
antagonists or other drugs
that can cause CNS
stimulation such as
Detomidine in horses.

Zylkene/ Vetoquinol Veterinary Place
PO Food supplement Vomiting and diarrhea are
It is useful for reducing the possible
anxiety felt during stressful
situations (thunderstorms,
visits to the vet, moving, a
new pet)
Give the first dose at least 24
hours before anxiety is
expected

Simparica/ Sarolaner Plumbs Online
PO Ectoparasiticide (Systemic Should not be used in dogs
Drug) younger than 6 months of age
Used for treatment and Not for use in cats.
prevention of flea infestations
and the treatment and control
of tick infestations in dogs.
*************Generic names in bold
 References

Acatak Duostar (Fluazuron / Ivermectin) (n.d.). In Animal Health Direct.

Dichlorophen (n.d.). In National Center for Biotechnology Information. Retrieved November 27, 2016, from PubChem.

Edwards, S. H. (2014, April). Nonsteroidal Anti-inflammatory Drugs. In Merck Veterinay Manual.

Forney, B. (n.d.). MECLOFENAMATE FOR VETERINARY USE. In Wedgewood Pharmacy.

Goodfriend, T. L. (2006, February). AldosteroneA Hormone of Cardiovascular Adaptation and Maladaptation. In Wiley Onilne

Library.

Ipacec (n.d.). In Drugs.com. Retrieved November 26, 2016.

Lactated Ringer's (n.d.). In Drugs.com. Retrieved November 26, 2016.

Merton Boothe, D. (2015, November). Tiamulin Fumarate. In Merck Veterinay Manual.

(n.d.). In Plumb's Veterinary Drugs. Retrieved November, 2016, from https://www.plumbsveterinarydrugs.com/#!/search

Sulfonamides and Trimethoprim (Systemic) (n.d.). In Drugs.com.

Wanamaker, B. P., & Lockett Massey, K. (2015). Applied Pharmacology for Veterinary Technicians (5th ed.). St. Louis, MO: Elsevier.

Zylkene for Dogs (n.d.). In Veterinary Place. Retrieved from from http://www.veterinaryplace.com/dog-medicine/zylkene/

Zylkene. (n.d.). Retrieved from http://www.vetoquinolusa.com/content/zylkene#tab_section_2